Bright and Stable NIR‐II J‐Aggregated AIE Dibodipy‐Based Fluorescent Probe for Dynamic In Vivo Bioimaging
Abstract
Organic dyes emitting in the second near‐infrared (NIR‐II, 900–1700 nm) window, with high molar extinction coefficients (MEC) and quantum yields (QY) in aqueous, are essential for in vivo bioimaging and biosensing. In this work, we developed a dibodipy‐based aggregation‐induced emission (AIE) fluorescent probe, THPP, to meet this aim. THPP exhibits a high MEC and has intensified absorption and emission in J‐aggregated state, which significantly enhance the fluorescence intensity (≈55 folds) and extend the maximal absorption/emission wavelengths to 970/1010 nm in NIR‐II region. Based on the bright THPP, imaging with a high frame rate (34 frames per second) at a deep “valid penetration depth” up to 6 mm can be achieved. This enabled simultaneous and dynamic imaging of vasculatures and deep tissues. Besides, we succeeded in monitoring the respiratory rate of acute‐lung‐injury mice and tracing the collateral circulation process with a high frame rate.
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An incorporation of the free rotating TPA groups led to a low Φfl in polar solvents due to the TICT effect.
“An incorporation of the free rotating TPA groups led to a low Φfl in polar solvents due to the TICT effect.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [152]
The restriction of the formation of its TICT state led to a 150-fold enhancement in Φfl in a nonpolar solvent.
“The restriction of the formation of its TICT state led to a 150-fold enhancement in Φfl in a nonpolar solvent.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [152]
A fluorescent probe, THPP, based on the rigidified planar core structure of di-BODIPY, showed roughly an order of magnitude higher molar extinction coefficient than conventional D-A-D systems.
“A fluorescent probe, THPP, based on the rigidified planar core structure of di-BODIPY, showed roughly an order of magnitude higher molar extinction coefficient than conventional D-A-D systems (Figure 7d).152”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [152]
The aggregation of the THPP molecules in water/THF mixtures revealed a further increase in Φfl that was accompanied by a shortened fluorescence lifetime, a strong red-shift of the fluorescence spectra (1006 nm), and a spectral narrowing (fwhm from 65 to 36 nm).
“The aggregation of the THPP molecules in water/THF mixtures revealed a further increase in Φfl that was accompanied by a shortened fluorescence lifetime, a strong red-shift of the fluorescence spectra (1006 nm), and a spectral narrowing (fwhm from 65 to 36 nm).”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [152]
Benefiting from an extended π-conjugation system of di-BODIPY, the absorption and emission wavelengths in polar solvents shifted to 900 and 920 nm, respectively.
“Benefiting from an extended π-conjugation system of di-BODIPY, the absorption and emission wavelengths in polar solvents shifted to 900 and 920 nm, respectively.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [152]
Donor-acceptor engineering leads to weak absorption at long wavelengths.
“Worse still, D-A engineering leads to weak absorption in the long wavelengths20.”
From Alleviating NIR-II emission quenching in ring-fused fluorophore via manipulating dimer populations for superior fluorescence imaging (2025) · cites this paper as [20]
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Zhang, X., Chen, Y., He, H., Wang, S., Lei, Z., & Zhang, F. (2021) · Angewandte Chemie · doi:10.1002/ange.202109728 · Cited by 25 · see citing works
Self-citationMeng, J., Feng, Z., Qian, S., Wang, C., Li, X., Gao, L., Ding, Z., Qian, J., & Liu, Z. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212760 · Cited by 25 · see citing works
Yu, Y., Wang, Y., Wu, B., Yu, Q., Ye, J., Chen, Y., Qian, J., Li, Y., & Yin, S. (2025) · Small · doi:10.1002/smll.202504607 · Cited by 25 · see citing works
Recent Advances in Nanomaterials for Diagnosis, Treatments, and Neurorestoration in Ischemic Stroke
Lin, X., Li, N., & Tang, H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.885190 · Cited by 24 · see citing works
Zhang, Y., Zhou, L., Zhang, L., Luo, W. H., Shen, W., Li, M., & He, R. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.05.070 · Cited by 23 · see citing works
- Authors
- Zhang, Q., Yu, P., Fan, Y., Sun, C., He, H., Liu, X., Lu, L., Zhao, M., Zhang, H., & Zhang, F.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Fan, Yong
- Zhang, Fan
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-12-23
- Volume
- 60
- Issue
- 8
- Pages
- 3967-3973
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3088121390
- Cited by
- 216
- References
- 101
- Citations by year
- 2026: 22 · 2025: 38 · 2024: 33 · 2023: 34 · 2022: 55 · 2021: 32 · 2020: 1
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21725502, 51961145403, 21904023, 21908030)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- aggregation-induced emission, J-aggregation, second near-infrared window, in vivo imaging, deep tissue imaging, vascular imaging, acute lung injury, respiratory rate estimation, collateral circulation, ultrafast imaging, molar absorptivity
- MeSH terms
- Animals, Biocompatible Materials, Cerebral Veins, Fluorescent Dyes, Micelles, Propiophenones, Quantum Theory, Spectroscopy, Near-Infrared, Mice, Nanoparticles, Acute Lung Injury, Signal-To-Noise Ratio, Optical Imaging
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