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Cited by 207Circadian rhythm and melatoninHypothalamic control of reproductive hormonesSleep and Wakefulness Research

An effect of castration and testosterone replacement on a circadian pacemaker in mice (Mus musculus).

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Daan, S, Damassa, D, Pittendrigh, C S, Smith, E R·1975·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.72.9.3744PMC PMC433074
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Abstract

Castration of mice in freerunning conditions (total darkness, DD) causes a reduction of running wheel activity in the beginning of the active period (alpha) and stimulates activity at the end of alpha. Simultaneously, the period (tau) of the freerunning rhythm is increased. Both effects are abolished by implantation of a Silastic capsule from which a physiological dose of testosterone is released at a constant rate. The results are tentatively explained by differential endocrine influences on two oscillating components in the pacemaker of the circadian activity rhythm.

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Crossref · 10.1073/pnas.72.9.3744

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  • In adult laboratory rodents, a wide variety of gonadal hormones can affect the phase of circadian rhythms.

    “Indeed, in adult laboratory rodents a wide variety of gonadal hormones can affect the phase of circadian rhythms, including estrogens, progestins, androgens, and non-traditional neuroactive steroids (e.g., rats: [8, 17], hamsters: [49, 51, 129], mice: [23, 47, 78, 90], degus: [80, 100]).”

    From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [47]

  • Gonadal hormones can influence other circadian parameters including endogenous period, rhythm amplitude, range of entrainment, zeitgeber sensitivity, and oscillator coupling.

    “Gonadal hormones can influence other circadian parameters as well, including endogenous period [7, 23, 47, 49, 91, 129, 212], rhythm amplitude [8, 17, 100], range of entrainment [49], zeitgeber sensitivity [23, 51, 79, 81], and oscillator coupling [126, 128, 187].”

    From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [47]

  • Castrated adult male rodents under entrained and free-running conditions had activity that was more dispersed across the active period, such that activity at the beginning of their active period in the early night was less cohesive, diminished, lost, or delayed.

    “For example, castrated adult male rodents under entrained and free-running conditions had activity that was more dispersed across the active period [128], such that activity at the beginning of their active period in the early night was less cohesive, diminished, lost, or delayed [47, 49, 78, 90, 128, although see 23 and 80].”

    From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [47]

  • Administration of testosterone or dihydrotestosterone to castrated adult males restored normal circadian activity patterns, and estrogen treatment reconsolidated rhythms in ovariectomized rats.

    “In these previous studies, the administration of testosterone or dihydrotestosterone to castrated adult males was able to restore the normal circadian activity patterns [47, 78, 90, 128] and estrogen treatment was able to reconsolidate rhythms in ovariectomized rats [187, 203].”

    From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [47]

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Research works printed but not linked: 7

  1. [3]Menaker, M. (1974). "Aspects of the physiology of circadian rhythmicity in the vertebrate central nervous system," in The Neurosciences, IIIrd Study Program, eds. Schmitt, F. O. & Worden, G. O. (MIT Press, Cambridge, Mass.), pp. 479–489. 4.
  2. [8]Pittendrigh, C. S. & Daan, S. (1975) "A functional analysis of circadian pacemakers in nocturnal rodents. I. The stability and lability of spontaneous frequency," J. Comp. Physiol., in press.
  3. [13]Daan, S. & Pittendrigh, C. S. (1975) "A functional analysis of circadian pacemakers in nocturnal rodents. III. Heavy water and constant light: homeostasis of frequency?," J. Comp. Physiol., in press.
  4. [15]Pittendrigh, C. S. & Daan, S. (1975) "A functional analysis of circadian pacemakers in nocturnal rodents. V. Pacemaker complexity: A clock for all seasons," J. Comp. Physiol., in press.
  5. [14]Pittendrigh, C. S. (1974) "Circadian oscillations in cells and the circadian organization of multi-cellular systems,"in The Neurosciences, Third Study Program, eds. (Schmitt, F. O. & Worden, G. O. (MIT Press, Cambridge Mass.), pp. 437–458.
  6. [16]Gwinner, E. (1975) "Effects of season and external testosterone on the freerunning circadian activity rhythms of European starlings," J. Comp. Physiol., in press.
  7. [17]Daan, S. (1975) "Light intensity and the timing of daily activity in finches,"The Ibis, in press.

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Authors
Daan, S., Damassa, D., Pittendrigh, C. S., & Smith, E. R.
Affiliations
Stanford University (US)
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1975-09
Volume
72
Issue
9
Pages
3744-3747
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.72.9.3744
PMC
PMC433074
OpenAlex
W2146972815
Cited by
207
References
7
Citations by year
2026: 4 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 8
FWCI
3.18
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
castration, testosterone replacement therapy, circadian pacemaker, circadian activity rhythm, wheel running, period length, mice
MeSH terms
Animals, Behavior, Animal, Castration, Circadian Rhythm, Drug Implants, Male, Mice, Inbred C57BL, Motor Activity, Testosterone, Mice

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