Cited by 2,164Peroxisome Proliferator-Activated ReceptorsFatty Acid Research and HealthCholesterol and Lipid Metabolism

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Open access

Kliewer, Steven A., Sundseth, Scott S., Jones, Stacey A., Brown, Peter J., Wisely, G. Bruce, Koble, Cecilia S., Devchand, Pallavi, Wahli, Walter, Willson, Timothy M., Lenhard, James M., Lehmann, Jürgen M.·1997·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.94.9.4318PMC PMC20720

Open this paper in CoChat — free account

Abstract

Peroxisome proliferator-activated receptors (PPARs) alpha and gamma are key regulators of lipid homeostasis and are activated by a structurally diverse group of compounds including fatty acids, eicosanoids, and hypolipidemic drugs such as fibrates and thiazolidinediones. While thiazolidinediones and 15-deoxy-Delta12, 14-prostaglandin J2 have been shown to bind to PPARgamma, it has remained unclear whether other activators mediate their effects through direct interactions with the PPARs or via indirect mechanisms. Here, we describe a novel fibrate, designated GW2331, that is a high-affinity ligand for both PPARalpha and PPARgamma. Using GW2331 as a radioligand in competition binding assays, we show that certain mono- and polyunsaturated fatty acids bind directly to PPARalpha and PPARgamma at physiological concentrations, and that the eicosanoids 8(S)-hydroxyeicosatetraenoic acid and 15-deoxy-Delta12,14-prostaglandin J2 can function as subtype-selective ligands for PPARalpha and PPARgamma, respectively. These data provide evidence that PPARs serve as physiological sensors of lipid levels and suggest a molecular mechanism whereby dietary fatty acids can modulate lipid homeostasis.

Integrity signals

Registry

Crossref · 10.1073/pnas.94.9.4318

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,857
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint
Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,181
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028
Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators
Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,652
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,402
Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
Dreyer, C., Krey, G. D., Keller, H., Givel, F., Helftenbein, G., & Wahli, W. (1992) · Cell · doi:10.1016/0092-8674(92)90031-7 · Cited by 1,393
The PPARα–leukotriene B4 pathway to inflammation control
Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345
Self-citation

Flagged first, then by citations

Show all 41 references

Research works printed but not linked: 1

A L Catapano Pharmacol Rev 26, 331–340 (1992).

