Cited by 335RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers

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Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics

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Dahlman, James E., Kauffman, Kevin J., Xing, Yiping, Shaw, Taylor E., Mir, Faryal F., Dlott, Chloe C., Langer, Robert, Anderson, Daniel G., Wang, Eric T.·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1620874114PMC PMC5338412

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Abstract

Significance: The effectiveness of nucleic acid drugs is limited by inefficient delivery to target tissues and cells and by unwanted accumulation in off-target organs. Although thousands of chemically distinct nanoparticles can be synthesized, nanoparticles designed to deliver nucleic acids in vivo were first tested in cell culture, yielding poor predictions for delivery in vivo. To facilitate testing of many nanoparticles in vivo, we designed and optimized a high-throughput DNA barcoding system to simultaneously measure nucleic acid delivery mediated by dozens of distinct nanoparticles in a single mouse. This nano-barcoding system can be used to study hundreds, or even thousands, of nanoparticles directly in vivo and could dramatically accelerate the discovery and understanding of nanoparticle drug delivery systems.

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Authors: Dahlman, J. E., Kauffman, K. J., Xing, Y., Shaw, T. E., Mir, F. F., Dlott, C. C., Langer, R., Anderson, D. G., & Wang, E. T.
Affiliations: Georgia Institute of Technology (US)
Koch Institute for Integrative Cancer Research At MIT (US)
Harvard–MIT Division of Health Sciences and Technology (US)
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139;
University of Florida (US)
ORCID: Dahlman, James E.
Kauffman, Kevin J.
Dlott, Chloe C.
Anderson, Daniel G.
Wang, Eric T.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-02-06
Volume: 114
Issue: 8
Pages: 2060-2065
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1620874114
PMC: PMC5338412
OpenAlex: W2586934391
Cited by: 335
References: 39
Citations by year: 2026: 50 · 2025: 62 · 2024: 53 · 2023: 43 · 2022: 40 · 2021: 22 · 2020: 24 · 2019: 13 · 2018: 18 · 2017: 10
FWCI: 7.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 181 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Funders: HHS | National Institutes of Health (DP5-OD017865)
National Science Foundation (1122374)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords: nanoparticle biodistribution, siRNA delivery, structure-activity relationship
MeSH terms: Animals, Cell Separation, Pharmaceutical Preparations, Factor VII, Female, Flow Cytometry, Liver, Lung, Mice, Inbred C57BL, Nucleic Acids, Tissue Distribution, Drug Delivery Systems, RNA Interference, RNA, Small Interfering, Mice, Nanoparticles, Drug Discovery, DNA Barcoding, Taxonomic, Molecular Targeted Therapy

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Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics

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