Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 810

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

Open access
Yang, Shi Qi, Lin, Hui Zhi, Lane, M. Daniel, Clemens, Mark, Diehl, Anna Mae·1997·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.94.6.2557
Open this paper in CoChat — free account

Abstract

Genetically obese fatty/fatty rats and obese/obese mice exhibit increased sensitivity to endotoxin hepatotoxicity, quickly developing steatohepatitis after exposure to low doses of lipopolysaccharide (LPS). Among obese animals, females are more sensitive to endotoxin liver injury than males. LPS induction of tumor necrosis factor α (TNFα), the proven affecter of endotoxin liver injury, is no greater in the livers, white adipose tissues, or sera of obese animals than in those of lean controls. Indeed, the lowest serum concentrations of TNF occur in female obese rodents, which exhibit the most endotoxin-induced liver injury. Several cytokines that modulate the biological activity of TNF are regulated abnormally in the livers of obese animals. After exposure to LPS, mRNA of interferon γ, which sensitizes hepatocytes to TNF toxicity, is overexpressed, and mRNA levels of interleukin 10, a TNF inhibitor, are decreased. The phagocytic activity of liver macrophages and the hepatic expression of a gene encoding a macrophage-specific receptor are also decreased in obesity. This new animal model of obesity-associated liver disease demonstrates that hepatic macrophage dysfunction occurs in obesity and suggests that this might promote steatohepatitis by sensitizing hepatocytes to endotoxin.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.94.6.2557

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 47

  1. 10.7326/0003-4819-103-1-147 · DOI
  2. 10.1002/hep.1840120505 · DOI · Paper page
  3. 10.1097/00005792-196209000-00003 · DOI · Paper page
  4. J F Silverman, K F O’Brien, S Long, N Lettett, P G Khazanie, W J Pories, T Norris, J F Caro Am J Gastroenterol 85, 1349–1355 (1990).
  5. 10.1016/0046-8177(89)90249-9 · DOI · Paper page
  6. 10.1002/hep.1840110114 · DOI · Paper page
  7. 10.1016/0016-5085(94)90235-6 · DOI · Paper page
  8. 10.1002/hep.1840010212 · DOI
  9. 10.1111/j.1600-0676.1987.tb00355.x · DOI
  10. J Ludwig, T R Viggiano, D B McGill, B J Ott Mayo Clin Proc 55, 434–438 (1980). · DOI · Paper page
  11. 10.1016/0016-5085(88)90183-7 · DOI · Paper page
  12. 10.1016/S0016-5085(19)33180-4 · DOI · Paper page
  13. 10.1016/S0168-8278(86)80006-X · DOI · Paper page
  14. 10.1055/s-2007-1007347 · DOI · Paper page
  15. 10.1016/S0021-9258(18)52371-1 · doi:10.1016/s0021-9258(18)52371-1
  16. 10.1016/0003-2697(87)90021-2 · DOI · Paper page
  17. 10.1074/jbc.271.30.17974 · DOI
  18. R Rai, S Q Yang, C McClain, C L Karp, A S Klein, A M Diehl Am J Physiol 270, G909–G918 (1996).
  19. 10.1126/science.273.5272.228 · DOI · Paper page
  20. 10.1097/00024382-199610000-00003 · DOI
  21. J D Torosis, K W Barwick, J D Miller Hepatology 9, 237–242 (1985).
  22. 10.1146/annurev.cb.09.110193.001533 · DOI · Paper page
  23. 10.1146/annurev.iy.10.040192.002211 · doi:10.1146/annurev.iy.10.040192.002211 · Paper page
  24. 10.1016/0168-8278(89)90012-3 · doi:10.1016/0168-8278(89)90012-3
  25. 10.1615/CritRevEukarGeneExpr.v4.i2-3.20 · DOI
  26. 10.1016/S0168-8278(05)80154-0 · DOI
  27. 10.1016/S0168-8278(94)80256-4 · DOI
  28. 10.1038/370218a0 · DOI · Paper page
  29. 10.1073/pnas.88.23.10535 · DOI · Paper page
  30. 10.1002/hep.1840070603 · doi:10.1002/hep.1840070603
  31. 10.1002/jlb.54.1.23 · DOI
  32. R Honchel, L Marsano, D Cohen, S Shedlofsky, C McClain J Lab Clin Med 117, 202–208 (1991).
  33. 10.1016/0041-008X(91)90247-C · DOI
  34. M Leist, F Gantner, I Bohlinger, P G Germann, G Tiegs, A Wendel J Immunol 153, 1778–1788 (1994). · DOI · Paper page
  35. 10.1016/0003-9861(92)90161-O · DOI
  36. 10.1002/j.1460-2075.1993.tb05978.x · DOI · Paper page
  37. 10.1016/0006-2952(89)90208-6 · DOI · Paper page
  38. 10.1002/hep.1840200228 · DOI
  39. 10.1016/0016-5085(95)90149-3 · DOI
  40. 10.1006/taap.1995.1125 · DOI · Paper page
  41. 10.1111/j.1432-1033.1990.tb19222.x · DOI · Paper page
  42. E S Fox, S A Broitman, P Thomas Lab Invest 63, 733–736 (1990).
  43. 10.1006/clin.1995.1052 · DOI
  44. 10.1126/science.271.5249.665 · DOI · Paper page
  45. 10.1126/science.7624777 · DOI · Paper page
  46. 10.1126/science.7624776 · DOI · Paper page
  47. 10.1073/pnas.93.13.6231 · DOI · Paper page

Cited by

Metadata

Authors
Yang, S. Q., Lin, H. Z., Lane, M. D., Clemens, M., & Diehl, A. M.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1997-03-18
Volume
94
Issue
6
Pages
2557-2562
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.94.6.2557
OpenAlex
W2022763702
Cited by
810
References
5
FWCI
15.81
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.