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Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy

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Bortezomib-induced neurotoxicity in human neurons is the consequence of nicotinamide adenine dinucleotide depletion

Snavely, A. R., Heo, K., Petrova, V., Ho, T. S., Huang, X., Hermawan, C., Kagan, R. D., Deng, T., Singeç, I., Chen, L., et al. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049358 · Cited by 18 · see citing works

The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products

Garb, J., Amitai, G., Lu, A., Ofir, G., Brandis, A. S., Mehlman, T., Kranzusch, P. J., & Sorek, R. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302251 · Cited by 17 · see citing works

Therapeutic Significance of microRNA-Mediated Regulation of PARP-1 in SARS-CoV-2 Infection

Dash, S., Dash, C., & Pandhare, J. (2021) · Non-Coding RNA · doi:10.3390/ncrna7040060 · Cited by 17 · see citing works

Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model

Takaso, Y., Noda, M., Hattori, T., Roboon, J., Hatano, M., Sugimoto, H., Brenner, C., Yamamoto, Y., Okamoto, H., Higashida, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73984-3 · Cited by 17 · see citing works

Current and Emerging Pharmacotherapeutic Interventions for the Treatment of Peripheral Nerve Disorders

Chiang, J. C. B., Arnold, R., Dhanapalaratnam, R., Markoulli, M. P., & Krishnan, A. V. (2022) · Pharmaceuticals · doi:10.3390/ph15050607 · Cited by 16 · see citing works

SARM1 can be a potential therapeutic target for spinal cord injury

Lu, Q., Botchway, B. O. A., Zhang, Y., Jin, T., & Liu, X. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04195-4 · Cited by 16 · see citing works

Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons

Alexandris, A. S., Ryu, J., Rajbhandari, L., Harlan, R., McKenney, J., Wang, Y., Aja, S. M., Graham, D. R. M., Venkatesan, A., & Koliatsos, V. E. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105808 · Cited by 16 · see citing works

NAD+ metabolism in peripheral neuropathic pain

Dai, Y., Lin, J., Ren, J., Zhu, B., Wu, C., & Yu, L. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105435 · Cited by 15 · see citing works

A duplex structure of SARM1 octamers stabilized by a new inhibitor

Khazma, T., Golan-Vaishenker, Y., Guez-Haddad, J., Grossman, A., Sain, R., Weitman, M., Plotnikov, A. N., Zalk, R., Yaron, A., Hons, M., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04641-3 · Cited by 14 · see citing works

Die in pieces: How Drosophila sheds light on neurite degeneration and clearance

Sapar, M. L., & Han, C. (2019) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2019.03.010 · Cited by 14 · see citing works

Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications

Berry, D., Ene, J., Nathani, A., Singh, M. S., Li, Y., & Zeng, C. (2024) · Biomedicines · doi:10.3390/biomedicines12030489 · Cited by 14 · see citing works

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses

Mani, A., Mendel, M., Westwood, P., Bonardi, C., Saal, W., Topp, A., Bilyard, M., Brigo, A., Wittwer, M., Benz, J., et al. (2025) · npj Drug Discovery. · doi:10.1038/s44386-025-00016-3 · Cited by 13 · see citing works

Cross-talk in NAD+ metabolism: insights from Saccharomyces cerevisiae

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Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway

Parsons, R. B., Kocinaj, A., Ruiz-Pulido, G., Prendergast, S. A., Parsons, A. E., Facey, P. D., & Hirth, F. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac077 · Cited by 13 · see citing works

Risks and rewards of targeting NAD+ homeostasis in the brain

Li, C., & Wu, L. E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111545 · Cited by 13 · see citing works

Nicotinamide Adenine Dinucleotide (NAD + )-Dependent Signaling in Neurological Disorders

Bresque, M., Esteve, D., Pehar, M., & Vargas, M. R. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0241 · Cited by 12 · see citing works

SARM1 senses dsDNA to promote NAD+ degradation and cell death

Wang, L., Liu, Q., Li, S., Wang, N., Chen, Y., Chen, J., Wang, L., Huang, Y., Sun, Z., Dong, L., et al. (2025) · Cell · doi:10.1016/j.cell.2025.09.026 · Cited by 14 · see citing works

The histone deacetylases Rpd3 and Hst1 antagonistically regulate de novo NAD+ metabolism in the budding yeast Saccharomyces cerevisiae

Groth, B., Huang, C.-C., & Lin, S.-J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102410 · Cited by 11 · see citing works

