Cited by 488Cytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

Open access

Bowman, Tammy, Broome, Martin A., Sinibaldi, Dominic, Wharton, Walker, Pledger, W. J., Sedivy, John M., Irby, Rosalyn, Yeatman, Timothy, Courtneidge, Sara A., Jove, Richard·2001·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.131568898PMC PMC34666

Open this paper in CoChat — free account

Abstract

Signal transducer and activator of transcription (STAT) proteins perform key roles in mediating signaling by cytokines and growth factors, including platelet-derived growth factor (PDGF). In addition, Src family kinases activate STAT signaling and are required for PDGF-induced mitogenesis in normal cells. One STAT family member, Stat3, has been shown to have an essential role in cell transformation by the Src oncoprotein. However, the mechanisms by which STAT-signaling pathways contribute to mitogenesis and transformation are not fully defined. We show here that disruption of Stat3 signaling by using dominant-negative Stat3β protein in NIH 3T3 fibroblasts suppresses c-Myc expression concomitant with inhibition of v-Src-induced transformation. Ectopic expression of c-Myc is able to partially reverse this inhibition, suggesting that c-Myc is a downstream effector of Stat3 signaling in v-Src transformation. Furthermore, c -myc gene knockout fibroblasts are refractory to transformation by v-Src, consistent with a requirement for c-Myc protein in v-Src transformation. In normal NIH 3T3 cells, disruption of Stat3 signaling with dominant-negative Stat3β protein inhibits PDGF-induced mitogenesis in a manner that is reversed by ectopic c-Myc expression. Moreover, inhibition of Src family kinases with the pharmacologic agent, SU6656, blocks Stat3 activation by PDGF. These findings, combined together, delineate the signaling pathway, PDGF → Src → Stat3 → Myc, that is important in normal PDGF-induced mitogenesis and subverted in Src transformation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.131568898

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

STATs and Gene Regulation
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Stat3 as an Oncogene
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,227
PROTEIN-TYROSINE KINASES
Hunter, T. R., & Cooper, J. A. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.004341 · Cited by 2,142
STATs in oncogenesis
Bowman, T., Garcia, R., Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203527 · Cited by 1,743
Self-citation
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
Catlett-Falcone, R., Landowski, T. H., Oshiro, M. M., Turkson, J., Levitzki, A., Savino, R., Ciliberto, G., Moscinski, L., Fernández-Luna, J. L., Nuñez, G., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80011-4 · Cited by 1,638
Self-citation
Molecular themes in oncogenesis
Bishop, J. M. (1991) · Cell · doi:10.1016/0092-8674(91)90636-d · Cited by 1,629
The role of STATs in transcriptional control and their impact on cellular function
Bromberg, J., & Darnell, J. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203476 · Cited by 1,201
Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein
Yu, C.-L., Meyer, D. J., Campbell, G. S., Larner, A. C., Carter-Su, C., Schwartz, J., & Jove, R. (1995) · Science · doi:10.1126/science.7541555 · Cited by 931
Self-citation

Flagged first, then by citations

Show all 54 references

Research works printed but not linked: 4

R Garcia, C L Yu, A Hudnall, R Catlett, K L Nelson, T Smithgall, D J Fujita, S P Ethier, R Jove Cell Growth Differ 8, 1267–1276 (1997).
M K Mateyak, A J Obaya, S Adachi, J M Sedivy Cell Growth Differ 8, 1039–1048 (1997).
G Niu, R Heller, R Catlett-Falcone, D Coppola, M Jaroszeski, W Dalton, R Jove, H Yu Cancer Res 59, 5059–5063 (1999).
A V Bazarov, S Adachi, S F Li, M K Mateyak, S Wei, J M Sedivy Cancer Res 61, 1178–1186 (2001).

