CoChat
Sign Up
Cited by 34Circadian rhythm and melatoninHypothalamic control of reproductive hormonesEstrogen and related hormone effects

Estradiol deficiency during development modulates the expression of circadian and daily rhythms in male and female aromatase knockout mice

Brockman, Rebecca, Bunick, David, Mahoney, Megan M.·2011·Hormones and Behavior
DOI 10.1016/j.yhbeh.2011.07.011
Open this paper in CoChat — free account

Abstract

Gonadal steroids modify the phase, amplitude and period of circadian rhythms. To further resolve the role of estradiol, we examined daily patterns of activity, circadian free running period and behavioral responses to light pulses using aromatase deficient (ArKO) mice. These animals lack the enzyme necessary to produce estradiol. We hypothesized that circulating estrogens during development and adulthood modulate the amount of activity, the temporal relationship of activity patterns relative to a light:dark cycle, and the free running period. Intact and gonadectomized male and female ArKO and wildtype (WT) littermates were used. WT males, but not ArKO males, retained the ability to respond to steroid hormones; the time of activity onset, free running period in constant darkness, and total daily activity were significantly different in gonadectomized compared to intact males. In contrast, gonadectomy did not alter the expression of these variables in ArKO males. ArKO females had a longer free running period in constant darkness compared to WT females regardless of gonadal state. Ovariectomized ArKO females had a significantly delayed activity onset when compared to intact ArKO females and ovariectomized WT females, despite all 3 groups being estrogen deficient. Phase shifts in response to light pulses given at different times of the day revealed an interaction between genotype, sex, and circulating steroids. These results from ArKO animals strongly suggest an organizational effect of estradiol during a critical period of development on the expression of biological rhythms.

Integrity signals

Registry

Crossref · 10.1016/j.yhbeh.2011.07.011

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In adult laboratory rodents, a wide variety of gonadal hormones can affect the phase of circadian rhythms.

    “Indeed, in adult laboratory rodents a wide variety of gonadal hormones can affect the phase of circadian rhythms, including estrogens, progestins, androgens, and non-traditional neuroactive steroids (e.g., rats: [8, 17], hamsters: [49, 51, 129], mice: [23, 47, 78, 90], degus: [80, 100]).”

    From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [23]

  • Some sex differences in circadian parameters are activated by the different hormonal milieu of adult males and females, and some arise organizationally during development.

    “Although some of these sex differences are activated by the different hormonal milieu of adult males and females, some sex differences also arise organizationally during development [23].”

    From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [23]

  • Gonadal hormones can influence other circadian parameters including endogenous period, rhythm amplitude, range of entrainment, zeitgeber sensitivity, and oscillator coupling.

    “Gonadal hormones can influence other circadian parameters as well, including endogenous period [7, 23, 47, 49, 91, 129, 212], rhythm amplitude [8, 17, 100], range of entrainment [49], zeitgeber sensitivity [23, 51, 79, 81], and oscillator coupling [126, 128, 187].”

    From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [23]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Brockman, R., Bunick, D., & Mahoney, M. M.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Mahoney, Megan M.
ORCID
Mahoney, Megan M.
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2011-09
Volume
60
Issue
4
Pages
439-447
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2011.07.011
OpenAlex
W1991072541
Cited by
34
References
44
Citations by year
2025: 3 · 2023: 1 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
1.18
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
Department of Comparative Biosciences and the College of Veterinary Medicine
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
estradiol deficiency, aromatase knockout mice, circadian rhythm, daily rhythms, free-running period, activity patterns, gonadectomy, ovariectomy, organizational effects of hormones, critical periods of development, sex differences, sex steroids
MeSH terms
Animals, Aromatase, Biological Clocks, Castration, Circadian Rhythm, Estradiol, Female, Genotype, Male, Mice, Inbred C57BL, Motor Activity, Running, Mice, Knockout, Growth and Development, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review