Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
Open accessAbstract
Social relations between humans critically depend on our affective experiences of others. Oxytocin enhances prosocial behavior, but its effect on humans' affective experience of others is not known. We tested whether oxytocin influences affective ratings, and underlying brain activity, of faces that have been aversively conditioned. Using a standard conditioning procedure, we induced differential negative affective ratings in faces exposed to an aversive conditioning compared with nonconditioning manipulation. This differential negative evaluative effect was abolished by treatment with oxytocin, an effect associated with an attenuation of activity in anterior medial temporal and anterior cingulate cortices. In amygdala and fusiform gyrus, this modulation was stronger for faces with direct gaze, relative to averted gaze, consistent with a relative specificity for socially relevant cues. The data suggest that oxytocin modulates the expression of evaluative conditioning for socially relevant faces via influences on amygdala and fusiform gyrus, an effect that may explain its prosocial effects.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Previous studies indicate that oxytocin may induce sex-dependent changes in amygdala activation to emotional stimuli, but in opposite directions to the present findings.
“Previous studies on amygdala responses to fearful faces and fearful/threatening scenes (14 -17, 30) and social risk (31) have also indicated that OXT may induce sex-dependent changes in amygdala activation to emotional stimuli.”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [30]
Intranasal oxytocin administration in fragile X syndrome may work mechanistically by dampening amygdala reactivity toward socially threatening and anxiety-provoking stimuli, decreasing HPA axis activation, and increasing social motivation.
“Intranasal OT administration in FXS may work mechanistically by dampening amygdala reactivity toward socially threatening and anxiety-provoking stimuli (Kirsch et al., 2005; Petrovic et al., 2008), decreasing HPA axis activation, and increasing social motivation (Witt et al., 1992).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Petrovic et al., 2008
OXT's effects on anxiety and social behavior are mediated through OXT's effects on amygdala reactivity and/or amygdala-frontal connectivity.
“Recent functional neuroimaging studies suggest that these effects are mediated through OXT's effects on amygdala reactivity and/or amygdala-frontal connectivity.”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Petrovic et al, 2008
The insula and amygdala seem to be key target regions in the brain, with oxytocin modulating amygdala responsiveness to emotional faces or social stimuli in general.
“In this context, the insula17 as well as the amygdala seem to be key target regions in the brain, with oxytocin modulating amygdala responsiveness to emotional faces18–22 or social stimuli in general23.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [22]
The tested type of intranasal OT delivery, but not peripherally delivered OT that produces similar blood levels, replicates prior findings of reduced right amygdala activation in response to emotional stimuli after OT treatment.
“Results indicate that the tested type of intranasal OT delivery -but not peripherally delivered OT that produces similar blood levels -replicates prior findings of reduced right amygdala activation in response to emotional stimuli after OT treatment (Domes et al., 2007;Labuschagne et al., 2010;Petrovic et al., 2008).”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Petrovic et al., 2008
Inhaling OT reduces BOLD activation in the amygdala when viewing or associating aversive social stimuli, during trust formation, in response to pain, and in response to infant crying.
“Human functional neuroimaging studies have shown that inhaling OT reduces BOLD (blood-oxygen-level dependent) activation in the amygdala when viewing or associating aversive social stimuli (Kirsch, 2005; Petrovic et al., 2008), during trust formation (Baumgartner et al., 2008), in response to pain (Singer et al., 2008), and in response to infant crying (Riem et al., 2011).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Petrovic et al., 2008
OT is highly involved in the regulation of social recognition, by facilitating social memory and selective attention to socially-relevant information through action in the medial amygdala.
“OT is highly involved in the regulation of social recognition, by facilitating social memory and selective attention to socially-relevant information through action in the medial amygdala (Petrovic et al., 2008; Samuelsen and Meredith, 2011).”
From Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers (2014) · cites this paper as Petrovic et al., 2008
Petrovic et al. (2008) found that oxytocin reduced the negative evaluation of a face predicting unpleasant electric shocks.
“Petrovic et al. (2008) found that oxytocin reduced the negative evaluation of a face predicting unpleasant electric shocks.”
From Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions (2013) · cites this paper as Petrovic et al. (2008)
OT dampens amygdala activation in response to fear-inducing stimuli.
“possibly through dampening amygdala activation in response to fear-inducing stimuli [16], [17]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [17]
Previous research strongly suggests that intranasal administration of OT can reliably influence socially relevant judgments and ratings, relative to placebo.
“While previous research strongly suggests that intranasal administration of OT can reliably influence socially relevant judgments and ratings, relative to placebo [58], [17], [5]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [17]
Amygdala activity tends to be reduced by OT administration upon exposure to threatening stimuli.
“its activity here tends to be reduced by OT administration upon exposure to threatening stimuli [18], [16], [17].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [17]
The finding that OT decreased amygdala activity during avoidance of negative stimuli is in line with the anxiolytic action of OT via inhibiting amygdala responses to threatening stimuli.
“This finding is in line with the anxiolytic action of OT via inhibiting amygdala responses to threatening stimuli (Kirsch et al., 2005; Petrovic et al., 2008).”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Petrovic et al., 2008
OT has an anxiolytic action via inhibiting amygdala responses to threatening stimuli.
“the anxiolytic action of OT via inhibiting amygdala responses to threatening stimuli (Kirsch et al., 2005; Petrovic et al., 2008)”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Petrovic et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reinforcement Learning: An Introduction
Sutton, R. S., & Barto, A. G. (1998) · IEEE Transactions on Neural Networks · doi:10.1109/tnn.1998.712192 · Cited by 27,225 · see citing works
The fusiform face area: a module in human extrastriate cortex specialized for face perception
Kanwisher, N., McDermott, J., & Chun, M. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04302.1997 · Cited by 7,738 · see citing works
Rescorla, R. A. (1972) · Medical Entomology and Zoology · Cited by 7,268 · see citing works
The distributed human neural system for face perception
Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01482-0 · Cited by 4,891 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · cited 6× · see citing works
“Thus, an oxytocin effect in humans should be evident in altered behavior (Kosfeld et al., 2005) and also in how we affectively experience others.”
BackgroundMethodResultInfluentialThe amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · cited 2× · see citing works
“One expression of this is augmentation of activity in fusiform face area (FFA) to fearful facial expressions (Vuilleumier and Pourtois, 2007), in addition to influences on subcortical and brainstem structures involved in behavioral fear responses (Davis and Whalen, 2001).”
BackgroundFunctional imaging of brain responses to pain. A review and meta-analysis (2000)
Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171 · see citing works
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · cited 3× · see citing works
“Oxytocin effects on affective evaluations In line with previous studies in which oxytocin was administrated externally (Pitman et al., 1993; Heinrichs et al., 2003, 2004; Kirsch et al., 2005; Kosfeld et al., 2005; Domes et al., 2007a), we did not observe any significant effect on mood ratings…”
BackgroundMethodEmotion and Cognition: Insights from Studies of the Human Amygdala
Phelps, E. A. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070234 · Cited by 1,798 · cited 11× · see citing works
“We used a sequence with axial slices tilted by 30° and a flip angle of 90° that reduces signal dropout attributable to susceptibility-induced field inhomogeneities in amygdala and orbitofrontal cortex (Obfc) (Deichmann et al., 2002).”
BackgroundInfluentialPhelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753 · cited 2× · see citing works
“In the placebo group, we observed increased activity in the extended/dorsal amygdala and in other regions previously shown to be involved in fear conditioning and extinction such as insula, Obfc, and ACC (Gottfried and Dolan, 2004; Phelps et al., 2004; Kalisch et al., 2006; Milad et al., 2007).”
BackgroundEmpathic neural responses are modulated by the perceived fairness of others
Singer, T., Seymour, B., O'Doherty, J. P., Stephan, K. E., Dolan, R. J., & Frith, C. D. (2006) · Nature · doi:10.1038/nature04271 · Cited by 1,726 · cited 3× · see citing works
“Moreover, because social-affective responses are modified with respect to our experience of others (Singer et al., 2006), we conjectured that oxytocin on acquired negative affective ratings related to social stimuli.”
BackgroundInfluentialSelf-citationEffects of Attention and Emotion on Face Processing in the Human Brain
Vuilleumier, P., Armony, J. L., Driver, J., & Dolan, R. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00328-2 · Cited by 1,664 · cited 2× · see citing works
“, 2002) especially when the face signals threat (Morris et al., 1998; Vuilleumier et al., 2001) and that this interaction between face and fear processing is dependent on amygdala influences (Vuilleumier et al.”
BackgroundSelf-citationOxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · cited 5× · see citing works
“Several studies using this method have reported oxytocindependent effects on behavior or brain function (Pitman et al., 1993; Heinrichs et al., 2003, 2004; Kirsch et al., 2005; Kosfeld et al., 2005; Domes et al., 2007a).”
BackgroundMethodResultInfluentialGaze fixation and the neural circuitry of face processing in autism
Dalton, K. M., Nacewicz, B. M., Johnstone, T., Schaefer, H. S., Gernsbacher, M. A., Goldsmith, H. H., Alexander, A. L., & Davidson, R. J. (2005) · Nature Neuroscience · doi:10.1038/nn1421 · Cited by 1,543 · cited 3× · see citing works
“Both syndromes involve abnormal processing of faces: although amygdala activation is heightened in autism for faces with direct gaze (Dalton et al., 2005), it is suppressed in Williams syndrome for fearful faces (Meyer-Lindenberg et al., 2005).”
BackgroundTemporal difference models and reward-related learning in the human brain
O'Doherty, J. P., Dayan, P., Friston, K., Critchley, H., & Dolan, R. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00169-7 · Cited by 1,522 · see citing works
Self-citationLaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., & Phelps, E. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80475-4 · Cited by 1,402 · see citing works
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · cited 1× · see citing works
“It has been shown previously that nanopeptides pass the blood– brain barrier reliably after intranasal application (Born et al., 2002).”
BackgroundA mechanism for impaired fear recognition after amygdala damage
Adolphs, R., Gosselin, F., Buchanan, T. W., Tranel, D., Schyns, P., & Damasio, A. R. (2005) · Nature · doi:10.1038/nature03086 · Cited by 1,331 · cited 5× · see citing works
“The amygdala also plays a key role in processing social cues such as direction of eye gaze, manifest in an enhanced amygdala response to direct compared with averted gaze (Kawashima et al., 1999; George et al., 2001; Haxby et al., 2002; Adolphs et al., 2005).”
BackgroundInfluentialOxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
A neuromodulatory role for the human amygdala in processing emotional facial expressions
Morris, J. (1998) · Brain · doi:10.1093/brain/121.1.47 · Cited by 1,291 · cited 1× · see citing works
“…that the FFA processes face identity (Kawashima et al., 1999; George et al., 2001; Haxby et al., 2002) especially when the face signals threat (Morris et al., 1998; Vuilleumier et al., 2001) and that this interaction between face and fear processing is dependent on amygdala influences…”
BackgroundHuman neural systems for face recognition and social communication
Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01330-0 · Cited by 1,287 · cited 10× · see citing works
“The amygdala also plays a key role in processing social cues such as direction of eye gaze, manifest in an enhanced amygdala response to direct compared with averted gaze (Kawashima et al., 1999; George et al., 2001; Haxby et al., 2002; Adolphs et al., 2005).”
BackgroundMethodInfluentialMilad, M. R., Wright, C. I., Orr, S. P., Pitman, R. K., Quirk, G. J., & Rauch, S. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.011 · Cited by 1,197 · cited 16× · see citing works
“No significant evaluative fear conditioning treatment interaction [(CSag CSag )placebo (CSag CSag )oxytocin] was observed in insula, FFA, amygdala, or caudal ACC.”
BackgroundMethodInfluentialDe Houwer, J., Thomas, S., & Baeyens, F. (2001) · Psychological Bulletin · doi:10.1037/0033-2909.127.6.853 · Cited by 1,181 · see citing works
Vuilleumier, P., & Pourtois, G. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.06.003 · Cited by 1,115 · cited 11× · see citing works
“We used a sequence with axial slices tilted by 30° and a flip angle of 90° that reduces signal dropout attributable to susceptibility-induced field inhomogeneities in amygdala and orbitofrontal cortex (Obfc) (Deichmann et al., 2002).”
BackgroundInfluentialAutomatic and intentional brain responses during evaluation of trustworthiness of faces
Winston, J. S., Strange, B. A., O'Doherty, J., & Dolan, R. J. (2002) · Nature Neuroscience · doi:10.1038/nn816 · Cited by 993 · cited 1× · see citing works
“These two dimensions, fear and social cue processing, interact in the amygdala as when a face signals threat (Vuilleumier and Pourtois, 2007) and in judgment of untrustworthiness (Winston et al., 2002).”
BackgroundSelf-citationDistant influences of amygdala lesion on visual cortical activation during emotional face processing
Vuilleumier, P., Richardson, M. P., Armony, J. L., Driver, J., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1341 · Cited by 955 · cited 1× · see citing works
“…face identity (Kawashima et al., 1999; George et al., 2001; Haxby et al., 2002) especially when the face signals threat (Morris et al., 1998; Vuilleumier et al., 2001) and that this interaction between face and fear processing is dependent on amygdala influences (Vuilleumier et al., 2004).”
BackgroundSelf-citationBrain systems mediating aversive conditioning: an event-related fMRI study
Büchel, C., Morris, J., Dolan, R. J., & Friston, K. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80476-6 · Cited by 951 · see citing works
Self-citationActivation of the left amygdala to a cognitive representation of fear
Phelps, E. A., O'Connor, K. J., Gatenby, J. C., Gore, J. C., Grillon, C., & Davis, M. (2001) · Nature Neuroscience · doi:10.1038/86110 · Cited by 895 · see citing works
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833 · see citing works
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · cited 3× · see citing works
“The fact that the amygdala expresses high concentrations of oxytocin receptors (Insel and Shapiro, 1992; Veinante and Freund-Mercier, 1997; Huber et al., 2005), which act by inhibiting activity in the basolateral amygdala through the influence of GABA (Huber et al.”
BackgroundOxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · cited 4× · see citing works
“Two previous human studies have reported reduced fearrelated activation of amygdala after oxytocin (Kirsch et al., 2005; Domes et al., 2007).”
BackgroundMethodInfluentialThe role of awareness in Pavlovian conditioning: empirical evidence and theoretical implications.
Lovibond, P., & Shanks, D. (2002) · Journal of experimental psychology. Animal behavior processes · doi:10.1037/0097-7403.28.1.3 · Cited by 748 · see citing works
Plasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728 · cited 2× · see citing works
“It has been suggested that an underlying cause for deficits in social interaction in autistics is a malfunctioning oxytocin system (Bartz and Hollander, 2006; Hammock and Young, 2006; Carter, 2007; Heinrichs and Gaab, 2007), evidenced in lower oxytocin levels than in normal controls (Modahl et al., 1998; Green et al.,…”
BackgroundNeuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624 · cited 8× · see citing works
“Animal studies have shown that oxytocin is involved in regulating social interactions, mediating increased approach behavior toward conspecifics (Lim and Young, 2006).”
BackgroundResultInfluentialTemporal difference models describe higher-order learning in humans
Seymour, B., O'Doherty, J. P., Dayan, P., Koltzenburg, M., Jones, A. K., Dolan, R. J., Friston, K. J., & Frackowiak, R. S. (2004) · Nature · doi:10.1038/nature02581 · Cited by 605 · see citing works
Self-citationBornhövd, K., Quante, M., Glauche, V., Bromm, B., Weiller, C., & Büchel, C. (2002) · Brain · doi:10.1093/brain/awf137 · Cited by 584 · see citing works
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 553 · cited 2× · see citing works
“, 2001) and an association with specific variants of the oxytocin receptor gene (Wu et al., 2005; Ylisaukko-oja et al., 2006).”
BackgroundTopographic organization of projections from the amygdala to the visual cortex in the macaque monkey
Amaral, D. G., Behniea, H., & Kelly, J. L. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)01001-1 · Cited by 552 · see citing works
The neuroendocrine basis of social recognition
Ferguson, J. N., Young, L. J., & Insel, T. R. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2002.0229 · Cited by 494 · see citing works
Kalisch, R., Korenfeld, E., Stephan, K. E., Weiskopf, N., Seymour, B., & Dolan, R. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2021-06.2006 · Cited by 493 · cited 21× · see citing works
“No significant evaluative fear conditioning treatment interaction [(CSag CSag )placebo (CSag CSag )oxytocin] was observed in insula, FFA, amygdala, or caudal ACC.”
BackgroundMethodResultInfluentialSelf-citationOxytocin, vasopressin, and social recognition in mammals
Bielsky, I. F., & Young, L. J. (2004) · Peptides · doi:10.1016/j.peptides.2004.05.019 · Cited by 460 · cited 2× · see citing works
“At first glance, this might seem to conflict with findings that oxytocin receptor knock-out mice have lower social recognition of conspecifics (Ferguson et al., 2002; Bielsky and Young, 2004).”
ResultUnderstanding autism: Insights from mind and brain
Hill, E. L., & Frith, U. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1209 · Cited by 452 · cited 2× · see citing works
“, 2006), whereas autistic people show impaired social functioning (Hill and Frith, 2003).”
BackgroundOpponent appetitive-aversive neural processes underlie predictive learning of pain relief
Seymour, B., O'Doherty, J. P., Koltzenburg, M., Wiech, K., Frackowiak, R., Friston, K., & Dolan, R. (2005) · Nature Neuroscience · doi:10.1038/nn1527 · Cited by 439 · see citing works
Self-citationSex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432 · cited 5× · see citing works
“It has been suggested that an underlying cause for deficits in social interaction in autistics is a malfunctioning oxytocin system (Bartz and Hollander, 2006; Hammock and Young, 2006; Carter, 2007; Heinrichs and Gaab, 2007), evidenced in lower oxytocin levels than in normal controls (Modahl et al.”
BackgroundInfluentialThe human amygdala plays an important role in gaze monitoring
Kawashima, R., Sugiura, M., Kato, T., Nakamura, A., Hatano, K., Ito, K., Fukuda, H., Kojima, S., & Nakamura, K. (1999) · Brain · doi:10.1093/brain/122.4.779 · Cited by 430 · cited 3× · see citing works
“Error bars indicate SE. gaze, consistent with a specific modulation of socially relevant threat stimuli (Kawashima et al., 1999; George et al., 2001; Haxby et al., 2002; Adolphs et al., 2005).”
BackgroundMeyer-Lindenberg, A., Mervis, C. B., & Faith Berman, K. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1906 · Cited by 411 · cited 1× · see citing works
“Patients with Williams syndrome show high sociability and empathy (Meyer-Lindenberg et al., 2006), whereas autistic people show impaired social functioning (Hill and Frith, 2003).”
BackgroundBrain Responses to the Acquired Moral Status of Faces
Singer, T., Kiebel, S. J., Winston, J. S., Dolan, R. J., & Frith, C. (2004) · Neuron · doi:10.1016/s0896-6273(04)00014-5 · Cited by 410 · see citing works
Self-citationOxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404 · cited 2× · see citing works
“It has been suggested that an underlying cause for deficits in social interaction in autistics is a malfunctioning oxytocin system (Bartz and Hollander, 2006; Hammock and Young, 2006; Carter, 2007; Heinrichs and Gaab, 2007), evidenced in lower oxytocin levels than in normal controls (Modahl et al., 1998; Green et al.,…”
BackgroundNeural correlates of genetically abnormal social cognition in Williams syndrome
Meyer-Lindenberg, A., Hariri, A. R., Munoz, K. E., Mervis, C. B., Mattay, V. S., Morris, C. A., & Berman, K. F. (2005) · Nature Neuroscience · doi:10.1038/nn1494 · Cited by 357 · cited 3× · see citing works
“, 2005), it is suppressed in Williams syndrome for fearful faces (Meyer-Lindenberg et al., 2005).”
BackgroundGottfried, J. A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1314 · Cited by 353 · cited 3× · see citing works
“In the placebo group, we observed increased activity in the extended/dorsal amygdala and in other regions previously shown to be involved in fear conditioning and extinction such as insula, Obfc, and ACC (Gottfried and Dolan, 2004; Phelps et al., 2004; Kalisch et al., 2006; Milad et al., 2007).”
BackgroundMethodSelf-citationThe Role of Social Groups in the Persistence of Learned Fear
Olsson, A., Ebert, J. P., Banaji, M. R., & Phelps, E. A. (2005) · Science · doi:10.1126/science.1113551 · Cited by 339 · see citing works
George, N., Driver, J., & Dolan, R. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0769 · Cited by 323 · cited 7× · see citing works
“The amygdala also plays a key role in processing social cues such as direction of eye gaze, manifest in an enhanced amygdala response to direct compared with averted gaze (Kawashima et al., 1999; George et al., 2001; Haxby et al., 2002; Adolphs et al., 2005).”