Sorted by citations

Items 401–486 of 486

Characteristic features of proliferation and differentiation of cambial and daughter cells in morphofunctional zones in normal epithelium and cancer in age aspect
Yavisheva, T. M., & Shcherbakov, S. D. (2011) · Advances in Gerontology · doi:10.1134/s2079057011010140 · Cited by 4
BPIFB2 is highly expressed in “cold” lung adenocarcinoma and decreases T cell chemotaxis via activation of the STAT3 pathway
Zhang, J., Yü, P., Zhao, Q., Guo, R., Shan, J., Liu, F., Wang, J., & Zhang, Y. (2022) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2022.101804 · Cited by 4
The critical role of the phosphorylation of STAT3 at Y705 in ALCL-associated NPM-ALK-induced transforming activity.
Lin, X., Korai, A., Nakazawa, Y., Tago, K., & Funakoshi-Tago, M. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112128 · Cited by 3
Engineered Nanobody-Bearing Extracellular Vesicles Enable Precision Trop2 Knockdown in Resistant Breast Cancer
Lazarte, J. M. S., Aare, M., Padakanti, S. C., Bagde, A., Nathani, A., Meeks, Z., Sun, L. J., Li, Y., & Singh, M. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17101318 · Cited by 3
Signal regulatory protein α dynamically mediates macrophage polarization facilitated alleviation of ischemic diseases
Liu, H., Yuan, Y., Johnson, T. K., Jing, C., Zhang, M., Huang, J., Zen, K., Li, L., & Zhu, D. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01325-2 · Cited by 4
Phyto-Sesquiterpene Lactones Prevent the Development of Multidrug Resistance in TNBC via ABC Transporters Inhibition and STAT3/MYC Signaling
Chang, Y., Wu, I., Lee, C.-H., & Hung, C. (2025) · Cancers · doi:10.3390/cancers17081321 · Cited by 3
Inhibition of STAT3 activation by KT-18618 via the disruption of the interaction between JAK3 and STAT3
Shin, D., Jung, S. N., Yun, J., Lee, C. W., Han, D. C., Kim, B., Min, Y. K., Kang, N. S., & Kwon, B. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.02.017 · Cited by 3
5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells
Crosta, M. D., Arena, A., Benedetti, R., Montani, M. S. G., & Cirone, M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46030156 · Cited by 4
Defective IFNα/γ-induced STAT3 protein activation in human malignant melanoma cells
Boudny (2008) · Molecular Medicine Reports · doi:10.3892/mmr_00000049 · Cited by 3
Gap junctions mediate STAT5-independent β-casein expression in CID-9 mammary epithelial cells
Talhouk, R., Khalil, A., Bajjani, R., Rahme, G. J., & El-Sabban, M. E. (2011) · Cell Communication & Adhesion · doi:10.3109/15419061.2011.639468 · Cited by 3
LPS-induced Src family kinases activity mediates IL-10 production through activation of STAT3 in peripheral blood mononuclear cells of patients with Behçet's Disease
Kandemir, S. İ., Tekin, M. A., Bozkurt, M., Dagli, A. Z., & Taş, S. K. (2017) · Cellular and Molecular Biology · doi:10.14715/cmb/2017.63.10.18 · Cited by 3
STAT3 and Transactivation of Steroid Hormone Receptors
Lee, S. O., & Gao, A. C. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)70011-x · Cited by 3
STAT Proteins as Molecular Targets for Cancer Therapy
Buettner, R., Kortylewski, M., Pardoll, D. M., Yu, H., & Jove, R. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_41 · Cited by 3
Self-citation
Cedrol impedes lung cancer metastasis by reducing tumor-associated macrophage polarization mediated by MYC-driven aerobic glycolysis
Li, Q., Liu, Y., Zhang, L., Zheng, Y., Feng, X., & Wang, Y. (2025) · Human Cell · doi:10.1007/s13577-025-01299-4 · Cited by 2
Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence
Zarco, N., Dovas, A., Farias, V., Nagaiah, N. K. H., Haddock, A. N., Sims, P. A., Hambardzumyan, D., Meyer, C. T., Canoll, P., Rosenfeld, S. S., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111311 · Cited by 2
Regulation of the Jak/STATs Pathways by Histone Deacetylases
Woods, D. M., Lienlaf, M., Sotomayor, E. M., Seto, E., & Villagra, A. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-8039-6_7 · Cited by 1
Role of STAT3 as a Negative Regulator in Mac2- Binding Protein Expression
Park, Y. P., Kim, J.-T., Yang, Y. D., Lim, J., Yoon, D. Y., Kim, J. W., & Lee, H. G. (2008) · Annals of Laboratory Medicine · doi:10.3343/kjlm.2008.28.3.230 · Cited by 2
