Perfluorododecanoic Acid Exposure Induced Developmental Neurotoxicity in Zebrafish Embryos
Abstract
Perfluorododecanoic acid (PFDoA), an artificial perfluorochemical, has been widely distributed in different ambient media and has been reported to have the potential to cause developmental neurotoxicity. However, the specific mechanism is largely unknown. In the current study, zebrafish embryos were treated with 0, 0.24, 1.2, and 6 mg/L PFDoA for 120 h. Exposure to PFDoA causes serious decreases in hatching delay, body length, as well as decreased locomotor speed in zebrafish larvae. Additionally, the acetylcholine (ACh) content as well as acetylcholinesterase (AChE) activity were determined to be significantly downregulated in PFDoA treatment groups. The level of dopamine was upregulated significantly after treating with 1.2 and 6 mg/L of PFDoA. Gene expressions related to the nervous system development were also analyzed, with the exception of the gene mesencephalic astrocyte-derived neurotrophic factor (manf), which is upregulated in the 6 mg/L treatment group. All other genes were significantly downregulated in larvae in the PFDoA group in different degrees. In general, the results demonstrated that PFDoA exposure could result in the disruption of the cholinergic system, dopaminergic signaling, and the central nervous system.
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A decrease in locomotor speed was seen in zebrafish larvae exposed to 0.24, 1.2, or 6 mg/L PFDoA, in addition to decreased expression of acetylcholine (Ach) at 6 mg/L and AchE at 1.2 and 6 mg/L.
“A decrease in locomotor speed was also seen in zebrafish larvae exposed to 0.24, 1.2, or 6 mg/L PFDoA, in addition to decreased expression of acetylcholine (Ach) at 6 mg/L and AchE at 1.2 and 6 mg/L (Guo et al., 2018).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Guo et al., 2018
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- Authors
- Guo, X., Zhang, S., Lu, S., Zheng, B., Xie, P., Chen, J., Li, G., Liu, C., Wu, Q., Cheng, H., & Sang, N.
- Affiliations
- Chinese Research Academy of Environmental Sciences (CN)
- Shanxi University (CN)
- Chinese Academy of Sciences (CN)
- Huazhong Agricultural University (CN)
- Corresponding author
- Lu, Shaoyong
- ORCID
- Venue
- Environmental Pollution
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 241
- Pages
- 1018-1026
- ISSN
- 0269-7491 (ISSN-L)
- OpenAlex
- W2807274558
- Cited by
- 58
- References
- 90
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 6 · 2023: 14 · 2022: 11 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Pollution (publishedVersion)
- PubMed (publishedVersion)
- Institute of Hydrobiology, CAS Institutional Repository (submittedVersion)
- Funders
- National Natural Science Foundation of China (41601544)
- Ministry of Science and Technology of China (2015FY11-0900)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Keywords
- perfluorododecanoic acid, developmental neurotoxicity, zebrafish embryos, acetylcholinesterase, acetylcholine, dopamine, cholinergic system, dopaminergic signaling, brain development, MANF, locomotion speed, hatching delay, perfluorochemicals
- MeSH terms
- Animals, Embryo, Nonmammalian, Fluorocarbons, Larva, Lauric Acids, Nervous System, Water Pollutants, Chemical, Zebrafish, Signal Transduction, Down-Regulation, Up-Regulation, Gene Expression, Zebrafish Proteins
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