Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,857

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint

Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,181

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,652

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,402

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

Dreyer, C., Krey, G. D., Keller, H., Givel, F., Helftenbein, G., & Wahli, W. (1992) · Cell · doi:10.1016/0092-8674(92)90031-7 · Cited by 1,393

The PPARα–leukotriene B4 pathway to inflammation control

Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525

Ecotoxicology of human pharmaceuticals

Fent, K., Weston, A. A., & Caminada, D. (2006) · Aquatic Toxicology · doi:10.1016/j.aquatox.2005.09.009 · Cited by 3,223

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism

Desvergne, B., & Wahli, W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0380 · Cited by 3,115

The mechanisms of action of PPARs

Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659

Metabolism and Functions of Lipids and Fatty Acids in Teleost Fish

Tocher, D. R. (2003) · Reviews in Fisheries Science · doi:10.1080/713610925 · Cited by 2,708

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075

Fat and Beyond: The Diverse Biology of PPARγ

Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

Nolte, R. T., Wisely, G. B., Westin, S. K., Cobb, J. E., Lambert, M. H., Kurokawa, R., Rosenfeld, M. G., Willson, T. M., Glass, C. K., & Milburn, M. V. (1998) · Nature · doi:10.1038/25931 · Cited by 1,979

Transcriptional regulation of adipogenesisPreprint

Rosen, E. D., Walkey, C. J., Puigserver, P., & Spiegelman, B. M. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 1,908

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H.-W., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81574-3 · Cited by 1,861

The PPARs: From Orphan Receptors to Drug Discovery

Willson, T. M., Brown, P. J., Sternbach, D. D., & Henke, B. R. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990554g · Cited by 1,816

Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism

Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E., & Fruchart, J.-C. (1998) · Circulation · doi:10.1161/01.cir.98.19.2088 · Cited by 1,786

Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance

Calder, P. C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.010 · Cited by 1,717

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos, L. H. M. L. M., Araújo, A. N., Fachini, A., Pena, A., Delerue-Matos, C. M., & Montenegro, M. C. B. S. M. (2009) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2009.10.100 · Cited by 1,638

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80900-9 · Cited by 1,534

Eicosanoid storm in infection and inflammation

Dennis, E. A., & Norris, P. C. (2015) · Nature Reviews Immunology · doi:10.1038/nri3859 · Cited by 1,517

Omega-3 fatty acids and inflammatory processes: from molecules to man

Calder, P. C. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160474 · Cited by 1,456

Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice

Lim, H. J., Paria, B. C., Das, S., Dinchuk, J. E., Langenbach, R. I., Trzăskos, J. M., & Dey, S. K. (1997) · Cell · doi:10.1016/s0092-8674(00)80402-x · Cited by 1,426

Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

Calder, P. C. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04374.x · Cited by 1,429

Inflammation and cancer: how hot is the link?

Aggarwal, B. B., Shishodia, S., Sandur, S. K., Pandey, M. K., & Sethi, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.029 · Cited by 1,312

Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4

Lee, J. Y., Sohn, K. H., Rhee, S. H., & Hwang, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011695200 · Cited by 1,299

Molecular Regulation of Adipogenesis

Rosen, E. D., & Spiegelman, B. M. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.145 · Cited by 1,310

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

Manolagas, S. C. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0024 · Cited by 1,234

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

Grygiel-Górniak, B. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-17 · Cited by 1,079

The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

Vega, R. B., Huss, J. M., & Kelly, D. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1868-1876.2000 · Cited by 1,195

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80467-0 · Cited by 1,169

Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature

Carey, H. V., Andrews, M. T., & Martin, S. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00008.2003 · Cited by 1,145

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

He, T., Chan, T. A.-T., Vogelstein, B., & Kinzler, K. W. (1999) · Cell · doi:10.1016/s0092-8674(00)81664-5 · Cited by 1,083

STRUCTURE, FUNCTION, AND DIETARY REGULATION OF Δ6, Δ5, AND Δ9 DESATURASES

Nakamura, M., & Nara, T. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.121803.063211 · Cited by 1,111

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α

Fu, J., Gaetani, S., Oveisi, F., Verme, J., Serrano, A., de Fonseca, F. D., Rosengarth, A., Luecke, H., Giacomo, B. D., Tarzia, G., et al. (2003) · Nature · doi:10.1038/nature01921 · Cited by 1,113

Cross-Regulation of C/EBPα and PPARγ Controls the Transcriptional Pathway of Adipogenesis and Insulin Sensitivity

Wu, Z., Rosen, E. D., Brun, R. P., Hauser, S., Adelmant, G., Troy, A. E., McKeon, C., Darlington, G., & Spiegelman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80306-8 · Cited by 1,015

