A polygenic theory of schizophrenia.

The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615 · see citing works

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works

Schizophrenia

Owen, M. J., Sawa, A., & Mortensen, P. B. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01121-6 · Cited by 1,870 · see citing works

Differential susceptibility to the environment: an evolutionary--neurodevelopmental theory

Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2011) · Development and Psychopathology · doi:10.1017/s0954579410000611 · Cited by 1,564 · see citing works

Intermediate phenotypes and genetic mechanisms of psychiatric disorders

Meyer-Lindenberg, A., & Weinberger, D. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1993 · Cited by 1,216 · see citing works

Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies

Winkler, A. M., Kochunov, P., Blangero, J., Almasy, L., Zilles, K., Fox, P. T., Duggirala, R., & Glahn, D. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.028 · Cited by 1,172 · see citing works

Gene expression elucidates functional impact of polygenic risk for schizophrenia

Fromer, M., Roussos, P., Sieberts, S. K., Johnson, J. S., Kavanagh, D. H., Perumal, T. M., Ruderfer, D. M., Oh, E. C., Topol, A., Shah, H. R., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4399 · Cited by 1,091 · see citing works

Rare coding variants in ten genes confer substantial risk for schizophrenia

Singh, T., Poterba, T., Curtis, D., Akil, H., Al Eissa, M., Barchas, J. D., Bass, N., Bigdeli, T. B., Breen, G., Bromet, E. J., et al. (2022) · Nature · doi:10.1038/s41586-022-04556-w · Cited by 983 · see citing works

Strong association of de novo copy number mutations with sporadic schizophrenia

Xu, B., Roos, J. L., Levy, S., van Rensburg, E. J., Gogos, J. A., & Karayiorgou, M. (2008) · Nature Genetics · doi:10.1038/ng.162 · Cited by 813 · see citing works

Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models

Wolfers, T., Doan, N. T., Kaufmann, T., Alnæs, D., Moberget, T., Agartz, I., Buitelaar, J. K., Ueland, T., Melle, I., Franke, B., et al. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.2467 · Cited by 508 · see citing works

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

Schizophrenia Working Group of the Psychiatric Genomics Consortium, Loh, P.-R., Bhatia, G., Gusev, A., Finucane, H. K., Bulik-Sullivan, B. K., Pollack, S. J., de Candia, T. R., Lee, S. H., Wray, N. R., et al. (2015) · Nature Genetics · doi:10.1038/ng.3431 · Cited by 449 · see citing works

Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis

Mier, D., Kirsch, P., & Meyer-Lindenberg, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.36 · Cited by 464 · see citing works

Toward constructing an endophenotype strategy for bipolar disorders

Hasler, G., Drevets, W. C., Gould, T. D., Gottesman, I. I., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.006 · Cited by 423 · see citing works

Endophenotypes in the Genetic Analyses of Mental Disorders

Cannon, T. D., & Keller, M. C. (2006) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.2.022305.095232 · Cited by 399 · see citing works

Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk

Moskvina, V, Craddock, N., Holmans, P., Nikolov, I., Pahwa, J. S., Green, E., Wellcome Trust Case Control Consortium, Owen, M. J., & O'Donovan, M. C. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.133 · Cited by 363 · see citing works

Genetics of schizophrenia: new findings and challenges

Gejman, P. V., Sanders, A. R., & Kendler, K. S. (2011) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082410-101459 · Cited by 183 · see citing works

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

Singh, T., Neale, B. M., & Daly, M. J. (2020) · doi:10.1101/2020.09.18.20192815 · Cited by 980 · see citing works

Early interventions in risk groups for schizophrenia: what are we waiting for?

Sommer, I. E., Bearden, C. E., van Dellen, E., Breetvelt, E. J., Duijff, S. N., Maijer, K., van Amelsvoort, T., de Haan, L., Gur, R. E., Arango, C., et al. (2016) · npj Schizophrenia · doi:10.1038/npjschz.2016.3 · Cited by 140 · see citing works

De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia

GROUP Investigators, Rees, E., Han, J., Morgan, J., Carrera, N., Escott-Price, V., Pocklington, A. J., Duffield, M., Hall, L. S., Legge, S. E., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0565-2 · Cited by 129 · see citing works

Common alleles contribute to schizophrenia in CNV carriers

Tansey, K. E., Rees, E., Linden, D. E., Ripke, S., Chambert, K. D., Moran, J. L., McCarroll, S. A., Holmans, P., Kirov, G., Walters, J., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.143 · Cited by 132 · see citing works

Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses

Visscher, P. M., Goddard, M. E., Derks, E. M., & Wray, N. R. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.65 · Cited by 138 · see citing works

Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potential

Chamberlain, S. R., & Menzies, L. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.36 · Cited by 123 · see citing works

Relational interventions for child maltreatment: Past, present and future perspectives

Toth, S. L., Gravener-Davis, J. A., Guild, D. J., & Cicchetti, D. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000795 · Cited by 124 · see citing works

Vantage sensitivity: environmental sensitivity to positive experiences as a function of genetic differences

Pluess, M. (2017) · Journal of Personality · doi:10.1111/jopy.12218 · Cited by 90 · see citing works

Brain Structure and Subclinical Symptoms: A Dimensional Perspective of Psychopathology in the Depression and Anxiety Spectrum

Besteher, B., Gaser, C., & Nenadić, I. (2020) · Neuropsychobiology · doi:10.1159/000501024 · Cited by 83 · see citing works

Estimating the effect size of the 15Q11.2 BP1–BP2 deletion and its contribution to neurodevelopmental symptoms: recommendations for practice

Jønch, A. E., Douard, E., Moreau, C., Van Dijck, A., Passeggeri, M., Kooy, F., Puechberty, J., Campbell, C., Sanlaville, D., Lefroy, H., et al. (2019) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2018-105879 · Cited by 75 · see citing works

Exome arrays capture polygenic rare variant contributions to schizophrenia

Richards, A. L., Leonenko, G., Walters, J. T., Kavanagh, D. H., Rees, E. G., Evans, A., Chambert, K. D., Moran, J. L., Goldstein, J., Neale, B. M., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddv620 · Cited by 50 · see citing works

Genome-wide association analysis of copy number variation in recurrent depressive disorder

Rucker, J. J. H., Breen, G., Pinto, D., Pedroso, I., Lewis, C. M., Cohen-Woods, S., Uher, R., Schosser, A., Rivera, M., Aitchison, K. J., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2011.144 · Cited by 51 · see citing works

Partial Support for an Interaction Between a Polygenic Risk Score for Major Depressive Disorder and Prenatal Maternal Depressive Symptoms on Infant Right Amygdalar Volumes

Acosta, H., Kantojärvi, K., Hashempour, N., Pelto, J., Scheinin, N. M., Lehtola, S. J., Lewis, J. D., Fonov, V. S., Collins, D. L., Evans, A., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa158 · Cited by 34 · see citing works

Concepts and Misconceptions about the Polygenic Additive Model Applied to Disease

Visscher, P. M., & Wray, N. R. (2015) · Human Heredity · doi:10.1159/000446931 · Cited by 30 · see citing works