Powering the Immune System: Mitochondria in Immune Function and Deficiency
Open accessAbstract
Mitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and tissue-specific processes. Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding. Concurrently, immunodeficiencies arising from perturbation of mitochondrial elements are increasingly recognized. Recent observations of immune dysfunction and increased incidence of infection in patients with primary mitochondrial disorders further support an important role for mitochondria in the proper function of the immune system. Here we review current findings.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Highly proliferative cells such as cancer cells and activated T cells rely on mitochondrial metabolites to form biomass.
“Rather than being dysfunctional, highly proliferative cells such as cancer cells and activated T cells rely on mitochondrial metabolites to form biomass.5,65”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E. H., Angus, D. C., Cook, D., Cohen, J., Opal, S. M., Vincent, J., & Ramsay, G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050454.01978.3b · Cited by 5,976 · see citing works
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329 · see citing works
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401 · see citing works
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 2× · see citing works
“Upon cognate antigen encounter, while oxidative phosphorylation remains an effective source of energy, c-Myc upregulation [33] and estrogen related receptor alpa (EERalpha) signaling [34] activate the aerobic glycolytic pathway in order to meet the increased energetic needs (reviewed in [35]).”
BackgroundJonjić, S., Mutter, W., Weiland, F., Reddehase, M. J., & Koszinowski, U. H. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.4.1199 · Cited by 2,106 · see citing works
Michalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091 · see citing works
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
Pagliarini, D. J., Calvo, S. E., Chang, B., Sheth, S. A., Vafai, S. B., Ong, S.-E., Walford, G. A., Sugiana, C., Boneh, A., Chen, W. K., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.016 · Cited by 1,994 · see citing works
Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works
Molecular identification of a danger signal that alerts the immune system to dying cells
Shi, Y., Evans, J. E., & Rock, K. L. (2003) · Nature · doi:10.1038/nature01991 · Cited by 1,684 · see citing works
Tlr signalling augments macrophage bactericidal activity through mitochondrial ros
West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659 · see citing works
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595 · see citing works
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Pearce, E. L., Walsh, M. C., Cejas, P. J., Harms, G. M., Shen, H., Wang, L.-S., Jones, R. G., & Choi, Y. (2009) · Nature · doi:10.1038/nature08097 · Cited by 1,559 · see citing works
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.007 · Cited by 1,540 · see citing works
Mitochondria in innate immune responses
West, A. P., Shadel, G. S., & Ghosh, S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2975 · Cited by 1,376 · see citing works
Fueling Immunity: Insights into Metabolism and Lymphocyte Function
Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works
Hou, F., Sun, L., Zheng, H., Skaug, B. A., Jiang, Q., & Chen, Z. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.041 · Cited by 1,274 · see citing works
Metabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244 · see citing works
Yegutkin, G. G. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.024 · Cited by 1,155 · see citing works
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
Sukumar, M., Liu, J., Ji, Y., Subramanian, M., Crompton, J. G., Yu, Z., Roychoudhuri, R., Palmer, D. C., Muranski, P., Karoly, E. D., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69589 · Cited by 952 · see citing works
Nucleotide signalling during inflammation
Idzko, M., Ferrari, D., & Eltzschig, H. K. (2014) · Nature · doi:10.1038/nature13085 · Cited by 909 · see citing works
O’Sullivan, D., van der Windt, G. J. W., Huang, S. C.-C., Curtis, J. D., Chang, C.-H., Buck, M. D., Qiu, J., Smith, A. M., Lam, W. Y., DiPlato, L. M., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.005 · Cited by 790 · see citing works
Mitochondrial disorders as windows into an ancient organelle
