The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism
Open accessAbstract
Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non-cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory processes that determine microglial actions in pathological states. We examined the role of glucocorticoid receptors (GRs), activated by glucocorticoids released in response to stress and known to regulate inflammation, in DN survival. Overall GR level was decreased in substantia nigra of PD patients and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. GR changes, specifically in the microglia after MPTP treatment, revealed a rapid augmentation in the number of microglia displaying nuclear localization of GR. Mice with selective inactivation of the GR gene in macrophages/microglia (GR(LysMCre)) but not in DNs (GR(DATCre)) showed increased loss of DNs after MPTP intoxication. This DN loss in GR(LysMCre) mice was not prevented by corticosterone treatment, in contrast to the protection observed in control littermates. Moreover, absence of microglial GRs augmented microglial reactivity and led to their persistent activation. Analysis of inflammatory genes revealed an up-regulation of Toll-like receptors (TLRs) by MPTP treatment, particularly TLR9, the level of which was high in postmortem parkinsonian brains. The regulatory control of GR was reflected by higher expression of proinflammatory genes (e.g., TNF-α) with a concomitant decrease in anti-inflammatory genes (e.g., IL-1R2) in GR(LysMCre) mice. Indeed, in GR(LysMCre) mice, alterations in phosphorylated NF-κB levels indicated its protracted activation. Together, our data indicate that GR is important in curtailing microglial reactivity, and its deregulation in PD could lead to sustained inflammation-mediated DN injury.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“TLR9 was found to be overexpressed in the substantia nigra and putamen of PD patients and in striatum of a PD mouse model,316”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [316]
In the citing paper
“Upon MPTP intoxication (115) or intra-striatal injection of LPS (116), this strain exhibited greater neuronal loss, microglia reactivity, and expression of pro-inflammatory genes than age-matched controls.”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [115]
Citations
Cites
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Neuroinflammation in Parkinson’s disease: A target for neuroprotection?
Hirsch, E. C., & Hunot, S. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70062-6 · Cited by 1,984
Self-citationControl of microglial neurotoxicity by the fractalkine receptor
Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531
Shaping the nuclear action of NF-κB
Chen, L., & Greene, W. C. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1368 · Cited by 1,248
Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046 · cited 2×
“However, by day 7, this activation had declined (in mutants and controls), an observation in accordance with past studies (22).”
BackgroundResultSaijo, K., Winner, B., Carson, C. T., Collier, J. G., Boyer, L., Rosenfeld, M. G., Gage, F. H., & Glass, C. K. (2009) · Cell · doi:10.1016/j.cell.2009.01.038 · Cited by 957
Microglial activation and dopamine terminal loss in early Parkinson's disease
Ouchi, Y., Yoshikawa, E., Sekine, Y., Futatsubashi, M., Kanno, T., Ogusu, T., & Torizuka, T. (2005) · Annals of Neurology · doi:10.1002/ana.20338 · Cited by 869
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647
Cited by
Sorted by citations
Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668
Microglia and neurodegeneration: The role of systemic inflammation
Cunningham, C. (2013) · Glia · doi:10.1002/glia.22350 · Cited by 769
Neuroinflammation in Parkinson's disease
Hirsch, E. C., Vyas, S., & Hunot, S. (2012) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70065-7 · Cited by 657
Self-citationNeurotoxin-based models of Parkinson's disease
Bové, J., & Perier, C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.057 · Cited by 534
Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
Jellinger, K. A. (2011) · Movement Disorders · doi:10.1002/mds.23795 · Cited by 480
The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain
Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419