Sorted by citations

Items 501–600 of 1,002

Alcoholic Liver Injury in the Rat Is Associated with Reduced Expression of Peroxisome Proliferator-α (PPARα)-Regulated Genes and Is Ameliorated by PPARα Activation
Nanji, A. A., Dannenberg, A. J., Jokelainen, K., & Bass, N. M. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.064717 · Cited by 107
Molecular Mechanisms of Cytochrome P-450 Induction by Xenobiotics: An Expanded Role for Nuclear Hormone Receptors
Savas, Ü., Griffin, K. J., & Johnson, E. F. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.5.851 · Cited by 106
Lauric Acid Is an Inhibitor of Clostridium difficile Growth in Vitro and Reduces Inflammation in a Mouse Infection Model
Yang, H.-T., Chen, J.-W., Rathod, J., Jiang, Y.-Z., Tsai, P.-J., Hung, Y.-P., Ko, W.-C., Paredes-Sabja, D., & Huang, I.-H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02635 · Cited by 117
Toxicological consequences of altered peroxisome proliferator-activated receptor γ (PPARγ) expression in the liver: insights from models of obesity and type 2 diabetes11Abbreviations: PPAR, peroxisome proliferator-activated receptor; 15d-PGJ2, 15-deoxy-Δ12,14-prostaglandin J2; NEFA, non-esterified fatty acid; T2DM, type 2 (non-insulin-dependent) diabetes mellitus; LPS, lipopolysaccharide; NSAIDs, nonsteroidal anti-inflammatory drugs; IL, interleukin; TNF α, tumor necrosis factor-α; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; and TZD, thiazolidinedione.
Boelsterli, U. A., & Bedoucha, M. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00817-6 · Cited by 103
Peroxisome Proliferator-induced Long Chain Acyl-CoA Thioesterases Comprise a Highly Conserved Novel Multi-gene Family Involved in Lipid Metabolism
Hunt, M. C., Nousiainen, S. E. B., Huttunen, M., Orii, K. E., Svensson, T., & Alexson, S. E. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34317 · Cited by 106
Expression of PPAR and RXR Isoforms in the Developing Rat and Human Term Placentas
Wang, Q., Fujii, H., & Knipp, G. T. (2002) · Placenta · doi:10.1053/plac.2002.0855 · Cited by 108
A Licorice Ethanolic Extract with Peroxisome Proliferator-Activated Receptor-γ Ligand-Binding Activity Affects Diabetes in KK-Ay Mice, Abdominal Obesity in Diet-Induced Obese C57BL Mice and Hypertension in Spontaneously Hypertensive Rats
Mae, T., Kitahara, M., Nishiyama, T., Tsukagawa, M., Konishi, E., Kishida, H., Kuroda, M., Mimaki, Y., Sashida, Y., Takahashi, K., et al. (2003) · Journal of Nutrition · doi:10.1093/jn/133.11.3369 · Cited by 105
Cyclooxygenase-2 Is Induced in Monocytes by Peroxisome Proliferator Activated Receptor γ and Oxidized Alkyl Phospholipids from Oxidized Low Density Lipoprotein
Pontsler, A. V., Hilaire, A. S., Marathe, G. K., Zimmerman, G. A., & McIntyre, T. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109546200 · Cited by 105
A Tailored Therapy for the Metabolic Syndrome
Etgen, G. J., Oldham, B. A., Johnson, W. T., Broderick, C. L., Montrose, C., Brozinick, J. T., Misener, E. A., Bean, J. S., Bensch, W. R., Brooks, D. A., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1083 · Cited by 104
TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation
Xie, S., Lee, Y.-F., Kim, E., Chen, L.-M., Ni, J., Fang, L., Liu, S., Lin, S.-J., Abe, J., Berk, B. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905724106 · Cited by 104
The biochemistry of oleate induction: Transcriptional upregulation and peroxisome proliferation
Gurvitz, A., & Rottensteiner, H. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.07.011 · Cited by 111
PPARs and the kidney in metabolic syndrome
Ruan, X. Z., Zheng, F., & Guan, Y. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00152.2007 · Cited by 103
Transcriptional Regulation of the Mouse Uncoupling Protein-2 Gene
Medvedev, A. V., Snedden, S. K., Raimbault, S., Ricquier, D., & Collins, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010587200 · Cited by 101
Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milkPreprint
Wan, Y., Saghatelian, A., Chong, L.-W., Zhang, C.-L., Cravatt, B. F., & Evans, R. M. (2007) · Genes & Development · doi:10.1101/gad.1567207 · Cited by 104
Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages
Im, D. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.094 · Cited by 104
Role of Peroxisome Proliferator‐Activated Receptors in Inflammation Control
Youssef, J., & Badr, M. Z. (2004) · BioMed Research International · doi:10.1155/s1110724304308065 · Cited by 105
Glucose-Induced Preproinsulin Gene Expression Is Inhibited by the Free Fatty Acid Palmitate
Ritz-Laser, B., Meda, P., Constant, I., Klages, N., Charollais, A., Morales, A., Magnan, C., Ktorza, A., & Philippé, J. (1999) · Endocrinology · doi:10.1210/endo.140.9.6953 · Cited by 114
Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development
Moulson, C. L., Martin, D. R., Lugus, J. J., Schaffer, J. E., Lind, A. C., & Miner, J. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0431186100 · Cited by 103
Dietary modulation of peroxisome proliferator-activated receptor gamma
