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Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation
Open accessAbstract
Significance: This study demonstrates that antiangiogenic therapy increases tumor blood perfusion in a subset of newly diagnosed glioblastoma patients, and that it is these patients who survive longer when this expensive and potentially toxic therapy is combined with standard radiation and chemotherapy. This study provides fresh insights into the selection of glioblastoma patients most likely to benefit from antiangiogenic treatments.
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Metadata
- Authors
- Batchelor, T. T., Gerstner, E. R., Emblem, K. E., Duda, D. G., Kalpathy-Cramer, J., Snuderl, M., Ancukiewicz, M., Polaskova, P., Pinho, M. C., Jennings, D., Plotkin, S. R., Chi, A. S., Eichler, A. F., Dietrich, J., Hochberg, F. H., Lu-Emerson, C., Iafrate, A. J., Ivy, S. P., Rosen, B. R., Loeffler, J. S., Wen, P. Y., Sorensen, A. G., & Jain, R. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-11-04
- Volume
- 110
- Issue
- 47
- Pages
- 19059-19064
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2146628652
- Cited by
- 340
- References
- 9
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- green
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