Pathogenesis of Parkinson's disease
Hirsch, E. C., Jenner, P., & Przedborski, S. (2013) · Movement Disorders · doi:10.1002/mds.25032 · Cited by 336
Niranjan, R. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8483-x · Cited by 338
Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration
Vyas, S., Rodrigues, A. J., Silva, J. M., Tronche, F., Almeida, O. F. X., Sousa, N., & Sotiropoulos, I. (2016) · Neural Plasticity · doi:10.1155/2016/6391686 · Cited by 297
Self-citationRole of Microglia TLRs in Neurodegeneration
Fiebich, B. L., Batista, C. R. A., Saliba, S. W., Yousif, N. M., & de Oliveira, A. C. P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00329 · Cited by 291
Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization
Howes, O. D., & McCutcheon, R. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.278 · Cited by 288
The role of Toll-like receptors and neuroinflammation in Parkinson’s disease
Heidari, A., Yazdanpanah, N., & Rezaei, N. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02496-w · Cited by 275
Neurodegeneration and Inflammation in Parkinson's disease
Phani, S., Loike, J. D., & Przedborski, S. (2012) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70064-5 · Cited by 263
Stress, depression and Parkinson's disease
Hemmerle, A. M., Herman, J. P., & Seroogy, K. B. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.035 · Cited by 225
Du, X., & Pang, T. Y. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00032 · Cited by 221
Glia and alpha-synuclein in neurodegeneration: A complex interaction
Brück, D., Wenning, G. K., Stefanova, N., & Fellner, L. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.003 · Cited by 213
de Pablos, R. M., Herrera, A. J., Espinosa-Oliva, A. M., Sarmiento, M., Muñoz, M. F., Machado, A., & Venero, J. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-34 · Cited by 201
Inflammation in Parkinson's Disease
Tüfekçi, K. U., Meuwissen, R. L. J., Genç, Ş., & Genç, K. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-398314-5.00004-0 · Cited by 205
Ten Unsolved Questions About Neuroinflammation in Parkinson's Disease
Hirsch, É. C., & Standaert, D. G. (2020) · Movement Disorders · doi:10.1002/mds.28075 · Cited by 196
Picca, A., Guerra, F., Calvani, R., Romano, R., Coelho-Júnior, H. J., Bucci, C., & Marzetti, E. (2021) · Biomolecules · doi:10.3390/biom11101508 · Cited by 189
Reduced T helper and B lymphocytes in Parkinson's disease
Stevens, C. H., Rowe, D. B., Morel‐Kopp, M., Orr, C., Russell, T., Ranola, M., Wård, C., & Halliday, G. M. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.07.015 · Cited by 200
Krashia, P., Cordella, A., Nobili, A., La Barbera, L., Federici, M., Leuti, A., Campanelli, F., Natale, G., Marino, G., Calabrese, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11928-w · Cited by 188
Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior
Svensson, M., Lexell, J. E., & Deierborg, T. (2014) · Neurorehabilitation and neural repair · doi:10.1177/1545968314562108 · Cited by 202
Hypothalamic‐Pituitary‐Adrenal (HPA) Axis and Aging
Gupta, D., & Morley, J. E. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130049 · Cited by 210
Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles
Vanpouille-Box, C., Hoffmann, J. A., & Galluzzi, L. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0043-2 · Cited by 183
Depression as a Glial-Based Synaptic Dysfunction
Rial, D., Lemos, C., Pinheiro, H., Duarte, J. M., Gonçalves, F. Q., Real, J. I., Prediger, R. D., Gonçalves, N., Gomes, C. A., Canas, P. M., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00521 · Cited by 193
Chronic stress as a risk factor for Alzheimer’s disease
Machado, A., Herrera, A. J., de Pablos, R. M., Espinosa‐Oliva, A. M., Soto, M. S., Ayala, A., Venero, J. L., Santiago, M., Villarán, R. F., Delgado‐Cortés, M. J., et al. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0035 · Cited by 187
Inflammation in Parkinson’s disease: role of glucocorticoids
Herrero, M.-T., Estrada, C., Maatouk, L., & Vyas, S. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00032 · Cited by 175
“In vivo, Serine 276 phosphorylation of P65 subunit of NF-κB, indicative of its activation, was sustained in MPTP-lesioned SNpc and striatum of mutant GR microglial mice (Ros-Bernal et al., 2011).”
