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Cited by 579

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Mechanotransduction and flow across the endothelial glycocalyx

Open access
Weinbaum, Sheldon, Zhang, Xiaobing, Han, Yuefeng, Vink, Hans, Cowin, Stephen C.·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1332808100
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Abstract

In this inaugural paper, we shall provide an overview of the endothelial surface layer or glycocalyx in several roles: as a transport barrier, as a porous hydrodynamic interface in the motion of red and white cells in microvessels, and as a mechanotransducer of fluid shearing stresses to the actin cortical cytoskeleton of the endothelial cell. These functions will be examined from a new perspective, the quasiperiodic ultrastructural model proposed in Squire et al. [Squire, J. M., Chew, M., Nneji, G., Neal, C., Barry, J. & Michel, C. (2001)J. Struct. Biol.136, 239–255] for the 3D organization of the endothelial surface layer and its linkage to the submembranous scaffold. We shall show that the core proteins in the bush-like structures comprising the matrix have a flexural rigidity,EI, that is sufficiently stiff to serve as a molecular filter for plasma proteins and as an exquisitely designed transducer of fluid shearing stresses. However,EI is inadequate to prevent the buckling of these protein structures during the intermittent motion of red cells or the penetration of white cell microvilli. In these cellular interactions, the viscous draining resistance of the matrix is essential for preventing adhesive molecular interactions between proteins in the endothelial membrane and circulating cellular components.

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Metadata

Authors
Weinbaum, S., Zhang, X., Han, Y., Vink, H., & Cowin, S. C.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2003-06-16
Volume
100
Issue
13
Pages
7988-7995
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1332808100
OpenAlex
W2034248554
Cited by
579
References
38
FWCI
7.93
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Mechanotransduction and flow across the endothelial glycocalyx. https://app.cochat.ai/papers/10.1073/pnas.1332808100
The paper
Weinbaum, S., Zhang, X., Han, Y., Vink, H., & Cowin, S. C. (2003). Mechanotransduction and flow across the endothelial glycocalyx. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1332808100

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.