Vafai, S. B., & Mootha, V. K. (2012) · Nature · doi:10.1038/nature11707 · Cited by 733 · see citing works
Mitochondria: master regulators of danger signalling
Galluzzi, L., Kepp, O., & Kroemer, G. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3479 · Cited by 733 · see citing works
Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects
BONNEFONT, J. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.06.004 · Cited by 637 · see citing works
NLRX1 is a regulator of mitochondrial antiviral immunity
Moore, C. B., Bergstralh, D. T., Duncan, J. A., Lei, Y. L., Morrison, T. E., Zimmermann, A. G., Accavitti-Loper, M. A., Madden, V. J., Sun, L., Ye, Z., et al. (2008) · Nature · doi:10.1038/nature06501 · Cited by 586 · see citing works
Diagnostic criteria for respiratory chain disorders in adults and children
Bernier, F. P., Boneh, A., Dennett, X., Chow, C. W., Cleary, M., & Thorburn, D. R. (2002) · Neurology · doi:10.1212/01.wnl.0000033795.17156.00 · Cited by 574 · see citing works
Metabolic switching and fuel choice during T‐cell differentiation and memory development
van der Windt, G. J. W., & Pearce, E. L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01150.x · Cited by 563 · see citing works
Caro‐Maldonado, A., Wang, R., Nichols, A., Kuraoka, M., Milasta, S., Sun, L., Gavin, A. L., Abel, E. D., Kelsoe, G. H., Green, D. R., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302062 · Cited by 553 · see citing works
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
van der Windt, G. J. W., O’Sullivan, D., Everts, B., Huang, S. C.-C., Buck, M. D., Curtis, J. D., Chang, C.-H., Smith, A. M., Ai, T., Faubert, B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221740110 · Cited by 523 · see citing works
Monogenic Mitochondrial Disorders
Koopman, W. J. H., Willems, P. H. G. M., & Smeitink, J. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1012478 · Cited by 515 · see citing works
Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
Gubser, P. M., Bantug, G. R., Razik, L., Fischer, M., Dimeloe, S., Höenger, G., Müller-Durovic, B., Jauch, A., & Hess, C. (2013) · Nature Immunology · doi:10.1038/ni.2687 · Cited by 487 · see citing works
Steroid hormone synthesis in mitochondria
Miller, W. L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.04.014 · Cited by 479 · see citing works
Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels
Schenk, U., Westendorf, A. M., Radaelli, E., Casati, A., Ferro, M., Fumagalli, M., Verderio, C., Buer, J., Scanziani, E., & Grassi, F. (2008) · Science Signaling · doi:10.1126/scisignal.1160583 · Cited by 410 · see citing works
Doughty, C. A., Bleiman, B. F., Wagner, D. J., Dufort, F. J., Mataraza, J. M., Roberts, M. F., & Chiles, T. C. (2006) · Blood · doi:10.1182/blood-2005-12-4788 · Cited by 369 · see citing works
Revving the Engine: Signal Transduction Fuels T Cell Activation
Jones, R. G., & Thompson, C. B. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.008 · Cited by 349 · see citing works
Systematic identification of human mitochondrial disease genes through integrative genomics
Calvo, S. E., Jain, M., Xie, X. S., Sheth, S. A., Chang, B., Goldberger, O., Spinazzola, A., Zeviani, M., Carr, S. A., & Mootha, V. K. (2006) · Nature Genetics · doi:10.1038/ng1776 · Cited by 344 · see citing works
Yang, Z., Fujii, H., Mohan, S. V., Goronzy, J. J., & Weyand, C. M. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130252 · Cited by 334 · see citing works
Tattoli, I., Carneiro, L. A. M., Jéhanno, M., Magalhaes, J. G., Shu, Y., Philpott, D. J., Arnoult, D., & Girardin, S. E. (2008) · EMBO Reports · doi:10.1038/sj.embor.7401161 · Cited by 321 · see citing works
Woehrle, T., Yip, L., Elkhal, A., Sumi, Y., Chen, Y., Yao, Y., Insel, P. A., & JUNGER, W. G. (2010) · Blood · doi:10.1182/blood-2010-04-277707 · Cited by 315 · see citing works
Threshold Effect and Tissue Specificity
Rossignol, R., Malgat, M., Mazat, J.-P., & Letellier, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33426 · Cited by 288 · see citing works
Schenk, U., Frascoli, M., Proietti, M., Geffers, R., Traggiai, E., Buer, J., Ricordi, C., Westendorf, A. M., & Grassi, F. (2011) · Science Signaling · doi:10.1126/scisignal.2001270 · Cited by 286 · see citing works
Self-citationCogswell, A. M., Stevens, R. J., & Hood, D. A. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.2.c383 · Cited by 286 · see citing works
Autocrine regulation of T‐cell activation by ATP release and P2X 7 receptors