International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors

Michalik, L., Auwerx, J. H., Berger, J. P., Chatterjee, K., Glass, C. K., Gonzalez, F. J., Grimaldi, P. A., Kadowaki, T., Lazar, M. A., O’Rahilly, S., et al. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.5 · Cited by 1,022

Differentiation and reversal of malignant changes in colon cancer through PPARγ

Sarraf, P., Mueller, E., Jones, D. M., King, F. J., DeAngelo, D. J., Partridge, J. B., Holden, S. A., Chen, L. B., Singer, S., Fletcher, C. D. �., et al. (1998) · Nature Medicine · doi:10.1038/2030 · Cited by 983

Sorting out the roles of PPAR in energy metabolism and vascular homeostasis

Lefebvre, P. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27989 · Cited by 962

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

Chinetti, G., Fruchart, J.-C., & Staels, B. (2000) · Inflammation Research · doi:10.1007/s000110050622 · Cited by 954

Ppars are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

Varga, T., Czimmerer, Z., & Nagy, L. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.02.014 · Cited by 933

SXR, a novel steroid and xenobioticsensing nuclear receptorPreprint

Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., van Meter, C. M., Ong, E. S., & Evans, R. M. (1998) · Genes & Development · doi:10.1101/gad.12.20.3195 · Cited by 912

Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages

Chinetti, G., Griglio, S., Antonucci, M., Pineda‐Torra, I., Delerive, P., Majd, Z., Fruchart, J., Chapman, J., Najïb, J., & Staels, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25573 · Cited by 912

Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors

Lee, C., Olson, P., & Evans, R. M. (2003) · Endocrinology · doi:10.1210/en.2003-0288 · Cited by 891

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

Bertilsson, G., Heidrich, J., Svensson, K., Åsman, M., Jendeberg, L., Sydow‐Báckman, M., OHLSSON, R. I., Postlind, H., Blomquist, P., & Berkenstam, A. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12208 · Cited by 876

Mechanisms of Action of (n-3) Fatty Acids,

Calder, P. C. (2012) · Journal of Nutrition · doi:10.3945/jn.111.155259 · Cited by 920

Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)

Aoyama, T., Peters, J. M., Iritani, N., Nakajima, T., Furihata, K., Hashimoto, T., & Gonzalez, F. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5678 · Cited by 867

Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase

Huang, J. T., Welch, J. S., Ricote, M., Binder, C. J., Willson, T. M., Kelly, C., Witztum, J. L., Funk, C. D., Conrad, D. J., & Glass, C. K. (1999) · Nature · doi:10.1038/22572 · Cited by 864

Orphan Nuclear Receptors: From Gene to Function

Giguère, V. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0378 · Cited by 871

Terminal Differentiation of Human Breast Cancer through PPARγ

Mueller, E., Sarraf, P., Tontonoz, P., Evans, R. M., Martin, K. J., Zhang, M., Fletcher, C., Singer, S., & Spiegelman, B. M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80047-7 · Cited by 850

Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR‐γ2 transcription factor and TGF‐β/BMP signaling pathways

Moerman, E., Teng, K., Lipschitz, D., & Lecka-Czernik, B. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00127.x · Cited by 840

Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice

Li, A. C., Brown, K. K., Silvestre, M., Willson, T. M., Palinski, W., & Glass, C. K. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10370 · Cited by 836

Regulation of energy metabolism by long-chain fatty acids

Nakamura, M., Yudell, B. E., & Loor, J. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.12.001 · Cited by 858

A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response

Su, C. G., Wen, X., Bailey, S. T., Jiang, W. G., Rangwala, S. M., Keilbaugh, S. A., Flanigan, A., Murthy, S., Lazar, M. A., & Wu, G. D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7145 · Cited by 769

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767

Dietary Habits and Their Relations to Insulin Resistance and Postprandial Lipemia in Nonalcoholic Steatohepatitis

Musso, G., Gambino, R., Michieli, F. D., Cassader, M., Rizzetto, M., Durazzo, M., Fagà, E., Silli, B., & Pagano, G. (2003) · Hepatology · doi:10.1053/jhep.2003.50132 · Cited by 772

Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

Ricote, M., Huang, J. T., Fajas, L., Li, A. I., Welch, J. S., Najïb, J., Witztum, J. L., Auwerx, J. H., Palinski, W., & Glass, C. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7614 · Cited by 724

Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale

Calder, P. C. (2009) · Biochimie · doi:10.1016/j.biochi.2009.01.008 · Cited by 721

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

Saltiel, A. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00239-2 · Cited by 688

Embryo Implantation

Carson, D. D., Bagchi, I. C., Dey, S., Enders, A. C., Fazleabas, A. T., Lessey, B. A., & Yoshinaga, K. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9767 · Cited by 690

Integrated physiology and systems biology of PPARα

Kersten, S. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.02.002 · Cited by 701