A Novel Low-Risk Germline Variant in the SH2 Domain of the SRC Gene Affects Multiple Pathways in Familial Colorectal Cancer
Skopelitou, D., Miao, B., Srivastava, A., Kumar, A., Kuświk, M., Dymerska, D., Paramasivam, N., Schlesner, M., Lubiński, J., Hemminki, K., et al. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11040262 · Cited by 2
Curcumin and Genistein Role in Regulation of STAT-3 in Pancreatic Cancer
Rajitha, B., & Nagaraju, G. P. (2017) · Springer eBooks · doi:10.1007/978-981-10-6728-0_32 · Cited by 2
The RKIP and STAT3 Axis in Cancer Chemotherapy: Opposites Attract
Chatterjee, D., Sabo, E., Resnick, M. B., Yeung, K. C., & Chin, Y. E. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-474-2_10 · Cited by 2
Signaling through the Jak-Stat pathway: Regulation of tyrosine kinase activity
Saharinen, P. (2002) · Työväentutkimus Vuosikirja · Cited by 2
REGULATION OF STAT5 ACTIVATION
Paukku, K. (2003) · Työväentutkimus Vuosikirja · Cited by 1
Hesperetin Induces Apoptosis of Human Gastric Adenocarcinoma Cells
Yang, J. Y., Kim, H. W., Woo, H. J., Kim, J. Y., Park, M., & Kim, S. (2025) · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters · doi:10.15616/bsl.2025.31.2.137 · Cited by 1
Precision targeting of SRC signaling in glioblastoma: Mechanistic insights and bilosome nanotechnology
Madalageri, M., Sadashivanavar, V., Kinnal, R., Atchou, K., & Pai, K. S. R. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154083 · Cited by 1
In silico Analysis of Transcription Factors Associated to Differentially Expressed Genes in Irradiated Glioblastoma Cell Lines
Godoy, P. R. D. V., S., S., S., F., В.А., Е., Passos, G. A. S., & T., E. (2013) · InTech eBooks · doi:10.5772/53299 · Cited by 1
The Role of Signal Transducer and Activator of Transcription 3 (Stat3) in Stretch Injury to Bladder Smooth Muscle Cells
Halachmi, S., AITKEN, K. J., Szybowska, M., Sabha, N., Dessouki, S., Lorenzo, A. J., Tse, D., & Bägli, D. (2007) · Journal of Pediatric Urology · doi:10.1016/j.jpurol.2007.01.047 · Cited by 1
Tyrosine Kinase Signaling Pathways in Normal and Cancer Cells
Marcinkowska, E., & Gocek, E. (2016) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-319-46091-8_1 · Cited by 1
EGFR Resistance
Bourdeanu, L., Liu, E. Y., Brint, S., & Langdon, D. E. (2017) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-319-70142-4_4 · Cited by 1
Cancer Immunology
Pardoll, D. M. (2008) · Elsevier eBooks · doi:10.1016/b978-0-443-06694-8.50009-9 · Cited by 1
c-Myc, Apoptosis, and Disordered Tissue Growth
Khan, M., & Pelengaris, S. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-200-7_6 · Cited by 1
Role of Stat3 in Regulating HIF-1alpha Expression and Tumor Angiogenesis
Briggs, J. (2005) · Digital Commons - University of South Florida (University of South Florida) · Cited by 1
Constitutively Active STATs and Cellular Transformation
Dechow, T. N., & Bromberg, J. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_40 · Cited by 1
Physiological and Pharmacological Regulation of the STAT3 Pathway in Cancer
Xiang, M. H. (2013) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 1
Identification of Novel STAT3 Target Genes Associated with Oncogenesis
Haviland, R. (2011) · Digital Commons - University of South Florida (University of South Florida) · Cited by 1
The Ezrin Signalling Network as a Potential Novel Marker in Breast Cancer Metastasis
Mak, H. (2010) · QSpace (Queen's University Library) · Cited by 1
IKKα kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapyPreprint
Pecharromán, I., Solé, L., Villanueva, D. A., Lobo‐Jarne, T., Alonso‐Marañón, J., Bertran, J., Guillén, Y., Montoto, Á., Martínez‐Iniesta, M., García‐Hernández, V., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.13.544711 · Cited by 1
EGFRvIII Expression and Signaling in head and neck squamous cell carcinoma
Wheeler, S. E. (2012) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Dendritic Cells and Coregulatory Signals: Immune Checkpoint Blockade to Stimulate Immunotherapy
Pardoll, D. M. (2007) · Elsevier eBooks · doi:10.1016/b978-012372551-6/50078-x
Life or cell death: identifying c-Myc regulated genes in two distinct tissues
Robson, S. C. (2026) · Warwick Research Archive Portal (University of Warwick) · doi:10.82444/warw.33480907