BackgroundInfluentialSelf-citationO'Doherty, J. P., Buchanan, T. W., Seymour, B., & Dolan, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2005.11.014 · Cited by 322 · see citing works
Self-citationA. Bartz, J., & Hollander, E. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.018 · Cited by 311 · cited 6× · see citing works
“It has been suggested that an underlying cause for deficits in social interaction in autistics is a malfunctioning oxytocin system (Bartz and Hollander, 2006; Hammock and Young, 2006; Carter, 2007; Heinrichs and Gaab, 2007), evidenced in lower oxytocin levels than in normal controls (Modahl et al.”
BackgroundResultInfluentialOxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 289 · cited 5× · see citing works
“It has been suggested that an underlying cause for deficits in social interaction in autistics is a malfunctioning oxytocin system (Bartz and Hollander, 2006; Hammock and Young, 2006; Carter, 2007; Heinrichs and Gaab, 2007), evidenced in lower oxytocin levels than in normal controls (Modahl et al.”
BackgroundInfluentialPain Pathways Involved in Fear Conditioning Measured with Fear-Potentiated Startle: Lesion Studies
Shi, C., & Davis, M. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00420.1999 · Cited by 282 · see citing works
Amygdala Automaticity in Emotional Processing
DOLAN, R. J., & VUILLEUMIER, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07093.x · Cited by 263 · see citing works
Self-citationRole of the amygdala in processing visual social stimuli
Adolphs, R., & Spezio, M. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)56020-0 · Cited by 254 · cited 1× · see citing works
“Both threat (Phelps, 2006) and social (Haxby et al., 2002; Adolphs and Spezio, 2006) signals activate amygdala, which in turn modulates cortical areas involved in emotional and social processing.”
BackgroundCompensation of susceptibility-induced bold sensitivity losses in echo-planar fMRI imaging
Deichmann, R., Josephs, O., Hutton, C., Corfield, D. R., & Turner, R. (2002) · NeuroImage · doi:10.1006/nimg.2001.0985 · Cited by 253 · see citing works
Cognitive biases in anxiety and attention to threat.
Mathews, A., Mackintosh, B., & Fulcher, E. (1997) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(97)01092-9 · Cited by 245 · cited 2× · see citing works
“Slowing of CS relative to CS RTs during a testing phase after conditioning has been reported previously (Kalisch et al., 2006) and is likely to reflect interference of emotion on a simultaneous cognitive task (Mathews et al., 1997).”
BackgroundThe role of the human amygdala in the production of conditioned fear responses
Knight, D. C., Nguyen, H. T., & Bandettini, P. A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.03.020 · Cited by 218 · see citing works
Predictability modulates the affective and sensory-discriminative neural processing of pain
Carlsson, K., Andersson, J., Petrovic, P., Petersson, K. M., Öhman, A., & Ingvar, M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.027 · Cited by 208 · see citing works
Selective amnesic effects of oxytocin on human memory
Heinrichs, M., Meinlschmidt, G., Wippich, W., Ehlert, U., & Hellhammer, D. H. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.020 · Cited by 205 · cited 2× · see citing works
“Oxytocin effects on affective evaluations In line with previous studies in which oxytocin was administrated externally (Pitman et al., 1993; Heinrichs et al., 2003, 2004; Kirsch et al., 2005; Kosfeld et al., 2005; Domes et al., 2007a), we did not observe any significant effect on mood ratings…”
MethodThe neurobiology of social recognition, approach, and avoidance
Young, L. J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01268-9 · Cited by 173 · cited 2× · see citing works
“Oxytocin, a nanopeptide produced within hypothalamic paraventricular nuclei, modulates these processes in animals (Insel et al., 2001; Young, 2002; Debiec, 2005; Lim and Young, 2006) and facilitates prosocial behavior by both increasing approach but also suppressing avoidance (Bartz and Hollander,…”
BackgroundCheng, D. T., Knight, D. C., Smith, C. N., Stein, E. A., & Helmstetter, F. J. (2003) · Behavioral Neuroscience · doi:10.1037//0735-7044.117.1.3 · Cited by 160 · see citing works
Kapp, B. S., Supple, W. F., & Whalen, P. J. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.81 · Cited by 152 · see citing works
Pitman, R. K., Orr, S. P., & Lasko, N. B. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90035-f · Cited by 150 · cited 5× · see citing works
“Several studies using this method have reported oxytocindependent effects on behavior or brain function (Pitman et al., 1993; Heinrichs et al., 2003, 2004; Kirsch et al., 2005; Kosfeld et al., 2005; Domes et al., 2007a).”
BackgroundMethodResultInfluentialContingency awareness in human aversive conditioning involves the middle frontal gyrus
Carter, R. M., O’Doherty, J. P., Seymour, B., Christof Koch, A., & Dolan, R. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.09.011 · Cited by 148 · see citing works
Self-citationCheng, D. T., Knight, D. C., Smith, C. N., et al. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.1.3 · Cited by 138 · see citing works
Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families
Ylisaukko‐oja, T., Alarcón, M., Cantor, R. M., Auranen, M., Vanhala, R., Kempas, E., von Wendt, L., Järvelä, I. E., Geschwind, D. H., & Peltonen, L. (2005) · Annals of Neurology · doi:10.1002/ana.20722 · Cited by 136 · cited 2× · see citing works
“, 2001) and an association with specific variants of the oxytocin receptor gene (Wu et al., 2005; Ylisaukko-oja et al., 2006).”
BackgroundKapp, B. S., Supple, W. F., & Whalen, P. J. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.81 · Cited by 120 · see citing works
Tabbert, K., Stark, R. M., Kirsch, P., & Vaitl, D. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.03.038 · Cited by 118 · see citing works
Context-dependent Deactivation of the Amygdala during Pain
Petrović, P., Carlsson, K., Petersson, K. M., Hansson, P. T., & Ingvar, M. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/0898929041920469 · Cited by 102 · see citing works
Intact electrodermal skin conductance responses after bilateral amygdala damage
Tranel, D., & Damásio, H. (1989) · Neuropsychologia · doi:10.1016/0028-3932(89)90046-8 · Cited by 97 · see citing works
Dębiec, J. (2005) · BioEssays · doi:10.1002/bies.20301 · Cited by 90 · cited 5× · see citing works
“Oxytocin is also implicated in inhibition of fear-related processes (Debiec, 2005).”
BackgroundInfluentialNeuroendocrine mechanisms of stress and social interaction: Implications for mental disorders
Heinrichs, M., & Gaab, J. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3280146a13 · Cited by 79 · cited 5× · see citing works
“It has been suggested that an underlying cause for deficits in social interaction in autistics is a malfunctioning oxytocin system (Bartz and Hollander, 2006; Hammock and Young, 2006; Carter, 2007; Heinrichs and Gaab, 2007), evidenced in lower oxytocin levels than in normal controls (Modahl et al.”