Marion‐Letellier, R., Déchelotte, P., Iacucci, M., & Ghosh, S. K. (2008) · Gut · doi:10.1136/gut.2008.162859 · Cited by 103
Short Communication: PPARγ Mediates a Direct Antiangiogenic Effect of ω3-PUFAs in Proliferative Retinopathy
Stahl, A., Sapieha, P. S., Connor, K. M., SanGiovanni, J. P., Chen, J., Aderman, C. M., Willett, K. L., Krah, N. M., Dennison, R. J., Seaward, M. R., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.221317 · Cited by 104
Analysis of the mouse and human acyl‐CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs 1
Hunt, M. C., Rautanen, A., Westin, M. A. K., Svensson, T., & Alexson, S. E. H. (2006) · The FASEB Journal · doi:10.1096/fj.06-6042com · Cited by 102
A modified high-fat diet induces insulin resistance in rat skeletal muscle but not adipocytes
Wilkes, J. J., Bonen, A., & Bell, R. C. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.4.e679 · Cited by 102
L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor γ
Elbrecht, A., Chen, Y., Adams, A., Berger, J. P., Griffin, P. R., Klatt, T., Zhang, B., Menke, J. G., Zhou, G., Smith, R. G., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7913 · Cited by 102
Expression of peroxisome proliferator‐activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists
Yoshimura, R., Matsuyama, M., Segawa, Y., Hase, T., Mitsuhashi, M., Tsuchida, K., Wada, S., Kawahito, Y., Sano, H., & Nakatani, T. (2003) · International Journal of Cancer · doi:10.1002/ijc.10980 · Cited by 104
Metabolic host response and therapeutic approaches to influenza infection
Keshavarz, M., Solaymani‐Mohammadi, F., Namdari, H., Arjeini, Y., Mousavi, M. J., & Rezaei, F. (2020) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-020-00211-2 · Cited by 102
Very-Long-Chain and Branched-Chain Fatty Acyl-CoAs Are High Affinity Ligands for the Peroxisome Proliferator-Activated Receptor α (PPARα)
Hostetler, H. A., Kier, A. B., & Schroeder, F. (2006) · Biochemistry · doi:10.1021/bi060198l · Cited by 100
Is Iodine A Gatekeeper of the Integrity of the Mammary Gland?
Aceves, C., Anguiano, B., & Delgado, G. (2005) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-005-5401-5 · Cited by 100
Activation of Mitogen-Activated Protein Kinases by Peroxisome Proliferator-Activated Receptor Ligands: An Example of Nongenomic Signaling
Gardner, O., Dewar, B. J., & Graves, L. M. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.012260 · Cited by 99
Fine metabolic regulation in ruminants via nutrient–gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-α activation
Bionaz, M., Thering, B. J., & Loor, J. J. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002777 · Cited by 100
Co-regulation of Tissue-specific Alternative Human Carnitine Palmitoyltransferase Iβ Gene Promoters by Fatty Acid Enzyme Substrate
Yu, G.-S., Lu, Y., & Gulick, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32901 · Cited by 100
Editor's Note: Suppression of Tumor Cell Growth Both in Nude Mice and in Culture by n-3 Polyunsaturated Fatty Acids: Mediation through Cyclooxygenase-Independent Pathways
Boudreau, M. D., Sohn, K. H., Rhee, S. H., Lee, S. W., Hunt, J. D., & Hwang, D. H. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-2362 · Cited by 99
Structure-Based Drug Design of a Novel Family of PPARγ Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities
Lu, I.-L., Huang, C.-F., Peng, Y., Lin, Y., Hsieh, H., Chen, C., Lien, T., Lee, H., Mahindroo, N., Prakash, E., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051129s · Cited by 99
Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting
Palou, M., Priego, T., Sánchez, J., Villegas, E., Rodríguez, A. M., Palou, A., & Picó, C. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0461-1 · Cited by 103
Metabolic and Endocrine Effects of a Polyunsaturated Fatty Acid-Rich Diet in Polycystic Ovary Syndrome
Kasim-Karakas, S. E., Almario, R. U., Gregory, L., Wong, R., Todd, H., & Lasley, B. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030666 · Cited by 99
Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design
Montanari, R., Saccoccia, F., Scotti, E., Crestani, M., Godio, C., Gilardi, F., Loiodice, F., Fracchiolla, G., Laghezza, A., Tortorella, P., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800733h · Cited by 100
The pleiotropic function of PPARγ in the placenta
Schaiff, W. T., Barak, Y., & Sadovsky, Y. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.02.009 · Cited by 109
Induced expression of adipophilin mRNA in human macrophages stimulated with oxidized low‐density lipoprotein and in atherosclerotic lesions
Wang, X., Reape, T. J., Li, X., Rayner, K., Webb, C. L., Burnand, K. G., & Lysko, P. G. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01521-5 · Cited by 99
Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators
Corton, J. C., Lapinskas, P. J., & Gonzalez, F. J. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00232-8 · Cited by 99
Peroxisome Proliferator-activated Receptor β/δ Regulates Very Low Density Lipoprotein Production and Catabolism in Mice on a Western Diet
