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Oxytocin receptor gene ( OXTR ) is related to psychological resources
Open accessAbstract
Psychological resources--optimism, mastery, and self-esteem--buffer the deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largely mediated by the influence of OXTR on psychological resources.
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“and have lower levels of optimism, mastery, and self-esteem (Saphire-Bernstein et al., 2011)”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Saphire-Bernstein et al., 2011
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- 10.1037/0022-3514.67.6.1063 · DOI · Paper page
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“, 2015), and have lower levels of optimism, mastery, and self-esteem (Saphire-Bernstein et al., 2011), whereas reduced positive affect (Lucht et al.”
BackgroundSensitive Parenting Is Associated with Plasma Oxytocin and Polymorphisms in the OXTR and CD38 Genes
Feldman, R., Zagoory-Sharon, O., Weisman, O., Schneiderman, I., Gordon, I., Maoz, R., Shalev, I., & Ebstein, R. P. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.025 · Cited by 393
Metadata
- Authors
- Saphire-Bernstein, S., Way, B. M., Kim, H. S., Sherman, D. K., & Taylor, S. E.
- Affiliations
- University of California, Los Angeles (US)
- The Ohio State University (US)
- University of California, Santa Barbara (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-08-31
- Volume
- 108
- Issue
- 37
- Pages
- 15118-15122
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3174632
- OpenAlex
- W2109332215
- Cited by
- 262
- References
- 59
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 7 · 2022: 13 · 2021: 18 · 2020: 27 · 2019: 16 · 2018: 17 · 2017: 20 · 2016: 20 · 2015: 31 · 2014: 25 · 2013: 23 · 2012: 18
- FWCI
- 30.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0729532)
- National Institute on Aging (AG 030309, R01AG030309)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Applied Psychology › Optimism, Hope, and Well-being
- Keywords
- oxytocin receptor gene, oxytocin receptor, rs53576, single nucleotide polymorphisms, optimism, mastery, self-esteem, psychological resources, stress buffering, depressive symptoms, genetic association, mediation analysis, heritability
- MeSH terms
- Adolescent, Adult, Depression, Female, Genotype, Humans, Male, Mental Processes, Models, Psychological, Receptors, Oxytocin, Young Adult
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