BackgroundInfluentialTabbert, K., Stark, R. M., Kirsch, P., & Vaitl, D. (2005) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.01.007 · Cited by 76 · see citing works
Chapter 4 Oxytocin: who needs it?
Insel, T. R., Gingrich, B., & Young, L. J. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33005-4 · Cited by 62 · cited 2× · see citing works
“Oxytocin, a nanopeptide produced within hypothalamic paraventricular nuclei, modulates these processes in animals (Insel et al., 2001; Young, 2002; Debiec, 2005; Lim and Young, 2006) and facilitates prosocial behavior by both increasing approach but also suppressing avoidance (Bartz and Hollander,…”
BackgroundTime course of amygdala activation during aversive conditioning depends on attention
Straube, T., Weiß, T., Mentzel, H.-J., & Miltner, W. H. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.08.021 · Cited by 60 · see citing works
Compensation of susceptibility induced BOLD sensitivity losses in echo-planar fMRI imaging
Deichmann, R., & Turner, R. (2001) · NeuroImage · doi:10.1016/s1053-8119(01)91351-5 · Cited by 11 · see citing works
Morris, J. S., Buchel, C., & Dolan, R. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0891 · Cited by 9 · see citing works
Self-citationVeinante, P., & Freund-Mercier, M.-J. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970707)383:3
Flagged first, then by citations
Cited by
Sorted by citations
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
“Additional brain imaging studies using different stimuli and experimental approaches replicated the dampening effect of OXT on amygdala activity in male”
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · see citing works
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
“Similarly, intranasal Oxt attenuates feelings of negativity towards faces conditioned with negative affective ratings, particularly in faces with direct gaze (Petrovic et al., 2008).”
InfluentialThe oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954 · see citing works
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941 · see citing works
“It has been proposed that oxytocin enhances affiliation partly by reducing fear of social unfaithfulness and by suppressing avoidance behavior (14) and that it reduces the activity of the amygdala, resulting in a decrease of fear responses (14, 24, 25).”
BackgroundOxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799 · see citing works
“Recently, a study reported that 32 IU intranasal OT attenuated the effect of aversive conditioning of neutral faces [127], which was associated with reduced activity in the caudal anterior cingulate cortex and the right medial temporal lobe.”
BackgroundThe Neuroscience of Social Decision-Making
Rilling, J. K., & Sanfey, A. G. (2011) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131647 · Cited by 775 · see citing works
“…that the neuropeptide oxytocin (OT) reduces amygdala activity in male subjects (Baumgartner et al. 2008, Domes et al. 2007, Kirsch et al. 2005, Petrovic et al. 2008, Singer et al. 2008) although not in women (Domes et al. 2010), and others have shown that OT also increases behavioral…”
Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., Dziobek, I., Gallinat, J., Wagner, M., Maier, W., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5538-09.2010 · Cited by 771 · see citing works
“…during exposure to fear-evoking faces or scenes (Kirsch et al., 2005), and therefore OT may facilitate amygdala activity under positive, prosocial/empathy-provoking conditions and inhibit it under more aversive and stressful conditions where stimuli are avoided (see also Petrovic et al., 2008).”
BackgroundThe Peptide That Binds: A Systematic Review of Oxytocin and its Prosocial Effects in Humans
MacDonald, K., & MacDonald, T. M. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673220903523615 · Cited by 585 · see citing works
Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.123 · Cited by 549 · see citing works
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521 · see citing works
“A number of studies have provided evidence that the amygdala might be a key structure for the mediation of the social cognitive effects of OXT (Domes et al., 2007a; Kirsch et al., 2005; Petrovic et al., 2008; Singer et al., 2008).”
BackgroundResultInfluentialModulating social behavior with oxytocin: How does it work? What does it mean?
Churchland, P. S., & Winkielman, P. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.003 · Cited by 464 · see citing works
“Petrovic et al. (2008) used 4 puffs per nostril for a total of 32 IU.”
MethodDe Dreu, C. K. W. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.009 · Cited by 455 · see citing works
“Results showed that oxytocin reduced the activation of the amygdala and attenuated its coupling to brainstem centers responsible for autonomic and behavioral components of fear (see also Petrovic et al., 2008).”
Bos, P. A., Panksepp, J., Bluthé, R.-M., & Honk, J. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.01.002 · Cited by 429 · see citing works
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
Oxytocin Makes a Face in Memory Familiar
Rimmele, U., Hediger, K., Heinrichs, M., & Klaver, P. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4260-08.2009 · Cited by 402 · see citing works
“Of note, one of these studies revealed oxytocin induced blood oxygen leveldependent signal changes also in the fusiform gyrus (Petrovic et al., 2008).”
BackgroundSex differences in autism spectrum disorder: a review
Ferri, S. L., Abel, T., & Brodkin, E. S. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0874-2 · Cited by 392 · see citing works
Riem, M. M. E., Bakermans-Kranenburg, M. J., Pieper, S., Tops, M., Boksem, M. A. S., Vermeiren, R. R. J. M., van IJzendoorn, M. H., & Rombouts, S. A. R. B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.006 · Cited by 366 · see citing works
Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366 · see citing works
“OT attenuates negative affective evaluations associated with aversively conditioned faces through modulation of the amygdala and fusiform gyrus in non-clinical adults (Petrovic et al., 2008), further outlining the action of OTon the amygdala during the perception of threatening social cues.”
BackgroundThe origins of altruism in offspring care.
Preston, S. D. (2013) · Psychological Bulletin · doi:10.1037/a0031755 · Cited by 368 · see citing works
A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research
MacDonald, E., Dadds, M. R., Brennan, J. L., Williams, K., Levy, F., & Cauchi, A. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.015 · Cited by 352 · see citing works
Oxytocin enhances brain function in children with autism
Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312857110 · Cited by 336 · see citing works
Declerck, C. H., Boone, C., & Kiyonari, T. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.01.006 · Cited by 331 · see citing works
Morrison, S. E., & Salzman, C. D. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.02.007 · Cited by 341 · see citing works
“Many studies have shown that activation of the amygdala is correlated with fear learning in Pavlovian conditioning paradigms; recently, for example, amygdala activity was connected to the association of specific faces with shock [74,75], an effect which seems to be abolished (both behaviorally and neurally) by the pro…”
Theodoridou, A., Rowe, A. C., Penton-Voak, I. S., & Rogers, P. J. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.019 · Cited by 318 · see citing works
“Most human studies that investigate behavioural effects of experimental OT administration recruit only members of the male population (e.g. Petrovic et al., 2008; Domes et al., 2007a, 2007b; Kirsch et al., 2005; Guastella et al., 2008).”
InfluentialRilling, J. K., DeMarco, A. C., Hackett, P. D., Thompson, R., Ditzen, B., Patel, R., & Pagnoni, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.013 · Cited by 303 · see citing works
“…to reduce the salience of negative social stimuli and increase the salience of positive social stimuli (Heinrichs et al., 2003; Baumgartner et al., 2008; Guastella et al., 2008; Petrovic et al., 2008; Unkelbach et al., 2008; Heinrichs et al., 2009; Theodoridou et al., 2009; Gamer et al., 2010).”