Regulation of bax activation and apoptosis by src and acetylated mutant p53
Woods, N. T. (2008) · Digital Commons - University of South Florida (University of South Florida)
Interleukin-21 Induces Apoptosis of Diffuse Large B Cell Lymphomas via Activation of the STAT3 - c-Myc Intracellular Signaling Pathway
Sarosiek, K. A. (2009)
The Crucial Role of c-Src Tyrosine Kinase in Bone Metabolism
Peruzzi, B., Rucci, N., & Teti, A. M. (2012) · InTech eBooks · doi:10.5772/37995
THE PHARMACOGENOMICS OF EGFR-DEPENDENT NSCLC: PREDICTING AND ENHANCING RESPONSE TO TARGETED EGFR THERAPY
Balko, J. M. (2009) · UKnowledge (University of Kentucky)
Leukämische Fusionsproteine mit Tyrosinkinase-Aktivität induzieren eine konstitutive Aktivierung von STAT1, STAT3 und STAT5 und verursachen eine maligne Transformation von hämatopoetischen Vorläuferzellen
Pau, M. J. (2004) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.2709
Efeitos do Silenciamento de E2F1 e HEB, Fatores de Transcrição Preditos In Silico, em Células de Glioblastoma Irradiadas com Raios Gama.
Godoy, P. R. D. V. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2013.tde-13062013-094602
Introducing STAT 3-C into Non-Tumorigenic Prostate Epithelial Cells
Bromberg, J., Azare, J., & Lee, S. J. (2017) · Columbia Undergraduate Science Journal
MUTATIONS IN STAT3 ASSOCIATED WITH HUMAN HYPER IgE SYNDROME ENHANCE NFκB AND MAPK-MEDIATED GENE EXPRESSION
Greeley, N. R. (2012) · Digital Commons-TMC (Texas Medical Center)
Interactions Transcription Factor, STAT3 Network of Monomeric IgE: Effect on Microphthalmia Immunological Trigger of Mast Cells by
Sonnenblick, A., Levy, C., & Razin, E. (2011)
ROLE OF CELL ADHESION MICROENVIRONMENT AND THE SRC/STAT3 AXIS IN AUTOCRINE HGF SIGNALING DURING BREAST TUMOURIGENESIS
Starova, B. (2008) · QSpace (Queen's University Library)
The Jak-Stat Pathway of Cytokine Signaling
Croker, B. A., & Nicola, N. A. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-747-5_3
Src Family Tyrosine Kinases: Implications for Mammary Tumor Progression
Marcotte, R., & Muller, W. J. (2011) · Springer eBooks · doi:10.1007/978-0-387-69805-2_16
ROLE OF STAT3 IN HUMAN NK CELL FUNCTIONS
Phatarpekar, P. V. (2015) · Digital Commons-TMC (Texas Medical Center)
Las células madre pluripotentes son propagadas en un medio de cultivo novedoso que preserva sus propiedades fundamentales y aumenta su proliferación, asociada a la presencia de una isoforma de fibronectina que incluye el exón EDA
Losino, N. (2013) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Prevention and Treatment of Head and Neck Cancer with Natural Compound Inhibitors of STAT3
Leeman‐Neill, R. J. (2008) · D-Scholarship@Pitt (University of Pittsburgh)
Regulation of telomerase by genistein in human prostate cancer cells
Chau, M. N. (2008) · DigitalGeorgetown (Georgetown University Library)
A novel molecular target for cancer therapy:signal transducer and activator of transcription 3
Li, C., & Xu, Q. (2010) · Academic Journal of Second Military Medical University · doi:10.3724/sp.j.1008.2009.00722
Untersuchungen zur Prozessierung und
Pfreundschuh, M. G. (2009)
Regulation of EMT and metastasis by mutual inhibition of AP4 and miR-15a/16-1 in colorectal cancer
Shi, L. (2014) · doi:10.5282/edoc.17629
Signalling and crosstalk in cytokine pathways: mathematical modelling and quantitative analysis
Khatibi, S. (2016) · Minerva Access (University of Melbourne)
Human Kaposi's Sarcoma-associated Herpesvirus: Molecular Biology and Oncogenesis
Dillon, P., & Damania, B. (2009) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812833471_0006
The role of Src kinases in cytokine induced signalling in haemopoietic cells.
Tatton, E. L. (2003) · OpenGrey (Institut de l'Information Scientifique et Technique)
Elucidating the role of E2F2 loss in mediating human breast cancer metastasis
Yuwanita, I. (2015) · Michigan State University Libraries · doi:10.25335/m5w99n
STATs in Health and Disease
Liongue, C., Lewis, R. S., & Ward, A. C. (2016) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-42949-6_1
NFAT Signaling and the Tumorigenic Microenvironment of the Prostate
Chen, F. (2015)
RhoGTPase signaling in cell polarity and gene regulation.
Johansson, A. (2006) · Uppsala University Publications (Uppsala University)
