The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations
Open accessAbstract
We profiled microRNAs (miRNAs) in cell-free serum and plasma samples from human volunteers using deep sequencing of barcoded small RNA cDNA libraries. By introducing calibrator synthetic oligonucleotides during library preparation, we were able to calculate the total as well as specific concentrations of circulating miRNA. Studying trios of samples from newborn babies and their parents we detected placental-specific miRNA in both maternal and newborn circulations and quantitated the relative contribution of placental miRNAs to the circulating pool of miRNAs. Furthermore, sequence variation in the placental miRNA profiles could be traced to the specific placenta of origin. These deep sequencing profiles, which may serve as a model for tumor or disease detection, allow us to define the repertoire of miRNA abundance in the circulation and potential uses as biomarkers.
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Cites
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Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
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Self-citationRegulation of mRNA Translation and Stability by microRNAs
Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-103103 · Cited by 3,214
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
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Blood Cell Origin of Circulating MicroRNAs: A Cautionary Note for Cancer Biomarker Studies
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MicroRNA regulation by RNA-binding proteins and its implications for cancer
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Dynamic isomiR regulation in Drosophila development
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Cited by
Clinical relevance of circulating cell-free microRNAs in cancer
Schwarzenbach, H., Nishida, N., Calin, G. A., & Pantel, K. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.5 · Cited by 969
Akat, K. M., Moore-McGriff, D., Morozov, P., Brown, M., Gogakos, T., Correa Da Rosa, J., Mihailovic, A., Sauer, M., Ji, R., Ramarathnam, A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401724111 · Cited by 254
Self-citationExtracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain
Pegtel, D. M., Peferoen, L., & Amor, S. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0516 · Cited by 232
Honegger, A., Schilling, D., Bastian, S., Sponagel, J., Kuryshev, V., Sültmann, H., Scheffner, M., Hoppe-Seyler, K., & Hoppe-Seyler, F. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004712 · Cited by 222
Benmoussa, A., Lee, C. H. C., Laffont, B., Savard, P., Laugier, J., Boilard, E., Gilbert, C., Fliss, I., & Provost, P. (2016) · The Journal of Nutrition · doi:10.3945/jn.116.237651 · Cited by 212
Metadata
- Authors
- Williams, Z., Ben-Dov, I. Z., Elias, R., Mihailovic, A., Brown, M., Rosenwaks, Z., & Tuschl, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-02-25
- Volume
- 110
- Issue
- 11
- Pages
- 4255-4260
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1996301440
- Cited by
- 339
- References
- 8
- FWCI
- 14.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Williams, Z., Ben-Dov, I. Z., Elias, R., Mihailovic, A., Brown, M., Rosenwaks, Z., & Tuschl, T. (2013). Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1214046110
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