InfluentialDe Dreu, C. K. W., & Kret, M. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.020 · Cited by 297 · see citing works
“There is evidence too that intranasal oxytocin dampens amygdala responses to fear-provoking stimuli (33,34), although this is seen especially in male subjects (35,36) and may be contingent on early life experiences (16,37,38).”
BackgroundBethlehem, R. A. I., van Honk, J., Auyeung, B., & Baron-Cohen, S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.011 · Cited by 285 · see citing works
“Using a fear-conditioning paradigm Petrovic et al. (2008) have shown OT effects in the anterior cingulate and an effect in the amygdala for direct gaze.”
BackgroundMethodInfluentialThe Interpersonal Dimension of Borderline Personality Disorder: Toward a Neuropeptide Model
Stanley, B., & Siever, L. J. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09050744 · Cited by 291 · see citing works
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.001 · Cited by 283 · see citing works
“Intranasal OXT has also been found to decrease responses in anterior medial temporal and anterior cingulate cortices to faces that have been aversively conditioned by an electric shock [155].”
BackgroundThe contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283 · see citing works
The animal and human neuroendocrinology of social cognition, motivation and behavior
McCall, C., & Singer, T. (2012) · Nature Neuroscience · doi:10.1038/nn.3084 · Cited by 273 · see citing works
Self-citationOxytocin receptor gene ( <i>OXTR</i> ) is related to psychological resources
Saphire-Bernstein, S., Way, B. M., Kim, H. S., Sherman, D. K., & Taylor, S. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113137108 · Cited by 262 · see citing works
“(46) also found an effect of intranasal oxytocin on dACC activation.”
BackgroundChang, S. W. C., Barter, J. W., Ebitz, R. B., Watson, K. K., & Platt, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114621109 · Cited by 252 · see citing works
“Finally, OT reduces the subjective evaluation of aversively conditioned faces, and this reduction is accompanied by suppressed BOLD responses in the amygdala and the fusiform gyrus (42).”
BackgroundOxytocin facilitates protective responses to aversive social stimuli in males
Striepens, N., Scheele, D., Kendrick, K. M., Becker, B., Schäfer, L., Schwalba, K., Reul, J., Maier, W., & Hurlemann, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208852109 · Cited by 242 · see citing works
“In humans, OXT reduced emotional ratings to aversively conditioned (25) and angry faces (14).”
BackgroundSinger, T., Snozzi, R., Bird, G., Petrovic, P., Silani, G., Heinrichs, M., & Dolan, R. J. (2008) · Emotion · doi:10.1037/a0014195 · Cited by 248 · see citing works
“Reduced amygdala activation due to OT has been shown in previous fMRI studies using a similar protocol to exogenously apply OT via a nasal spray (Baumgartner et al., 2008; Domes, Heinrichs, Glascher et al., 2007; Kirsch et al., 2005; Petrovic et al., 2008).”
MethodSelf-citationAuyeung, B., Lombardo, M. V., Heinrichs, M., Chakrabarti, B., Sule, A., Deakin, J. B., Bethlehem, R. A. I., Dickens, L., Mooney, N., Sipple, J. A. N., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.146 · Cited by 234 · see citing works
“10,18,20,23,24,39 It has also been suggested that oxytocin could reduce anxiety through amygdala-dependent mechanisms, 40,41 which may provide an additional bene fi t in social interactions.”
Nonapeptide mechanisms of social cognition, behavior and species-specific social systems
Goodson, J. L., & Thompson, R. R. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.08.020 · Cited by 261 · see citing works
“When the faces depict direct gaze, OT also suppresses fusiform gyrus responses [44].”
BackgroundPrefrontal–amygdala circuits in social decision-making
Gangopadhyay, P., Chawla, M., Monte, O. D., & Chang, S. W. C. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00738-9 · Cited by 247 · see citing works
Oxytocin and human social behavior.
Campbell, A. (2010) · Personality and Social Psychology Review · doi:10.1177/1088868310363594 · Cited by 232 · see citing works
“Imaging studies have demonstrated reduced amygdala activation, taken to signal fear reduction, in response to threatening faces after OT administration (Kirsch et al., 2005; Petrovic et al., 2008), indicating that OT can reduce stress without social contact.”
BackgroundThe Role of Oxytocin in Human Affect: A Novel Hypothesis
Kemp, A. H., & Guastella, A. J. (2011) · Current Directions in Psychological Science · doi:10.1177/0963721411417547 · Cited by 228 · see citing works
Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity
Spengler, F. B., Schultz, J., Scheele, D., Essel, M., Maier, W., Heinrichs, M., & Hurlemann, R. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.04.015 · Cited by 229 · see citing works
The evolutionary psychology of women's aggression
Campbell, A. C. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0078 · Cited by 235 · see citing works
“OT enhances activity in the ACC and increases its connectivity with the amygdala [115,116].”
BackgroundChen, F. S., Kumsta, R., von Dawans, B., Monakhov, M., Ebstein, R. P., & Heinrichs, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113079108 · Cited by 268 · see citing works
Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218 · see citing works
Baribeau, D. A., & Anagnostou, E. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00335 · Cited by 229 · see citing works
Puglia, M. H., Lillard, T. S., Morris, J. P., & Connelly, J. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422096112 · Cited by 216 · see citing works
“Several other studies have also proposed a strong link between the endogenous oxytocin system and dACC structure and function (44, 45, 49).”
BackgroundGenetic origins of social networks in rhesus macaques
Brent, L. J. N., Heilbronner, S. R., Horvath, J. E., Gonzalez-Martinez, J., Ruiz-Lambides, A., Robinson, A. G., Skene, J. H. P., & Platt, M. L. (2013) · Scientific Reports · doi:10.1038/srep01042 · Cited by 220 · see citing works
Prenatal and postnatal hormone effects on the human brain and cognition
Bonnie Auyeung, B., Lombardo, M. V., & Baron‐Cohen, S. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1268-2 · Cited by 219 · see citing works
“Regions in these studies which are affected by oxytocin, such as the amygdala, fusiform gyrus, ventromedial prefrontal cortex, insula, superior temporal gyrus, and inferior frontal gyrus [108], are consistently atypical in conditions where difficulties in social cognition are a defining feature as in ASC [45, 95].”
BackgroundOxytocin facilitates the extinction of conditioned fear in humans
Eckstein, M., Becker, B., Scheele, D., Scholz, C., Preckel, K., Schlaepfer, T. E., Grinevich, V., Kendrick, K. M., Maier, W., & Hurlemann, R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.015 · Cited by 210 · see citing works
“When administered after Pavlovian fear conditioning, intranasal OXT attenuates the negative evaluation of previously conditioned faces (24) and enhances the recall of extinction assessed with fear potentiated startle responses (25).”