Akiyama, T. E., Lambert, G., Nicol, C. J., Matsusue, K., Peters, J. M., Brewer, H. B., & Gonzalez, F. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312802200 · Cited by 97
Pioglitazone Upregulates Angiotensin Converting Enzyme 2 Expression in Insulin-Sensitive Tissues in Rats with High-Fat Diet-Induced Nonalcoholic Steatohepatitis
Zhang, W., Xu, Y.-Z., Liu, B., Wu, R., Yang, Y., Xiao, X., & Zhang, X. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/603409 · Cited by 98
Obesity: molecular bases of a multifactorial problem
Palou, A., Serra, F. A., Bonet, M. L., & Picó, C. (2000) · European Journal of Nutrition · doi:10.1007/s003940070017 · Cited by 99
Ligand Activation of Peroxisome Proliferator–Activated Receptor β/δ (PPARβ/δ) Attenuates Carbon Tetrachloride Hepatotoxicity by Downregulating Proinflammatory Gene Expression
Shan, W., Palkar, P. S., Murray, I. A., McDevitt, E. I., Kennett, M. J., Kang, B. H., Isom, H. C., Perdew, G. H., Gonzalez, F. J., & Peters, J. M. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn142 · Cited by 97
Fatty Acid-binding Protein 5 (FABP5) Regulates Cognitive Function Both by Decreasing Anandamide Levels and by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ) in the Brain
Yu, S., Levi, L., Casadesús, G., Kunos, G., & Noy, N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.559062 · Cited by 97
Dietary n−3 and n−6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study
Lu, Y., Feskens, E. J. M., Dollé, M. E. T., Imholz, S., Verschuren, W. M. M., Müller, M. M., & Boer, J. M. A. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29130 · Cited by 98
Metabolic fate of saturated and monounsaturated dietary fats: The Mediterranean diet revisited from epidemiological evidence to cellular mechanisms
Bergouignan, A., Momken, I., Schoeller, D. A., Simon, C., & Blanc, S. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.02.004 · Cited by 99
Halofenate Is a Selective Peroxisome Proliferator–Activated Receptor γ Modulator With Antidiabetic Activity
Allen, T. L., Zhang, F., Moodie, S. A., Clemens, L. E., Smith, A. G., Gregoire, F. M., Bell, A., Muscat, G. E. O., & Gustafson, T. A. (2006) · Diabetes · doi:10.2337/db06-0618 · Cited by 97
Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells
Brocker, C. N., Yue, J., Kim, D., Qu, A., Bonzo, J. A., & Gonzalez, F. J. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00205.2016 · Cited by 93
Mediator Subunit Gal11p/MED15 Is Required for Fatty Acid-dependent Gene Activation by Yeast Transcription Factor Oaf1p
Thakur, J. K., Arthanari, H., Yang, F., Chau, K. H., Wagner, G., & Näär, A. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808263200 · Cited by 96
The modulatory effects of prostaglandin‐E on cytokine production by human peripheral blood mononuclear cells are independent of the prostaglandin subtype
Dooper, M. M. B. W., Wassink, L., M’Rabet, L., & Graus, Y. (2002) · Immunology · doi:10.1046/j.1365-2567.2002.01474.x · Cited by 96
A Functional Polymorphism in a STAT5B Site of the Human PPARγ3 Gene Promoter Affects Height and Lipid Metabolism in a French Population
Meirhaeghe, A., Fajas, L., Gouilleux, F., Cottel, D., Helbecque, N., Auwerx, J. H., & Amouyel, P. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000051382.28752.fe · Cited by 93
Nuclear receptors as drug targets for metabolic disease
Schulman, I. G. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.07.002 · Cited by 95
Nuclear receptors in neurodegenerative diseases
Skerrett, R., Malm, T., & Landreth, G. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.019 · Cited by 94
Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR
Luckert, C., Ehlers, A., Buhrke, T., Seidel, A., Lampen, A., & Hessel‐Pras, S. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.06.243 · Cited by 95
Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells
Ajmone‐Cat, M. A., Salvatori, M. L., Simone, R. D., Mancini, M., Biagioni, S., Bernardo, A., Cacci, E., & Minghetti, L. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22783 · Cited by 99
Modulation of peroxisome proliferator–activated receptor γ stability and transcriptional activity in adipocytes by resveratrol
Floyd, Z. E., Wang, Z. Q., Kilroy, G. E., & Cefalu, W. T. (2008) · Metabolism · doi:10.1016/j.metabol.2008.04.006 · Cited by 95
In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)α and PPARγ and quantitative analysis of in vivo induction pathway
Takeuchi, S., Matsuda, T., Kobayashi, S., Takahashi, T., & Kojima, H. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.08.011 · Cited by 100
Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection
Asatryan, A., & Bazan, N. G. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.783076 · Cited by 99
Pathogenesis of Alcoholic Liver Disease. Newer Mechanisms of Injury.
Crabb, D. W. (1999) · The Keio Journal of Medicine · doi:10.2302/kjm.48.184 · Cited by 95
Omega-3 fatty acids decrease oxidative stress and inflammation in macrophages from patients with small abdominal aortic aneurysm
