Effects of sex and COMT genotype on environmentally modulated cognitive control in mice

Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia

Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works

The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry

Robbins, T. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1154-7 · Cited by 1,282 · see citing works

Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement

Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S. J., Theobald, D. E. H., Lääne, K., Peña, Y., Murphy, E. R., Shah, Y., Probst, K., et al. (2007) · Science · doi:10.1126/science.1137073 · Cited by 1,188 · see citing works

Catechol <i>O</i> -methyltransferase <i>val</i> ^<i>158</i> <i>-met</i> genotype and individual variation in the brain response to amphetamine

Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893 · see citing works

A Meta-Analytic Review of Gender Differences in ADHD

Gershon, J., & Gershon, J. (2002) · Journal of Attention Disorders · doi:10.1177/108705470200500302 · Cited by 875 · see citing works

Catechol- <i>O</i> -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

Gogos, J. A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., & Karayiorgou, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9991 · Cited by 864 · see citing works

Human Catechol- <i>O</i> -Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure

Nackley, A. G., Shabalina, S. A., Tchivileva, I. E., Satterfield, K., Korchynskyi, O., Makarov, S. S., Maixner, W., & Diatchenko, L. (2006) · Science · doi:10.1126/science.1131262 · Cited by 848 · see citing works

Sex Differences in the Risk of Schizophrenia: Evidence From Meta-analysis

Aleman, A., Kahn, R. S., & Selten, J.-P. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.565 · Cited by 818 · see citing works

Sex influences on the neurobiology of learning and memoryPreprint

Andreano, J. M., & Cahill, L. F. (2009) · Learning & Memory · doi:10.1101/lm.918309 · Cited by 684 · see citing works

Executive Subprocesses in Working Memory

Goldberg, T. E., Egan, M. F., Gscheidle, T., Coppola, R., Weickert, T. W., Kolachana, B. S., Goldman, D. A., & Weinberger, D. R. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.889 · Cited by 580 · see citing works

Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex

Granon, S., Passetti, F., Thomas, K. L., Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01208.2000 · Cited by 546 · see citing works

Dissociable Contributions of the Orbitofrontal and Infralimbic Cortex to Pavlovian Autoshaping and Discrimination Reversal Learning: Further Evidence for the Functional Heterogeneity of the Rodent Frontal Cortex

Chudasama, Y., & Robbins, T. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08771.2003 · Cited by 543 · see citing works

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

National Research Council (2003) · National Academies Press eBooks · doi:10.17226/10732 · Cited by 530 · see citing works

The Cerebral Cortex of the Rat and Visual Attentional Function: Dissociable Effects of Mediofrontal, Cingulate, Anterior Dorsolateral, and Parietal Cortex Lesions on a Five-Choice Serial Reaction Time Task

Muir, J. L., Everitt, B. J., & Robbins, T. W. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.3.470 · Cited by 503 · see citing works

The neuropsychiatry of impulsivity

Chamberlain, S. R., & Sahakian, B. J. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3280ba4989 · Cited by 419 · see citing works

Catechol-O-Methyltransferase Inhibition Improves Set-Shifting Performance and Elevates Stimulated Dopamine Release in the Rat Prefrontal Cortex

Tunbridge, E. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1124-04.2004 · Cited by 418 · see citing works

The Cortical Dopamine System: Role in Memory and Cognition

Goldman, P. S. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60846-7 · Cited by 393 · see citing works

Catechol-O-Methyltransferase (COMT): A Gene Contributing to Sex Differences in Brain Function, and to Sexual Dimorphism in the Predisposition to Psychiatric Disorders

Harrison, P. J., & Tunbridge, E. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301543 · Cited by 308 · see citing works

Effect of Catechol- <i>O</i> -Methyltransferase <i> val ¹⁵⁸ met </i> Genotype on Attentional Control

Blasi, G., Mattay, V. S., Bertolino, A., Elvevåg, B., Callicott, J. H., Das, S., Kolachana, B. S., Egan, M. F., Goldberg, T. E., & Weinberger, D. R. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0476-05.2005 · Cited by 294 · see citing works

Genetic Dissection of the Role of Catechol- <i>O</i> -Methyltransferase in Cognition and Stress Reactivity in Mice

Papaleo, F., Crawley, J. N., Song, J., Lipska, B. K., Pickel, J., Weinberger, D. R., & Chen, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2077-08.2008 · Cited by 288 · see citing works

Site-Specific Role of Catechol- O -Methyltransferase in Dopamine Overflow within Prefrontal Cortex and Dorsal Striatum

Yavich, L., Forsberg, M., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0665-07.2007 · Cited by 269 · see citing works

Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies

Taylor, S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.76 · Cited by 264 · see citing works

Topical Review: Fetal Testosterone and Sex Differences in Typical Social Development and in Autism

Knickmeyer, R. C., & Baron-Cohen, S. (2006) · Journal of Child Neurology · doi:10.1177/08830738060210101601 · Cited by 230 · see citing works

Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

Käenmäki, M., Tammimäki, A., Myöhänen, T. T., Pakarinen, K., Amberg, C., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06889.x · Cited by 188 · see citing works

The met158 allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case–control study and meta-analysis

Pooley, E. C., Fineberg, N. A., & Harrison, P. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001951 · Cited by 167 · see citing works

Endocannabinoid signaling is critical for habit formation

Hilário, M. R. F. (2007) · Frontiers in Integrative Neuroscience · doi:10.3389/neuro.07.006.2007 · Cited by 164 · see citing works

Catecholamines and Aggression: The Role of COMT and MAO Polymorphisms

Volavka, J., Bilder, R. M., & Nolan, K. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1330.023 · Cited by 158 · see citing works

The Effects of Catechol O-methyltransferase Genotype on Brain Activation Elicited by Affective Stimuli and Cognitive Tasks

Heinz, A., & Smolka, M. N. (2006) · Reviews in the Neurosciences · doi:10.1515/revneuro.2006.17.3.359 · Cited by 148 · see citing works

Seeing the unexpected: How sex differences in stress responses may provide a new perspective on the manifestation of psychiatric disorders

Klein, L. C., & Corwin, E. J. (2002) · Current Psychiatry Reports · doi:10.1007/s11920-002-0072-z · Cited by 128 · see citing works

Genetic Deletion of A2AAdenosine Receptors in the Striatum Selectively Impairs Habit Formation: Figure 1.

Yu, C., Gupta, J. F., Chen, J., & Yin, H. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4215-09.2009 · Cited by 128 · see citing works

Suicidal behavior in patients with schizophrenia is related to COMT polymorphism

Nolan, K. A., Volavka, J., Czobor, P., Cseh, A., Lachman, H. M., Saito, T., Tiihonen, J., Putkonen, A., Hallikainen, T., Kotilainen, I., et al. (2000) · Psychiatric Genetics · doi:10.1097/00041444-200010030-00003 · Cited by 114 · see citing works

Family‐based and case‐control association studies of catechol‐<i>O</i>‐methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism

Qian, Q., Wang, Y., Zhou, R., Li, J., Wang, B., Glatt, S., & Faraone, S. V. (2003) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10064 · Cited by 113 · see citing works

Gender- and morphine dose-linked expression of spontaneous somatic opiate withdrawal in mice

Papaleo, F., & Contarino, A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.02.009 · Cited by 107 · see citing works

Polymorphisms in Dopamine System Genes Are Associated With Individual Differences in Attention in Infancy

Holmboe, K., Nemoda, Z., Fearon, R. M. P., Csibra, G., Sasvári-Székely, M., & Johnson, M. H. (2010) · Developmental Psychology · doi:10.1037/a0018180 · Cited by 102 · see citing works

Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake

Perry, J. L., Nelson, S. E., Anderson, M. M., Morgan, A. D., & Carroll, M. E. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.03.012 · Cited by 100 · see citing works

Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: A preliminary study

Biederman, J., Kim, J. W., Doyle, A. E., Mick, E., Fagerness, J., Smoller, J. W., & Faraone, S. V. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30874 · Cited by 100 · see citing works

Meta-analysis of Association Between a Catechol-O-Methyltransferase Gene Polymorphism and Attention Deficit Hyperactivity Disorder

Cheuk, D., & Wong, V. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9076-5 · Cited by 85 · see citing works

Decreased motivation to eat in µ‐opioid receptor‐deficient mice

Papaleo, F., Kieffer, B. L., Tabarin, A., & Contarino, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05595.x · Cited by 79 · see citing works

Gender differences in delay-discounting under mild food restriction

Koot, S., van den Bos, R., Adriani, W., & Giovanni Laviola, A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.01.006 · Cited by 69 · see citing works

Association between Catechol-O-Methyltransferase Functional Polymorphism and Male Suicide Completers

Ono, H., Shirakawa, O., Nushida, H., Ueno, Y., & Maeda, K. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300470 · Cited by 65 · see citing works

A microdialysis study of the medial prefrontal cortex of adolescent and adult rats

Staiti, A. M., Morgane, P. J., Galler, J. R., Grivetti, J. Y., Bass, D. C., & Mokler, D. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.005 · Cited by 62 · see citing works

Impulsivity in mania

Swann, A. C. (2009) · Current Psychiatry Reports · doi:10.1007/s11920-009-0073-2 · Cited by 62 · see citing works

Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes

O’Tuathaigh, C. M. P., Clarke, G. A., Walsh, J., Desbonnet, L., Petit, E., O’Leary, C., Tighe, O., Clarke, N. E., Karayiorgou, M., Gogos, J. A., et al. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001581 · Cited by 61 · see citing works

Sex Modulates the Associations Between the COMT Gene and Personality Traits

Chen, C., Chen, C., Moyzis, R. K., Dong, Q., He, Q., Zhu, B., Li, J., Li, H., Li, J., & Lessard, J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.39 · Cited by 54 · see citing works

Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine

Hamidovic, A., Dlugos, A. M., Palmer, A. A., & de Wit, H. (2010) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833a1f3c · Cited by 52 · see citing works

COMT as a Drug Target for Cognitive Functions and Dysfunctions

Scheggia, D., Sannino, S., Scattoni, M. L., & Papaleo, F. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712800672481 · Cited by 52 · see citing works

The effect of estradiol on catechol-O-methyltransferase activity in rat liver

Cohn, C. K., & Axelrod, J. (1971) · Life Sciences · doi:10.1016/0024-3205(71)90335-3 · Cited by 49 · see citing works

Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice

Segall, S. K., Nackley, A. G., Diatchenko, L. B., Lariviere, W. R., Lu, X., Marron, J. S., Grabowski-Boase, L., Walker, J. R., Slade, G. D., Gauthier, J., et al. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00633.x · Cited by 37 · see citing works

Sexual Dimorphism and Laterality in the Evolution of the Primate Prefrontal Cortex

Smaers, J. B., Mulvaney, P. I., Soligo, C., Zilles, K., & Amunts, K. (2012) · Brain, Behavior and Evolution · doi:10.1159/000336115 · Cited by 25 · see citing works

Animal Models of Genetic Effects on Cognition

Papaleo, F., Weinberger, D. R., & Chen, J. (2009) · The MIT Press eBooks · doi:10.7551/mitpress/7447.003.0006 · Cited by 3 · see citing works

Let’s call the whole thing off: evaluating gender and sex differences in executive function

Grissom, N. M., & Reyes, T. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0179-5 · Cited by 306 · see citing works

Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice

Jendryka, M., Palchaudhuri, M., Ursu, D., van der Veen, B., Liss, B., Kätzel, D., Nissen, W., & Pekcec, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-41088-2 · Cited by 296 · see citing works

Statistical learning of language: Theory, validity, and predictions of a statistical learning account of language acquisition

Erickson, L., & Thiessen, E. D. (2015) · Developmental Review · doi:10.1016/j.dr.2015.05.002 · Cited by 246 · see citing works

Sex differences in impulsive action and impulsive choice

Weafer, J. J., & de Wit, H. (2013) · Addictive Behaviors · doi:10.1016/j.addbeh.2013.10.033 · Cited by 245 · see citing works

The Stomach-Derived Hormone Ghrelin Increases Impulsive Behavior

Anderberg, R. H., Hansson, C., Fenander, M., Richard, J. E., Dickson, S. L., Nissbrandt, H., Bergquist, F., & Skibicka, K. P. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.297 · Cited by 103 · see citing works

A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia

Malan‐Müller, S., Kilian, S., van den Heuvel, L. L., Bardien, S., Asmal, L., Warnich, L., Emsley, R. A., Hemmings, S. M. J., & Seedat, S. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.11.011 · Cited by 98 · see citing works

Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments

Carroll, M. E., & Smethells, J. R. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00175 · Cited by 93 · see citing works

Animal models of gene–environment interaction in schizophrenia: A dimensional perspective

Ayhan, Y., McFarland, R., & Pletnikov, M. V. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.002 · Cited by 81 · see citing works

Dopamine transporter (DAT) genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder

Mereu, M., Contarini, G., Buonaguro, E. F., Latte, G., Managò, F., Iasevoli, F., de Bartolomeis, A., & Papaleo, F. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.037 · Cited by 66 · see citing works

Sex differences in animal models of schizophrenia shed light on the underlying pathophysiology

Hill, R. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.014 · Cited by 61 · see citing works

COMT Genetic Reduction Produces Sexually Divergent Effects on Cortical Anatomy and Working Memory in Mice and Humans

Sannino, S., Gozzi, A., Cerasa, A., Piras, F., Scheggia, D., Managò, F., Damiano, M., Galbusera, A., Erickson, L. C., Tonelli, D. D. P., et al. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu053 · Cited by 60 · see citing works

Sex Differences in COMT Polymorphism Effects on Prefrontal Inhibitory Control in Adolescence

White, T. P., Loth, E., Rubia, K., A, L. K. M., Whelan, R., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Conrod, P., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.107 · Cited by 57 · see citing works

Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed

Cirzi, C., Dyckow, J., Legrand, C., Schott, J., Guo, W., Pérez-Hernández, D., Hisaoka, M., Parlato, R., Pitzer, C., van der Hoeven, F., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112507 · Cited by 45 · see citing works

Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission

Godar, S. C., & Bortolato, M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00071 · Cited by 47 · see citing works

Modeling neurodevelopmental cognitive deficits in tasks with cross‐species translational validity

Cope, Z. A., Powell, S. B., & Young, J. W. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12268 · Cited by 45 · see citing works

Measuring discrimination- and reversal learning in mouse models within 4 days and without prior food deprivationPreprint

Remmelink, E., Smit, A. B., Verhage, M., & Loos, M. (2016) · Learning & Memory · doi:10.1101/lm.042085.116 · Cited by 44 · see citing works

Generation and Characterization of Humanized Mice Carrying COMT158 Met/Val Alleles

Risbrough, V. B., Ji, B., Hauger, R., & Zhou, X. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.29 · Cited by 41 · see citing works

Putative therapeutic targets for symptom subtypes of adult ADHD: D4 receptor agonism and COMT inhibition improve attention and response inhibition in a novel translational animal model

Tomlinson, A., Grayson, B., Marsh, S., Hayward, A., Marshall, K. M., & Neill, J. C. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.11.016 · Cited by 41 · see citing works

Cognitive flexibility deficits in a mouse model for the absence of full‐length dystrophin

Remmelink, E., Aartsma-Rus, A. M., Smit, A. B., Verhage, M., Loos, M., & van Putten, M. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12301 · Cited by 39 · see citing works

Adolescence is the starting point of sex-dichotomous COMT genetic effects

Sannino, S., Padula, M. C., Managò, F., Schaer, M., Schneider, M., Armando, M., Scariati, E., Béna, F., Mereu, M., Pontillo, M., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.109 · Cited by 34 · see citing works

Dopamine and cognitive control: Sex-by-genotype interactions influence the capacity to switch attention

Gurvich, C., & Rossell, S. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.11.045 · Cited by 33 · see citing works

An updated review on animal models to study attention-deficit hyperactivity disorder

Kim, D., Yadav, D., & Song, M. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02893-0 · Cited by 36 · see citing works

Sex-dichotomous effects of functional COMT genetic variations on cognitive functions disappear after menopause in both health and schizophrenia

Papaleo, F., Sannino, S., Piras, F., & Spalletta, G. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.10.005 · Cited by 32 · see citing works

Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype

Zhang, Y., Chen, M., Chen, J., Wu, Z., Yu, S., Fang, Y.-R., & Zhang, C. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3410-4 · Cited by 32 · see citing works

Attentional Control in Adolescent Mice Assessed with a Modified Five Choice Serial Reaction Time Task

Ciampoli, M., Contarini, G., Mereu, M., & Papaleo, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-10112-8 · Cited by 32 · see citing works

Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat

Kline, R., Exposto, F. G., O’Buckley, S. C., Westlund, K. N., & Nackley, A. G. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.064 · Cited by 26 · see citing works

Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks

Reynolds, L. M., Faure, P., & Barik, J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03110-0 · Cited by 26 · see citing works

Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex

Scheggia, D., Zamberletti, E., Realini, N., Mereu, M., Contarini, G., Ferretti, V., Managò, F., Margiani, G., Brunoro, R., Rubino, T., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.126 · Cited by 24 · see citing works

Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis

Ye, Q., & Kim, J. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.06.016 · Cited by 23 · see citing works

Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats

McCane, A. M., DeLory, M. J., Timm, M. M., Janetsian-Fritz, S. S., Lapish, C. C., & Czachowski, C. L. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.08.007 · Cited by 18 · see citing works

Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity

Barkus, C., Korn, C., Stumpenhorst, K., Laatikainen, L. M., Ballard, D., Lee, S., Sharp, T., Harrison, P. J., Bannerman, D. M., Weinberger, D. R., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.119 · Cited by 20 · see citing works

Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders

Palamarchuk, I. S., Slavich, G. M., Vaillancourt, T., & Rajji, T. K. (2023) · BMC Neuroscience · doi:10.1186/s12868-023-00831-2 · Cited by 24 · see citing works

The divergent impact of COMT Val158Met on executive function in children with and without attention‐deficit/hyperactivity disorder

Jin, J., Liu, L., Gao, Q., Chan, R. C. K., Li, H., Chen, Y., Wang, Y., & Qian, Q. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12270 · Cited by 18 · see citing works

Dopaminergic function in relation to genes associated with risk for schizophrenia

Moran, P. M., O’Tuathaigh, C. M. P., Papaleo, F., & Waddington, J. L. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63425-2.00004-0 · Cited by 18 · see citing works

Sex Differences in Opioid Response Linked to OPRM1 and COMT genes DNA Methylation/Genotypes Changes in Patients with Chronic Pain

Agulló, L., Muriel, J., Margarit, C., Escorial, M., Garcia, D., Herrero, M. J., Hervás, D., Sandoval, J., & Peiró, A. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12103449 · Cited by 17 · see citing works

Adolescent cannabinoid exposure interacts with other risk factors in schizophrenia: A review of the evidence from animal models

Dunn, A. L., Michie, P. T., Hodgson, D. M., & Harms, L. R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.028 · Cited by 15 · see citing works

Genetic factors underlying attention and impulsivity: mouse models of attention-deficit/hyperactivity disorder

Itohara, S., Kobayashi, Y., & Nakashiba, T. (2014) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2014.09.002 · Cited by 16 · see citing works

Interaction of genotype and environment: effect of strain and housing conditions on cognitive behavior in rodent models of schizophrenia

Turner, K. M., & Burne, T. H. J. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00097 · Cited by 16 · see citing works

Sex chromosome complement affects multiple aspects of reversal‐learning task performance in mice

Aarde, S. M., Genner, R. M., Hrncir, H., Arnold, A. P., & Jentsch, D. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12685 · Cited by 16 · see citing works

The development of compulsive coping behaviour is associated with a downregulation of Arc in a Locus Coeruleus neuronal ensemble

Velázquez-Sánchez, C., Mureşan, L., Martí‐Prats, L., & Belin, D. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01522-y · Cited by 15 · see citing works

Progesterone attenuates impulsive action in a Go/No-Go task for sucrose pellets in female and male rats

Swalve, N. L., Smethells, J. R., & Carroll, M. E. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.08.001 · Cited by 14 · see citing works

Sex-dependent differences in animal cognition

Koszałka, A., Lustyk, K., & Pytka, K. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105374 · Cited by 13 · see citing works

Sexually divergent effect of COMT Val/met genotype on subcortical volumes in schizophrenia

Bollettini, I., Spangaro, M., Poletti, S., Lorenzi, C., Pirovano, A., Vai, B., Smeraldi, E., Cavallaro, R., & Benedetti, F. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9748-1 · Cited by 11 · see citing works

In vivo calcium extrusion from accumbal astrocytes reduces anxiety-like behaviors but increases compulsive-like responses and compulsive ethanol drinking in mice

Peyton, L., Haroon, H., Umpierre, A. D., Essa, H., Bruce, R., Wu, L., & Choi, D. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110320 · Cited by 10 · see citing works

A schizophrenia relevant 5-Choice Serial Reaction Time Task for mice assessing broad monitoring, distractibility and impulsivity

Huang, H., Guadagna, S., Mereu, M., Ciampoli, M., Pruzzo, G., Ballard, T. M., & Papaleo, F. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4611-z · Cited by 10 · see citing works

Moderate prenatal ethanol exposure leads to attention deficits in both male and female rats

Wang, R., Martin, C. D., Lei, A. L., Hausknecht, K. A., Ishiwari, K., Oubraim, S., Wang, A., Richards, J. B., Haj‐Dahmane, S., & Shen, R. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14599 · Cited by 9 · see citing works

Adolescent nutritional influences on the brain: implications for eating behaviors

Lazzaro, M., Mills, A. M., & Noble, E. E. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110570 · Cited by 8 · see citing works

Relations between catechol‐O‐methyltransferase Val158Met genotype and inhibitory control development in childhood

Bowers, M. E., Buzzell, G. A., Salo, V. C., Troller‐Renfree, S. V., Hodgkinson, C. A., Goldman, D. A., Gorodetsky, E. K., McDermott, J. M., Henderson, H. A., & Fox, N. A. (2019) · Developmental Psychobiology · doi:10.1002/dev.21901 · Cited by 7 · see citing works

Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward prediction

Peterson, S., Maheras, A., Wu, B., Chavira, J., & Keiflin, R. (2023) · eLife · doi:10.7554/elife.93509 · Cited by 6 · see citing works

Sex-specific responses to juvenile stress on the dopaminergic system in an animal model of attention-deficit hyperactivity disorder

Jung, D. H., Lee, H. J., Choi, Y. W., Shin, H. K., & Choi, B. T. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114352 · Cited by 6 · see citing works

Dissociating motor impairment from five-choice serial reaction time task performance in a mouse model of Angelman syndrome

Negrón-Moreno, P. N., Diep, D. T., Guoynes, C. D., & Sidorov, M. S. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.968159 · Cited by 5 · see citing works

A NewT. gondiiMouse Model of Gene-Environment Interaction Relevant to Psychiatric Disease

Kannan, G., Prandovszky, E., Severance, E. G., Yolken, R. H., & Pletnikov, M. V. (2018) · Scientifica · doi:10.1155/2018/7590958 · Cited by 4 · see citing works

Dopaminergic Genes Polymorphisms and Prefrontal Cortex Efficiency Among Obese People - Whether Gender is a Differentiating Factor?

Bieliński, M. K., Lesiewska, N., Junik, R., Kamińska, A., Tretyn, A., & Borkowska, A. (2019) · Current Molecular Medicine · doi:10.2174/1566524019666190424143653 · Cited by 4 · see citing works

The inconsistent mediating effect of catechol O methyl transferase Val158Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients

Xu, H., Zhou, Y., Xiu, M., Chen, D., Wang, W., Wang, L., & Zhang, X. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.993859 · Cited by 4 · see citing works

Alterations in KIDINS220/ARMS Expression Impact Sensory Processing and Social Behavior in Adult Mice

Albini, M., Almacellas‐Barbanoj, A., Krawczun-Rygmaczewska, A., Ciano, L., Benfenati, F., Michetti, C., & Cesca, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042334 · Cited by 4 · see citing works

Sex‐specific effects of COMT Val158Met polymorphism on corpus callosum structure: A whole‐brain diffusion‐weighted imaging study

El‐Hage, W., Cléry, H., Andersson, F., Filipiak, I., de Schotten, M. T., Gohier, B., & Surguladze, S. (2017) · Brain and Behavior · doi:10.1002/brb3.786 · Cited by 3 · see citing works

DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact

Rawlings-Mortimer, F., Gullino, L. S., Rühling, S., Ashton, A., Barkus, C., & Johansen‐Berg, H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281264 · Cited by 3 · see citing works

Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward prediction

Peterson, S., Maheras, A., Wu, B., Chavira, J., & Keiflin, R. (2024) · eLife · doi:10.7554/elife.93509.4 · Cited by 3 · see citing works

The Genetics of Impulsivity: A Synthesis of Findings in Humans and Rodent Models

Jupp, B., & Dalley, J. W. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3777-6_3 · Cited by 3 · see citing works

Characterization of a differential reinforcement of low rates of responding task in non-deprived male and female rats: Role of Sigma-1 receptors

Sabino, V., Blasio, A., Ferragud, A., Quadir, S. G., Iyer, M. R., Rice, K. C., & Cottone, P. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108786 · Cited by 2 · see citing works

BK channel dysfunction disrupts attention-controlled behaviors and altered perseverative responses in murine instrumental learning

Arake, M., Ohta, H., Nozawa, T., Satoh, Y., Fujita, M., Nakata, T., Meredith, A. L., Shinomiya, N., Ishizuka, T., & Morimoto, Y. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115015 · Cited by 2 · see citing works

Assessing the stability of responding of male mice in the touchscreen 5 choice serial reaction time task: Focus on premature responding

Rahbarnia, A., Abela, A. R., & Fletcher, P. J. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16232 · Cited by 2 · see citing works

Dopaminergic signalling and behavioural alterations by Comt–Dtnbp1 genetic interaction and their clinical relevance

Managò, F., Scheggia, D., Pontillo, M., Mereu, M., Mastrogiacomo, R., Udayan, G., Valentini, P., Tata, M. C., Weinberger, D. R., Weickert, C. S., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16147 · Cited by 3 · see citing works

Shifts in attentional demand are accompanied by sex-specific patterns of insula-frontal cortical interactions in mice

Harr, A. E., O’Leary, M. R., Vogt, E., Suresh, S., & Hallock, H. L. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121890 · Cited by 1 · see citing works

Modeling Cognitive Impairment

Managò, F., Huang, H., & Papaleo, F. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00006-7 · Cited by 1 · see citing works

An overview of correlations between schizophrenia and 22q11.2 deletion syndrome

Armando, M., Pontillo, M., Crescenzo, F. D., Correale, C., Simoni, E. D., Papaleo, F., Saba, R., & Vicari, S. (2013) · SERVAL (Université de Lausanne) · Cited by 1 · see citing works

Repetitive Transcranial Magnetic Stimulation in Addiction

Martinotti, G., Pettorruso, M., Montemitro, C., Ekhtiari, H., Hanlon, C. A., Spagnolo, P. A., Stein, E. A., & Giannantonio, M. D. (2020) · Springer eBooks · doi:10.1007/978-3-030-43356-7_11 · Cited by 1 · see citing works

Neurogenetics, Genome-Wide Association and Candidate Gene Studies

Haller, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-46331-1_3 · Cited by 1 · see citing works

Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward predictionPreprint

Peterson, S., Maheras, A. L., Wu, B., Chavira, J., & Keiflin, R. (2024) · bioRxiv · doi:10.1101/2023.08.28.555217 · Cited by 7 · see citing works

