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Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
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Signal transducer and activator of transcription (STAT) proteins perform key roles in mediating signaling by cytokines and growth factors, including platelet-derived growth factor (PDGF). In addition, Src family kinases activate STAT signaling and are required for PDGF-induced mitogenesis in normal cells. One STAT family member, Stat3, has been shown to have an essential role in cell transformation by the Src oncoprotein. However, the mechanisms by which STAT-signaling pathways contribute to mitogenesis and transformation are not fully defined. We show here that disruption of Stat3 signaling by using dominant-negative Stat3β protein in NIH 3T3 fibroblasts suppresses c-Myc expression concomitant with inhibition of v-Src-induced transformation. Ectopic expression of c-Myc is able to partially reverse this inhibition, suggesting that c-Myc is a downstream effector of Stat3 signaling in v-Src transformation. Furthermore, c -myc gene knockout fibroblasts are refractory to transformation by v-Src, consistent with a requirement for c-Myc protein in v-Src transformation. In normal NIH 3T3 cells, disruption of Stat3 signaling with dominant-negative Stat3β protein inhibits PDGF-induced mitogenesis in a manner that is reversed by ectopic c-Myc expression. Moreover, inhibition of Src family kinases with the pharmacologic agent, SU6656, blocks Stat3 activation by PDGF. These findings, combined together, delineate the signaling pathway, PDGF → Src → Stat3 → Myc, that is important in normal PDGF-induced mitogenesis and subverted in Src transformation.
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“In addition, the STAT3 target gene MYC, which itself encodes a transcription factor, is also a potent promoter of cell growth and is required for Src-mediated cellular transformation via STAT3.45”
From Critical analysis of the potential for targeting STAT3 in human malignancy (2013) · cites this paper as [45]
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“These membrane-associated non-RTKs are transducers of mitogenic signaling emanating from a number of RTKs, including EGFR, HER2, fibroblast growth factor receptor, platelet-derived growth factor, colonystimulating factor-1 receptor and hepatocyte growth receptor (Muthuswamy et al., 1994; Belsches et al., 1997; Mao et…”
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Metadata
- Authors
- Bowman, T., Broome, M. A., Sinibaldi, D., Wharton, W., Pledger, W. J., Sedivy, J. M., Irby, R., Yeatman, T., Courtneidge, S. A., & Jove, R.
- Affiliations
- University of South Florida (US)
- Pfizer (United States) (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-06-12
- Volume
- 98
- Issue
- 13
- Pages
- 7319-7324
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC34666
- OpenAlex
- W2042794591
- Cited by
- 488
- References
- 54
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 8 · 2023: 24 · 2022: 12 · 2021: 13 · 2020: 12 · 2019: 13 · 2018: 13 · 2017: 20 · 2016: 15 · 2015: 24 · 2014: 21 · 2013: 20 · 2012: 30
- FWCI
- 11.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Moffitt Cancer Center
- National Cancer Institute (R01CA055652, CA-55652, CA 67360, R01CA067360)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- STAT3, c-Myc, v-Src, Src family kinases, platelet-derived growth factor, cell transformation, SU6656, STAT signaling, NIH3T3 cells, oncogenic transformation
- MeSH terms
- Animals, Cell Division, Cell Line, Transformed, Cell Transformation, Neoplastic, DNA-Binding Proteins, Gene Expression Regulation, Models, Biological, Platelet-Derived Growth Factor, Recombinant Proteins, Signal Transduction, Trans-Activators, Genes, myc, Proto-Oncogene Proteins c-myc, Genes, src, 3T3 Cells, STAT3 Transcription Factor, Mice
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