Cited by 83Mitochondrial Function and PathologyAutophagy in Disease and TherapyImmune Response and Inflammation

Powering the Immune System: Mitochondria in Immune Function and Deficiency

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Walker, Melissa A., Volpi, Stefano, Sims, Katherine B., Walter, Jolan E., Traggiai, Elisabetta·2014·Journal of Immunology Research

Abstract

Mitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and tissue-specific processes. Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding. Concurrently, immunodeficiencies arising from perturbation of mitochondrial elements are increasingly recognized. Recent observations of immune dysfunction and increased incidence of infection in patients with primary mitochondrial disorders further support an important role for mitochondria in the proper function of the immune system. Here we review current findings.

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Crossref · 10.1155/2014/164309

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  • Highly proliferative cells such as cancer cells and activated T cells rely on mitochondrial metabolites to form biomass.

    “Rather than being dysfunctional, highly proliferative cells such as cancer cells and activated T cells rely on mitochondrial metabolites to form biomass.5,65”

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Authors
Walker, M. A., Volpi, S., Sims, K. B., Walter, J. E., & Traggiai, E.
Affiliations
  • Massachusetts General Hospital (US)
  • University of Genoa (IT)
  • Novartis (Switzerland) (CH)
Corresponding author
  • Walker, Melissa A.
  • Traggiai, Elisabetta
Venue
Journal of Immunology Research
Publisher
Wiley
Published
2014
Volume
2014
Pages
1-8
ISSN
  • 2314-7156 (ISSN-L)
  • 2314-8861
OpenAlex
W2132571570
Cited by
83
References
78
Citations by year
2026: 7 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 14 · 2020: 10 · 2019: 14 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 5
FWCI
0.50
Type
journal article
Language
en
Open access
Locations
  • Journal of Immunology Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
  • The Novartis Repository (Novartis) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
mitochondria, immune function, innate immunity, adaptive immunity, immunodeficiency, primary mitochondrial disorders, oxidative phosphorylation, mitochondrial signaling, infection susceptibility
MeSH terms
Humans, Immune System, Immunity, Innate, Mitochondria, Mutation, Models, Immunological, Genetic Predisposition to Disease, Mitochondrial Diseases, Adaptive Immunity

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