Lung Tumorigenesis Transcription 3 in Antitumor Immunity during Carcinogen-Induced Inhibitory Roles of Signal Transducer and Activator of
Ihara, S., Kida, H., & Arase, H. (2012)
Targeting a Trigger: Platelet Derived Growth Factor Receptor Alpha in the Nodal Metastasis of Papillary Thyroid Cancer
Adewuyi, E. (2016) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3mk65k27
Resolving the molecular complexity of brain tumors through machine learning approaches for precision medicine
Sandanaraj, E. (2019) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/136519
Plant-derived small molecule inhibitors as modulators of EMT pathway in cancer chemoprevention
Ullah, M. F., Bhat, S. H., Tariq, M., Abuduhier, F. M., Ashraf, G. M., & Ahmad, A. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-323-91095-8.00008-8
Paracrine and autocrine functions of PDGF in malignant disease.
Sjöblom, T. (2002) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Faculty Opinions recommendation of Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways.
Toker, A., & White, C. D. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.10060956.11471056
Castration Induced Neuroendocrine Mediated Progression of Prostate Cancer
Evans, C. P. (2008) · Defense Technical Information Center (DTIC) · doi:10.21236/ada492892
IKKα kinase coordinates BRD4 and STAT3 signaling to subvert DNA damage-based anticancer therapyPreprint
Pecharromán, I., Bertran, J., Villanueva, D. A., Guillén, Y., Solé, L., Lobo‐Jarne, T., Alonso‐Marañón, J., Martínez, M., García‐Hernández, V., Gimenez, G., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1922801/v1
Data from Anoikis, Initiated by Mcl-1 Degradation and Bim Induction, Is Deregulated during Oncogenesis
Woods, N. T., Yamaguchi, H., Lee, F. Y., Bhalla, K. N., & Wang, H. (2023) · doi:10.1158/0008-5472.c.6496463
Data from Activation of Stat3 in Human Melanoma Promotes Brain Metastasis
Xie, T.-X., Huang, F.-J., Aldape, K. D., Kang, S.-H., Liu, M., Gershenwald, J. E., Xie, K., Sawaya, R. A., & Huang, S. (2023) · doi:10.1158/0008-5472.c.6494936
Data from Activation of Stat3 in Human Melanoma Promotes Brain Metastasis
Xie, T.-X., Huang, F.-J., Aldape, K. D., Kang, S.-H., Liu, M., Gershenwald, J. E., Xie, K., Sawaya, R. A., & Huang, S. (2023) · doi:10.1158/0008-5472.c.6494936.v1
Data from Malignant Transformation but not Normal Cell Growth Depends on Signal Transducer and Activator of Transcription 3
Schlessinger, K., & Levy, D. E. (2023) · doi:10.1158/0008-5472.c.6493839.v1
Data from Anoikis, Initiated by Mcl-1 Degradation and Bim Induction, Is Deregulated during Oncogenesis
Woods, N. T., Yamaguchi, H., Lee, F. Y., Bhalla, K. N., & Wang, H. (2023) · doi:10.1158/0008-5472.c.6496463.v1
Data from Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis
Nagaraj, N. S., Smith, J. J., Revetta, F. L., Washington, M. K., & Merchant, N. B. (2023) · doi:10.1158/1535-7163.c.6531773
Data from Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis
Nagaraj, N. S., Smith, J. J., Revetta, F. L., Washington, M. K., & Merchant, N. B. (2023) · doi:10.1158/1535-7163.c.6531773.v1
IKKα kinase coordinates BRD4 and STAT3 signaling to subvert DNA damage-based anticancer therapyPreprint
Pecharromán, I., Solé, L., Villanueva, D. A., Bertran, J., Guillén, Y., Lobo‐Jarne, T., Alonso‐Marañón, J., Martínez, M., García‐Hernández, V., Gimenez, G., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-1922801/v2
Apoptosis regulation in multiple myeloma.
Dimberg, L. Y. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Influence of hypoxia on tumour cell susceptibility to cytotoxic T lymphocyte mediated lysis
Noman, M. Z. (2012) · theses.fr (ABES) · doi:10.70675/306da2eez5bc3z478ez83c5zdc39407a896e
Régulation de la signalisation oncogénique de Src par l'adaptateur SLAP dans les cellules de cancer colorectal
Naudin, C. (2012) · theses.fr (ABES) · doi:10.70675/2d33d548z48baz433bzab22za40a44ff2ad1
Régulation de la signalisation de Src par son domaine N-terminal intrinsèquement désordonné
Aponte, E. (2018) · theses.fr (ABES) · doi:10.70675/28c1b781z0090z4f71zbca5z99055521b3ea
PTPRT/D MUTATION OR PROMOTER METHYLATION: IMPLICATIONS FOR STAT3 INHIBITION
Peyser, N. D. (2015) · D-Scholarship@Pitt (University of Pittsburgh)

