Cited by 263Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorOptimism, Hope, and Well-being

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Oxytocin receptor gene ( OXTR ) is related to psychological resources

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Saphire-Bernstein, Shimon, Way, Baldwin M., Kim, Heejung S., Sherman, David K., Taylor, Shelley E.·2011·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1113137108PMC PMC3174632

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Abstract

Psychological resources--optimism, mastery, and self-esteem--buffer the deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largely mediated by the influence of OXTR on psychological resources.

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Authors: Saphire-Bernstein, S., Way, B. M., Kim, H. S., Sherman, D. K., & Taylor, S. E.
Affiliations: University of California, Los Angeles (US)
The Ohio State University (US)
University of California, Santa Barbara (US)
ORCID: Way, Baldwin M.
Kim, Heejung S.
Sherman, David K.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2011-08-31
Volume: 108
Issue: 37
Pages: 15118-15122
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1113137108
PMC: PMC3174632
OpenAlex: W2109332215
Cited by: 262
References: 59
Citations by year: 2026: 4 · 2025: 9 · 2024: 10 · 2023: 7 · 2022: 13 · 2021: 18 · 2020: 27 · 2019: 16 · 2018: 17 · 2017: 20 · 2016: 20 · 2015: 31 · 2014: 25 · 2013: 23 · 2012: 18
FWCI: 30.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (0729532)
National Institute on Aging (AG 030309, R01AG030309)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Applied Psychology › Optimism, Hope, and Well-being
Keywords: oxytocin receptor gene, oxytocin receptor, rs53576, single nucleotide polymorphisms, optimism, mastery, self-esteem, psychological resources, stress buffering, depressive symptoms, genetic association, mediation analysis, heritability
MeSH terms: Adolescent, Adult, Depression, Female, Genotype, Humans, Male, Mental Processes, Models, Psychological, Receptors, Oxytocin, Young Adult

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Oxytocin receptor gene ( OXTR ) is related to psychological resources

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