Variation in the Oxytocin Receptor Gene Is Associated with Pair-Bonding and Social Behavior
Walum, H., Lichtenstein, P., Neiderhiser, J. M., Reiss, D., Ganiban, J. M., Spotts, E. L., Pedersen, N. L., Anckarsäter, H., Larsson, H., & Westberg, L. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.002 · Cited by 211 · see citing works
Dodhia, S., Hosanagar, A., Fitzgerald, D. A., Labuschagne, I., Wood, A. G., Nathan, P. J., & Phan, K. L. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.53 · Cited by 209 · see citing works
Paloyelis, Y., Doyle, O. M., Zelaya, F. O., Maltezos, S., Williams, S. C., Fotopoulou, A., & Howard, M. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.005 · Cited by 187 · see citing works
“Biological P IN-OT on amygdala functional connectivity (105) or amygdala response involving left (92,98,113,114) or right amygdala laterality (97,100,101).”
Carson, D. S., Berquist, S. W., Trujillo, T. H., Garner, J. P., Hannah, S. L., Hyde, S. A., Sumiyoshi, R. D., Jackson, L. P., Moss, J. K., Strehlow, M. C., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.132 · Cited by 196 · see citing works
Oxytocin, the peptide that bonds the sexes also divides them
Gao, S., Becker, B., Luo, L., Geng, Y., Zhao, W., Yin, Y., Hu, J., Gao, Z., Gong, Q., Hurlemann, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602620113 · Cited by 186 · see citing works
Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications
Kohls, G., Chevallier, C., Troiani, V., & Schultz, R. T. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-10 · Cited by 197 · see citing works
“[157-163].”
When do people cooperate? The neuroeconomics of prosocial decision making
Declerck, C. H., Boone, C., & Emonds, G. (2012) · Brain and Cognition · doi:10.1016/j.bandc.2012.09.009 · Cited by 209 · see citing works
Oxytocin increases amygdala reactivity to threatening scenes in females
Lischke, A., Gamer, M., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.011 · Cited by 194 · see citing works
“…to threatening scenes following OT treatment in females sharply contrasts with the observation of attenuated amygdala activity in response to threat-related scenes (Kirsch et al., 2005) and faces (Domes et al., 2007a; Gamer et al., 2010; Kirsch et al., 2005; Petrovic et al., 2008) in males.”
BackgroundInfluentialSmith, K. E., Porges, E. C., Norman, G. J., Connelly, J. J., & Decety, J. (2014) · Social Neuroscience · doi:10.1080/17470919.2013.863223 · Cited by 195 · see citing works
“In addition, variation inOXTR has been implicated in social information processing (Petrovic et al., 2008; Tost et al., 2010) and social communication, with GG individuals being better at detecting some emotions in others (Rodrigues et al., 2009).”
BackgroundOxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety
Ziegler, C., Dannlowski, U., Bräuer, D., Stevens, S., Laeger, I., Wittmann, H., Kugel, H., Dobel, C., Hurlemann, R., Reif, A., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.2 · Cited by 193 · see citing works
Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse
Schorscher-Petcu, A., Sotocinal, S., Ciura, S., Dupre, A., Ritchie, J., Sorge, R. E., Crawley, J. N., Hu, S.-B., Nishimori, K., Young, L. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1594-10.2010 · Cited by 189 · see citing works
“The central and peripheral effects of OXT are thought to be mediated by its binding to a single isoform of the OTR (Gimpl and Fahrenholz, 2001), which activates the phospholipase C (PLC ) signal transduction pathway (Arnaudeau et al., 1994; Ku et al., 1995; Phaneuf et al., 1995).”
BackgroundBrain oxytocin: how puzzle stones from animal studies translate into psychiatry
Grinevich, V., & Neumann, I. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0802-9 · Cited by 189 · see citing works
“[138, 140–142], fear [143, 144], empathy [145, 146], trust”
Brain oxytocin in social fear conditioning and its extinction: involvement of the lateral septum
Zoicas, I., Slattery, D. A., & Neumann, I. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.156 · Cited by 189 · see citing works
The effect of intranasal administration of oxytocin on fear recognition
Fischer-Shofty, M., Shamay-Tsoory, S. G., Harari, H., & Levkovitz, Y. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.09.003 · Cited by 184 · see citing works
Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Aoki, Y., Takao, H., Kawakubo, Y., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3181 · Cited by 183 · see citing works
Duque-Wilckens, N., Steinman, M. Q., Busnelli, M., Chini, B., Yokoyama, S., Pham, M., Laredo, S. A., Hao, R., Perkeybile, A. M., Minie, V. A., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.024 · Cited by 181 · see citing works
Riedl, R., & Javor, A. (2011) · Journal of Neuroscience Psychology and Economics · doi:10.1037/a0026318 · Cited by 180 · see citing works
Wigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179 · see citing works
“001 1182 Left BA 13 (222) Left BA 22 (219) Left BA 38 (174) Left BA 6 (165) Left BA 21 (120) Left BA 43 (70) Left BA 44 (39) Left BA 4 (37) Left BA 47 (31) Left BA 42 (26) Left BA 9 (19) Left BA 20 (12)”
Neurobehavioral foundation of environmental reactivity.
Moore, S. R., & Depue, R. A. (2015) · Psychological Bulletin · doi:10.1037/bul0000028 · Cited by 181 · see citing works
Borderline personality disorder, mentalization, and the neurobiology of attachment.
Fonagy, P., Luyten, P., & Strathearn, L. (2011) · Infant Mental Health Journal · doi:10.1002/imhj.20283 · Cited by 194 · see citing works
Human neuroimaging of oxytocin and vasopressin in social cognition
Zink, C. F., & Meyer-Lindenberg, A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.016 · Cited by 176 · see citing works
“When considering the eye gaze of the face stimuli, the activity in the right amygdala was found to be diminished by oxytocin only to aversely conditioned faces of high social relevance (direct gaze), which strongly activated amygdala under placebo (Petrovic et al., 2008).”
BackgroundInfluentialMaking room for oxytocin in understanding depression
McQuaid, R. J., McInnis, O. A., Abizaid, A. B., & Anisman, H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.005 · Cited by 172 · see citing works
Association between the oxytocin receptor gene and amygdalar volume in healthy adults
Inoue, H., Yamasue, H., Tochigi, M., Abe, O., Liu, X., Kawamura, Y., Takei, K., Suga, M., Yamada, H., Rogers, M. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.019 · Cited by 164 · see citing works
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162 · see citing works
“ics and, in general, the pro-social features of the neuropeptide [166].”
Oxytocin, cortisol, and triadic family interactions
Gordon, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.08.008 · Cited by 158 · see citing works
Anxiolytic-like effect of oxytocin in the simulated public speaking test
de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111400642 · Cited by 154 · see citing works
“OT attenuates negative affective evaluations associated with aversively conditioned faces through modulation of the amygdala and fusiform gyrus in non-clinical adults (Petrovic et al., 2008).”
