Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects
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Associations of oxytocin receptor gene (OXTR) variants and autism spectrum disorders (ASD) have been reported in earlier studies; in one of the studies associations with IQ and daily living skills were found additionally. Variations of the oxytocin receptor gene might also regulate affect, attachment and separation beyond the diagnostic borders of autism. We tested hypotheses of associations between positive and negative affects and social and emotional loneliness (285 adults), IQ (117 adolescents) and polymorphisms of the oxytocin receptor gene (OXTR rs53576, rs2254298 and rs2228485) in normal subjects. Individuals with the oxytocin OXTR rs53576 A/A genotype showed lower positive affect scores (F=5.532, df=1; p=0.019). This effect was restricted to males (F=13.098, df=1; p=0.00047). Haplotypes constructed with the three markers were associated with positive affect (p=0.0012), negative affect (p<0.0001) and emotional loneliness (p<0.0001). Non-verbal intelligence was significantly reduced in rs53576 A/A adolescents (T=2.247, p=0.027). Our findings support a role for the oxytocin receptor haplotypes in the generation of affectivity, emotional loneliness and IQ.
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Reduced positive affect and reward dependence were found in men only among carriers of the A allele in rs53576.
“whereas reduced positive affect (Lucht et al., 2009) and reward dependence (Tost et al., 2010) were found in men only.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Lucht et al., 2009
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- Authors
- Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., Völzke, H., Freyberger, H. J., Herrmann, F. H., Kroemer, H., & Rosskopf, D.
- Affiliations
- Universität Greifswald (DE)
- Heidelberg University (DE)
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Lucht, Michael J.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 33
- Issue
- 5
- Pages
- 860-866
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W1992733985
- Cited by
- 271
- References
- 43
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 18 · 2017: 15 · 2016: 26 · 2015: 23 · 2014: 27 · 2013: 31 · 2012: 24
- FWCI
- 24.28
- Type
- journal article
- Language
- en
- Open access
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion, cc-by)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- oxytocin receptor gene, OXTR polymorphisms, positive affect, negative affect, emotional loneliness, social loneliness, nonverbal intelligence, haplotypes, rs53576, autism spectrum disorder, sex differences, genetic association
- MeSH terms
- Adolescent, Adult, Affect, Aged, Autistic Disorder, Child, Female, Genetic Markers, Haplotypes, Humans, Intelligence, Loneliness, Male, Middle Aged, Polymorphism, Genetic, Receptors, Oxytocin, Young Adult
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