Cited by 176Neuroscience and Music PerceptionNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex

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Happel, Max F. K., Niekisch, Hartmut, Castiblanco Rivera, Laura L., Ohl, Frank W., Deliano, Matthias, Frischknecht, Renato·2014·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1310272111PMC PMC3932855

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Abstract

Significance: The brain’s extracellular matrix (ECM) mediates structural stability by enwrapping synaptic contacts fundamental for long-term memory storage. Whether the ECM in the adult brain might thereby govern learning-related plasticity, lifelong memory reformation, and higher cognitive functions is largely unknown. Here, we enzymatically degraded the ECM in the auditory cortex of adult Mongolian gerbils during a reversal learning task. Such local weakening of the structurally rigid ECM specifically accelerated strategy changes required for reversal learning. It neither affected general sensory learning nor erased already established, learned memory traces. Thus, ECM modulation might promote the cognitive flexibility that can build on learned behaviors, and has further implications to develop new tools for guided neuroplasticity with therapeutic potential.

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Authors: Happel, M. F. K., Niekisch, H., Castiblanco Rivera, L. L., Ohl, F. W., Deliano, M., & Frischknecht, R.
Affiliations: Otto-von-Guericke-Universität Magdeburg (DE)
Department of Systems Physiology of Learning and
Center for Behavioral Brain Sciences (DE)
Leibniz Institute for Neurobiology (DE)
ORCID: Happel, Max F. K.
Ohl, Frank W.
Deliano, Matthias
Frischknecht, Renato
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2014-02-03
Volume: 111
Issue: 7
Pages: 2800-2805
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1310272111
PMC: PMC3932855
OpenAlex: W2074133215
Cited by: 176
References: 47
Citations by year: 2026: 9 · 2025: 18 · 2024: 11 · 2023: 11 · 2022: 13 · 2021: 15 · 2020: 22 · 2019: 12 · 2018: 14 · 2017: 18 · 2016: 12 · 2015: 10 · 2014: 10
FWCI: 9.30
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Leibniz-Gemeinschaft
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: extracellular matrix, auditory cortex, cognitive flexibility, reversal learning, synaptic plasticity, neuroplasticity, Mongolian gerbil
MeSH terms: Acoustic Stimulation, Analysis of Variance, Animals, Auditory Cortex, Cognition, Discrimination Learning, Extracellular Matrix, Fluorescence, Gerbillinae, Immunohistochemistry, Male, Neuronal Plasticity, Reversal Learning, Memory, Long-Term

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Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex

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