The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations
Open accessAbstract
We profiled microRNAs (miRNAs) in cell-free serum and plasma samples from human volunteers using deep sequencing of barcoded small RNA cDNA libraries. By introducing calibrator synthetic oligonucleotides during library preparation, we were able to calculate the total as well as specific concentrations of circulating miRNA. Studying trios of samples from newborn babies and their parents we detected placental-specific miRNA in both maternal and newborn circulations and quantitated the relative contribution of placental miRNAs to the circulating pool of miRNAs. Furthermore, sequence variation in the placental miRNA profiles could be traced to the specific placenta of origin. These deep sequencing profiles, which may serve as a model for tumor or disease detection, allow us to define the repertoire of miRNA abundance in the circulation and potential uses as biomarkers.
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Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626
Self-citationRegulation of mRNA Translation and Stability by microRNAs
Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-103103 · Cited by 3,214
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605
Blood Cell Origin of Circulating MicroRNAs: A Cautionary Note for Cancer Biomarker Studies
Pritchard, C. C., Kroh, E., Wood, B., Arroyo, J. D., Dougherty, K. J., Miyaji, M. M., Tait, J. F., & Tewari, M. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0370 · Cited by 879
MicroRNA regulation by RNA-binding proteins and its implications for cancer
van Kouwenhove, M., Kedde, M., & Agami, R. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3107 · Cited by 617
Dynamic isomiR regulation in Drosophila development
Fernandez-Valverde, S. L., Taft, R. J., & Mattick, J. S. (2010) · RNA · doi:10.1261/rna.2379610 · Cited by 208
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Clinical relevance of circulating cell-free microRNAs in cancer
Schwarzenbach, H., Nishida, N., Calin, G. A., & Pantel, K. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.5 · Cited by 969
Akat, K. M., Moore-McGriff, D., Morozov, P., Brown, M., Gogakos, T., Correa Da Rosa, J., Mihailovic, A., Sauer, M., Ji, R., Ramarathnam, A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401724111 · Cited by 254
Self-citationExtracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain
Pegtel, D. M., Peferoen, L., & Amor, S. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0516 · Cited by 232
Honegger, A., Schilling, D., Bastian, S., Sponagel, J., Kuryshev, V., Sültmann, H., Scheffner, M., Hoppe-Seyler, K., & Hoppe-Seyler, F. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004712 · Cited by 222
Benmoussa, A., Lee, C. H. C., Laffont, B., Savard, P., Laugier, J., Boilard, E., Gilbert, C., Fliss, I., & Provost, P. (2016) · The Journal of Nutrition · doi:10.3945/jn.116.237651 · Cited by 212
MicroRNAs in placental health and disease
Mouillet, J.-F., Ouyang, Y., Coyne, C. B., & Sadovsky, Y. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.05.057 · Cited by 195
MicroRNAs as biomarkers for CNS disease
Rao, P., Benito, E., & Fischer, A. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00039 · Cited by 171
Geekiyanage, H., Rayatpisheh, S., Wohlschlegel, J. A., Brown, R., & Ambros, V. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008323117 · Cited by 148
Sources and Functions of Extracellular Small RNAs in Human Circulation
Fritz, J. V., Heintz-Buschart, A., Ghosal, A., Wampach, L., Etheridge, A., Galas, D., & Wilmes, P. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050711 · Cited by 121
Krauskopf, J., Caiment, F., Claessen, S. M., Johnson, K. J., Warner, R. L., Schomaker, S. J., Burt, D. A., Aubrecht, J., & Kleinjans, J. C. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfu232 · Cited by 93
Circulating microRNAs as Promising Tumor Biomarkers
(2014) · Advances in Clinical Chemistry · doi:10.1016/bs.acc.2014.09.007 · Cited by 40
Dear, J. W., & Antoine, D. J. (2014) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2014.880650 · Cited by 34
Dysregulation and Diagnostic Potential of microRNA in Alzheimer’s Disease
Pan, Y., Liu, R., Terpstra, E., Wang, Y., Qiao, F., Wang, J., Tong, Y., & Pan, B. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150451 · Cited by 29
MicroRNAs in B-cells: From normal differentiation to treatment of malignancies
Marques, S. C., Laursen, M. B., Bødker, J. S., Kjeldsen, M. K., Falgreen, S., Schmitz, A., Bøgsted, M., Johnsen, H. E., & Dybkaer, K. (2015) · Oncotarget · doi:10.18632/oncotarget.3057 · Cited by 26
Izumi, N., Shoji, K., Kiuchi, T., Katsuma, S., & Tomari, Y. (2023) · RNA · doi:10.1261/rna.079380.122 · Cited by 13
Valbuena, G. N., Apostolidou, S., Roberts, R., Barnes, J., Alderton, W., Harper, L., Jacobs, I., Menon, U., & Keun, H. C. (2019) · Scientific Reports · doi:10.1038/s41598-019-51948-6 · Cited by 13
Blocking of targeted microRNAs from next-generation sequencing libraries
Roberts, B. S., Hardigan, A. A., Kirby, M. K., Fitz-Gerald, M. B., Wilcox, C. M., Kimberly, R. P., & Myers, R. M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv724 · Cited by 8
Metadata
- Authors
- Williams, Z., Ben-Dov, I. Z., Elias, R., Mihailovic, A., Brown, M., Rosenwaks, Z., & Tuschl, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-02-25
- Volume
- 110
- Issue
- 11
- Pages
- 4255-4260
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1996301440
- Cited by
- 339
- References
- 8
- FWCI
- 14.80
- Type
- journal article
- Language
- en
- Open access
- green
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