Meital, L. T., Windsor, M., Perissiou, M., Schulze, K., Magee, R., Kuballa, A., Golledge, J., Bailey, T. G., Askew, C. D., & Russell, F. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-49362-z · Cited by 94
Reduction of Circulating Cholesterol and Apolipoprotein Levels during Sepsis
Fraunberger, P., Schaefer, S., Werdan, K., Walli, A. K., & Seidel, D. (1999) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1999.059 · Cited by 94
A causal relationship between unscheduled eicosanoid signaling and tumor development: cancer chemoprevention by inhibitors of arachidonic acid metabolism
Marks, F., Müller‐Decker, K., & Fürstenberger, G. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00301-2 · Cited by 95
Up-Regulation of Uncoupling Protein 3 Gene Expression by Fatty Acids and Agonists for PPARs in L6 Myotubes
Son, C., Hosoda, K., Matsuda, J., Fujikura, J., Yonemitsu, S., Iwakura, H., Masuzaki, H., Ogawa, Y., Hayashi, T., Itoh, H., et al. (2001) · Endocrinology · doi:10.1210/endo.142.10.8446 · Cited by 95
Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite
Clingman, C. C., Deveau, L. M., Hay, S. A., Genga, R. M. J., Shandilya, S. M. D., Massi, F., & Ryder, S. (2014) · eLife · doi:10.7554/elife.02848 · Cited by 92
Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats
Hussein, O. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i3.361 · Cited by 93
Phenolics with PPAR-γ ligand-Binding activity obtained from licorice ( Glycyrrhiza uralensis Roots) and ameliorative effects of glycyrin on genetically diabetic KK-A y mice
Kuroda, M., Mimaki, Y., Sashida, Y., Mae, T., Kishida, H., Nishiyama, T., Tsukagawa, M., Konishi, E., Takahashi, K., Kawada, T., et al. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.09.052 · Cited by 93
Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator–Activated Receptor Alpha (PPARα)
Thomas, M., Burk, O., Klumpp, B., Kandel, B. A., Damm, G., Weiß, T. S., Klein, K., Schwab, M. G., & Zanger, U. M. (2013) · Molecular Pharmacology · doi:10.1124/mol.112.082503 · Cited by 92
PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism
van Diepen, J. A., Jansen, P. A. M., Ballak, D. B., Hijmans, A., Hooiveld, G. J. E. J., Rommelaere, S., Galland, F., Naquet, P., Rutjes, F. P. J. T., Mensink, R. P., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.04.013 · Cited by 92
Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism
Jia, Y., Bhuiyan, M. J. H., Jun, H., Lee, J. H., Hoang, M. H., Lee, H.-J., Kim, N., Lee, D., Hwang, K. Y., Hwang, B. Y., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.07.095 · Cited by 92
Dietary effects of arachidonate-rich fungal oil and fish oil on murine hepatic and hippocampal gene expression.
Berger, A., Mutch, D. M., German, J. B., & Roberts, M. (2002) · Lipids in Health and Disease · doi:10.1186/1476-511x-1-2 · Cited by 90
The Activity of PPARγ in Primary Human Trophoblasts Is Enhanced by Oxidized Lipids
Schild, R. L., Schaiff, W. T., Carlson, M. G., Cronbach, E. J., Nelson, D. M., & Sadovsky, Y. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8284 · Cited by 93
PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
Majdalawieh, A. F., & Ro, H.-S. (2010) · Nuclear Receptor Signaling · doi:10.1621/nrs.08004 · Cited by 94
The role of peroxisome proliferator-activated receptor gamma in diabetes and obesity
Celi, F. S., & Shuldiner, A. R. (2002) · Current Diabetes Reports · doi:10.1007/s11892-002-0078-2 · Cited by 91
Top‐down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model
Martin, F., Wang, Y., Sprenger, N., Yap, I. K. S., Rezzi, S., Ramadan, Z., Peré‐Trepat, E., Rochat, F., Cherbut, C., van Bladeren, P., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.40 · Cited by 90
Molecular Mechanisms of Adipocyte Differentiation
Tong, Q., & Hotamışlıgil, G. S. (2001) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1011863414321 · Cited by 91
Interleukin 1β Induces Type II-secreted Phospholipase A2 Gene in Vascular Smooth Muscle Cells by a Nuclear Factor κB and Peroxisome Proliferator-activated Receptor-mediated Process
Couturier, C., Brouillet, A., Couriaud, C., Koumanov, K. S., Bereziat, G., & Andréani, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23085 · Cited by 91
Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting
Brocker, C. N., Kim, D., Melia, T., Karri, K., Velenosi, T. J., Takahashi, S., Aibara, D., Bonzo, J. A., Levi, M., Waxman, D. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19554-7 · Cited by 88
Membrane lipid alterations in the metabolic syndrome and the role of dietary oils
Perona, J. S. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.015 · Cited by 91
Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ
Shang, J., Brust, R., Mosure, S. A., Bass, J., Munoz‐Tello, P., Lin, H., Hughes, T., Tang, M., Ge, Q., Kamenekca, T. M., et al. (2018) · eLife · doi:10.7554/elife.43320 · Cited by 95
Multiple variants of the peroxisome proliferator-activated receptor (PPAR) γ are expressed in the liver of Atlantic salmon (Salmo salar)
