Cited by 19Posttraumatic Stress Disorder ResearchEpigenetics and DNA MethylationChild Abuse and Trauma

NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors

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Vukojevic, Vanja, Coynel, David, Ghaffari, Navid R., Freytag, Virginie, Elbert, Thomas, Kolassa, Iris-Tatjana, Wilker, Sarah, McGaugh, James L. +2 more·2020·Proceedings of the National Academy of Sciences

Abstract

Significance: In the present study we investigated the epigenetic pattern of genes involved in the regulation of glucocorticoid receptor signaling in two African populations of heavily traumatized individuals. The strongest link between regional methylation and posttraumatic stress disorder (PTSD) risk and symptoms was observed for NTRK2 , which has been shown to play an important role in memory formation. NTRK2 methylation was not related to trauma load, suggesting that methylation differences preexisted the trauma. Furthermore, NTRK2 methylation was found to be related to memory and memory-related brain activity in healthy nontraumatized individuals. The present findings suggest that epigenetic modifications of NTRK2 are involved in memory modulation in health, and in influencing risk and symptoms of PTSD in case of traumatic experiences.

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Crossref · 10.1073/pnas.2008415117

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  • Trauma-related variation has been described in pathways relevant to neurodevelopment, immune-inflammatory signaling, circadian regulation, metabolism, and memory formation.

    “Trauma-related variation has also been described in pathways relevant to neurodevelopment, immune-inflammatory signaling, circadian regulation, metabolism, and memory formation (7–9).”

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Authors
Vukojevic, V., Coynel, D., Ghaffari, N. R., Freytag, V., Elbert, T., Kolassa, I.-T., Wilker, S., McGaugh, J. L., Papassotiropoulos, A., & de Quervain, D. J.-F.
Affiliations
  • Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland;
  • University of Basel (CH)
  • University of Konstanz (DE)
  • Universität Ulm (DE)
  • Bielefeld University (DE)
  • University of California, Irvine (US)
  • Transfaculty Research Platform, University of Basel, CH-4055 Basel, Switzerland;
Corresponding author
McGaugh, James L.
Venue
Proceedings of the National Academy of Sciences
Published
2020-08-17
Volume
117
Issue
35
Pages
21667-21672
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W3060305832
Cited by
19
References
89
Citations by year
2026: 6 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 1 · 2021: 2
FWCI
0.50
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • edoc (University of Basel) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • PUB – Publications at Bielefeld University (Bielefeld University) (submittedVersion)
Funders
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (159740)
  • Deutsche Forschungsgemeinschaft (NA)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
NTRK2, DNA methylation, post-traumatic stress disorder, glucocorticoid receptor signaling, epigenetics, memory formation, trauma survivors, African populations, PTSD risk
MeSH terms
Adult, Aged, Brain, Female, Glucocorticoids, Humans, Male, Membrane Glycoproteins, Memory, Middle Aged, Receptors, Glucocorticoid, Risk Factors, Rwanda, Stress Disorders, Post-Traumatic, Uganda, Survivors, DNA Methylation, Polymorphism, Single Nucleotide, Receptor, trkB, Epigenesis, Genetic

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