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Expression and alternate splicing of apolipoprotein E receptor 2 in brain

Clatworthy, A.E., Stockinger, W., Christie, R.H., Schneider, W.J., Nimpf, J., Hyman, B.T., Rebeck, G.W.·1999·Neuroscience
DOI 10.1016/s0306-4522(98)00489-8
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Abstract

Apolipoprotein E isoforms affect the risk of developing Alzheimer's disease. Apolipoprotein E-associated risk may be related to its binding to and clearance by cell surface receptors, including members of the low-density lipoprotein receptor family. We examined the brain expression of the most recently identified member of this receptor family, apolipoprotein E receptor 2, in human brain and placenta. We analysed apolipoprotein E receptor 2 messenger RNA by reverse transcription-polymerase chain reaction and apolipoprotein E receptor 2 protein by immunohistochemistry. Four exons of the apolipoprotein E receptor 2 message were alternately spliced in both fetal and adult brain tissue. Exon 5, encoding three of the seven ligand binding repeats, was absent in the apolipoprotein E receptor 2 messenger RNA examined. Apolipoprotein E receptor 2 messages lacking exon 8, encoding an epidermal growth factor precursor repeat, exon 15, encoding the O-glycosylation region, or exon 18, encoding a cytoplasmic domain, were also present as minor splice variants in the brain and placenta. No differences were observed in the pattern of apolipoprotein E receptor 2 splicing between control and Alzheimer brains. Immunohistochemistry of mouse brain showed that apolipoprotein E receptor 2 was expressed in neurons throughout the brain, with strong expression in pyramidal neurons of the hippocampus, granule cells of the dentate gyrus, cortical neurons and Purkinje cells of the cerebellum. Thus, apolip…

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  • Activated astrocytes used in the experiments express both LDLR and LRP by immunostaining.

    “By immunostaining, these activated astrocytes express both the LDLR and LRP (data not shown), consistent with the previous observations summarized above that these are the two primary members of the LDLR family that are expressed by activated astrocytes (4 -7, 29 -31).”

    From Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures (2000) · cites this paper as [31]

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Research works printed but not linked: 43

