The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer
Open accessAbstract
Significance: Survival of cancer patients can be greatly improved by an ideal theranostic platform capable of early detection and effective treatment of tumors. Layer-by-layer (LbL) assembly is a well-established technology and matches the requirement of modularity and versatility for such a theranostic platform. Second near-infrared window (NIR-II) fluorescence imaging is a promising modality with high resolution, deep penetration, and diminished noise. This work, for the first time to our knowledge, establishes a modular and versatile LbL platform for NIR-II agents and presents a head-to-head in vivo comparison of available NIR-II probes. We successfully achieve the selective, noninvasive, and safe detection of high-grade serous ovarian tumors in an orthotopic murine model. These LbL NIR-II probes promise the development of an NIR-II based theranostic platform of disease diagnosis, progression, and treatment.
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“The completed LbL NPs, with a layered structure consisting of NIR-II emissive core/PLA/DXS/PLA/HA, possessed zeta potentials of approximately −30 mV and hydrodynamic diameters within the optimal range (10–200 nm) for systemic delivery (22, 23), except the SWNT (280 nm) because its unique elongated shape was not recogn…”
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Cited by
Hu, Z., Fang, C., Li, B., Zhang, Z., Cao, C., Cai, M., Su, S., Sun, X., Shi, X., Li, C., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0494-0 · Cited by 1,126
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A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging
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Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Metadata
- Authors
- Dang, X., Gu, L., Qi, J., Correa, S., Zhang, G., Belcher, A. M., & Hammond, P. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-04-25
- Volume
- 113
- Issue
- 19
- Pages
- 5179-5184
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2342399740
- Cited by
- 189
- References
- 8
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dang, X., Gu, L., Qi, J., Correa, S., Zhang, G., Belcher, A. M., & Hammond, P. T. (2016). Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1521175113
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