Fiber density between rhinal cortex and activated ventrolateral prefrontal regions predicts episodic memory performance in humans
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The prefrontal cortex (PFC) is assumed to contribute to goal-directed episodic encoding by exerting cognitive control on medial temporal lobe (MTL) memory processes. However, it is thus far unclear to what extent the contribution of PFC-MTL interactions to memory manifests at a structural anatomical level. We combined functional magnetic resonance imaging and fiber tracking based on diffusion tensor imaging in 28 young, healthy adults to quantify the density of white matter tracts between PFC regions that were activated during the encoding period of a verbal free-recall task and MTL subregions. Across the cohort, the strength of fiber bundles linking activated ventrolateral PFC regions and the rhinal cortex (comprising the peri- and entorhinal cortices) of the MTL correlated positively with free-recall performance. These direct white matter connections provide a basis through which activated regions in the PFC can interact with the MTL and contribute to interindividual differences in human episodic memory.
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Diffusion tensor imaging and fMRI studies show strong links between the PFC and medial temporal lobe during episodic encoding.
“Diffusion tensor imaging and functional magnetic resonance imaging (fMRI) studies show strong links between the PFC and medial temporal lobe during episodic encoding (Schott et al., 2011; Schott et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Schott et al., 2011
Brain imaging studies indicate strong links between the PFC and medial temporal lobe during episodic encoding.
“brain imaging studies indicating strong links between the PFC and medial temporal lobe during episodic encoding”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Schott et al., 2011
Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · see citing works
Episodic memory: from mind to brain
Tulving, E. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135114 · Cited by 4,950 · see citing works
Squire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680 · see citing works
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Behrens, T. E. J., Johansen-Berg, H., Woolrich, M. W., Smith, S. M., Wheeler-Kingshott, C. A. M., Boulby, P. A., Barker, G. J., Sillery, E. L., Sheehan, K., Ciccarelli, O., et al. (2003) · Nature Neuroscience · doi:10.1038/nn1075 · Cited by 2,330 · see citing works
Fiber tracking: principles and strategies – a technical review
Mori, S., & van Zijl, P. C. M. (2002) · NMR in Biomedicine · doi:10.1002/nbm.781 · Cited by 2,019 · see citing works
Differential Effects of Early Hippocampal Pathology on Episodic and Semantic Memory
Vargha-Khadem, F., Gadian, D. G., Watkins, K. E., Connelly, A., Van Paesschen, W., & Mishkin, M. (1997) · Science · doi:10.1126/science.277.5324.376 · Cited by 1,746 · see citing works
Building Memories: Remembering and Forgetting of Verbal Experiences as Predicted by Brain Activity
Wagner, A. D., Schacter, D. L., Rotte, M., Koutstaal, W., Maril, A., Dale, A. M., Rosen, B. R., & Buckner, R. L. (1998) · Science · doi:10.1126/science.281.5380.1188 · Cited by 1,620 · see citing works
Perirhinal and parahippocampal cortices of the macaque monkey: Cortical afferents
Suzuki, W., & Amaral, D. G. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500402 · Cited by 1,134 · see citing works
Neuropsychological studies of the frontal lobes.
Stuss, D. T., & Benson, D. F. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.95.1.3 · Cited by 1,073 · see citing works
Observing the transformation of experience into memory
Paller, K. A., & Wagner, A. D. (2002) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01845-3 · Cited by 852 · see citing works
The entorhinal cortex of the monkey: II. Cortical afferents
Insausti, R., Amaral, D. G., & Cowan, W. M. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902640306 · Cited by 835 · see citing works
Goldman‐Rakic, P. S., Selemon, L. D., & Schwartz, M. L. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90166-0 · Cited by 782 · see citing works
Source memory impairment in patients with frontal lobe lesions.
Janowsky, J., Shimamura, A., & Squire, L. (1989) · Neuropsychologia · doi:10.1016/0028-3932(89)90184-x · Cited by 687 · see citing works
Blumenfeld, R., & Ranganath, C. (2007) · The Neuroscientist · doi:10.1177/1073858407299290 · Cited by 634 · see citing works
Anatomical organization of the parahippocampal-hippocampal network
WITTER, M. P., WOUTERLOOD, F. G., NABER, P. A., & VAN HAEFTEN, T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06716.x · Cited by 567 · see citing works
Frontal lobes and the temporal organization of memory.
Milner, B. A., Petrides, M., & Ml, S. (1985) · PubMed · Cited by 458 · see citing works
Functional neuroanatomy of the parahippocampal region: The lateral and medial entorhinal areas
Kerr, K. M., Agster, K. L., Furtak, S. C., & Burwell, R. D. (2007) · Hippocampus · doi:10.1002/hipo.20315 · Cited by 433 · see citing works
Otten, L. J. (2001) · Brain · doi:10.1093/brain/124.2.399 · Cited by 412 · see citing works
Impaired use of organizational strategies in free recall following frontal lobe damage
Gershberg, F. B. (1995) · Neuropsychologia · doi:10.1016/0028-3932(95)00103-a · Cited by 376 · see citing works
Frontal lobe damage produces episodic memory impairment
Wheeler, M., Stuss, D., & Tulving, E. (1995) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700000655 · Cited by 362 · see citing works
DTI mapping of human brain connectivity: Statistical fibre tracking and virtual dissection
Hagmann, P., Thiran, J.-P., Jonasson, L., Vandergheynst, P., Clarke, S., Maeder, P., & Meuli, R. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00142-3 · Cited by 326 · see citing works
The neural basis of episodic memory: evidence from functional neuroimaging
Rugg, M. D., Otten, L. J., & Henson, R. N. A. (2002) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1102 · Cited by 326 · see citing works
Frontal Lobes, Memory, and Aging
Moscovitch, M., & Winocur, G. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb38135.x · Cited by 319 · see citing works
Pruessner, J. C. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.12.1342 · Cited by 297 · see citing works
Vascular Factors in Cognitive Impairment‐Where Are We Now?
Hachinski, V., & Muñoz, D. G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06343.x · Cited by 296 · see citing works
Organizational strategies with unilateral or bilateral frontal lobe injury in word learning tasks.
Stuss, D. T., ALEXANDER, M. P., Palumbo, C. L., Buckle, L., Sayer, L., & Pogue, J. (1994) · Neuropsychology · doi:10.1037/0894-4105.8.3.355 · Cited by 261 · see citing works
Strategic search and retrieval inhibition: The role of the frontal lobes
della Rocchetta, A. I., & Milner, B. A. (1993) · Neuropsychologia · doi:10.1016/0028-3932(93)90049-6 · Cited by 260 · see citing works
Schott, B. H., Seidenbecher, C. I., Fenker, D. B., Lauer, C. J., Bunzeck, N., Bernstein, H.-G., Tischmeyer, W., Gundelfinger, E. D., Heinze, H.-J., & Düzel, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3463-05.2006 · Cited by 214 · see citing works
Self-citationEichenbaum, H., & Lipton, P. A. (2008) · Hippocampus · doi:10.1002/hipo.20500 · Cited by 209 · see citing works
The frontal cortex and memory for temporal order
McAndrews, M. P., & Milner, B. A. (1991) · Neuropsychologia · doi:10.1016/0028-3932(91)90051-9 · Cited by 195 · see citing works
Davachi, L., Maril, A., & Wagner, A. D. (2001) · Journal of Cognitive Neuroscience · doi:10.1162/089892901753294356 · Cited by 194 · see citing works
Diehl, B., Busch, R. M., Duncan, J. S., Piao, Z. H., Tkach, J. A., & Lüders, H. O. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01596.x · Cited by 192 · see citing works
A study of rotationally invariant and symmetric indices of diffusion anisotropy
Papadakis, N. G., Xing, D., Houston, G. C., Smith, J. M., Smith, M. I., James, M. F., Parsons, A. A., Huang, C. L.-H., Hall, L. D., & Carpenter, T. A. (1999) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(99)00029-6 · Cited by 179 · see citing works
Riley, J. D., Franklin, D. L., Choi, V., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2009.02508.x · Cited by 176 · see citing works
White Matter Integrity and Cognitive Impairment in First-Episode Psychosis
Pérez‐Iglesias, R., Tordesillas‐Gutiérrez, D., McGuire, P. K., Barker, G. J., Roiz‐Santiáñez, R., Mata, I. F., de Lucas, E. M., Rodríguez-Sánchez, J. M., Ayesa‐Arriola, R., Vázquez‐Barquero, J. L., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09050716 · Cited by 148 · see citing works
Neural correlates of verbal memory encoding during semantic and structural processing tasks
Baker, J. T., Sanders, A. L., Maccotta, L., & Buckner, R. L. (2001) · Neuroreport · doi:10.1097/00001756-200105080-00039 · Cited by 120 · see citing works
Cognitive neuroscience of episodic memory encoding
Buckner, R. L., Logan, J., Donaldson, D. I., & Wheeler, M. E. (2000) · Acta Psychologica · doi:10.1016/s0001-6918(00)00057-3 · Cited by 112 · see citing works
Cohen, M. X., Elger, C. E., & Weber, B. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.004 · Cited by 106 · see citing works
Memory strategies with brain damage
Hirst, W. C., & Volpe, B. T. (1988) · Brain and Cognition · doi:10.1016/0278-2626(88)90060-7 · Cited by 105 · see citing works
Fletcher, P. C., Stephenson, C., Carpenter, T. A., Donovan, T., & Bullmore, E. T. (2003) · Cortex · doi:10.1016/s0010-9452(08)70875-x · Cited by 97 · see citing works
Classification and Recall of Pictures After Unilateral Frontal or Temporal Lobectomy
della Rocchetta, A. I. (1986) · Cortex · doi:10.1016/s0010-9452(86)80045-4 · Cited by 92 · see citing works
Topographical and laminar distribution of cortical input to the monkey entorhinal cortex
Mohedano‐Moriano, A., Pró-Sistiaga, P., Jiménez, M. D. M. A., Artacho‐Pérula, E., Serrano, A. M. I., Marcos, P., Cebada‐Sánchez, S., Martínez‐Ruiz, J., Muñoz, M., Blaizot, X., et al. (2007) · Journal of Anatomy · doi:10.1111/j.1469-7580.2007.00764.x · Cited by 82 · see citing works
Is prefrontal cortex involved in cued recall? A neuropsychological test of PET findings
Diane Swick, A., & Knight, R. T. (1996) · Neuropsychologia · doi:10.1016/0028-3932(96)00011-5 · Cited by 79 · see citing works
Development and organization of ocular dominance bands in primary visual cortex of the sable ferret
Ruthazer, E. S., Baker, G. E., & Stryker, M. P. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990503)407:2 · Cited by 46 · see citing works
Associative Learning Impairments in Patients with Frontal Lobe Damage
Dimitrov, M., Granetz, J., Peterson, M., Hollnagel, C., Alexander, G. E., & Grafman, J. H. (1999) · Brain and Cognition · doi:10.1006/brcg.1999.1121 · Cited by 38 · see citing works
Fuentemilla, L., Càmara, E., Münte, T. F., Krämer, U. M., Toni Cunillera, B., Marco‐Pallarés, J., Tempelmann, C., & Rodríguez‐Fornells, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5270-08.2009 · Cited by 36 · see citing works
Takahashi, E., Ohki, K., & Kim, D. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm204 · Cited by 31 · see citing works
The Time Course of Ventrolateral Prefrontal Cortex Involvement in Memory Formation
Machizawa, M. G., Kalla, R., Walsh, V., et al. (2010) · Journal of Neurophysiology · doi:10.1152/jn.90937.2008 · Cited by 27 · see citing works
A close relationship between verbal memory and SN/VTA integrity in young and older adults
Düzel, S., Schütze, H., Stallforth, S., Kaufmann, J., Bodammer, N., Bunzeck, N., Münte, T. F., Lindenberger, U., Heinze, H., & Düzel, E. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.06.001 · Cited by 27 · see citing works
Self-citationBodammer, N., Kaufmann, J., Kanowski, M., & Tempelmann, C. (2009) · Physics in Medicine and Biology · doi:10.1088/0031-9155/54/4/013 · Cited by 13 · see citing works
Self-citationCortico-hippocampal communication by way of parallel parahippocampal-subicular pathways.
Lavenex (2000) · Pure Amsterdam UMC · doi:10.1002/1098-1063(2000)10:4 · Cited by 1 · see citing works
Episodic memory, semantic memory, and amnesia
Squire, L. R., & Zola, S. M. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1998)8:3
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- Authors
- Schott, B. H., Niklas, C., Kaufmann, J., Bodammer, N. C., Machts, J., Schütze, H., & Düzel, E.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Department of Neurology,
- Max Planck Institute for Human Development (DE)
- University Hospital Magdeburg (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-03-14
- Volume
- 108
- Issue
- 13
- Pages
- 5408-5413
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3069158
- OpenAlex
- W2081980063
- Cited by
- 44
- References
- 52
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 5
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- DZNE Pub (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- episodic memory, ventrolateral prefrontal cortex, rhinal cortex, free recall, individual differences, diffusion tensor imaging, tractography
- MeSH terms
- Adult, Behavior, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Mental Recall, Temporal Lobe, Prefrontal Cortex, Young Adult, Diffusion Tensor Imaging
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