NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors
Open accessAbstract
Significance: In the present study we investigated the epigenetic pattern of genes involved in the regulation of glucocorticoid receptor signaling in two African populations of heavily traumatized individuals. The strongest link between regional methylation and posttraumatic stress disorder (PTSD) risk and symptoms was observed for NTRK2 , which has been shown to play an important role in memory formation. NTRK2 methylation was not related to trauma load, suggesting that methylation differences preexisted the trauma. Furthermore, NTRK2 methylation was found to be related to memory and memory-related brain activity in healthy nontraumatized individuals. The present findings suggest that epigenetic modifications of NTRK2 are involved in memory modulation in health, and in influencing risk and symptoms of PTSD in case of traumatic experiences.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Trauma-related variation has been described in pathways relevant to neurodevelopment, immune-inflammatory signaling, circadian regulation, metabolism, and memory formation.
“Trauma-related variation has also been described in pathways relevant to neurodevelopment, immune-inflammatory signaling, circadian regulation, metabolism, and memory formation (7–9).”
From Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics (2026) · cites this paper as [9]
Cites
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673 · see citing works
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250 · see citing works
Self-citationEpigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203 · see citing works
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296 · see citing works
Self-citationNeurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195 · see citing works
The Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818 · see citing works
Biological studies of post-traumatic stress disorder
Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., Milad, M. R., & Liberzon, I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3339 · Cited by 1,529 · see citing works
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · see citing works
Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008) · Epigenetics · doi:10.4161/epi.3.2.6034 · Cited by 1,432 · see citing works
Two cortical systems for memory-guided behaviour
Ranganath, C., & Ritchey, M. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3338 · Cited by 1,377 · see citing works
The Trk family of neurotrophin receptors
Barbacid, M. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251107 · Cited by 1,281 · see citing works
The parietal cortex and episodic memory: an attentional account
Cabeza, R. E. L., Ciaramelli, E., Olson, I. R., & Moscovitch, M. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2459 · Cited by 1,198 · see citing works
Stress and glucocorticoids impair retrieval of long-term spatial memory
de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L. (1998) · Nature · doi:10.1038/29542 · Cited by 1,182 · see citing works
Self-citationPost-Traumatic Stress Disorder
Yehuda, R. (2002) · New England Journal of Medicine · doi:10.1056/nejmra012941 · Cited by 1,134 · see citing works
TrkB signalling pathways in LTP and learning
Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055 · see citing works
Zhang, X., Odom, D. T., Koo, S.-H., Conkright, M. D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501076102 · Cited by 992 · see citing works
Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy
Mueller, B. R., & Bale, T. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1424-08.2008 · Cited by 988 · see citing works
Prefrontal and medial temporal lobe interactions in long-term memory
Simons, J. S., & Spiers, H. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1178 · Cited by 961 · see citing works
Klein, R., Nanduri, V., Jing, S., Lamballe, F., Tapley, P., Bryant, S., Cordon-Cardo, C., Jones, K. R., Reichardt, L. F., & Barbacid, M. (1991) · Cell · doi:10.1016/0092-8674(91)90628-c · Cited by 958 · see citing works
SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips
Maksimovic, J., Gordon, L., & Oshlack, A. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r44 · Cited by 826 · see citing works
Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation
Yehuda, R., Daskalakis, N. P., Bierer, L. M., Bader, H. N., Klengel, T., Holsboer, F., & Binder, E. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.005 · Cited by 782 · see citing works
Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773 · see citing works
Acute cortisone administration impairs retrieval of long-term declarative memory in humans
de Quervain, D. J.-F., Roozendaal, B., Nitsch, R. M., McGaugh, J. L., & Hock, C. (2000) · Nature Neuroscience · doi:10.1038/73873 · Cited by 745 · see citing works
Self-citationHistone acetylation: molecular mnemonics on the chromatin
Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680 · see citing works
Cortisol and post-traumatic stress disorder in adults: Systematic review and meta-analysis
Meewisse, M.-L., Reitsma, J. B., De Vries, G.-J., Gersons, B. P. R., & Olff, M. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.024877 · Cited by 661 · see citing works
Davies, M. N., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R. A., Milosavljevic, A., Troakes, C., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r43 · Cited by 630 · see citing works
Comprehensive analysis of DNA methylation data with RnBeads
Assenov, Y., Müller, F., Lutsik, P., Walter, J., Lengauer, T., & Bock, C. (2014) · Nature Methods · doi:10.1038/nmeth.3115 · Cited by 587 · see citing works
Mehta, D., Klengel, T., Conneely, K. N., Smith, A. K., Altmann, A., Pace, T. W., Rex-Haffner, M., Loeschner, A., Gonik, M., Mercer, K. B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217750110 · Cited by 548 · see citing works
Radtke, K. M., Ruf, M., Gunter, H. M., Dohrmann, K., Schauer, M., Meyer, A., & Elbert, T. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.21 · Cited by 511 · cited 1× · see citing works
“In both rodents (45–47) and humans (27, 29, 48, 49), NR3C1 methylation is typically set perinatally.”