Andersen, Ø., Eijsink, V. G. H., & Thomassen, M. S. (2000) · Gene · doi:10.1016/s0378-1119(00)00350-4 · Cited by 89
The role of the endocannabinoid system in lipogenesis and fatty acid metabolism
Vettor, R., & Pagano, C. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.10.002 · Cited by 90
The acute effects of olive oil v . cream on postprandial thermogenesis and substrate oxidation in postmenopausal women
Soares, M. J., Cummings, S. J., Mamo, J. C. L., Kenrick, M., & Piers, L. S. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20031047 · Cited by 89
Peroxisome proliferator activated receptor agonists
Kersten, S., & Wahli, W. (2000) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0348-8393-1_9 · Cited by 89
Selective targeting of cyclooxygenase-2 reveals its role in renal medullary interstitial cell survival
Hao, C., Kömhoff, M., Guan, Y., Redha, R., & Breyer, M. D. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.277.3.f352 · Cited by 89
Metabolism and functions of highly unsaturated fatty acids: An update
Nakamura, M., Cho, H. P., Xu, J., Tang, Z., & Clarke, S. D. (2001) · Lipids · doi:10.1007/s11745-001-0806-5 · Cited by 92
Peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma
Rumi, M. A. K., Sato, H., Ishihara, S., Kawashima, K., Hamamoto, S., Kazumori, H., Okuyama, T., Fukuda, R., Nagasue, N., & Kinoshita, Y. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1821 · Cited by 88
9‐oxo‐10(E),12(E)‐octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes
Kim, Y., Hirai, S., Takahashi, H., Goto, T., Ohyane, C., Tsugane, T., Konishi, C., Fujii, T., Inai, S., Iijima, Y., et al. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000264 · Cited by 88
The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants
Dupont, J., Scaramuzzi, R. J., & Reverchon, M. (2014) · animal · doi:10.1017/s1751731114000937 · Cited by 88
Peroxisome Proliferator‐Activated Receptors as Mediators of Phthalate‐Induced Effects in the Male and Female Reproductive Tract: Epidemiological and Experimental Evidence
Latini, G., Scoditti, E., Verrotti, A., Felice, C. D., & Massaro, M. (2007) · PPAR Research · doi:10.1155/2008/359267 · Cited by 93
Peroxisome proliferator-activated receptors in vascular biology and atherosclerosis: Emerging insights for evolving paradigms
Plutzky, J. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0067-3 · Cited by 87
Correlation between expression of peroxisome proliferator-activated receptor β and squamous differentiation in epidermal and tracheobronchial epithelial cells
Matsuura, H., Adachi, H., Smart, R. C., Xu, X., Arata, J., & Jetten, A. M. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00214-7 · Cited by 89
Bezafibrate is a dual ligand for PPARα and PPARβ: studies using null mice
Peters, J. M., Aoyama, T., Burns, A., & Gonzalez, F. J. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(03)00065-9 · Cited by 92
Impact of the Pro12Ala polymorphism of the PPAR-γ2 gene on serum triacylglycerol response to n−3 fatty acid supplementation
Lindi, V., Schwab, U., Louheranta, A. M., Laakso, M., Vessby, B. O., Hermansen, K., Storlien, L. H., Riccardi, G., & Rivellese, A. A. (2003) · Molecular Genetics and Metabolism · doi:10.1016/s1096-7192(03)00065-9 · Cited by 86
Activation of the orphan receptor RIP14 by retinoids
Zavacki, A. M., Lehmann, J. M., Seol, W., Willson, T. M., Kliewer, S. A., & Moore, D. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.7909 · Cited by 87
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
Ercolano, G., Gomez‐Cadena, A., Dumauthioz, N., Vanoni, G., Kreutzfeldt, M., Wyss, T., Michalik, L., Loyon, R., Ianaro, A., Ho, P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22764-2 · Cited by 87
Lipid sensing and lipid sensors
Grimaldi, P. A. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7278-5 · Cited by 89
Genes, Diet and Type 2 Diabetes Mellitus: A Review
Dedoussis, G. V., Kaliora, A. C., & Panagiotakos, D. B. (2007) · The Review of Diabetic Studies · doi:10.1900/rds.2007.4.13 · Cited by 91
A Novel Pathway Involving Progesterone Receptor, 12/15-Lipoxygenase-derived Eicosanoids, and Peroxisome Proliferator-activated Receptor γ Regulates Implantation in Mice
Li, Q., Cheon, Y., Kannan, A., Shanker, S., Bagchi, I. C., & Bagchi, M. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311773200 · Cited by 86
Serum lipids regulate dendritic cell CD1 expression and function
Leslie, D. S., Dascher, C. C., Cembrola, K., Townes, M. A., Hava, D. L., Hugendubler, L., Mueller, E., Fox, L. M., Roura‐Mir, C., Moody, D. B., et al. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02842.x · Cited by 86
Lipid concentrations and semen quality: the LIFE study
Schisterman, E. F., Mumford, S. L., Chen, Z., Browne, R. W., Barr, D. B., Kim, S., & Louis, G. M. B. (2014) · Andrology · doi:10.1111/j.2047-2927.2014.00198.x · Cited by 90
Digging deep into the pockets of orphan nuclear receptors: insights from structural studies
Benoit, G., Malewicz, M., & Perlmann, T. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.05.007 · Cited by 86

