CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

Chang, C.-H., Curtis, J. D., Maggi, L. B., Faubert, B., Villarino, A. V., O’Sullivan, D., Huang, S. C.-C., van der Windt, G. J. W., Blagih, J., Qiu, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.016 · Cited by 2,204

Lineage relationship and protective immunity of memory CD8 T cell subsets

Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864

Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.007 · Cited by 1,540

Molecular and functional profiling of memory CD8 T cell differentiation.

Kaech, S., Hemby, S., Kersh, E., & Ahmed, R. (2002) · Cell · doi:10.1016/s0092-8674(02)01139-x · Cited by 1,081

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila , and Humans

Bricker, D. K., Taylor, E. B., Schell, J. C., Orsak, T., Boutron, A., Chen, Y.-C., Cox, J. E., Cardon, C. M., Van Vranken, J. G., Dephoure, N., et al. (2012) · Science · doi:10.1126/science.1218099 · Cited by 843

Fuel feeds function: energy metabolism and the T-cell response

Fox, C. J., Hammerman, P. S., & Thompson, C. B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1710 · Cited by 841

Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak

Majewski, N., Nogueira, V., Bhaskar, P. T., Coy, P. E., Skeen, J. E., Gottlob, K., Chandel, N. S., Thompson, C. B., Robey, R. B., & Hay, N. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.014 · Cited by 638

Metabolic switching and fuel choice during T‐cell differentiation and memory development

van der Windt, G. J. W., & Pearce, E. L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01150.x · Cited by 563

Response of naïve and memory CD8+ T cells to antigen stimulation in vivo

Veiga‐Fernandes, H., Walter, U., Bourgeois, C., McLean, A. R., & Rocha, B. (2000) · Nature Immunology · doi:10.1038/76907 · Cited by 547

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

Rathmell, J. C., Heiden, M. G. V., Harris, M. H., Frauwirth, K. A., & Thompson, C. B. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00066-6 · Cited by 467

Competitive glucose metabolism as a target to boost bladder cancer immunotherapy

Afonso, J., Santos, L. L., Longatto‐Filho, A., & Baltazar, F. (2020) · Nature Reviews Urology · doi:10.1038/s41585-019-0263-6 · Cited by 138

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

Olenchock, B. A., Rathmell, J. C., & Heiden, M. G. V. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.013 · Cited by 141

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

Zhang, L., Tschumi, B. O., Lopez-Mejia, I. C., Oberle, S. G., Meyer, M., Samson, G., Rüegg, M. A., Hall, M. N., Fajas, L., Zehn, D., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.095 · Cited by 134

ARID5B regulates metabolic programming in human adaptive NK cells

Cichocki, F. M., Wu, C., Zhang, B., Felices, M., Tesi, B., Tuininga, K., Dougherty, P., Taras, E., Hinderlie, P., Blazar, B. R., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172168 · Cited by 131

Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation

Heckler, M., Ali, L. R., Clancy-Thompson, E., Li, Q., Ventre, K. S., Lenehan, P., Roehle, K., Luoma, A., Boelaars, K., Peters, V., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1540 · Cited by 133

Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation

Nguyen, H. D., Chatterjee, S., Haarberg, K. M. K., Wu, Y., Bastian, D. A., Heinrichs, J. L., Fu, J., Daenthanasanmak, A., Schutt, S. D., Shrestha, S., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82587 · Cited by 130

Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1

Kunisawa, J., Sugiura, Y., Wake, T., Nagatake, T., Suzuki, H., Nagasawa, R., Shikata, S., Honda, K., Hashimoto, E., Suzuki, Y., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.063 · Cited by 129

Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

Ho, P.-C., & Liu, P.-S. (2016) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-016-0109-1 · Cited by 124

Cellular metabolism of myeloid cells in sepsis

Arts, R. J. W., Gresnigt, M. S., Joosten, L. A. B., & Netea, M. G. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0216-066r · Cited by 126

Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches

Klein, K., He, K., Younes, A. I. A., Barsoumian, H. B., Chen, D., Ozgen, T., Mosaffa, S., Patel, R. R., Gu, M., Novaes, J. A. M. D. O., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573326 · Cited by 126