BackgroundSelf-citationWeaver, I. C. G., D'Alessio, A. C., Brown, S. E., Hellstrom, I. C., Dymov, S., Sharma, S., Szyf, M., & Meaney, M. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4164-06.2007 · Cited by 508 · see citing works
Glucocorticoids and the regulation of memory in health and disease
de Quervain, D. J. ‐., Aerni, A., Schelling, G., & Roozendaal, B. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.002 · Cited by 496 · see citing works
Stress, glucocorticoids and memory: implications for treating fear-related disorders
de Quervain, D., Schwabe, L., & Roozendaal, B. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.155 · Cited by 484 · see citing works
Braun, P. R., Han, S., Hing, B., Nagahama, Y., Gaul, L. N., Heinzman, J. T., Grossbach, A. J., Close, L., Dlouhy, B. J., Howard, M. A., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0376-y · Cited by 467 · see citing works
Interleaving brain systems for episodic and recognition memory.
Aggleton, J., & Brown, M. W. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.08.003 · Cited by 465 · see citing works
Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr416 · Cited by 460 · see citing works
Hannon, E., Lunnon, K., Schalkwyk, L., & Mill, J. (2015) · Epigenetics · doi:10.1080/15592294.2015.1100786 · Cited by 455 · see citing works
Different molecular cascades in different sites of the brain control memory consolidation
Izquierdo, I., Bevilaqua, L. R., Rossato, J. I., Bonini, J. S., Medina, J. H., & Cammarota, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.005 · Cited by 452 · see citing works
Post-traumatic stress disorder, hormones, and memory.
Pitman, R. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90033-4 · Cited by 447 · see citing works
Roozendaal, B., & McGaugh, J. L. (2011) · Behavioral Neuroscience · doi:10.1037/a0026187 · Cited by 445 · see citing works
Self-citationMineka, S., & Oehlberg, K. A. (2008) · Acta Psychologica · doi:10.1016/j.actpsy.2007.11.007 · Cited by 406 · see citing works
Cazorla, M., Prémont, J., Mann, A., Girard, N., Kellendonk, C., & Rognan, D. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43992 · Cited by 392 · see citing works
Bernard, R., Kerman, I. A., Thompson, R. C., Jones, E. G., Bunney, W. E., Barchas, J. D., Schatzberg, A. F., Myers, R. M., Akil, H., & Watson, S. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.44 · Cited by 372 · see citing works
RnBeads 2.0: comprehensive analysis of DNA methylation data
Müller, F., Scherer, M., Assenov, Y., Lutsik, P., Walter, J., Lengauer, T., & Bock, C. (2019) · Genome biology · doi:10.1186/s13059-019-1664-9 · Cited by 369 · see citing works
DNA methylation changes in plasticity genes accompany the formation and maintenance of memory
Halder, R., Hennion, M., Vidal, R. O., Shomroni, O., Rahman, R.-U., Rajput, A., Centeno, T. P., van Bebber, F., Capece, V., Vizcaino, J. C. G., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4194 · Cited by 358 · see citing works
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus
Suderman, M., McGowan, P. O., Sasaki, A., Huang, T. C. T., Hallett, M. T., Meaney, M. J., Turecki, G., & Szyf, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121260109 · Cited by 327 · see citing works
Skaper, S. D. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708783885174 · Cited by 326 · see citing works
Yehuda, R., Cai, G., Golier, J. A., Sarapas, C., Galea, S., Ising, M., Rein, T., Schmeidler, J., Müller-Myhsok, B., Holsboer, F., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.034 · Cited by 294 · see citing works
Yehuda, R., Flory, J. D., Bierer, L. M., Henn-Haase, C., Lehrner, A., Desarnaud, F., Makotkine, I., Daskalakis, N. P., Marmar, C. R., & Meaney, M. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.006 · Cited by 293 · see citing works
Making lasting memories: Remembering the significant
McGaugh, J. D. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1301209110 · Cited by 291 · see citing works
Self-citationDNA Methylation Signatures within the Human Brain
Ladd‐Acosta, C., Pevsner, J., Sabunciyan, S., Yolken, R. H., Webster, M. J., Dinkins, T., Callinan, P. A., Fan, J., Potash, J. B., & Feinberg, A. P. (2007) · The American Journal of Human Genetics · doi:10.1086/524110 · Cited by 277 · see citing works