Authors: Bowman, T., Broome, M. A., Sinibaldi, D., Wharton, W., Pledger, W. J., Sedivy, J. M., Irby, R., Yeatman, T., Courtneidge, S. A., & Jove, R.
Affiliations: University of South Florida (US)
Pfizer (United States) (US)
ORCID: Pledger, W. J.
Sedivy, John M.
Yeatman, Timothy
Courtneidge, Sara A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2001-06-12
Volume: 98
Issue: 13
Pages: 7319-7324
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.131568898
PMC: PMC34666
OpenAlex: W2042794591
Cited by: 488
References: 54
Citations by year: 2026: 2 · 2025: 9 · 2024: 8 · 2023: 24 · 2022: 12 · 2021: 13 · 2020: 12 · 2019: 13 · 2018: 13 · 2017: 20 · 2016: 15 · 2015: 24 · 2014: 21 · 2013: 20 · 2012: 30
FWCI: 11.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Moffitt Cancer Center
National Cancer Institute (R01CA055652, CA-55652, CA 67360, R01CA067360)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: STAT3, c-Myc, v-Src, Src family kinases, platelet-derived growth factor, cell transformation, SU6656, STAT signaling, NIH3T3 cells, oncogenic transformation
MeSH terms: Animals, Cell Division, Cell Line, Transformed, Cell Transformation, Neoplastic, DNA-Binding Proteins, Gene Expression Regulation, Models, Biological, Platelet-Derived Growth Factor, Recombinant Proteins, Signal Transduction, Trans-Activators, Genes, myc, Proto-Oncogene Proteins c-myc, Genes, src, 3T3 Cells, STAT3 Transcription Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks