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Brain mast cells link the immune system to anxiety-like behavior

Nautiyal, Katherine M., Ribeiro, Ana C., Pfaff, Donald W., Silver, Rae·2008·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0809479105
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Abstract

Mast cells are resident in the brain and contain numerous mediators, including neurotransmitters, cytokines, and chemokines, that are released in response to a variety of natural and pharmacological triggers. The number of mast cells in the brain fluctuates with stress and various behavioral and endocrine states. These properties suggest that mast cells are poised to influence neural systems underlying behavior. Using genetic and pharmacological loss-of-function models we performed a behavioral screen for arousal responses including emotionality, locomotor, and sensory components. We found that mast cell deficient Kit W−sh/W−sh (sash −/− ) mice had a greater anxiety-like phenotype than WT and heterozygote littermate control animals in the open field arena and elevated plus maze. Second, we show that blockade of brain, but not peripheral, mast cell activation increased anxiety-like behavior. Taken together, the data implicate brain mast cells in the modulation of anxiety-like behavior and provide evidence for the behavioral importance of neuroimmune links.

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Metadata

Authors
Nautiyal, K. M., Ribeiro, A. C., Pfaff, D. W., & Silver, R.
Affiliations
  • Department of Psychology, Columbia University, 1190 Amsterdam Avenue, New York, NY 10027;
  • Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021;
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2008-11-18
Volume
105
Issue
46
Pages
18053-18057
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.0809479105
Cited by
167
References
10
Language
en
Licence
www.pnas.org/site/misc/userlicense.xhtml (vor, 174 d)

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