McGaugh, J. L. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-014954 · Cited by 271 · see citing works
Self-citationTurner, J. D., & Muller, C. P. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01822 · Cited by 256 · see citing works
CpGassoc: an R function for analysis of DNA methylation microarray data
Barfield, R., Kilaru, V., Smith, A. K., & Conneely, K. N. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts124 · Cited by 237 · see citing works
Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders
Schiele, M. A., & Domschke, K. (2018) · Genes, Brain and Behavior · doi:10.1111/gbb.12423 · Cited by 233 · see citing works
Reductions in neurotrophin receptor mRNAs in the prefrontal cortex of patients with schizophrenia
Weickert, C. S., Ligons, D. L., Romanczyk, T. B., Ungaro, G., Hyde, T. M., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001678 · Cited by 199 · see citing works
van Zuiden, M., Geuze, E., Willemen, H. L. D. M., Vermetten, E., Maas, M., Heijnen, C. J., & Kavelaars, A. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10050706 · Cited by 190 · see citing works
A deletion variant of the α2b-adrenoceptor is related to emotional memory in Europeans and Africans
de Quervain, D. J. ‐., Kolassa, I., Ertl, V., Onyut, L. P., Neuner, F., Elbert, T. R., & Papassotiropoulos, A. (2007) · Nature Neuroscience · doi:10.1038/nn1945 · Cited by 176 · see citing works
Self-citationVukojevic, V., Kolassa, I.-T., Fastenrath, M., Gschwind, L., Spalek, K., Milnik, A., Heck, A., Vogler, C., Wilker, S., Demougin, P., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-14.2014 · Cited by 168 · see citing works
Self-citationde Quervain, D. J. ‐., & Papassotiropoulos, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510212103 · Cited by 167 · see citing works
Self-citationDNMIVD: DNA methylation interactive visualization database
Ding, W., Chen, J., Feng, G., Chen, G., Wu, J. F., Guo, Y., Ni, X., & Shi, T. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz830 · Cited by 166 · see citing works
Epigenetic modulation of glucocorticoid receptors in posttraumatic stress disorder
Labonté, B., Azoulay, N., Yerko, V, Turecki, G., & Brunet, A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.3 · Cited by 162 · see citing works
Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences
Roozendaal, B., Barsegyan, A., & Lee, S. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67006-x · Cited by 154 · see citing works
Association Study of Trauma Load andSLC6A4Promoter Polymorphism in Posttraumatic Stress Disorder
Kolassa, I., Ertl, V., Eckart, C., Glöckner, F., Kolassa, S., Papassotiropoulos, A., de Quervain, D. J. ‐., & Elbert, T. R. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04787blu · Cited by 150 · see citing works
Self-citationWilker, S., Pfeiffer, A., Kolassa, S., Koslowski, D., Elbert, T. R., & Kolassa, I. (2015) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v6.28306 · Cited by 146 · see citing works
Self-citationRevest, J., Roux, A. L., Roullot, V., Kaouane, N., Vallée, M., Kasanetz, F., Rougé‐Pont, F., Tronche, F., Desmedt, A., & Piazza, P. V. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.134 · Cited by 141 · see citing works
Variable Decay of Memory and Its Recovery in Cycloheximide-Treated Mice
Squire, L. R., & Barondes, S. H. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1416 · Cited by 137 · see citing works
Differentiating biological correlates of risk, PTSD, and resilience following trauma exposure
Yehuda, R., & Flory, J. D. (2007) · Journal of Traumatic Stress · doi:10.1002/jts.20260 · Cited by 137 · see citing works
Brain-derived neurotrophic factor as a drug target for CNS disorders
Pezet, S., & Malcangio, M. (2004) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.8.5.391 · Cited by 132 · see citing works
van Zuiden, M., Kavelaars, A., Geuze, E., Olff, M., & Heijnen, C. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.015 · Cited by 125 · see citing works
Adrenocortical suppression blocks the memory-enhancing effects of amphetamine and epinephrine.
Roozendaal, B., Carmi, O., & McGaugh, J. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1429 · Cited by 123 · see citing works
Self-citationCloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)
Nakagawara, A., Liu, X.-G., Ikegaki, N., White, P. S., Yamashiro, D. J., Nycum, L. M., Biegel, J. A., & Brodeur, G. M. (1995) · Genomics · doi:10.1016/0888-7543(95)80055-q · Cited by 109 · see citing works
Kohli, M., Salyakina, D., Pfennig, A., Lucae, S., Horstmann, S., Menke, A., Kloiber, S., Hennings, J., Bradley, B., Ressler, K., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.201 · Cited by 106 · see citing works
Cazorla, M., Jouvenceau, A., Rose, C., Guilloux, J.-P., Pilon, C., Dranovsky, A., & Prémont, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009777 · Cited by 99 · see citing works
Stuart, G. P., & Hulme, C. (2000) · Journal of Experimental Psychology Learning Memory and Cognition · doi:10.1037//0278-7393.26.3.796 · Cited by 88 · see citing works
Chang, S.-C., Koenen, K. C., Galea, S., Aiello, A. E., Soliven, R., Wildman, D. E., & Uddin, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039184 · Cited by 81 · see citing works
Alonso, P., Gratacòs, M., Menchón, J. M., Sáiz-Ruiz, J., Segalàs, C., Baca‐García, E., Labad, J., Fernández‐Piqueras, J., Real, E., Vaquero, C., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.020 · Cited by 75 · see citing works
Stuart, G. P., & Hulme, C. (2000) · Journal of Experimental Psychology Learning Memory and Cognition · doi:10.1037/0278-7393.26.3.796 · Cited by 71 · see citing works
Valent, A., Danglot, G., & Bernheim, A. (1997) · European Journal of Human Genetics · doi:10.1159/000484742 · Cited by 64 · see citing works
McGaugh, J. D. (2005) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.93405 · Cited by 56 · see citing works
Self-citationExome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD
Heck, A., Milnik, A., Vukojević, V., Petrovska, J., Egli, T., Singer, J., Escobar, P., Sengstag, T., Coynel, D., Freytag, V., et al. (2017) · Nature Human Behaviour · doi:10.1038/s41562-017-0081 · Cited by 35 · see citing works
Self-citationRea, I. M., Gillen, S., & Clarke, E. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600370 · Cited by 30 · see citing works
Heck, A., Fastenrath, M., Coynel, D., Auschra, B., Bickel, H., Freytag, V., Gschwind, L., Hartmann, F., Jessen, F., Kaduszkiewicz, H., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.1309 · Cited by 29 · see citing works
Self-citationA Deletion in Tropomyosin-Related Kinase B and the Development of Human Anxiety
Ernst, C., Wanner, B., Brezo, J., Vitaro, F., Tremblay, R. E., & Turecki, G. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.008 · Cited by 27 · see citing works
Kingsbury, T. J., & Krueger, B. K. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.04.004 · Cited by 22 · see citing works
A large-scale candidate gene analysis of mood disorders
Deo, A. J., Huang, Y., Hodgkinson, C. A., Xin, Y., Oquendo, M. A., Dwork, A. J., Arango, V., Brent, D. A., Goldman, D. A., Mann, J. J., et al. (2012) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32835d7028 · Cited by 20 · see citing works
The specific contribution of neuroimaging versus neurophysiological data to understanding cognition
Axmacher, N., Elger, C. E., & Fell, J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.01.028 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of memory under stress
Schwabe, L., Hermans, E. J., Joëls, M., & Roozendaal, B. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.020 · Cited by 188 · see citing works
Biological and Environmental Factors Affecting Risk and Resilience among Syrian Refugee Children
Javanbakht, A., Stenson, A. F., Nugent, N. R., Smith, A. K., Rosenberg, D., & Jovanović, T. (2021) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20210003 · Cited by 31 · see citing works
Gestational cadmium exposure impairs placental angiogenesis via activating GC/GR signaling
Shi, X.-T., Zhu, H.-L., Xu, X., Xiong, Y.-W., Dai, L.-M., Zhou, G.-X., Liu, W., Zhang, Y., Xu, D., & Wang, H. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112632 · Cited by 26 · see citing works
Anisman, H., Doubad, D., Asokumar, A., & Matheson, K. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105859 · Cited by 25 · see citing works
Chen, W., Wang, H., Ye, X., Hao, X., Yan, F., Wu, J., Li, D., Wang, Y., & Xu, L. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01044-6 · Cited by 19 · see citing works
Biomarkers of post-traumatic stress disorder from emotional trauma: A systematic review
Paganin, W., & Signorini, S. (2023) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2023.100328 · Cited by 16 · see citing works
Enacting biosocial complexity: Stress, epigenetic biomarkers and the tools of postgenomics
Chiapperino, L. (2024) · Social Studies of Science · doi:10.1177/03063127231222613 · Cited by 12 · see citing works
Clinical potential of epigenetic and microRNA biomarkers in PTSD
Wellington, N. J., Bouças, A. P., Lagopoulos, J., & Kuballa, A. (2024) · Journal of Neurogenetics · doi:10.1080/01677063.2024.2419098 · Cited by 9 · see citing works
Epigenetic Alterations in Post-Traumatic Stress Disorder: Comprehensive Review of Molecular Markers
Golubeva, E., Zeltser, A., Zorkina, Y., Ochneva, A., Tsurina, A. M., Andreyuk, D., Kostyuk, G. P., & Morozova, A. Y. (2024) · Complex Psychiatry · doi:10.1159/000541822 · Cited by 7 · see citing works
Epigenetics of violence against women: a systematic review of the literature
Bailo, P., Piccinini, A., Barbàra, G., Caruso, P., Bollati, V., & Gaudi, S. (2024) · Current Zoology · doi:10.1093/eep/dvae012 · Cited by 7 · see citing works
Peng, L., Liu, Z., Liu, P., Guo, W., Liu, T., Lei, Z., Chang, Q., Mi, Z., Lin, X., Wang, F., et al. (2024) · Gene · doi:10.1016/j.gene.2024.148807 · Cited by 2 · see citing works
Kac, E., Qi, Q., & Ryznar, R. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1769422 · Cited by 1 · see citing works
Sociobehavioral-induced epigenetic variation and psychiatric diseases
Petroff, R., Goodrich, J. M., Bakulski, K. M., & Dolinoy, D. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824010-6.00032-0
DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation
Huang, X., Chen, D., Wang, Y., Zhang, Y., Ntim, M., Ge, Y., & Wang, B. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i11.110581
Sadhukhan, D., Choudhury, R., Roy, S., Roy, A., Maitra, S., Ghosh, K., Mukherjee, J., Banerjee, T. K., Hui, S. P., Chakrabarti, S., et al. (2026) · medRxiv · doi:10.64898/2026.02.21.26346768
Ayala‐García, V. M., Valenzuela‐García, L. I., Ramos-Rosales, D. F., Fileto-González, D., López-Salas, A. Y., Úrtiz-Estrada, N., Cervantes-Flores, M., & Barraza-Salas, M. (2026) · Heliyon · doi:10.1016/j.heliyon.2026.e44926
Traumatic life experiences during critical periods lead to diverse developmental trajectories
Morelli, G., Visintin, G., Gelli, E., Serani, A., Bartolucci, M., Uccella, S., D’APRUZZO, M., Preiti, D., Chellali, M. M., Cucinelli, A., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102798
Sadhukhan, D., Chowdhury, R., Roy, S., Roy, A., Maitra, S., Ghosh, K., Mukherjee, J., Banerjee, T. K., Hui, S. P., Chakrabarti, S., et al. (2026) · European Journal of Neuroscience · doi:10.1111/ejn.70684
MEIJER, M., & Kobor, M. S. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19043-8.00001-3
- Authors
- Vukojevic, V., Coynel, D., Ghaffari, N. R., Freytag, V., Elbert, T., Kolassa, I.-T., Wilker, S., McGaugh, J. L., Papassotiropoulos, A., & de Quervain, D. J.-F.
- Affiliations
- Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland;
- University of Basel (CH)
- University of Konstanz (DE)
- Universität Ulm (DE)
- Bielefeld University (DE)
- University of California, Irvine (US)
- Transfaculty Research Platform, University of Basel, CH-4055 Basel, Switzerland;
- Corresponding author
- McGaugh, James L.
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2020-08-17
- Volume
- 117
- Issue
- 35
- Pages
- 21667-21672
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC7474665
- OpenAlex
- W3060305832
- Cited by
- 19
- References
- 89
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 1 · 2021: 2
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- edoc (University of Basel) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- PUB – Publications at Bielefeld University (Bielefeld University) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (159740)
- Deutsche Forschungsgemeinschaft (NA)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- NTRK2, DNA methylation, post-traumatic stress disorder, glucocorticoid receptor signaling, epigenetics, memory formation, trauma survivors, African populations, PTSD risk
- MeSH terms
- Adult, Aged, Brain, Female, Glucocorticoids, Humans, Male, Membrane Glycoproteins, Memory, Middle Aged, Receptors, Glucocorticoid, Risk Factors, Rwanda, Stress Disorders, Post-Traumatic, Uganda, Survivors, DNA Methylation, Polymorphism, Single Nucleotide, Receptor, trkB, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review