Yip, L., Woehrle, T., Corriden, R., Hirsh, M., Chen, Y., Inoue, Y., Ferrari, V., Insel, P. A., & JUNGER, W. G. (2009) · The FASEB Journal · doi:10.1096/fj.08-126458 · Cited by 284 · see citing works
Mitochondrial disease criteria
Morava, É., van den Heuvel, L. P., Hol, F. A., de Vries, M. C., Hogeveen, M., Rodenburg, R. J., & Smeitink, J. A. M. (2006) · Neurology · doi:10.1212/01.wnl.0000244435.27645.54 · Cited by 275 · see citing works
Lagresle‐Peyrou, C., Six, E. M., Pïcard, C., Rieux‐Laucat, F., Michel, V., Ditadi, A., Demerens, C., Morillon, E., Valensi, F., Simon-Stoos, K. L., et al. (2008) · Nature Genetics · doi:10.1038/ng.278 · Cited by 234 · see citing works
Clinical and genetic spectrum of mitochondrial neurogastrointestinal encephalomyopathy
Garone, C., Tadesse, S., & Hirano, M. (2011) · Brain · doi:10.1093/brain/awr245 · Cited by 217 · see citing works
Michalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C.-Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108856108 · Cited by 216 · see citing works
Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity
Lee, J., Walsh, M. C., Hoehn, K. L., James, D. E., Wherry, E. J., & Choi, Y. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302985 · Cited by 207 · see citing works
Large-scale chemical dissection of mitochondrial function
Wagner, B. K., Kitami, T., Gilbert, T. J., Peck, D., Ramanathan, A., Schreiber, S. L., Golub, T. R., & Mootha, V. K. (2008) · Nature Biotechnology · doi:10.1038/nbt1387 · Cited by 205 · see citing works
An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix
Arnoult, D., Soares, F., Tattoli, I., Castanier, C., Philpott, D. J., & Girardin, S. E. (2009) · Journal of Cell Science · doi:10.1242/jcs.051193 · Cited by 203 · see citing works
Bach, J. R., Rajaraman, R., Ballanger, F., Tzeng, A. C., Ishikawa, Y., Kulessa, R., & Bansal, T. (1998) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/00002060-199801000-00003 · Cited by 198 · see citing works
Laguna, R. K., Creasey, E. A., Li, Z., Valtz, N., & Isberg, R. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609012103 · Cited by 197 · see citing works
Extracellular ATP in T-lymphocyte activation: possible role in effector functions.
Filippini, A., Taffs, R. E., & Sitkovsky, M. V. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8267 · Cited by 193 · see citing works
Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides
Suzuki, K., Mori, A., Ishii, K. J., Saito, J., Singer, D. S., Klinman, D. M., Krause, P. R., & Kohn, L. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2285 · Cited by 189 · see citing works
Purinergic Signalling—An Overview
Burnstock, G. (2006) · Novartis Foundation symposium · doi:10.1002/9780470032244.ch4 · Cited by 178 · see citing works
Respiratory Chain Encephalomyopathies: A Diagnostic Classification
Walker, U. A., Collins, S. J., & Byrne, E. (2008) · European Neurology · doi:10.1159/000117269 · Cited by 175 · see citing works
Dufort, F. J., Bleiman, B. F., Gumina, M. R., Blair, D., Wagner, D. J., Roberts, M. F., Abu‐Amer, Y., & Chiles, T. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.4953 · Cited by 174 · see citing works
Glucose-dependent de Novo Lipogenesis in B Lymphocytes
Dufort, F. J., Gumina, M. R., Ta, N. L., Tao, Y., Heyse, S. A., Scott, D. A., Richardson, A. D., Seyfried, T. N., & Chiles, T. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.551051 · Cited by 160 · see citing works
Foell, D., Wittkowski, H., Ren, Z., Turton, J., Pang, G., Däbritz, J., Ehrchen, J. M., Heidemann, J., Borody, T. J., Roth, J., et al. (2008) · The Journal of Pathology · doi:10.1002/path.2394 · Cited by 154 · see citing works
Lymphocyte Ecto-5′-Nucleotidase Deficiency in Agammaglobulinemia
Edwards, N. L., Magilavy, D. B., Cassidy, J. T., & Fox, I. H. (1978) · Science · doi:10.1126/science.27864 · Cited by 150 · see citing works
Jefferies, J. L. (2013) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31372 · Cited by 134 · see citing works
LYMPHOCYTE PURINE 5'-NUCLEOTIDASE DEFICIENCY IN PRIMARY HYPOGAMMAGLOBULINÆMIA
Johnson, S. M., Asherson, G. L., Watts, R. W. E., North, M. E., Allsop, J., & WEBSTER, A. D. B. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91765-2 · Cited by 130 · see citing works
Schena, F., Volpi, S., Faliti, C. E., Penco, F., Santi, S., Proietti, M., Schenk, U., Damonte, G., Salis, A., Bellotti, M., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.022 · Cited by 95 · see citing works
Self-citationMitochondria: commanders of innate immunity and disease?