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

Rakhshandehroo, M., Knoch, B., Müller, M., & Kersten, S. (2010) · PPAR Research · doi:10.1155/2010/612089 · Cited by 1,020

PPAR gamma gene--a review

Janani, C., & Ranjitha Kumari, B. D. (2015) · Diabetes & Metabolic Syndrome: Clinical Research & Reviews · doi:10.1016/j.dsx.2014.09.015 · Cited by 735

REGULATION OF GENE EXPRESSION BY DIETARY FAT

Jump, D. Β., & Clarke, S. D. (1999) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.19.1.63 · Cited by 666

Essential Fatty Acids: Biochemistry, Physiology and Pathology

Das, U. N. (2006) · Biotechnology Journal · doi:10.1002/biot.200600012 · Cited by 650

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647

Omega-3 polyunsaturated fatty acids and cardiovascular diseases.

Lavie, C. J., Milani, R. V., Mehra, M. R., & Ventura, H. O. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.084 · Cited by 644

Nuclear Receptors and the Control of Metabolism

Francis, G. A., Fayard, E., Picard, F., & Auwerx, J. H. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142528 · Cited by 647

PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance

Klaunig, J. E., Babich, M. A., Baetcke, K. P., Cook, J. C., Corton, J. C., David, R. M., DeLuca, J. G., Lai, D. Y., McKee, R. H., Peters, J. M., et al. (2003) · Critical Reviews in Toxicology · doi:10.1080/713608372 · Cited by 616

PPARα Activators Inhibit Cytokine-Induced Vascular Cell Adhesion Molecule-1 Expression in Human Endothelial Cells

Marx, N., Sukhova, G. K., Collins, T., Libby, P., & Plutzky, J. (1999) · Circulation · doi:10.1161/01.cir.99.24.3125 · Cited by 603

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

Wang, L., Waltenberger, B., Pferschy‐Wenzig, E., Blunder, M., Liu, X., Malainer, C., Blažević, T., Schwaiger, S., Rollinger, J. M., Heiß, E. H., et al. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.018 · Cited by 617

Activators of the nuclear receptor PPARγ enhance colon polyp formation

Sáez, E., Tontonoz, P., Nelson, M. C., Alvarez, J. G. A., Tze Ming, U., Baird, S. M., Thomázy, V. A., & Evans, R. M. (1998) · Nature Medicine · doi:10.1038/2042 · Cited by 588

Peroxisome Proliferator-Activated Receptor Gamma Activators Inhibit Gene Expression and Migration in Human Vascular Smooth Muscle Cells

Marx, N., Schönbeck, U., Lazar, M. A., Libby, P., & Plutzky, J. (1998) · Circulation Research · doi:10.1161/01.res.83.11.1097 · Cited by 585

Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdeltaPreprint

Lim, H. J., Gupta, R. A., Ma, W., Paria, B. C., Moller, D. E., Morrow, J. D., DuBois, R. N., Trzaskos, J. M., & Dey, S. K. (1999) · Genes & Development · doi:10.1101/gad.13.12.1561 · Cited by 588

Peroxisome Proliferator–Activated Receptor γ and Metabolic Disease

Willson, T. M., Lambert, M. H., & Kliewer, S. A. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.341 · Cited by 590

Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics

Ulrich, C. M., Bigler, J., & Potter, J. D. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1801 · Cited by 554

“New” hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis

Chakravarthy, M. V., Pan, Z., Zhu, Y., Tordjman, K. M., Schneider, J. G., Coleman, T., TURK, J. W., & Semenkovich, C. F. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.04.002 · Cited by 557

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Matsuzaka, T., Shimano, H., Yahagi, N., Kato, T., Atsumi, A., Yamamoto, T., Inoue, N., Ishikawa, M., Okada, S., Ishigaki, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1662 · Cited by 557

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

Xu, H. E., Lambert, M. H., Montana, V. G., Plunket, K. D., Moore, L. B., Collins, J. L., Oplinger, J. A., Kliewer, S. A., Gampe, R. T., McKee, D. D., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241410198 · Cited by 554

Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists

Olefsky, J. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10843 · Cited by 536

Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver

Chakravarthy, M. V., Lodhi, I. J., Yin, L., Malapaka, R. R. V., Xu, H. E., TURK, J. W., & Semenkovich, C. F. (2009) · Journal of End-to-End-testing · doi:10.1016/j.cell.2009.05.036 · Cited by 536

Cannabinoid and cannabinoid‐like receptors in microglia, astrocytes, and astrocytomas

Stella, N. (2010) · Glia · doi:10.1002/glia.20983 · Cited by 556

The fatty acid transport function of fatty acid-binding proteins

Storch, J., & THUMSER, A. E. A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00046-9 · Cited by 532