  1. Argraves, 1995, The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase–plasminogen activator inhibitor type I complexes, J. biol. Chem., 270, 26550, 10.1074/jbc.270.44.26550 · DOI
  2. Bellosta, 1995, Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth, J. biol. Chem., 270, 27063, 10.1074/jbc.270.45.27063 · DOI · Paper page
  3. Brandes, 1997, Avian and murine LR8B and human apolipoprotein E receptor 2: differentially spliced products from corresponding genes, Genomics, 42, 185, 10.1006/geno.1997.4702 · DOI · Paper page
  4. Brown, 1986, A receptor-mediated pathway for cholesterol homeostasis, Science, 232, 34, 10.1126/science.3513311 · DOI · Paper page
  5. Bujo, 1995, Chicken oocytes and somatic cells express different splice variants of a multifunctional receptor, J. biol. Chem., 270, 23546, 10.1074/jbc.270.40.23546 · DOI
  6. Christie, 1996, Expression of the very low density lipoprotein receptor (VLDL-r), an apolipoprotein E receptor, in the central nervous system and in Alzheimer disease, J. Neuropath. exp. Neurol., 55, 491, 10.1097/00005072-199604000-00012 · DOI · Paper page
  7. Fagan, 1996, Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein, J. biol. Chem., 271, 30121, 10.1074/jbc.271.47.30121 · DOI · Paper page
  8. Hammand, 1997, Interaction of apolipoprotein J–amyloid β-peptide complex with low density lipoprotein receptor-related protein-2/megalin, J. biol. Chem., 272, 18644, 10.1074/jbc.272.30.18644 · DOI
  9. Hartmann, 1996, Alzheimer's disease βA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing, J. biol. Chem., 271, 13208, 10.1074/jbc.271.22.13208 · DOI
  10. Heegaard, 1995, Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator–type-1 plasminogen activator inhibitor complex, J. biol. Chem., 270, 20855, 10.1074/jbc.270.35.20855 · DOI
  11. Hollenbach, 1998, Confirmation of an association between a polymorphism in exon 3 of LRP and Alzheimer's disease, Neurology, 50, 1905, 10.1212/WNL.50.6.1905 · DOI
  12. Holtzman, 1995, Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line, Proc. natn. Acad. Sci. U.S.A., 92, 9480, 10.1073/pnas.92.21.9480 · DOI · Paper page
  13. Jordan, 1998, Isoform-specific effect of apolipoprotein E on cell survival and β-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures, J. Neurosci., 18, 195, 10.1523/JNEUROSCI.18-01-00195.1998 · DOI · Paper page
  14. Kang, 1997, Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease, Neurology, 49, 56, 10.1212/WNL.49.1.56 · DOI · Paper page
  15. Kim, 1997, Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene, J. biol. Chem., 272, 8498, 10.1074/jbc.272.13.8498 · DOI
  16. Kim, 1996, Human apolipoprotein E receptor 2, J. biol. Chem., 271, 8373, 10.1074/jbc.271.14.8373 · DOI · Paper page
  17. Knauer, 1996, Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP), Brain Res., 740, 6, 10.1016/S0006-8993(96)00711-1 · DOI
  18. Konig, 1992, Identification and differential expression of a novel alternative splice isoform of the βA4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells, J. biol. Chem., 267, 10804, 10.1016/S0021-9258(19)50090-4 · DOI
  19. Kounnas, 1995, LDL receptor-related protein, a multifunctional apoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation, Cell, 82, 331, 10.1016/0092-8674(95)90320-8 · DOI · Paper page
  20. Lendon, 1997, Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population, Neurosci. Lett., 222, 187, 10.1016/S0304-3940(97)13381-X · DOI
  21. Miyata, 1996, Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides, Nature Genet., 14, 55, 10.1038/ng0996-55 · DOI · Paper page
  22. Moestrup, 1992, Distribution of the a2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues, Cell Tiss. Res., 269, 375, 10.1007/BF00353892 · DOI
  23. Nathan, 1994, Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro, Science, 264, 850, 10.1126/science.8171342 · DOI · Paper page
  24. Novak, 1996, A new low density lipoprotein receptor homologue with 8 ligand binding repeats in brain of chicken and mouse, J. biol. Chem., 271, 11732, 10.1074/jbc.271.20.11732 · DOI · Paper page
  25. Pangalos, 1995, The chondroitin sulfate site of appican is formed by splicing out exon 15 of the amyloid precursor gene, J. biol. Chem., 270, 10388, 10.1074/jbc.270.18.10388 · DOI
  26. Pitas, 1987, Lipoproteins and their receptors in the central nervous system, J. biol. Chem., 262, 14352, 10.1016/S0021-9258(18)47945-8 · DOI · Paper page
  27. Rebeck, 1998, Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different APOE genotypes, Expl Neurol., 199, 175, 10.1006/exnr.1997.6710 · DOI
  28. Rebeck, 1995, Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the a2-macroglobulin receptor/low-density-lipoprotein receptor-related protein, Ann. Neurol., 37, 211, 10.1002/ana.410370212 · DOI · Paper page
  29. Rebeck, 1993, Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions, Neuron, 11, 575, 10.1016/0896-6273(93)90070-8 · DOI · Paper page
  30. Riddell, 1997, Apolipoprotein E inhibits platelet aggregation through the l-arginine:nitric oxide pathway, J. biol. Chem., 272, 89, 10.1074/jbc.272.1.89 · DOI · Paper page
  31. Russell, 1989, Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins, J. biol. Chem., 264, 21682, 10.1016/S0021-9258(20)88240-4 · DOI · Paper page
  32. Sandbrink, 1994, Similar alternative splicing of a non-homologous domain in βA4-amyloid protein precursor-like proteins, J. biol. Chem., 269, 14227, 10.1016/S0021-9258(17)36778-9 · DOI
  33. Strickland, 1995, LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism, Fedn Proc. Fedn Am. Socs exp. Biol., 9, 890
  34. Strittmatter, 1996, Apolipoprotein E and Alzheimer's disease, A. Rev. Neurosci., 19, 53, 10.1146/annurev.ne.19.030196.000413 · DOI · Paper page
  35. Strittmatter, 1994, Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease, Proc. natn. Acad. Sci. U.S.A., 91, 11183, 10.1073/pnas.91.23.11183 · DOI · Paper page
  36. Swanson, 1988, Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization, Proc. natn. Acad. Sci. U.S.A., 85, 9821, 10.1073/pnas.85.24.9821 · DOI
  37. Takahashi, 1995, Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipase, J. biol. Chem., 270, 15747, 10.1074/jbc.270.26.15747 · DOI
  38. Thinakaran, 1995, Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2, J. biol. Chem., 270, 16522, 10.1074/jbc.270.28.16522 · DOI
  39. Urmoneit, 1997, Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy, Lab. Invest., 77, 157
  40. Wavrant-DeVrieze, 1997, Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease, Neurosci. Lett., 227, 68, 10.1016/S0304-3940(97)00304-2 · DOI
  41. Wolf, 1992, Characterization and immunohistochemical localization of a2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain, Am. J. Path., 141, 37
  42. Zheng, 1994, Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/a2MR, and the receptor-associated protein (RAP), J. Histochem. Cytochem., 42, 531, 10.1177/42.4.7510321 · DOI
  43. Zlokovic, 1996, Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid β at the blood–brain and blood–cerebrospinal fluid barriers, Proc. natn. Acad. Sci. U.S.A., 93, 4229, 10.1073/pnas.93.9.4229 · DOI · Paper page

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Metadata

Authors
Clatworthy, A. E., Stockinger, W., Christie, R. H., Schneider, W. J., Nimpf, J., Hyman, B. T., & Rebeck, G. W.
Venue
Neuroscience
Publisher
Elsevier BV
Published
1999-05
Volume
90
Issue
3
Pages
903-911
ISSN
0306-4522
DOI
10.1016/s0306-4522(98)00489-8
Cited by
63
References
2
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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