Cloonan, S. M., & Choi, A. M. K. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.11.001 · Cited by 94 · see citing works
Heme metabolism and erythropoiesis
Chung, J., Chen, C., & Paw, B. H. (2012) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328351c48b · Cited by 92 · see citing works
Walker, M. A., Slate, N. G., Alejos, A. R., Volpi, S., Iyengar, S. R., Sweetser, D. A., Sims, K. B., & Walter, J. E. (2014) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2014.02.009 · Cited by 52 · see citing works
Self-citationModulation of Inflammation by Extracellular Nucleotides
Boeynaems, J., & Communi, D. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700233 · Cited by 51 · see citing works
de la Fuente, M. Á., Recher, M., Rider, N. L., Strauss, K. A., Morton, D. H., Adair, M., Bonilla, F. A., Ochs, H. D., Gelfand, E. W., Pessach, I. M., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.03.042 · Cited by 39 · see citing works
Self-citationProspective study on central venous line associated bloodstream infections
Wagner, M., Bonhoeffer, J., Erb, T. O., Glanzmann, R., Haecker, F.-M., Paulussen, M., Weibel, D. M., & Heininger, U. (2011) · Archives of Disease in Childhood · doi:10.1136/adc.2010.208595 · Cited by 38 · see citing works
Fatal Neonatal-Onset Mitochondrial Respiratory Chain Disease with T Cell Immunodeficiency
Reichenbach, J., Schubert, R., Horváth, R., Petersen, J., Fütterer, N., Malle, E. K., Stumpf, A., Gebhardt, B. R., Koehl, U., Schraven, B. L., et al. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000233252.60457.cf · Cited by 37 · see citing works
First reported case of Omenn syndrome in a patient with reticular dysgenesis
Henderson, L. A., Frugoni, F., Hopkins, G., Al–Herz, W., Weinacht, K. G., Comeau, A. M., Bonilla, F. A., Notarangelo, L. D., & Pai, S. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.045 · Cited by 36 · see citing works
Autophagy in Plasma Cell Pathophysiology
Oliva, L., & Cenci, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00103 · Cited by 34 · see citing works
Gessner, B. D., Gillingham, M. B., Wood, T., & Koeller, D. M. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.07.010 · Cited by 32 · see citing works
Tom70 imports antiviral immunity to the mitochondria
Lin, R., Paz, S., & Hiscott, J. (2010) · Cell Research · doi:10.1038/cr.2010.113 · Cited by 31 · see citing works
Flagged first, then by citations
1 of the 78 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The multifaceted contributions of mitochondria to cellular metabolism
Spinelli, J. B., & Haigis, M. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0124-1 · Cited by 1,935 · see citing works
The rise of mitochondria in medicine
Picard, M. A., Wallace, D. C., & Burelle, Y. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.07.003 · Cited by 454 · see citing works
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism
Wang, T., Cao, Y., Zheng, Q., Tu, J., Zhou, W., He, J., Zhong, J., Chen, Y., Wang, J., Cai, R., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.06.008 · Cited by 250 · see citing works
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity
Sharma, R., Reinstadler, B. M., Engelstad, K., Skinner, O. S., Stackowitz, E., Haller, R. G., Clish, C. B., Pierce, K. A., Walker, M. A., Fryer, R. H., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci136055 · Cited by 198 · see citing works
Self-citationBasith, S., Manavalan, B., Shin, T. H., Park, C. B., Lee, W. S., Kim, J., & Lee, G. (2022) · Nanomaterials · doi:10.3390/nano12152656 · Cited by 219 · see citing works
Microbiota-mitochondria inter-talk: Consequence for microbiota-host interaction
Saint-Georges-Chaumet, Y., & Edeas, M. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftv096 · Cited by 176 · see citing works
Mitochondrial function, ornamentation, and immunocompetence
Koch, R. E., Josefson, C. C., & Hill, G. E. (2016) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12291 · Cited by 172 · see citing works
SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury
Kurundkar, D., Kurundkar, A., Bone, N. B., Becker, E., Liu, W., Chacko, B. K., Darley-Usmar, V. M., Zmijewski, J. W., & Thannickal, V. J. (2019) · JCI Insight · doi:10.1172/jci.insight.120722 · Cited by 149 · see citing works
