The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.
Open accessAbstract
The temporal disappearance of natural antioxidants associated with human low density lipoprotein (LDL) in relation to the appearance of various classes of lipid hydroperoxides was investigated under three types of oxidizing conditions. Freshly isolated LDL from plasma of healthy subjects was free of detectable amounts of lipid hydroperoxides as measured by HPLC postcolumn chemiluminescence detection. Exposure of such LDL to a mild, constant flux of aqueous peroxyl radicals led to rapid and complete oxidation of ubiquinol-10, followed by slower partial depletion of lycopene, beta-carotene, and alpha-tocopherol. After an initial lag period of complete inhibition of detectable lipid peroxidation, formation of hydroperoxides of cholesterol esters, triglycerides, and phospholipids was observed. The onset of detectable lipid peroxidation corresponded closely with the completion of ubiquinol-10 consumption. However, small amounts of ascorbate, present as a contaminant in the LDL preparation, rather than ubiquinol-10 itself were responsible for the initial lag period. Thus, complete consumption of ubiquinol-10 was preceded by that of ascorbate, and exposure of ascorbate-free LDL to aqueous peroxyl radicals resulted in immediate formation of detectable amounts of lipid hydroperoxides. The rate of radical-mediated formation of lipid hydroperoxides in ascorbate-free LDL was low as long as ubiquinol-10 was present, but increased rapidly after its consumption, even though more than 80% and 95% of endogenous carotenoids and alpha-tocopherol, respectively, were still present. Qualitatively similar results were obtained when peroxyl radicals were generated within LDL or when the lipoprotein was exposed to oxidants produced by activated human polymorphonuclear leukocytes. LDL oxidation was reduced significantly by supplementing the lipoprotein preparation with physiological amounts of either ascorbate or ubiquinol-10. Our data show that ubiquinol-10 is much more efficient in inhibiting LDL oxidation than either lycopene, beta-carotene, or alpha-tocopherol.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870
Self-citation
Cited by
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703
Antioxidants in health and disease
Young, I. S., & Woodside, J. V. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.3.176 · Cited by 1,949
Ferroptosis: Mechanisms and links with diseases
Yan, H.-F., Zou, T., Tuo, Q.-Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00428-9 · Cited by 1,471
Mechanisms of free radical oxidation of unsaturated lipids
Porter, N. A., Caldwell, S. E., & Mills, K. A. (1995) · Lipids · doi:10.1007/bf02536034 · Cited by 1,208
Metabolism and function of coenzyme Q
Turunen, M., Olsson, J., & Dallner, G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2003.11.012 · Cited by 1,026
The antioxidant role of coenzyme Q
Bentinger, M., Brismar, K., & Dallner, G. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.006 · Cited by 543
Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383
Retsky, K. L., Freeman, M. W., & Frei, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54075-8 · Cited by 271
Self-citationHazell, L. J., van den Berg, J. J. M., & Stocker, R. (1994) · Biochemical Journal · doi:10.1042/bj3020297 · Cited by 267
Wang, Y., & Hekimi, S. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.12.007 · Cited by 256
Beal, M. F., Matthews, R. T., Tieleman, A., & Shults, C. W. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01192-x · Cited by 256
Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease
Shults, C. W., Flint Beal, M., Song, D., & Fontaine, D. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.003 · Cited by 223
Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis.
Freedman, J. E., Loscalzo, J., Benoit, S. E., Valeri, C. R., Barnard, M. R., & Michelson, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118522 · Cited by 171
Ultra-Endurance Exercise and Oxidative Damage: Implications for Cardiovascular Health
Knez, W. L., Coombes, J. S., & Jenkins, D. G. (2006) · Sports Medicine · doi:10.2165/00007256-200636050-00005 · Cited by 130
Implications of plasma thiol redox in disease
Oliveira, P. V. S., & Laurindo, F. R. M. (2018) · Clinical Science · doi:10.1042/cs20180157 · Cited by 127
Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer’s disease
Raina, A. K., Templeton, D. J., deak, J. C., Perry, G., & Smith, M. A. (1999) · Redox Report · doi:10.1179/135100099101534701 · Cited by 120
The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions
Pallotti, F., Bergamini, C., Lamperti, C., & Fato, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010128 · Cited by 109
Coenzyme Q and Its Role in the Dietary Therapy against Aging
Varela-López, A., Giampieri, F., Battino, M., & Quiles, J. (2016) · Molecules · doi:10.3390/molecules21030373 · Cited by 86
Coenzyme Q9 Provides Cardioprotection after Converting into Coenzyme Q10
Lekli, I., Das, S., Das, S., Mukherjee, S., Bak, I., Juhasz, B., Bagchi, D., Trimurtulu, G., Krishnaraju, A. V., Sengupta, K., et al. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf800035f · Cited by 15
Rimpelová, S., Kolář, M., Strnad, H., Ruml, T., Vítek, L., & Gbelcová, H. (2021) · Molecules · doi:10.3390/molecules26123528 · Cited by 8
Mine, Y., Takahashi, T., & Okamoto, T. (2021) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.20-185 · Cited by 5
Metadata
- Authors
- Stocker, R., Bowry, V. W., & Frei, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-03
- Volume
- 88
- Issue
- 5
- Pages
- 1646-1650
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2083259478
- Cited by
- 793
- References
- 1
- FWCI
- 22.10
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
