Oxytocin receptor gene and depressive symptoms associated with physiological reactivity to infant crying
Open accessAbstract
Both the oxytocin receptor (OXTR) gene and depressive symptoms have been associated with parenting behaviour. The OXTR GG genotype has been suggested to be related to more sensitive parenting, whereas depressive symptoms may affect sensitivity negatively. We examined the role of OXTR and the influence of depressive symptoms in explaining differences in physiological reactivity to infant crying. Heart rate responses of 40 healthy females without children (age 19-47 years, randomly selected half of twin pairs) were measured during the presentation of three episodes of infant cry sounds. Participants with the presumably more efficient variant of the oxytonergic system gene (OXTR GG) had more pronounced physiological reactivity to repeated cry sounds, except when they showed more symptoms of depression. Results were replicated in the second half of the twin sample. This is the first study to suggest effects of OXTR genotype on physiological reactivity to infant crying. Depressive symptoms may however suppress the effect of the OXTR GG genotype.
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Homozygous carriers of the minor allele (A) of rs53576 have been shown to exhibit lower interpersonal sensitivity.
“Homozygous carriers of the minor allele (A; hitherto referred to as ‘risk allele’) of rs53576 have been shown to exhibit lower interpersonal sensitivity59–62.”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [60]
AA-carriers exhibit lower interpersonal sensitivity.
“Previous studies have shown that AA-carriers exhibit lower interpersonal sensitivity59–62.”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [60]
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- Authors
- Riem, M. M. E., Pieper, S., Out, D., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H.
- Affiliations
- Leiden University (NL)
- Centre for Child and Family Studies, Leiden University, the Netherlands
- ORCID
- Riem, Madelon M. E.
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-04-16
- Volume
- 6
- Issue
- 3
- Pages
- 294-300
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC3110427
- OpenAlex
- W2098442530
- Cited by
- 113
- References
- 5
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 13 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 11 · 2012: 8
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
- Keywords
- oxytocin receptor gene, depressive symptoms, infant crying, physiological reactivity, heart rate, parenting sensitivity, oxytocinergic system, twin pairs, gene-environment interaction
- MeSH terms
- Acoustic Stimulation, Adult, Crying, Depression, Female, Genotype, Heart Rate, Humans, Infant, Middle Aged, Random Allocation, Parenting, Receptors, Oxytocin, Young Adult
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