Weindel, C. G., Bell, S. L., Huntington, T. E., Vail, K. J., Srinivasan, R., Patrick, K. L., & Watson, R. O. (2020) · eLife · doi:10.7554/elife.51071 · Cited by 121 · see citing works
Pathological Mechanisms Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Missailidis, D., Annesley, S. J., & Fisher, P. R. (2019) · Diagnostics · doi:10.3390/diagnostics9030080 · Cited by 119 · see citing works
The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals
Sathyabhama, M., Dharshini, L. C. P., Karthikeyan, A., Senthil, K., & Min, T. (2022) · Biomolecules · doi:10.3390/biom12101405 · Cited by 115 · see citing works
Mitochondrial function and abnormalities implicated in the pathogenesis of ASD
Castora, F. J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.015 · Cited by 104 · see citing works
Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens
Ramond, E., Jamet, A., Coureuil, M., & Charbit, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02461 · Cited by 96 · see citing works
Chang, J., Hoel, F., Liu, K., Wei, Y., Cheng, F., Kuo, S., Tronstad, K. J., & Liu, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-10870-5 · Cited by 98 · see citing works
Rationally Optimized Fluorescent Probe for Imaging Mitochondrial SO2 in HeLa Cells and Zebrafish
Chen, G., Zhou, W., Zhao, C., Liu, Y., Chen, T., Li, Y., & Tang, B. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01505 · Cited by 92 · see citing works
Emerging role of mitochondria in airborne particulate matter-induced immunotoxicity
Sharma, J., Parsai, K., Raghuwanshi, P., Ali, S. A., Tiwari, V., Bhargava, A., & Mishra, P. K. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.116242 · Cited by 66 · see citing works
Impact of pharmacological agents on mitochondrial function: a growing opportunity?
Stoker, M. L., Newport, E., Hulit, J., West, A. P., & Morten, K. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190280 · Cited by 52 · see citing works
Fungal Innate Immunity Induced by Bacterial Microbe-Associated Molecular Patterns (MAMPs)
IPCHO, S. V. S., Sundelin, T., Erbs, G., Kistler, H. C., Newman, M., & Olsson, S. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.027987 · Cited by 50 · see citing works
Gautam, S., Kumar, U., Kumar, M., Rana, D., & Dada, R. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.03.004 · Cited by 53 · see citing works
Cabon, L., Bertaux, A., Brunelle-Navas, M.-N., Nemazanyy, I., Scourzic, L., Delavallée, L., Vela, L., Baritaud, M., Bouchet, S., Lopez, C. K., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-017-0035-x · Cited by 47 · see citing works
Ledderose, C., Bao, Y., Ledderose, S., Woehrle, T., Heinisch, M., Yip, L., Zhang, J., Robson, S. C., Shapiro, N. I., & JUNGER, W. G. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv373 · Cited by 47 · see citing works
Targeting mitochondria in bone and cartilage diseases: A narrative review
Mendelsohn, D. H., Walter, N., Cheung, W., Wong, R. M. Y., Schönmehl, R., Winter, L., Khassawna, T. E., Heiß, C., Brochhausen, C., & Rupp, M. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103667 · Cited by 46 · see citing works
Catalán‐García, M., Garrabou, G., Morén, C., Guitart‐Mampel, M., Hernando, A., Díaz‐Ramos, A., González‐Casacuberta, I., Juárez‐Flores, D. L., Bañó, M. C., Enrich-Bengoa, J., et al. (2016) · Clinical Science · doi:10.1042/cs20160080 · Cited by 42 · see citing works
Mitochondrial function of immune cells in septic shock: A prospective observational cohort study
Merz, T. M., Pereira, A. J., Schürch, R., Schefold, J. C., Jakob, S. M., Takala, J. A., & Djafarzadeh, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178946 · Cited by 38 · see citing works
Liu, C., Ma, J., Zhang, J., Zhao, H., Zhu, Y., Qi, J., Liu, L., Zhu, L., Jiang, Y., Tang, G., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00505 · Cited by 34 · see citing works
Picking up a Fight: Fine Tuning Mitochondrial Innate Immune Defenses Against RNA Viruses
Dutta, S., Das, N., & Mukherjee, P. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01990 · Cited by 33 · see citing works
Oxidative Stress and Gut Microbiota * *Conflict of interest: None.
Marciano, F., & Vajro, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805377-5.00008-4 · Cited by 31 · see citing works
Aljohani, A. H., Al‐Mousa, H., Arnaout, R., Al‐Dhekri, H., Mohammed, R. W., Alsum, Z., Nicolas‐Jilwan, M., Alrogi, F., Al‐Muhsen, S., Alazami, A. M., et al. (2020) · Journal of Clinical Immunology · doi:10.1007/s10875-020-00851-1 · Cited by 30 · see citing works
Altered mitochondrial proteome and functional dynamics in patients with rheumatoid arthritis
Khanna, S., Padhan, P., Jaiswal, K. S., Jain, A., Ghosh, A., Tripathy, A., Gowda, H., Raghav, S. K., & Gupta, B. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.06.005 · Cited by 29 · see citing works
Lee, S., Jeon, Y., Jo, M., & Kim, H. (2021) · Experimental Neurobiology · doi:10.5607/en21021 · Cited by 29 · see citing works
Li, Y., Keller, A. L., Cryan, M. T., & Ross, A. E. (2021) · ACS Measurement Science Au · doi:10.1021/acsmeasuresciau.1c00026 · Cited by 28 · see citing works
Combination therapy with metformin and coenzyme Q10 in murine experimental autoimmune arthritis
Jhun, J., Lee, S., Kim, S. Y., Na, H. S., Kim, E., Kim, J. K., Jeong, J., Park, S. H., & Cho, M. (2015) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2015.1122619 · Cited by 28 · see citing works
Ma, L., Zhang, L., Li, J., Zhang, X., Xie, Y., Li, X., Yang, B., & Yang, H. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00745-z · Cited by 28 · see citing works
To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question
Hreich, S. J. D., Benzaquen, J., Hofman, P. M., & Vouret‐Craviari, V. (2021) · Purinergic Signalling · doi:10.1007/s11302-021-09811-9 · Cited by 27 · see citing works
Koch, R. E., & Hill, G. E. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12400 · Cited by 25 · see citing works
Campenhout, J. V., Buntinx, Y., Xiong, H.-Y., Wyns, A., Polli, A., Nijs, J., Aerts, J. L., Laeremans, T., & Hendrix, J. (2025) · Biomolecules · doi:10.3390/biom15030357 · Cited by 22 · see citing works
Lausberg, E., Gießelmann, S., Dewulf, J. P., Wiame, E., Holz, A., Salvarinova, R., van Karnebeek, C., Klemm, P., Ohl, K., Mull, M., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143078 · Cited by 22 · see citing works
Shah, E. J., Gurdziel, K., & Ruden, D. M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00511 · Cited by 20 · see citing works
Cellular metabolism in the defense against microbes
Pernas, L. F. (2021) · Journal of Cell Science · doi:10.1242/jcs.252023 · Cited by 20 · see citing works
Immunotherapy of Sepsis: Blind Alley or Call for Personalized Assessment?