Authors: Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., & Lehmann, J. M.
Affiliations: University of Lausanne (CH)
ORCID: Kliewer, Steven A.
Sundseth, Scott S.
Brown, Peter J.
Wahli, Walter
Willson, Timothy M.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1997-04-29
Volume: 94
Issue: 9
Pages: 4318-4323
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.94.9.4318
PMC: PMC20720
OpenAlex: W2139002144
Cited by: 2,164
References: 41
Citations by year: 2026: 33 · 2025: 37 · 2024: 47 · 2023: 34 · 2022: 47 · 2021: 62 · 2020: 54 · 2019: 59 · 2018: 59 · 2017: 56 · 2016: 49 · 2015: 76 · 2014: 76 · 2013: 61 · 2012: 64
FWCI: 35.08
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: peroxisome proliferator-activated receptors, PPARα, PPARγ, fatty acids, eicosanoids, fibrates, thiazolidinediones, 15-deoxy-Δ12,14-prostaglandin J2, ligand binding, lipid homeostasis, gene expression regulation, dietary fatty acids
MeSH terms: Animals, Hypolipidemic Agents, Binding, Competitive, Butyrates, Fatty Acids, Gene Expression Regulation, Humans, Ligands, Phenylurea Compounds, Recombinant Fusion Proteins, Species Specificity, Transcription Factors, Xenopus, Eicosanoids, Receptors, Cytoplasmic and Nuclear, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks