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Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
Open accessAbstract
Significance: The effectiveness of nucleic acid drugs is limited by inefficient delivery to target tissues and cells and by unwanted accumulation in off-target organs. Although thousands of chemically distinct nanoparticles can be synthesized, nanoparticles designed to deliver nucleic acids in vivo were first tested in cell culture, yielding poor predictions for delivery in vivo. To facilitate testing of many nanoparticles in vivo, we designed and optimized a high-throughput DNA barcoding system to simultaneously measure nucleic acid delivery mediated by dozens of distinct nanoparticles in a single mouse. This nano-barcoding system can be used to study hundreds, or even thousands, of nanoparticles directly in vivo and could dramatically accelerate the discovery and understanding of nanoparticle drug delivery systems.
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“Dahlman et al. designed and optimized a high-throughput DNA barcoding system for the detection of lipid nanoparticles carrying specific nucleic acid barcodes in normal or tumor tissues in vivo, which facilitates the discovery of nanoparticles targeting tumor tissues and cells.339”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [339]
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“However, barcoded nanoparticles allow in vivo high-throughput profiling of lipid nanoparticle distribution at the cell level121.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [121]
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Metadata
- Authors
- Dahlman, J. E., Kauffman, K. J., Xing, Y., Shaw, T. E., Mir, F. F., Dlott, C. C., Langer, R., Anderson, D. G., & Wang, E. T.
- Affiliations
- Georgia Institute of Technology (US)
- Koch Institute for Integrative Cancer Research At MIT (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139;
- University of Florida (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-02-06
- Volume
- 114
- Issue
- 8
- Pages
- 2060-2065
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5338412
- OpenAlex
- W2586934391
- Cited by
- 335
- References
- 39
- Citations by year
- 2026: 50 · 2025: 62 · 2024: 53 · 2023: 43 · 2022: 40 · 2021: 22 · 2020: 24 · 2019: 13 · 2018: 18 · 2017: 10
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- HHS | National Institutes of Health (DP5-OD017865)
- National Science Foundation (1122374)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- nanoparticle biodistribution, siRNA delivery, structure-activity relationship
- MeSH terms
- Animals, Cell Separation, Pharmaceutical Preparations, Factor VII, Female, Flow Cytometry, Liver, Lung, Mice, Inbred C57BL, Nucleic Acids, Tissue Distribution, Drug Delivery Systems, RNA Interference, RNA, Small Interfering, Mice, Nanoparticles, Drug Discovery, DNA Barcoding, Taxonomic, Molecular Targeted Therapy
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