Průcha, M., Zazula, R., & Rußwurm, S. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-016-0415-9 · Cited by 19 · see citing works
Zheng, L., Liu, L., Lin, L., Tang, H., Fan, X., Lin, H., & Li, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01186 · Cited by 19 · see citing works
Battaglia, S., Santis, S. D., Rutigliano, M., Sallustio, F., Picerno, A., Frassanito, M. A., Schaefer, I., Vacca, A., Moschetta, A., Seibel, P., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91559-8 · Cited by 18 · see citing works
Shah, E. J., Hüttemann, M., Sanderson, T. H., Gurdziel, K., & Ruden, D. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.628777 · Cited by 14 · see citing works
Negi, C. K., Khan, S., Dirven, H. A. A. M., Bajard, L., & Bláha, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084282 · Cited by 13 · see citing works
RNA-seq profiling, and impaired autophagic process in skeletal muscle of MELAS
Deng, J., Lu, Y., Xie, Z., Liu, J., Yuan, Y., & Wang, Z. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.005 · Cited by 14 · see citing works
Ramos, J. S., Dalleck, L. C., Stennett, R., Mielke, G. I., Keating, S. E., Murray, L. S., Hasnain, S. Z., Fassett, R. G., McGuckin, M. A., Croci, I., et al. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s251567 · Cited by 13 · see citing works
Insights into the modulation of the interferon response and NAD+in the context of COVID-19
Habeichi, N. J., Tannous, C., Yabluchanskiy, A., Altara, R., Mericskay, M., Booz, G. W., & Zouein, F. A. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1961768 · Cited by 10 · see citing works
Venugopalan, S. K., Shanmugarajan, T. S., Navaratnam, V., Mansor, S. M., & Ramanathan, S. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.08.068 · Cited by 9 · see citing works
Prohibitin: A hypothetical target for sex-based new therapeutics for metabolic and immune diseases
Mishra, S., & Nyomba, B. L. G. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219828362 · Cited by 10 · see citing works
The Reciprocal Interplay between Infections and Inherited Metabolic Disorders
Tummolo, A., & Melpignano, L. (2023) · Microorganisms · doi:10.3390/microorganisms11102545 · Cited by 8 · see citing works
Невойт, Г. В., Jaruševičius, G., Potyazhenko, M., Mintser, O. P., Bumblytė, I. A., & Vainoras, A. (2024) · Diseases · doi:10.3390/diseases12110277 · Cited by 9 · see citing works
Malhan, D., Schmidt‐Bleek, K., Duda, G. N., & Khassawna, T. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043569 · Cited by 8 · see citing works
Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
Harris, R., Yang, J., Pagan, K., Cho, S. J., & Stout-Delgado, H. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212097 · Cited by 9 · see citing works
Fois, A., Boucher‐Lafleur, A., Legault, J. T., Renaud, C., Morin, C., Rosiers, C. D., Coderre, L., Laprise, C., & Lesage, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239860 · Cited by 7 · see citing works
Wang, Y., Schughart, K., Pelaia, T. M., Chew, T., Kim, K., Karvunidis, T., Knippenberg, B., Teoh, S., Phu, A. L., Short, K. R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032524 · Cited by 6 · see citing works
Walker, M. A., Li, S., Livak, K. J., Karaa, A., Wu, C. J., & Mootha, V. K. (2024) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12726 · Cited by 6 · see citing works
Self-citationMercier, A., Clairet, C., Debuchy, R., Morais, D., Silar, P., & Brun, S. (2019) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2019.103257 · Cited by 5 · see citing works
Darden, C., Donkor, J. E., Korolkova, O. Y., Barozai, M. Y. K., & Chaudhuri, M. (2024) · mSphere · doi:10.1128/msphere.00558-23 · Cited by 4 · see citing works
Interaction Between Mitochondria and Caspases: Apoptotic and Non-Apoptotic Roles
Tiwari, M. (2015) · Cell Biology · doi:10.11648/j.cb.s.2015030201.14 · Cited by 4 · see citing works
Investigating Fatigue and Exercise Intolerance in a University Immunology Clinic
Ambrus, J. L. (2020) · Archives of Rheumatology & Arthritis Research · doi:10.33552/arar.2020.01.000505 · Cited by 4 · see citing works
Mitochondria – More than just batteries for cellular function
Reuter, S. (2022) · Acta Physiologica · doi:10.1111/apha.13852 · Cited by 4 · see citing works
Pang, Y., Guo, Y., Li, K., Ren, M., Jia, X., Li, Z., Wang, B., Yan, L., & Li, Z. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.05.103 · Cited by 3 · see citing works