Harnessing lactic acid bacteria for nicotinamide mononucleotide biosynthesis: a review of strategies and future directions

Kong, L., Li, X., Liu, T., Yao, Q., & Qin, J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1492179 · Cited by 10 · see citing works

Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications

Banerjee, P., Olmsted‐Davis, E. A., Deswal, A. M., Nguyen, M. T. H., Koutroumpakis, E., Palaskas, N., Lin, S. H., Kotla, S., Reyes‐Gibby, C. C., Yeung, S. J., et al. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.13 · Cited by 10 · see citing works

NAD in pathological cardiac remodeling: Metabolic regulation and beyond

Norambuena‐Soto, I., Deng, Y., Brenner, C., Lavandero, S., & Wang, Z. V. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167038 · Cited by 9 · see citing works

An updated review of YAP: A promising therapeutic target against cardiac aging?

Leng, J., Wang, C., Liang, Z., Qiu, F., Zhang, S., & Yuan, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127670 · Cited by 9 · see citing works

The curious case of SARM1: Dr. Jekyll and Mr. Hyde in cell death and immunity?

Sarkar, A., Kumari, N., & Mukherjee, P. (2021) · FEBS Journal · doi:10.1111/febs.16256 · Cited by 8 · see citing works

Biotechnological production of reduced and oxidized NAD+ precursors

Perez, R. Z., García-Saura, A. G., Scantlebery, A. M. L., Schomakers, B. V., Rabadán-Ros, R., van Weeghel, M., Houtkooper, R. H., & Sánchez‐Ferrer, Á. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112560 · Cited by 7 · see citing works

Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans

Khazma, T., Grossman, A., Guez-Haddad, J., Feng, C., Dabas, H., Sain, R., Weitman, M., Zalk, R., Isupov, M. N., Hammarlund, M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113026 · Cited by 7 · see citing works

Nicotinamide Riboside Supplementation Alleviates Testicular Aging Induced by Disruption of Qprt‐Dependent NAD + De Novo Synthesis in Mice

Xu, Y., Wang, H., Li, H., Wei, C., Zhu, Z., Zhao, Y., Zhu, J., Lei, M., Sun, Y., & Yang, Q. (2025) · Aging Cell · doi:10.1111/acel.70004 · Cited by 7 · see citing works

Nicotinamide riboside–amino acid conjugates that are stable to purine nucleoside phosphorylase

Hayat, F., & Migaud, M. E. (2020) · Organic & Biomolecular Chemistry · doi:10.1039/d0ob00134a · Cited by 7 · see citing works

Randomized, placebo-controlled, pilot clinical study evaluating acute Niagen®+ IV and NAD+ IV in healthy adultsPreprint

Hawkins, J., Idoine, R., Kwon, J., Shao, A. E., Dunne, E., Hawkins, E. M., Dawson, K., & Nkrumah-Elie, Y. M. (2024) · medRxiv · doi:10.1101/2024.06.06.24308565 · Cited by 7 · see citing works

Molsidomine provides neuroprotection against vincristine-induced peripheral neurotoxicity through soluble guanylyl cyclase activation

Utkina-Sosunova, I. V., Chiorazzi, A., Planell-Saguer, M. D., Li, H., Meregalli, C., Pozzi, E., Carozzi, V., Canta, A., Monza, L., Alberti, P., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-70294-w · Cited by 6 · see citing works

Fat mobilization without weight loss is a potentially rapid response to nicotinamide riboside in obese people: it’s time to test with exercise

Fluharty, N. T., & Brenner, C. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa109 · Cited by 6 · see citing works

Quantitative Analysis of Daporinad (FK866) and Its In Vitro and In Vivo Metabolite Identification Using Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry

Park, M., Lee, B. I., Choi, J., Park, Y., Park, S., Lim, J.-H., Lee, J., & Shin, Y. G. (2022) · Molecules · doi:10.3390/molecules27062011 · Cited by 5 · see citing works

The Role of SIRT1 in Neuropathic Pain from the Viewpoint of Neuroimmunity

Fan, Y., Dong, R., Zhang, H., Yu, B., & Han, L. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210705162610 · Cited by 5 · see citing works

Why Is Mom Stressed: Homeorhesis as the Potential Problem and Nicotinamide Riboside as the Potential Solution

Brenner, C. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519869679 · Cited by 5 · see citing works

Nicotinamide Adenine Dinucleotide Precursor Supplementation Modulates Neurite Complexity and Survival in Motor Neurons from Amyotrophic Lateral Sclerosis Models