Mitochondrial translation is required for sustained killing by cytotoxic T cells

Lisci, M., Barton, P. R., Randzavola, L. O., Ma, C. Y., Marchingo, J. M., Cantrell, D. A., Paupe, V., Prudent, J., Stinchcombe, J. C., & Griffiths, G. M. (2021) · Science · doi:10.1126/science.abe9977 · Cited by 122

Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy

Lian, X., Yang, K., Li, R., Li, M., Zuo, J., Zheng, B., Wang, W., Wang, P., & Zhou, S. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01486-5 · Cited by 120

Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity

Scharping, N. E., & Delgoffe, G. M. (2016) · Vaccines · doi:10.3390/vaccines4040046 · Cited by 120

Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity

Liebmann, M., Hucke, S., Koch, K., Eschborn, M., Ghelman, J., Chasan, A. I., Glander, S., Schädlich, M., Kuhlencord, M., Daber, N., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721049115 · Cited by 121

Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment

Hunt, E. G., Hurst, K. E., Riesenberg, B., Kennedy, A. S., Gandy, E. J., Andrews, A. M., Pauneto, C. D. M. A., Ball, L. E., Wallace, E. D., Gao, P., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.02.009 · Cited by 126

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

Bektas, A., Schurman, S. H., Gonzalez-Freire, M., Dunn, C. A., Singh, A. K., Macian, F., Cuervo, A. M., Sen, R., & Ferrucci, L. (2019) · Aging · doi:10.18632/aging.102438 · Cited by 116

Modulation of T Cell Metabolism and Function through Calcium Signaling

Fracchia, K. M., Pai, C., & Walsh, C. M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00324 · Cited by 117

Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease

Patel, C. H., & Powell, J. D. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.04.006 · Cited by 119

Metformin-based nanomedicines for reprogramming tumor immune microenvironment

Liu, J., Li, X., Li, Y., Gong, Q., & Luo, K. (2024) · Theranostics · doi:10.7150/thno.104872 · Cited by 114

CD4+ T-cell differentiation and function: Unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria

Almeida, L., Dhillon-LaBrooy, A., Carriche, G. M., Berod, L., & Sparwasser, T. D. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.03.033 · Cited by 117

Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer

Zhao, L., Liu, Y., Zhang, S., Wei, L., Cheng, H., Wang, J., & Wang, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04821-w · Cited by 115

Metabolic exhaustion in infection, cancer and autoimmunity

McKinney, E. F., & Smith, K. G. C. (2018) · Nature Immunology · doi:10.1038/s41590-018-0045-y · Cited by 112

Quiescence of Memory CD8+ T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4

Kalia, V., Penny, L. A., Yuzefpolskiy, Y., Baumann, F. M., & Sarkar, S. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.023 · Cited by 111

Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease

Moreno-Fernandez, M. E., Giles, D. A., Stankiewicz, T. E., Sheridan, R., Karns, R., Cappelletti, M., Lampe, K., Mukherjee, R., Sina, C., Sallese, A., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.93626 · Cited by 106

Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections

Panagioti, E., Klenerman, P., Lee, L. N., van der Burg, S. H., & Arens, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00276 · Cited by 106

Cancer-associated adipocytes as immunomodulators in cancer

Wu, Q., Li, B., Li, J., Sun, S., Yuan, J., & Sun, S. (2021) · Biomarker Research · doi:10.1186/s40364-020-00257-6 · Cited by 105

Obesity altered T cell metabolism and the response to infection

Green, W. D., & Beck, M. A. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.03.008 · Cited by 108

Vitamin D endocrinology on the cross-road between immunity and metabolism

Vanherwegen, A.-S., Gysemans, C. A., & Mathieu, C. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.018 · Cited by 107

Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

Fernández‐Ayala, D. J. M., Navas, P., & López‐Lluch, G. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111147 · Cited by 110

Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation

Bettencourt, I. A., & Powell, J. D. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601318 · Cited by 106

CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs

Chisolm, D. A., Savic, D., Moore, A. J., Ballesteros‐Tato, A., León, B., Crossman, D. K., Murre, C., Myers, R., & Weinmann, A. S. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.015 · Cited by 105

OXPHOS promotes apoptotic resistance and cellular persistence in T H 17 cells in the periphery and tumor microenvironment

Hong, H. S., Mbah, N. E., Shan, M., Loesel, K., Lin, L., Sajjakulnukit, P., Correa, L. O., Andren, A. C., Lin, J., Hayashi, A., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abm8182 · Cited by 106

Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8+ T Cells

Hurst, K. E., Lawrence, K. A., Essman, M. T., Walton, Z. J., Leddy, L. R., & Thaxton, J. E. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0182 · Cited by 102

Mitochondrial Dysfunction and the Aging Immune System

McGuire, P. J. (2019) · Biology · doi:10.3390/biology8020026 · Cited by 103

Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells

Clerc, I., Moussa, D. A., Vahlas, Z., Tardito, S., Oburoglu, L., Hope, T. J., Sitbon, M., Dardalhon, V., Mongellaz, C., & Taylor, N. N. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0084-1 · Cited by 108

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

Russell, S., Lamprecht, D. A., Mandizvo, T., Jones, T., Naidoo, V., Addicott, K. W., Moodley, C., Ngcobo, B., Crossman, D. K., Wells, G., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.034 · Cited by 103

Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming

Hirschberger, S., Strauß, G., Effinger, D., Marstaller, X., Ferstl, A., Müller, M. B., Wu, T., Hübner, M., Rahmel, T., Mascolo, H., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114323 · Cited by 99

Hypoxia-inducible factors regulate T cell metabolism and function

Phan, A. T., & Goldrath, A. W. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.08.004 · Cited by 103

Metabolic Stress in the Immune Function of T Cells, Macrophages and Dendritic Cells

Domblides, C., Lartigue, L., & Faustin, B. (2018) · Cells · doi:10.3390/cells7070068 · Cited by 99

Regulation of CD8+ T memory and exhaustion by the mTOR signals

Chen, Y., Xu, Z., Sun, H., Ouyang, X., Han, Y., Yu, H., Wu, N., Xie, Y., & Su, B. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01064-3 · Cited by 101

Metabolic regulation of immune responses: therapeutic opportunities

Aßmann, N., & Finlay, D. K. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83005 · Cited by 97

Metabolic regulation of macrophages in tissues

den Bossche, J. V., & Saraber, D. L. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.009 · Cited by 92

The Immune-Metabolic Basis of Effector Memory CD4+ T Cell Function under Hypoxic Conditions

Dimeloe, S., Mehling, M., Frick, C., Loeliger, J., Bantug, G. R., Sauder, U., Fischer, M., Belle, R., Develioglu, L., Tay, S., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501766 · Cited by 91

The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches

Bouhamida, E., Morciano, G., Perrone, M., Kahsay, A. E., Della Sala, M., Wieckowski, M. R., Fiorica, F., Pinton, P., Giorgi, C., & Patergnani, S. (2022) · Biology · doi:10.3390/biology11020300 · Cited by 87

Optimization of metabolism to improve efficacy during CAR-T cell manufacturing

Zhang, M., Jin, X. K., Sun, R., Xiong, X., Wang, J., Xie, D., & Zhao, M. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03165-x · Cited by 90

Targeting T Cell Immunometabolism for Cancer Immunotherapy; Understanding the Impact of the Tumor Microenvironment

Mockler, M. B., Conroy, M. J., & Lysaght, J. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00107 · Cited by 89

GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy

Shi, Y., Kotchetkov, I. S., Dobrin, A., Hanina, S., Rajasekhar, V. K., Healey, J. H., & Sadelain, M. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.05.006 · Cited by 86

Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation

Jones, N., Vincent, E. E., Cronin, J., Panetti, S., Chambers, M., Holm, S. R., Owens, S. E., Francis, N., Finlay, D. K., & Thornton, C. A. (2019) · Nature Communications · doi:10.1038/s41467-019-10023-4 · Cited by 88

Powering the Immune System: Mitochondria in Immune Function and Deficiency

Walker, M. A., Volpi, S., Sims, K. B., Walter, J. E., & Traggiai, E. (2014) · Journal of Immunology Research · doi:10.1155/2014/164309 · Cited by 83

Mechanisms underlying CD19-positive ALL relapse after anti-CD19 CAR T cell therapy and associated strategies

Nie, Y., Lu, W., Chen, D., Tu, H., Guo, Z., Zhou, X., Li, M., Tu, S., & Li, Y. (2020) · Biomarker Research · doi:10.1186/s40364-020-00197-1 · Cited by 85

Extracellular Flux Analysis to Monitor Glycolytic Rates and Mitochondrial Oxygen Consumption

Pelletier, M., Billingham, L. K., Ramaswamy, M., & Siegel, R. M. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-416618-9.00007-8 · Cited by 85

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

Böhme, J., Martínez, N., Li, S., Lee, A., Marzuki, M., Tizazu, A. M., Ackart, D. F., Haugen, J. D., Todd, A., Lachmandas, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19095-z · Cited by 84

Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells

Previte, D. M., Martins, C. P., O’Connor, E. C., Marré, M. L., Coudriet, G. M., Beck, N. W., Menk, A. V., Wright, R. H., Tse, H. M., Delgoffe, G. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.004 · Cited by 82

Fine tuning of immunometabolism for the treatment of rheumatic diseases

Rhoads, J. P., Major, A. S., & Rathmell, J. C. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.54 · Cited by 81

CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success

Long, K. B., Young, R. M., Boesteanu, A. C., Suhoski, M. M., Melenhorst, J. J., Lacey, S. F., Degaramo, D. A., Levine, B. L., & Fraietta, J. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02740 · Cited by 80

Epigenetic strategies to boost CAR T cell therapy

Akbari, B., Ghahri-Saremi, N., Soltantoyeh, T., Hadjati, J., Ghassemi, S., & Mirzaei, H. R. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.08.003 · Cited by 79

Insulin and cancer: a tangled web

Leitner, B. P., Siebel, S., Akingbesote, N. D., Zhang, X., & Perry, R. J. (2022) · Biochemical Journal · doi:10.1042/bcj20210134 · Cited by 79

Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells

Dwivedi, A., Karulkar, A., Ghosh, S., Rafiq, A., & Purwar, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03180 · Cited by 78

Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes

Konjar, Š., Frising, U. C., Ferreira, C., Hinterleitner, R., Mayassi, T., Zhang, Q., Blankenhaus, B., Haberman, N., Loo, Y., Guedes, J., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aan2543 · Cited by 75

The metabolic spectrum of memory T cells

O’Sullivan, D. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12274 · Cited by 80

Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges

Pacella, I., & Piconese, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01889 · Cited by 77

Targeting immune cell metabolism in kidney diseases

Basso, P. J., Andrade‐Oliveira, V., & Câmara, N. O. S. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00413-7 · Cited by 76

Fine-Tuning of CD8 + T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

Champagne, D., Hatle, K. M., Fortner, K. A., D’Alessandro, A., Thornton, T. M., Yang, R., Torralba, D., Tomás‐Cortázar, J., Jun, Y. W., Ahn, K. H., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.018 · Cited by 79

Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don’t Forget the Fuel

Irving, M. B., de Silly, R. V., Scholten, K. B. J., Dilek, N., & Coukos, G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00267 · Cited by 76

Memory CD8+ T Cells Balance Pro- and Anti-inflammatory Activity by Reprogramming Cellular Acetate Handling at Sites of Infection

Balmer, M. L., Ma, E. H., Thompson, A. J., Epple, R., Unterstab, G., Lötscher, J., Dehio, P., Schürch, C. M., Warncke, J. D., Perrin, G., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.07.004 · Cited by 73

TLR-Mediated Innate Production of IFN-γ by CD8+ T Cells Is Independent of Glycolysis

Salerno, F., Guislain, A., Cansever, D., & Wolkers, M. C. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501997 · Cited by 73

The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism

Kapnick, S. M., Pacheco, S. E., & McGuire, P. J. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.010 · Cited by 76

The Immune Consequences of Lactate in the Tumor Microenvironment

Harmon, C., O’Farrelly, C., & Robinson, M. W. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-43093-1_7 · Cited by 73

Nanoparticle-Mediated Lipid Metabolic Reprogramming of T Cells in Tumor Microenvironments for Immunometabolic Therapy

Kim, D., Wu, Y., Li, Q., & Oh, Y. (2021) · Nano-Micro Letters · doi:10.1007/s40820-020-00555-6 · Cited by 71

Metabolic plasticity and regulation of T cell exhaustion

Li, F., Liu, H., Zhang, D., Ma, Y., & Zhu, B. (2022) · Immunology · doi:10.1111/imm.13575 · Cited by 73

Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response

Martinez, R. J., & Evavold, B. D. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00468 · Cited by 71

Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis

Park, D. W., & Zmijewski, J. W. (2017) · Infection and Chemotherapy · doi:10.3947/ic.2017.49.1.10 · Cited by 71

Antitumor T-cell Reconditioning: Improving Metabolic Fitness for Optimal Cancer Immunotherapy

Rivadeneira, D. B., & Delgoffe, G. M. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0894 · Cited by 69

Targeting Drp1 and mitochondrial fission for therapeutic immune modulation

Simula, L., Campanella, M., & Campello, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104317 · Cited by 66

Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response

Chatterjee, S., Chakraborty, P., Daenthanasanmak, A., Iamsawat, S., Andrejeva, G., Luevano, L. A., Wolf, M. M., Baliga, U. K., Krieg, C., Beeson, C., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0706 · Cited by 66

Immune metabolism in PD-1 blockade-based cancer immunotherapy

Kumar, A., & Chamoto, K. (2020) · International Immunology · doi:10.1093/intimm/dxaa046 · Cited by 66

The Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes

Neto, J. C. R., Calder, P. C., Curi, R., Newsholme, P., Sethi, J. K., & Silveira, L. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168460 · Cited by 65

Hyperglycemia and Not Hyperinsulinemia Mediates Diabetes-Induced Memory CD8 T-Cell Dysfunction

Kavazović, I., Krapić, M., Beumer‐Chuwonpad, A., Polić, B., Wensveen, T. T., Lemmermann, N. A. W., van Gisbergen, K. P. J. M., & Wensveen, F. M. (2022) · Diabetes · doi:10.2337/db21-0209 · Cited by 64

Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review

Ron‐Harel, N., Sharpe, A. H., & Haigis, M. C. (2014) · Gerontology · doi:10.1159/000362502 · Cited by 66

Tumor microenvironmental influences on dendritic cell and T cell function: A focus on clinically relevant immunologic and metabolic checkpoints

Hargadon, K. M. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.37 · Cited by 63

CD8 + T-Cell Memory: The Why, the When, and the HowPreprint

Turner, S. T., Bennett, T. J., & Gruta, N. L. L. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a038661 · Cited by 65

Immunology of Kidney Disease

Foresto‐Neto, O., Menezes-Silva, L., Leite, J. A., Andrade-Silva, M., & Câmara, N. O. S. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090122-045843 · Cited by 64

T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

Chi, X., Luo, S., Ye, P., Hwang, W., Cha, J., Yan, X., & Yang, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1104771 · Cited by 62

The glucose transporter 2 regulates CD8+ T cell function via environment sensing

Fu, H., Vuononvirta, J., Fanti, S., Bonacina, F., d’Amati, A., Wang, G., Poobalasingam, T., Fankhaenel, M., Lucchesi, D., Coleby, R., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00913-9 · Cited by 62

NK Cell Metabolism and TGFβ – Implications for Immunotherapy

Slattery, K., & Gardiner, C. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02915 · Cited by 63

Polarized mitochondria as guardians of NK cell fitness

Surace, L., Doisne, J., Escoll, P., Marie, S., Dardalhon, V., Croft, C. A., Thaller, A., Topazio, D., Sparaneo, A., Cama, A., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020003458 · Cited by 69

Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet

Zhao, S., Peralta, R. M., Avina-Ochoa, N., Delgoffe, G. M., & Kaech, S. M. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101485 · Cited by 58

Fatty acid metabolism in adaptive immunity

Zhou, X., Zhu, X., & Zeng, H. (2021) · FEBS Journal · doi:10.1111/febs.16296 · Cited by 58

Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity

Soll, D., Chu, C.-F., Sun, S., Lutz, V., Arunkumar, M., Gachechiladze, M. A., Schäuble, S., Alissa-Alkhalaf, M., Nguyen, T. T. T., Khalil, M., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01918-6 · Cited by 58

Molecular characterization of HCMV‐specific immune responses: Parallels between CD8+ T cells, CD4+ T cells, and NK cells

Braga, F. A. V., Hertoghs, K. M. L., van Lier, R. A. W., & van Gisbergen, K. P. J. M. (2015) · European Journal of Immunology · doi:10.1002/eji.201545495 · Cited by 56

Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function

Bettonville, M., d'Aria, S., Weatherly, K., Porporato, P. E., Zhang, J., Bousbata, S., Sonveaux, P., & Braun, M. Y. (2018) · eLife · doi:10.7554/elife.30938 · Cited by 62

Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

Quinn, K. M., Hussain, T., Kraus, F., Formosa, L. E., Lam, W. K., Dagley, M. J., Saunders, E. C., Assmus, L. M., Wynne-Jones, E., Loh, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16633-7 · Cited by 56

TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells

Zhang, H., Liu, J., Yang, Z., Zeng, L., Wei, K., Zhu, L., Tang, L. V., Wang, D., Zhou, Y., Lv, J., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.06.002 · Cited by 56

NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells

Gupta, S. S., Sharp, R., Hofferek, C. J., Kuai, L., Dorn, G. W., Wang, J., & Chen, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.032 · Cited by 56

Metabolic regulation of T cell differentiation and function

Park, B. V., & Pan, F. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.027 · Cited by 58

A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis

Jaeger, M., Pinelli, M., Borghi, M., Costantini, C., Dindo, M., van Emst, L., Puccetti, M., Pariano, M., Ricaño-Ponce, I., Büll, C., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aar3558 · Cited by 57

Control of T Cell Metabolism by Cytokines and Hormones

Bishop, E. L., Gudgeon, N. H., & Dimeloe, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.653605 · Cited by 56

Regulation of activated T cell survival in rheumatic autoimmune diseases

Rosetti, F., Madera-Salcedo, I. K., Rodríguez‐Rodríguez, N., & Crispín, J. C. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00741-9 · Cited by 54

CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

Cho, J.-H., Kim, H.-O., Ju, Y.-J., Kye, Y.-C., Lee, G.-W., Lee, S.-W., Yun, C., Bottini, N., Webster, K. E., Goodnow, C. C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13373 · Cited by 52

Endothelial cell and T‐cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation

Certo, M., Elkafrawy, H., Pucino, V., Cucchi, D., Cheung, K. C.-P., & Mauro, C. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15002 · Cited by 54

Mitochondria and effector functions of human CD8* T cells

Fischer, M. (2015) · edoc (University of Basel) · doi:10.5451/unibas-006483297

Human memory CD8+ T-cells exhibit an intrinsic metabolic advantage as reflected by increased mitochondrial functionality and high glycolytic potential

Gubser, P. M. (2013) · edoc (University of Basel) · doi:10.5451/unibas-006161384

Energy to Burn

Mueller, K. L. (2012) · Science · doi:10.1126/science.335.6069.636-a

T cells require mitochondria to proliferate, function and generate memory

(2025) · Nature Immunology · doi:10.1038/s41590-025-02226-3 · Cited by 4

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

Gubser, P. M., Bantug, G. R., Razik, L., Fischer, M., Dimeloe, S., Höenger, G., Müller-Durovic, B., Jauch, A., & Hess, C. (2013) · Nature Immunology · doi:10.1038/ni.2687 · Cited by 500