Cited by 664Insect and Pesticide ResearchGut microbiota and healthInsect and Arachnid Ecology and Behavior

Honeybee gut microbiota promotes host weight gain via bacterial metabolism and hormonal signaling

Open access
Zheng, Hao, Powell, J. Elijah, Steele, Margaret I., Dietrich, Carsten, Moran, Nancy A.·2017·Proceedings of the National Academy of Sciences

Abstract

Social bees harbor a simple and specialized microbiota that is spatially organized into different gut compartments. Recent results on the potential involvement of bee gut communities in pathogen protection and nutritional function have drawn attention to the impact of the microbiota on bee health. However, the contributions of gut microbiota to host physiology have yet to be investigated. Here we show that the gut microbiota promotes weight gain of both whole body and the gut in individual honey bees. This effect is likely mediated by changes in host vitellogenin, insulin signaling, and gustatory response. We found that microbial metabolism markedly reduces gut pH and redox potential through the production of short-chain fatty acids and that the bacteria adjacent to the gut wall form an oxygen gradient within the intestine. The short-chain fatty acid profile contributed by dominant gut species was confirmed in vitro. Furthermore, metabolomic analyses revealed that the gut community has striking impacts on the metabolic profiles of the gut compartments and the hemolymph, suggesting that gut bacteria degrade plant polymers from pollen and that the resulting metabolites contribute to host nutrition. Our results demonstrate how microbial metabolism affects bee growth, hormonal signaling, behavior, and gut physicochemical conditions. These findings indicate that the bee gut microbiota has basic roles similar to those found in some other animals and thus provides a model in studies of host-microbe interactions.

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Crossref · 10.1073/pnas.1701819114

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  • Phycocyanin in Arthrospira platensis suppresses oxidative stress and leads to anti-inflammatory and insulin-sensitizing effects.

    “Phycocyanin in Arthrospira platensis suppresses oxidative stress and leads to anti-inflammatory and insulin-sensitizing effects [106,107,108].”

    From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [108]

    The ‘Gut Microbiota Promotes Host Body and Gut Weight Gain’ section discusses insulin-like signaling in honey bees, not insulin sensitization by phycocyanin. Searches for phycocyanin and Arthrospira platensis found no passage addressing the claimed oxidative-stress or anti-inflammatory effects; page numbers were not available in our copy. (LLM, conf=0.78)

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Authors
Zheng, H., Powell, J. E., Steele, M. I., Dietrich, C., & Moran, N. A.
Affiliations
  • The University of Texas at Austin (US)
  • Siemens Healthineers (Germany) (DE)
Venue
Proceedings of the National Academy of Sciences
Published
2017-04-18
Volume
114
Issue
18
Pages
4775-4780
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2605691951
Cited by
664
References
85
Citations by year
2026: 63 · 2025: 75 · 2024: 91 · 2023: 74 · 2022: 91 · 2021: 83 · 2020: 74 · 2019: 45 · 2018: 59 · 2017: 9
FWCI
47.76
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • HHS | National Institutes of Health (1R01-GM108477-01)
  • DOD | Defense Advanced Research Projects Agency (HR0011-15-C-0095)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect and Pesticide Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Insect and Arachnid Ecology and Behavior
Keywords
honey bee gut microbiota, short-chain fatty acids, gut pH, redox potential, oxygen gradients, insulin signaling, vitellogenin, gustatory response, host-microbe interactions, bee nutrition
MeSH terms
Gastrointestinal Microbiome, Animals, Bacteria, Bees, Body Weight, Insect Hormones, Signal Transduction

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