BackgroundResultNeural mechanisms of social decision-making in the primate amygdala
Chang, S. W. C., Fagan, N. A., Toda, K., Utevsky, A. V., Pearson, J. M., & Platt, M. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514761112 · Cited by 157 · see citing works
“Intranasal OT reliably modulates hemodynamic activity in the amygdala in healthy humans (28, 29, 31), children with autism (32), and rhesus macaques (30).”
BackgroundOxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions
Leknes, S., Wessberg, J., Ellingsen, D.-M., Chelnokova, O., Olausson, H., & Laeng, B. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss062 · Cited by 151 · see citing works
“Petrovic et al. (2008) found that oxytocin reduced the negative evaluation of a face predicting Oxytocin, pupils and emotional sensitivity unpleasant electric shocks.”
BackgroundQuintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149 · see citing works
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149 · see citing works
“These studies showed that OT modulates amygdala activity when viewing human face stimuli in a sexually dimorphic manner, with OT generally decreasing amygdala activation to emotional faces in men (Kirsch et al., 2005; Domes et al., 2007b; Petrovic et al., 2008) but increasing it in women (Domes et al.”
BackgroundEffects of intranasal oxytocin on 'compassion focused imagery'
Rockliff, H., Karl, A., McEwan, K., Gilbert, J., Matos, M., & Gilbert, P. (2011) · Emotion · doi:10.1037/a0023861 · Cited by 147 · see citing works
Mattie Tops, A., Koole, S. L., IJzerman, H., & Buisman‐Pijlman, F. T. A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.07.015 · Cited by 146 · see citing works
“Moreover, intranasal oxytocin abolished negative affective ratings of neutral faces induced by aversive conditioning, decreased right IFG responses and increased left IFG responses to the faces (Petrovic et al., 2008).”
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.020 · Cited by 143 · see citing works
“Intranasal OT administration in FXS may work mechanistically by dampening amygdala reactivity toward socially threatening and anxiety-provoking stimuli (Kirsch et al., 2005; Petrovic et al., 2008), decreasing HPA axis activation, and increasing social motivation (Witt et al.”
Gur, R., Tendler, A., & Wagner, S. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.022 · Cited by 144 · see citing works
Neuropeptides and central control of sexual behaviour from the past to the present: A review
Argiolas, A., & Melis, M. R. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.006 · Cited by 141 · see citing works
Emotion recognition and oxytocin in patients with schizophrenia
Averbeck, B. B., Bobin, T., Evans, S., & Shergill, S. S. (2011) · Psychological Medicine · doi:10.1017/s0033291711001413 · Cited by 144 · see citing works
“Related to this, oxytocin has also been shown to decrease negative affective evaluation of faces that have been negatively conditioned with shock, an effect also mediated by the amygdala (Petrovic et al. 2008).”
BackgroundTranslating mouse vocalizations: prosody and frequency modulation1
Lahvis, G. P., Alleva, E., & Scattoni, M. L. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00603.x · Cited by 143 · see citing works
“For instance, mice that lack a functional oxytocin allele, a molecule that plays a role in social bonding (Ferguson et al. 2000, 2002, Kavaliers et al. 2004, Mahler & Berridge 2009, Petrovic et al. 2008), emit fewer separation calls than their wild-type littermates (Winslow et al. 2000).”
BackgroundAcheson, D., Feifel, D., de Wilde, S., Mckinney, R., Lohr, J., & Risbrough, V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3099-4 · Cited by 141 · see citing works
“…initial extinction training in this study is somewhat surprising given the evidence for acute reductions in amygdala activation and anxiolytic effects after IN OT treatment in humans (Petrovic et al. 2008; de Oliveira et al. 2012; Labuschagne et al. 2010; Domes et al. 2007; Kirsch et al. 2005).”
BackgroundInfluentialInterplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors
Grinevich, V., & Stoop, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.016 · Cited by 139 · see citing works
“have emerged during evolution (Hodos and Butler, 1997; Kaas, 1989, 2008; Niven and Laughlin, 2008) and a number of recent break-through studies reported modulatory effects of OT visual and auditory signals in different orders of mammals (Domes et al., 2013; Freeman and Young, 2016; Kirsch et al., 2005; Marlin et al.,…”
The social brain: Neurobiological basis of affiliative behaviours and psychological well-being
Walker, S. C., & McGlone, F. P. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.008 · Cited by 138 · see citing works
“Neurally, part of OT’s effect appears to be a reduction in amygdala response to fear related stimuli (Petrovic et al., 2008).”
BackgroundHarari-Dahan, O., & Bernstein, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.007 · Cited by 135 · see citing works
A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135 · see citing works
The past, present and future of social neuroscience: A European perspective
Singer, T. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.109 · Cited by 133 · see citing works
“…2008; Knoch et al., 2006), as well as the use of intranasal administration of oxytocin to measure trust (Kosfeld et al., 2005) and other social capacities such as social learning (Petrovic et al., 2008a; Petrovic et al., 2008b), mind reading and empathy (Domes et al., 2007; Singer et al., 2008).”
BackgroundSelf-citationOxytocin blunts social vigilance in the rhesus macaque
Ebitz, R. B., Watson, K. K., & Platt, M. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305230110 · Cited by 132 · see citing works
“For example, OT reduces amygdala responses (12–14), self-reported affective responses (13), and self-reported arousal (15) following threat cues in humans.”
BackgroundMa, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.009 · Cited by 131 · see citing works
“By contrast, IN-OT may increase the capacity to regulate negative affect by increasing activity in the medial prefrontal cortex (mPFC [19,48,49]), ventral lateral prefrontal cortex (vlPFC [13,48,50,52,70]), and dorsal lPFC [49,70], which comprise the neural circuits for automatic and effortful regulation of emotion [6…”
BackgroundInfluentialMelis, M. R., & Argiolas, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.014 · Cited by 129 · see citing works
Wong, R. Y., Oxendine, S. E., & Godwin, J. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-348 · Cited by 128 · see citing works
“Oxytocin is thought to affect many social behaviors in humans [73] including having anxiolytic effects [74,75].”
- Authors
- Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. J.
- Affiliations
- Max Planck Society (DE)
- University College London (GB)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-06-25
- Volume
- 28
- Issue
- 26
- Pages
- 6607-6615
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2647078
- OpenAlex
- W1993130604
- Cited by
- 424
- References
- 80
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 17 · 2020: 22 · 2019: 13 · 2018: 25 · 2017: 23 · 2016: 22 · 2015: 44 · 2014: 47 · 2013: 45 · 2012: 38
- FWCI
- 43.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Wellcome Trust (078865)
- Vetenskapsrådet
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- oxytocin, evaluative conditioning, amygdala, fusiform gyrus, gaze direction, anterior cingulate cortex, prosocial behavior, social cognition
- MeSH terms
- Adult, Affect, Amygdala, Conditioning, Psychological, Facial Expression, Fixation, Ocular, Humans, Male, Neuropsychological Tests, Oxytocin, Pattern Recognition, Visual, Photic Stimulation, Social Behavior, Temporal Lobe, Visual Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
