The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.
Open accessAbstract
We have shown that UVA (320-380 nm) radiation, hydrogen peroxide, and sodium arsenite induce a stress protein of approximately 32 kDa in human skin fibroblasts. The synthesis and cloning of cDNA from arsenite-induced mRNA populations have now allowed us to unequivocally identify the 32-kDa protein as heme oxygenase. By mRNA analysis we have shown that the heme oxygenase gene is also induced in cultured human skin fibroblasts by UVA radiation, hydrogen peroxide, cadmium chloride, iodoacetamide, and menadione. The known antioxidant properties of heme catabolites taken together with the observation of a high level of induction of the enzyme in cells from an organ not involved in hemoglobin breakdown strongly supports the proposal that the induction of heme oxygenase may be a general response to oxidant stress and constitutes an important cellular defense mechanism against oxidative damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Berger, S. L., & Birkenmeier, C. S. (1979) · Biochemistry · doi:10.1021/bi00590a018 · Cited by 443
Cited by
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Strategies of antioxidant defense
SIES, H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18025.x · Cited by 1,976
Pharmacological and Clinical Aspects of Heme Oxygenase
Abraham, N. G., & Kappas, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07104 · Cited by 1,115
Heme oxygenase 1 is required for mammalian iron reutilization
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10919 · Cited by 1,016
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene
Sun, J., Hoshino, H., Takaku, K., Nakajima, O., Muto, A., Suzuki, H., Tashiro, S., Takahashi, S., Shibahara, S., Alam, J., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf516 · Cited by 637
Pro-oxidant and cytotoxic effects of circulating heme
Jeney, V., Balla, J., Yachie, A., Varga, Z., Vercellotti, G. M., Eaton, J. W., & Balla, G. (2002) · Blood · doi:10.1182/blood.v100.3.879 · Cited by 633
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015957026924 · Cited by 497
Transferrin Receptor Induction by Hypoxia
Tacchini, L., Bianchi, L., Bernelli-Zazzera, A., & Cairo, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24142 · Cited by 379
Oxidatively Generated Damage to Cellular DNA by UVB and UVA Radiation ,
Cadet, J., Douki, T., & Ravanat, J. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12368 · Cited by 355
Tsiftsoglou, A. S., Tsamadou, A. I., & Papadopoulou, L. C. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.017 · Cited by 281
Li, N., Venkatesan, M. I., Miguel, A., Kaplan, R., Gujuluva, C., Alam, J., & Nel, A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3393 · Cited by 267
Heme Degradation and Vascular Injury
Belcher, J. D., Beckman, J. D., Balla, G., Balla, J., & Vercellotti, G. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2822 · Cited by 257
Offord, E. A., Gautier, J.-C., Avanti, O., Scaletta, C., Runge, F., Krämer, K., & Applegate, L. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00831-6 · Cited by 254
Li, N., Kim, S., Wang, M., Froines, J., Sioutas, C., & Nel, A. (2002) · Inhalation Toxicology · doi:10.1080/089583701753678571 · Cited by 249
DNA damage by singlet oxygen and cellular protective mechanisms
Agnez-Lima, L. F., Melo, J. T. A., Silva, A. E., Oliveira, A. H. S., Timoteo, A. R. S., Lima-Bessa, K. M., Martinez, G. R., Medeiros, M. H. G., Di Mascio, P., Galhardo, R. S., et al. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2011.12.005 · Cited by 205
Whitekus, M. J., Li, N., Zhang, M., Wang, M., Horwitz, M. A., Nelson, S. K., Horwitz, L. D., Brechun, N., Diaz-Sanchez, D., & Nel, A. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.5.2560 · Cited by 198
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
Katoh, Y., Ikura, T., Hoshikawa, Y., Tashiro, S., Ito, T., Ohta, M., Kera, Y., Noda, T., & Igarashi, K. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.018 · Cited by 185
Pourzand, C., Watkin, R. D., Brown, J. E., & Tyrrell, R. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6751 · Cited by 176
Self-citationOzone exposure activates oxidative stress responses in murine skin
Valacchi, G., van der Vliet, A., Schock, B. C., Okamoto, T., Obermuller-Jevic, U., Cross, C. E., & Packer, L. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00240-8 · Cited by 120
Role of the Nrf2-heme oxygenase-1 pathway in silver nanoparticle-mediated cytotoxicity
Kang, S. J., Ryoo, I.-G., Lee, Y. J., & Kwak, M.-K. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.10.011 · Cited by 76
Sikiric, P., Seiwerth, S., Rucman, R., Turkovic, B., Rokotov, D. S., Brcic, L., Sever, M., Klicek, R., Radic, B., Drmic, D., et al. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883589 · Cited by 77
Iron, oxidative stress and the example of solar ultraviolet a radiation.
Aroun, A., Zhong, J. L., Tyrrell, R. M., & Pourzand, C. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05204g · Cited by 74
Self-citationRoles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation
Ikehata, H., & Yamamoto, M. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.09.038 · Cited by 73
Glial HO-1 expression, iron deposition and oxidative stress in neurodegenerative diseases
Schipper, H. M. (1999) · Neurotoxicity Research · doi:10.1007/bf03033339 · Cited by 72
The role of Nrf2 in ultraviolet A mediated heme oxygenase 1 induction in human skin fibroblasts
Zhong, J. L., Edwards, G. P., Raval, C., Li, H., & Tyrrell, R. M. (2010) · Photochemical & Photobiological Sciences · doi:10.1039/b9pp00068b · Cited by 65
Self-citationCytoprotective Effects of Heme Oxygenase in Acute Renal Failure
Akagi, R., Takahashi, T., & Sassa, S. (2005) · Contributions to Nephrology · doi:10.1159/000086044 · Cited by 53
Excretion of biliary compounds during intrauterine life
Macias, R. I., Marin, J. J., & Serrano, M. A. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.817 · Cited by 54
Potential protection of skin by acute UVA irradiation - from cellular to animal models
Tyrrell, R. M., & Reeve, V. E. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.02.002 · Cited by 53
Self-citationWertz, K., Seifert, N., Hunziker, P. B., Riss, G., Wyss, A., Lankin, C., & Goralczyk, R. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.018 · Cited by 52
Raval, C. M., Zhong, J. L., Mitchell, S. A., & Tyrrell, R. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.494 · Cited by 44
Self-citationYeh, S.-L., Hu, M.-L., & Huang, C.-S. (2005) · European Journal of Nutrition · doi:10.1007/s00394-004-0536-5 · Cited by 33
Deb, S., Johnson, E. E., Robalinho-Teixeira, R. L., & Wessling-Resnick, M. (2009) · BioMetals · doi:10.1007/s10534-009-9214-7 · Cited by 28
Pócsi, I., Jeney, V., Kertai, P., Pócsi, I., Emri, T., Gyémánt, G., Fésüs, L., Balla, J., & Balla, G. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700467 · Cited by 25
Canesin, G., Feldbrügge, L., Wei, G., Janovicova, L., Janikova, M., Csizmadia, E., Ariffin, J., Hedblom, A., Herbert, Z. T., Robson, S. C., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104983 · Cited by 19
Metadata
- Authors
- Keyse, S. M., & Tyrrell, R. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-01
- Volume
- 86
- Issue
- 1
- Pages
- 99-103
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2041553103
- Cited by
- 1,264
- References
- 1
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