The Genetics of Cognition in Schizophrenia: Combining Mouse and Human Studies

Scheggia, D., & Papaleo, F. (2017) · Wiley eBooks · doi:10.1002/9781118540770.ch6

role of brain iron loading in redox-epigenetic regulation of psychiatrics-like behavior

Ye, X. (2018) · doi:10.17760/d20285816

The Functional Role of the Anterior Insular Cortex in Cognitive Control

Yu, C. (2020) · CUNY Academic Works (City University of New York)

Childhood Disorders

Ellenbroek, B. A., & Youn, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801657-2.00008-2

Sex-dependent effect on the association of COMT Val158Met polymorphism with schizophrenia clinical symptoms and cognitive impairmentPreprint

Xu, H., Zhou, Y., Wang, J., Xiu, M., Chen, D., Wang, W., Wang, L., & Zhang, X. (2021) · Research Square · doi:10.21203/rs.3.rs-817886/v1

Sex Differences in Discrimination Behavior and Orbitofrontal Engagement During Context-Gated Reward PredictionPreprint

Peterson, S., Maheras, A., Chavira, J., Wu, B., & Keiflin, R. (2024) · eLife · doi:10.7554/elife.93509.2

Reviewer #3 (Public Review): Sex Differences in Discrimination Behavior and Orbitofrontal Engagement During Context-Gated Reward Prediction

(2024) · eLife · doi:10.7554/elife.93509.3.sa1

Reviewer #1 (Public Review): Sex Differences in Discrimination Behavior and Orbitofrontal Engagement During Context-Gated Reward Prediction

(2024) · eLife · doi:10.7554/elife.93509.3.sa3

Author response: Sex Differences in Discrimination Behavior and Orbitofrontal Engagement During Context-Gated Reward Prediction

Peterson, S., Maheras, A., Chavira, J., Wu, B., & Keiflin, R. (2024) · eLife · doi:10.7554/elife.93509.3.sa0

Reviewer #2 (Public Review): Sex Differences in Discrimination Behavior and Orbitofrontal Engagement During Context-Gated Reward Prediction

(2024) · eLife · doi:10.7554/elife.93509.3.sa2

eLife Assessment: Sex Differences in Discrimination Behavior and Orbitofrontal Engagement During Context-Gated Reward Prediction

Bradfield, L. A. (2024) · eLife · doi:10.7554/elife.93509.3.sa4

Sex Differences in Discrimination Behavior and Orbitofrontal Engagement During Context-Gated Reward PredictionPreprint

Peterson, S., Maheras, A., Chavira, J., Wu, B., & Keiflin, R. (2024) · eLife · doi:10.7554/elife.93509.3

COMT Genetic Reduction Produces Sexually Divergent Effects on Cortical Anatomy and Working Memory in Mice and Humans

Sannino, S., Gozzi, A., Cerasa, A., Piras, F., Scheggia, D., Managò, F., Damiano, M., Galbusera, A., Erickson, L. C., Tonelli, D. D. P., et al. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu053 · Cited by 60 · see citing works

Behavioral/Systems/Cognitive Genetic Dissection of the Role of Catechol-O- Methyltransferase in Cognition and Stress Reactivity in Mice

Chen, J. (2015)

Both the COMT Val158Met single-nucleotide polymorphism and sex-dependent differences influence response inhibition

Mione, V., Canterini, S., Brunamonti, E., Pani, P., Donno, F., Fiorenza, M. T., & Ferraina, S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00127 · Cited by 30 · see citing works

Genetic Dissection of the Role of Catechol- <i>O</i> -Methyltransferase in Cognition and Stress Reactivity in Mice

Papaleo, F., Crawley, J. N., Song, J., Lipska, B. K., Pickel, J., Weinberger, D. R., & Chen, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2077-08.2008 · Cited by 288 · see citing works

Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity

Barkus, C., Korn, C., Stumpenhorst, K., Laatikainen, L. M., Ballard, D., Lee, S., Sharp, T., Harrison, P. J., Bannerman, D. M., Weinberger, D. R., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.119 · Cited by 20 · see citing works