Macrophages in Human Atheroma Contain PPARγ

Marx, N., Sukhova, G. K., Murphy, C., Libby, P., & Plutzky, J. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65540-x · Cited by 526

Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and Inducer-specific Manner

Motojima, K., Passilly, P., Peters, J. M., Gonzalez, F. J., & Latruffe, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16710 · Cited by 531

Genome-wide profiling of PPARγ:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesisPreprint

Nielsen, R., Pedersen, T. Å., Hagenbeek, D., Moulos, P., Siersbæk, R., Megens, E., Denissov, S., Børgesen, M., Françoijs, K., Mandrup, S., et al. (2008) · Genes & Development · doi:10.1101/gad.501108 · Cited by 520

The role of PPAR-γ in macrophage differentiation and cholesterol uptake

Moore, K. J., Rosen, E. D., Fitzgerald, M. L., Randow, F., Andersson, L. P., Altshuler, D., Milstone, D. S., Mortensen, R. M., Spiegelman, B. M., & Freeman, M. W. (2001) · Nature Medicine · doi:10.1038/83328 · Cited by 518

Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

Morton, N. M., Paterson, J. M., Masuzaki, H., Holmes, M. C., Staels, B., Fievet, C., Walker, B. R., Flier, J. S., Mullins, J. J., & Seckl, J. R. (2004) · Diabetes · doi:10.2337/diabetes.53.4.931 · Cited by 512

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

Hertz, R., Magenheim, J., Berman, I., & Bar‐Tana, J. (1998) · Nature · doi:10.1038/33185 · Cited by 509

Cannabinoids go nuclear: evidence for activation of peroxisome proliferator‐activated receptors

O’Sullivan, S. E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707423 · Cited by 509

Orphan Nuclear Receptors: Shifting Endocrinology into Reverse

Kliewer, S. A., Lehmann, J. M., & Willson, T. M. (1999) · Science · doi:10.1126/science.284.5415.757 · Cited by 499

PPAR Signaling in the Control of Cardiac Energy Metabolism

Barger, P. M., & Kelly, D. P. (2000) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(00)00077-3 · Cited by 502

Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription

Tan, N.-S., Shaw, N. S., Vinckenbosch, N., Liu, P., Yasmin, R., Desvergne, B., Wahli, W., & Noy, N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5114-5127.2002 · Cited by 499

Conjugated linoleic acids: are they beneficial or detrimental to health?

Wahle, K. W. J., Heys, S. D., & Rotondo, D. (2004) · Progress in Lipid Research · doi:10.1016/j.plipres.2004.08.002 · Cited by 505

PPARδ regulates glucose metabolism and insulin sensitivity

Lee, C., Olson, P., Hevener, A. L., Mehl, I. R., Chong, L.-W., Olefsky, J. M., Gonzalez, F. J., Ham, J., Kang, H., Peters, J. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511253103 · Cited by 495

Molecular basis of skeletal muscle plasticity-from gene to form and function

Flück, M., & Hoppeler, H. H. (2003) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/s10254-002-0004-7 · Cited by 493

Action of epoxyeicosatrienoic acids on cellular function

Spector, A. A., & Norris, A. W. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00402.2006 · Cited by 487

Control of Macrophage Activation and Function by PPARs

Chawla, A. (2010) · Circulation Research · doi:10.1161/circresaha.110.216523 · Cited by 531

Androstane metabolites bind to and deactivate the nuclear receptor CAR-β

FORMAN, B. M., Tzameli, I., Choi, H., Chen, J., Simha, D., Seol, W., Evans, R. M., & Moore, D. D. (1998) · Nature · doi:10.1038/26996 · Cited by 476

The Properties of Lauric Acid and Their Significance in Coconut Oil

Dayrit, F. M. (2015) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-014-2562-7 · Cited by 479

An update on PPAR activation by cannabinoids

O'Sullivan, S. E. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13497 · Cited by 449

Structural basis for the activation of PPARγ by oxidized fatty acids

Itoh, T., Fairall, L., Amin, K., Inaba, Y., Szántó, A., Bálint, B. L., Nagy, L., Yamamoto, K., & Schwabe, J. W. R. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1474 · Cited by 471

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

Forman, B. M., Chen, J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4312 · Cited by 2,116

Fatty Acids Bind Directly to and Activate Peroxisome Proliferator-activated Receptors α and γ

Wolf, G. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01693.x · Cited by 22

Evidence for Direct Binding of Fatty Acids and Eicosanoids to Human Peroxisome Proliferators-Activated Receptor α

Murakami, K., Ide, T., Suzuki, M., Mochizuki, T., & Kadowaki, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0951 · Cited by 92

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

Schoonjans, K., Staels, B., & Auwerx, J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42003-6 · Cited by 1,216

Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism

Smith, S. A. (2002) · Biochemical Society Transactions · doi:10.1042/bst0301086 · Cited by 110