TFRC Germline Variants and Inborn Error of Immunity: Mechanistic Insights into Iron–Immune Crosstalk
Aljohani, A. H. (2026) · Journal of Clinical Immunology · doi:10.1007/s10875-026-01999-y · Cited by 2 · see citing works
Liu, A., Wei, Q., Lin, H., Ding, Y., Sun, Y. V., Zhao, D., He, J., Ma, Z., Li, F., Zhou, S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.793375 · Cited by 2 · see citing works
B cells race the clock to get a second wind
Phan, T. G., & Tangye, S. G. (2018) · Nature Immunology · doi:10.1038/s41590-018-0166-3 · Cited by 2 · see citing works
Ивановна, К. Н., Akulenko, M. V., & Прохоренко, И. Р. (2022) · International Journal of Applied and Fundamental Research (Международный журнал прикладных и фундаментальных исследований) · doi:10.17513/mjpfi.13422 · Cited by 1 · see citing works
Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global
Martins, I. J. (2015)
Introductory Chapter: Obesity—“OMICS” and Endocrinology
Gordeladze, J. O. (2017) · InTech eBooks · doi:10.5772/67685
Donnelly, R. P. (2016) · Arrow@dit (Dublin Institute of Technology)
Kumar, R., Rajput, N. K., Jolly, B., Narwade, A., & Bhardwaj, A. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.09.005
17q21.31 locus regulates Parkinson’s disease relevant pathways through KANSL1 activityPreprint
Hicks, A. R., O’Callaghan, B., Brenton, J., Grant‐Peters, M., Fairbrother-Browne, A., Perez, G. R., Loh, C. A., Reynolds, R. H., Gustavsson, E. K., Montgomery, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.17.641409 · Cited by 1 · see citing works
Fois, A., Deschênes, S., Bourel, C., Beauchamp, C., Lombard‐Vadnais, F., Ruiz, M., Charron, G., Coderre, L., Rosiers, C. D., Alikashani, A., et al. (2025) · Journal of Rare Diseases · doi:10.1007/s44162-025-00094-x
Siblings of FBXL4-related mitochondrial DNA depletion syndrome, leading to fatal fulminant pneumonia
Akiba, T., Shimada, S., Matsuda, S., Ishida, S., Baba, Y., Yamashita, A., Shoji, H., Okazaki, Y., & Murayama, K. (2025) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2025.101266
Islam, M. S. (2026) · Journal of Preventive Diagnostic and Treatment Strategies in Medicine · doi:10.4103/jpdtsm.jpdtsm_22_26
Myhre, V., Kaarbø, M., Yang, M., Fevang, B., Sousa, M. M., Reims, H. M., Lundin, K. E. A., Hov, J. R., Aukrust, P., Bjørås, M., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1875823
Santis, S. D., Rutigliano, M., Simone, F., Larocca, L., Matrella, M. L., Milella, M., Vavallo, A., Ditonno, P., Marrano, N., Mestice, A., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117230
Saiz, A. M., Jamous, R., Stötzel, S., Rahmati, M., Holmboe, L. V., Johnson, S. D., Øvrebø, Ø., Lauretis, A. D., Khassawna, T. E., Nogueira, L. P., et al. (2026) · Smart Medicine · doi:10.1002/smmd.70048
Yousefi, M., Adilbekov, Z., Balji, Y., Аубакирова, Г. А., Koshekbay, Z., Ghafarifarsani, H., & Ahmadifar, E. (2026) · Frontiers in Marine Science · doi:10.3389/fmars.2026.1917102
Oxidative stress: mechanisms, implications and emerging therapeutic strategies
Namratha, B., Martis, G. J., Sushma, S., Hakkimane, S. S., & Gaonkar, S. L. (2026) · Advances in Redox Research · doi:10.1016/j.arres.2026.100191
- Authors
- Walker, M. A., Volpi, S., Sims, K. B., Walter, J. E., & Traggiai, E.
- Affiliations
- Massachusetts General Hospital (US)
- University of Genoa (IT)
- Novartis (Switzerland) (CH)
- Corresponding author
- Walker, Melissa A.
- Traggiai, Elisabetta
- Venue
- Journal of Immunology Research
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-8
- ISSN
- 2314-7156 (ISSN-L)
- 2314-8861
- PMC
- PMC4189529
- OpenAlex
- W2132571570
- Cited by
- 83
- References
- 78
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 14 · 2020: 10 · 2019: 14 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 5
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Immunology Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- The Novartis Repository (Novartis) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- mitochondria, immune function, innate immunity, adaptive immunity, immunodeficiency, primary mitochondrial disorders, oxidative phosphorylation, mitochondrial signaling, infection susceptibility
- MeSH terms
- Humans, Immune System, Immunity, Innate, Mitochondria, Mutation, Models, Immunological, Genetic Predisposition to Disease, Mitochondrial Diseases, Adaptive Immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review