Hamilton, H. L., Akther, M., Anis, S., Colwell, C. B., Vargas, M. R., & Pehar, M. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0360 · Cited by 4 · see citing works

Development of a novel in vitro assay to screen for neuroprotective drugs against iatrogenic neurite shortening

Martínez, A. L., Brea, J. M., Barro, M., Monroy, X., Merlos, M., Burgueño, J., & Loza, M. I. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248139 · Cited by 4 · see citing works

Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism

Brüll, M., Multrus, S., Schäfer, M., Celardo, I., Karreman, C., & Leist, M. (2025) · Cell Death and Disease · doi:10.1038/s41419-024-07326-w · Cited by 3 · see citing works

Brain aging-dependent glioma traits reversible by NAD + /BDNF-mediated neuronal reactivationPreprint

Yamashita, D., Flanary, V. L., Munk, R. B., Sonomura, K., Ozaki, S., Kawaguchi, R., Suehiro, S., Bastola, S., Pavlyukov, M. S., Yamaguchi, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.10.334748 · Cited by 3 · see citing works

Integrated lipidomics and computational analyses reveal cardiolipin dysregulation as a therapeutic target in bortezomib-induced peripheral neuropathy

Tang, Y., Liu, J., & Gu, W. (2025) · Current Pharmaceutical Analysis · doi:10.1016/j.cpan.2025.02.002 · Cited by 2 · see citing works

Preventive Strategies for Chemotherapy-Induced Peripheral Neuropathy

Nielsen, S. W., & Herrstedt, J. (2021) · Springer eBooks · doi:10.1007/978-3-030-78663-2_4 · Cited by 2 · see citing works

A senescent metabolism-modulating hierarchical scaffold restores NAD+ homeostasis and redox balance for aged bone repair

Jiang, J., Chen, J., Wang, X., Zhang, X., Lv, H., Wu, C., Han, L., & Zhu, Y. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.06.036 · Cited by 1 · see citing works

Phagocytosis and self-destruction execute dendrite degeneration of Drosophila sensory neurons at distinct levels of NAD+ reductionPreprint

Ji, H., Sapar, M. L., Sarkar, A., Wang, B., & Han, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.26.173245 · Cited by 1 · see citing works

A Duplex Structure of SARM1 Octamers Induced by a New InhibitorPreprint

Khazma, T., Golan-Vaishenker, Y., Guez-Haddad, J., Grossman, A., Sain, R., Plotnikov, A. N., Zalk, R., Yaron, A., Hons, M., & Opatowsky, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.02.482641 · Cited by 1 · see citing works

SLC25A51 impacts drug sensitivity in AML cells by sustaining mitochondrial oxidative fluxPreprint

Lu, M., Busquets, J., Impedovo, V., Chang, Y.-T., Matsui, W. H., Tiziani, S., & Cambronne, X. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.15.516643 · Cited by 1 · see citing works

Assessing cellular senescence, NAD+ and ageing in chemotherapy related side-effects in colorectal cancer survivors

Wu, W. (2024) · doi:10.26481/dis.20240628ww

Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program

Geisler, S., Doan, R. A., Cheng, G., Cetinkaya‐Fisgin, A., Huang, S. X., Höke, A., Milbrandt, J., & DiAntonio, A. (2019) · JCI Insight · doi:10.1172/jci.insight.129920 · Cited by 146 · see citing works

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Di Stefano, M., Nascimento-Ferreira, I., Orsomando, G., Mori, V, Gilley, J., Brown, R., Janeckova, L., Vargas, M. E., Worrell, L. A., Loreto, A., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.164 · Cited by 246 · see citing works

Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy

Sasaki, Y., Araki, T., & Milbrandt, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2320-06.2006 · Cited by 269 · see citing works

Nicotinamide adenine dinucleotide prevents axonal degeneration.

Qi, X., Li, Z., Zhang, J., Liu, W., Lü, J., Peng, F., Yang, J., & Sun, J. (2009) · Journal of Shandong University

Exploring clinical markers of Axon degeneration processes in Chemotherapy-induced peripheral neuropathy among young adults receiving vincristine or paclitaxel

Knoerl, R., Mazzola, E., Pazyra‐Murphy, M. F., Ryback, B. A., Frazier, A. L., Freeman, R. L., Hammer, M. J., LaCasce, A. S., Ligibel, J. A., Luskin, M. R., et al. (2024) · BMC Neurology · doi:10.1186/s12883-024-03877-9 · Cited by 8 · see citing works