InfluentialSelf-citation3‐hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis
LeWitt, P. A., Li, J., Lü, M., Beach, T. G., Adler, C. H., & Guo, L. (2013) · Movement Disorders · doi:10.1002/mds.25555 · Cited by 171
Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
Noelker, C., Morel, L., Lescot, T., Osterloh, A., Alvarez-Fischer, D., Breloer, M., Henze, C., Depboylu, C., Skrzydelski, D., Michel, P. P., et al. (2013) · Scientific Reports · doi:10.1038/srep01393 · Cited by 164
Self-citationGlial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
Fellner, L., Jellinger, K. A., Wenning, G. K., & Stefanova, N. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0833-z · Cited by 162
Liao, J.-F., Cheng, Y.-F., You, S.-T., Kuo, W.-C., Huang, C.-W., Chiou, J.-J., Hsu, C.-C., Hsieh-Li, H.-M., Wang, S., & Tsai, Y.-C. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.07.036 · Cited by 159
Drouin-Ouellet, J., St-Amour, I., Saint-Pierre, M., Lamontagne-Proulx, J., Kriz, J., Barker, R. A., & Cicchetti, F. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu103 · Cited by 153
Bogie, J. F. J., Grajchen, E., Wouters, E., Corrales, A. G., Dierckx, T., Vanherle, S., Mailleux, J., Gervois, P., Wolfs, E., Dehairs, J., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191660 · Cited by 151
Regulation of microglia activation and deactivation by nuclear receptors
Saijo, K., Crotti, A., & Glass, C. K. (2012) · Glia · doi:10.1002/glia.22423 · Cited by 154
Chantong, B., Kratschmar, D. V., Nashev, L. G., Balázs, Z., & Odermatt, A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-260 · Cited by 152
Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies
Kouli, A., Horne, C. B., & Williams-Gray, C. H. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.042 · Cited by 143
Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor
Escoter-Torres, L., Caratti, G., Mechtidou, A., Tuckermann, J. P., Uhlenhaut, N. H., & Vettorazzi, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01859 · Cited by 156
Neuronal autophagy and mitophagy in Parkinson's disease
Lizama, B. N., & Chu, C. T. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100972 · Cited by 152
Campolo, M., Paterniti, I., Siracusa, R., Filippone, A., Esposito, E., & Cuzzocrea, S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.12.003 · Cited by 143
Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients
Fernández‐Santiago, R., Carballo‐Carbajal, I., Castellano, G., Torrent, R., Richaud, Y., Sánchez‐Danés, A., Vilarrasa‐Blasi, R., Sánchez‐Pla, Á., Mosquera, J. L., Soriano, J., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505439 · Cited by 138
LC–MS-Based Urinary Metabolite Signatures in Idiopathic Parkinson’s Disease
Luan, H., Liu, L., Meng, N., Tang, Z., Chua, K.-K., Chen, L., Song, J., Mok, V., Xie, L.-X., Li, M., et al. (2014) · Journal of Proteome Research · doi:10.1021/pr500807t · Cited by 134
Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad
Bekhbat, M., Rowson, S. A., & Neigh, G. N. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.05.001 · Cited by 142
Cao, Q., Shen, M., Li, R., Liu, Y., Zeng, Z., Zhou, J., Niu, D., Zhang, Q., Wang, R., Yao, J., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03454-y · Cited by 138
Park, G., Kim, H. G., Ju, M. S., Ha, S. K., Park, Y., Kim, S. Y., & Oh, M. S. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.57 · Cited by 119
Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions
Squillace, S., & Salvemini, D. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.05.004 · Cited by 117
Parkinson's disease in the nuclear age of neuroinflammation
Nolan, Y. M., Sullivan, A. M., & Toulouse, A. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.003 · Cited by 119
Yang, Y.-L., Cheng, X., Li, W.-H., Liu, M., Wang, Y.-H., & Du, G.-H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030491 · Cited by 116
Carrillo-de Sauvage, M. Á., Maatouk, L., Arnoux, I., Pasco, M., Sanz Diez, A., Delahaye, M., Herrero, M. T., Newman, T. A., Calvo, C. F., Audinat, E., et al. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.108 · Cited by 114
Self-citationProtective Microglia and Their Regulation in Parkinson’s Disease
Le, W., Wu, J., & Tang, Y. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00089 · Cited by 123
Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer’s Disease
Naseer, M. I., Bibi, F., Al-Qahtani, M. H., Chaudhary, A., Azhar, E. I., Kamal, M. A., & Yasir, M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660147 · Cited by 109
Atallah, A., Mhaouty‐Kodja, S., & Grange‐Messent, V. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16683961 · Cited by 105
Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson’s disease
Hallett, P. J., Engelender, S., & Ole Isacson, A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1532-2 · Cited by 105
Lin, H.-Y., Huang, B.-R., Yeh, W., Lee, C., Huang, S.-S., Lai, C., Lin, H., & Lu, D. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.020 · Cited by 99
Glucocorticoid impairs mitochondrial quality control in neurons
Choi, G. E., & Han, H. J. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105301 · Cited by 95
Maatouk, L., Compagnion, A.-C., Sauvage, M.-A. C.-D., Bemelmans, A.-P., Leclere-Turbant, S., Cirotteau, V., Tohme, M., Beke, A., Trichet, M., Bazin, V., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04569-y · Cited by 95
Self-citationToward an immune-mediated subtype of autism spectrum disorder
McDougle, C. J., Landino, S. M., Vahabzadeh, A., O’Rourke, J., Zurcher, N. R., Finger, B. C., Palumbo, M. L., Helt, J., Mullett, J. E., Hooker, J. M., et al. (2015) · Brain Research · doi:10.1016/j.brainres.2014.09.048 · Cited by 95
Molecular changes in the postmortem parkinsonian brain
Toulorge, D., Schapira, A. H. V., & Hajj, R. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13696 · Cited by 95
Rocha, S., Freitas, A., Guimarães, S., Vitorino, R. M. P., Aroso, M., & Gómez-Lázaro, M. (2017) · Antioxidants · doi:10.3390/antiox7010001 · Cited by 93
Fang, X. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1096271 · Cited by 84
Hu, W., Zhang, Y., Wu, W., Yin, Y., Huang, D., Wang, Y., Li, W., & Li, W. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.019 · Cited by 83
TRP Channels Role in Pain Associated With Neurodegenerative Diseases
Duitama, M., Vargas-López, V., Casas, Z., Albarracín, S. L., Sutachan, J. J., & Torres, Y. P. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00782 · Cited by 80
Relationship Between Obesity, Alzheimer’s Disease, and Parkinson’s Disease: an Astrocentric View
Martín-Jiménez, C., Gaitán-Vaca, D. M., Echeverría, V., González, J., & Barreto, G. E. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0193-8 · Cited by 80
Sugama, S., & Kakinuma, Y. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100111 · Cited by 80
Picard, K., St‐Pierre, M., Vecchiarelli, H. A., Bordeleau, M., & Tremblay, M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.104987 · Cited by 79
The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
Alexaki, V. I. (2021) · Cells · doi:10.3390/cells10071584 · Cited by 84
Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
Shan, C., Ghosh, A., Guo, X., Wang, S., Hou, Y., Li, S., & Liu, J. (2019) · Molecular Brain · doi:10.1186/s13041-019-0444-5 · Cited by 78
Inflammation and neurodegeneration: the story ‘retolled’
Drouin‐Ouellet, J., & Cicchetti, F. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.07.002 · Cited by 71
Maatouk, L., Yi, C., Sauvage, M.-A. C.-D., Compagnion, A., Hunot, S., Ezan, P., Hirsch, É. C., Koulakoff, A., Pfrieger, F. W., Tronche, F., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0150-3 · Cited by 72
Self-citationGibson, C. J., Hossain, M. M., Richardson, J. R., & Aleksunes, L. M. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.196543 · Cited by 68
Giacoppo, S., Rajan, T. S., Nicola, G. R. D., Iori, R., Rollin, P., Bramanti, P., & Mazzon, E. (2016) · Rejuvenation Research · doi:10.1089/rej.2016.1828 · Cited by 71
Srivastava, G., Dixit, A., Yadav, S., Patel, D. K., Prakash, O., & Singh, M. P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.005 · Cited by 65
Bel, E. A. D., Bortolanza, M., Pereira, M. D. S., Bariotto‐dos‐Santos, K., & Raisman‐Vozari, R. (2016) · Synapse · doi:10.1002/syn.21941 · Cited by 67
Takahashi, K., Nakagawasai, O., Nemoto, W., Kadota, S., Isono, J., Odaira, T., Sakuma, W., Arai, Y., Tadano, T., & Tan–No, K. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.013 · Cited by 64
Shin, W.-H., Jeon, M., Leem, E., Won, S.-Y., Jeong, K. H., Park, S., McLean, C., Lee, S. J., Jin, B. K., Jung, U. J., et al. (2015) · Scientific Reports · doi:10.1038/srep14764 · Cited by 65
Post-traumatic Stress Disorder and Risk of Parkinson Disease: A Nationwide Longitudinal Study
Chan, Y. E., Bai, Y., Hsu, J.-W., Huang, K., Su, T., Li, C., Lin, W.-C., Pan, T., Chen, T., Tsai, S., et al. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.03.012 · Cited by 61
Wang, X., Chi, J., Huang, D., Ding, L., Zhao, X., Jiang, L., Yu, Y., & Gao, F. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8297 · Cited by 61
The neuroendocrine control of the innate immune system in health and brain diseases
Bellavance, M., & Rivest, S. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01129.x · Cited by 61
Impact of aging immune system on neurodegeneration and potential immunotherapies
Liang, Z., Zhao, Y., Ruan, L., Zhu, L., Jin, K., Zhuge, Q., Su, D., & Zhao, Y. L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.07.006 · Cited by 64
Rietdijk, C. D., Wezel, R. J. A. V., Garssen, J., & Kraneveld, A. D. (2016) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2015.28 · Cited by 59
Microglial Responses to Brain Injury and Disease: Functional Diversity and New Opportunities
Lyu, J., Jiang, X., Leak, R. K., Shi, Y., Hu, X., & Chen, J. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00857-2 · Cited by 63
Effects of Paeonol on Anti-Neuroinflammatory Responses in Microglial Cells
Lin, C., Lin, H.-Y., Chen, J.-H., Tseng, W., Ko, P.-Y., Liu, Y.-S., Yeh, W., & Lu, D. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16048844 · Cited by 58
Yao, N., Wu, Y., Zhou, Y., Ju, L., Liu, Y., Ju, R., Duan, D., & Xu, Q. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.032 · Cited by 56
Corticosteroids limit microglial activation occurring during acute stress
Sugama, S., Takenouchi, T., Fujita, M., Kitani, H., Conti, B., & Hashimoto, M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.012 · Cited by 54
Extracellular Vesicles and the Stress System
Makrygianni, E. A., & Chrousos, G. P. (2022) · Neuroendocrinology · doi:10.1159/000527182 · Cited by 59
Sun, X., Ren, X., Chen, L., Gao, X.-Q., Xie, J., & Chen, W. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.09.040 · Cited by 53
Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy
Hunt, J. B., Nash, K. R., Placides, D. S., Moran, P., Selenica, M. B., Abuqalbeen, F., Ratnasamy, K., Slouha, N., Ospina, S. R., Savlia, M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3959-14.2015 · Cited by 57
Li, N., Liu, B.-W., Ren, W., Liu, J., Li, S., Fu, S., Zeng, Y., Xu, S. S., Yan, X., Gao, Y., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020190 · Cited by 52
TLR-Mediated Signal Transduction and Neurodegenerative Disorders
Adhikarla, S. V., Jha, N. K., Goswami, V. K., Sharma, A., Bhardwaj, A., Dey, A., Villa, C., Kumar, Y., & Jha, S. K. (2021) · Brain Sciences · doi:10.3390/brainsci11111373 · Cited by 50
Guo, X., Shan, C., Hou, Y., Zhu, G., Tao, B., Sun, L., Zhao, H., Ning, G., Li, S., & Liu, J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00343 · Cited by 50
Glucocorticoid receptor signaling in the brain and its involvement in cognitive function
Su, C., Huang, T., Zhang, M., Zhang, Y., Zeng, Y., & Chen, X. Y. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00355 · Cited by 52
Malikowska‐Racia, N., & Sałat, K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.001 · Cited by 50
Cell type specificity of glucocorticoid signaling in the adult mouse hippocampus
Viho, E. M. G., Buurstede, J. C., Berkhout, J. B., Mahfouz, A. E., & Meijer, O. C. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13072 · Cited by 47
Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation
Sorrells, S. F., Caso, J. R., Munhoz, C. D., Hu, C. K., Tran, K. V., Miguel, Z. D., Chien, B. Y., & Sapolsky, R. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4705-12.2013 · Cited by 46
Vitamin D and Parkinson's disease
Lương, K. V. Q., & Nguyễn, L. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23115 · Cited by 46
Neuroinflammation and Mitochondrial Dysfunction Link Social Stress to Depression
Hollis, F., Pope, B. S., Gorman‐Sandler, E., & Wood, S. K. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_300 · Cited by 47
Brain Physiology and Pathophysiology in Mental Stress
Alkadhi, K. A. (2013) · ISRN Physiology · doi:10.1155/2013/806104 · Cited by 48
Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice
Gao, L., Brenner, D., Llorens-Bobadilla, E., Saiz-Castro, G., Frank, T., Wieghofer, P., Hill, O., Thiemann, M., Karray, S., Prinz, M., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20132423 · Cited by 42
Relevance of chronic stress and the two faces of microglia in Parkinson's disease
Herrera, A. J., Espinosa-Oliva, A. M., Carrillo-Jiménez, A., Oliva-Martín, M. J., García-Revilla, J., García-Quintanilla, A., de Pablos, R. M., & Venero, J. L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00312 · Cited by 42
Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia
Kato, T. A., Hayakawa, K., Monji, A., & Kanba, S. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00053 · Cited by 43
Metadata
- Authors
- Ros-Bernal, F., Hunot, S., Herrero, M. T., Parnadeau, S., Corvol, J.-C., Lu, L., Alvarez-Fischer, D., Carrillo-de Sauvage, M. A., Saurini, F., Coussieu, C., Kinugawa, K., Prigent, A., Höglinger, G., Hamon, M., Tronche, F., Hirsch, E. C., & Vyas, S.
- Affiliations
- Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 7224, F-75005 Paris, France;
- Centre National de la Recherche Scientifique (FR)
- Clinical and Experimental Neuroscience, Centro de Investigación Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED), School of Medicine, University of Murcia, 30100 Murcia, Spain;
- Université Pierre et Marie Curie–Paris 06, F-75252 Paris Cedex 5, France;
- Inserm (FR)
- Pitié-Salpêtrière Hospital (FR)
- Philipps University of Marburg (DE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-04-05
- Volume
- 108
- Issue
- 16
- Pages
- 6632-6637
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3080980
- OpenAlex
- W2045465918
- Cited by
- 231
- References
- 33
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 20 · 2023: 7 · 2022: 11 · 2021: 22 · 2020: 10 · 2019: 17 · 2018: 14 · 2017: 15 · 2016: 17 · 2015: 20 · 2014: 16 · 2013: 16 · 2012: 21
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Fondation de France
- Centre National de la Recherche Scientifique
- Ministerio de Ciencia e Innovación
- Université Pierre et Marie Curie
- Association France Parkinson
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- glucocorticoid receptor, microglia, dopaminergic neuron loss, Parkinson's disease, MPTP-induced neurotoxicity, neuroinflammation, substantia nigra, TLR9, NF-κB signaling, corticosterone, microglial activation, TNF-α, IL1R2, non-cell autonomous neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Animals, Cell Nucleus, Female, Humans, Inflammation, Male, Mice, Transgenic, Parkinson Disease, Receptors, Glucocorticoid, Substantia Nigra, Up-Regulation, Microglia, MPTP Poisoning, Toll-Like Receptors, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
