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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Open accessAbstract
Peroxisome proliferator-activated receptors (PPARs) alpha and gamma are key regulators of lipid homeostasis and are activated by a structurally diverse group of compounds including fatty acids, eicosanoids, and hypolipidemic drugs such as fibrates and thiazolidinediones. While thiazolidinediones and 15-deoxy-Delta12, 14-prostaglandin J2 have been shown to bind to PPARgamma, it has remained unclear whether other activators mediate their effects through direct interactions with the PPARs or via indirect mechanisms. Here, we describe a novel fibrate, designated GW2331, that is a high-affinity ligand for both PPARalpha and PPARgamma. Using GW2331 as a radioligand in competition binding assays, we show that certain mono- and polyunsaturated fatty acids bind directly to PPARalpha and PPARgamma at physiological concentrations, and that the eicosanoids 8(S)-hydroxyeicosatetraenoic acid and 15-deoxy-Delta12,14-prostaglandin J2 can function as subtype-selective ligands for PPARalpha and PPARgamma, respectively. These data provide evidence that PPARs serve as physiological sensors of lipid levels and suggest a molecular mechanism whereby dietary fatty acids can modulate lipid homeostasis.
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“PPARs are nuclear hormone receptors that respond to binding of endogenous fatty acids and fatty acid derivatives such as eicosanoids, by regulating expression of genes within diverse cellular pathways including lipid metabolism and inflammation (Kliewer et al., 1997; Chinetti et al., 2000).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Kliewer et al., 1997
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Cites
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,857
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint
Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,181
Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028
Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,652
Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,402
Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
Dreyer, C., Krey, G. D., Keller, H., Givel, F., Helftenbein, G., & Wahli, W. (1992) · Cell · doi:10.1016/0092-8674(92)90031-7 · Cited by 1,393
The PPARα–leukotriene B4 pathway to inflammation control
Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345
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- A L Catapano Pharmacol Rev 26, 331–340 (1992).
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Yeon, J. E., Choi, K. M., Baik, S. H., Kim, K. O., Lim, H. J., PARK, K. H., Kim, J. Y., PARK, J., Kim, J. J., Bak, Y., et al. (2004) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03349.x · Cited by 72
Majeed, Y., Naguib, Y. M., Seymour, V. A. L., Wilson, L. A., Milligan, C. J., Agarwal, A. K., Sukumar, P., Naylor, J., & Beech, D. J. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.069922 · Cited by 71
VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids
Ruby, M. A., Goldenson, B., Orasanu, G., Johnston, T. P., Plutzky, J., & Krauss, R. M. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m005561 · Cited by 72
Wydooghe, E., Vandaele, L., Heras, S., Sutter, P. D., Deforce, D. L. D., Peelman, L. J., Schauwer, C. D., & Soom, A. V. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12241 · Cited by 69
Statins stimulate arachidonic acid release and prostaglandin I2 production in rat liver cells.
Levine, L. (2003) · Lipids in Health and Disease · doi:10.1186/1476-511x-2-1 · Cited by 72
LDL particle size: an important drug target?
Rajman, I., Eacho, P. I., Chowienczyk, P. J., & Ritter, J. M. (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00991.x · Cited by 51
Karaliota, S., Siafaka‐Kapadai, A., Gontinou, C., Psarra, K., & Mavri‐Vavayanni, M. (2009) · Obesity · doi:10.1038/oby.2009.177 · Cited by 75
Gauthier, A., Vassiliou, G., Benoist, F., & McPherson, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212989200 · Cited by 66
Itami, A., Watanabe, G., Shimada, Y., Hashimoto, Y., Kawamura, J., Kato, M., Hosotani, R., & Imamura, M. (2001) · International Journal of Cancer · doi:10.1002/ijc.1488 · Cited by 71
PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues
Costa, V., Gallo, M. A., Letizia, F., Aprile, M., Casamassimi, A., & Ciccodicola, A. (2010) · PPAR Research · doi:10.1155/2010/409168 · Cited by 75
The Rexinoid LG100754 Is a Novel RXR:PPARγ Agonist and Decreases Glucose Levelsin Vivo
Cesario, R. M., Klausing, K., Razzaghi, H., Crombie, D. L., Rungta, D. K., Heyman, R. A., & Lala, D. S. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.8.0677 · Cited by 71
PPARs in Inflammation, Atherosclerosis and Thrombosis
Duez, H., Fruchart, J., & Staels, B. (2001) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182670100800402 · Cited by 71
Antiepileptic popular ketogenic diet: emerging twists in an ancient story
Vamecq, J., Vallée, L., Lesage, F., Gressèns, P., & Stables, J. P. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.11.003 · Cited by 70
MacLaren, L. A., Güzeloğlu, A., Michel, F. J., & Thatcher, W. W. (2005) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.07.003 · Cited by 70
Effects of penthiopyrad on the development and behaviour of zebrafish in early-life stages
Qian, L., Qi, S., Cao, F., Zhang, J., Li, C., Song, M. O., & Wang, C. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.09.117 · Cited by 70
Fang, X., Hu, S., Watanabe, T., Weintraub, N. L., Snyder, G. D., Yao, J., Liu, Y., Shyy, J. Y.-J., Hammock, B. D., & Spector, A. A. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.085605 · Cited by 70
Keller, J. M., Collet, P., Bianchi, A., Huin‐Schohn, C., Krémarik, P., Bécuwe, P., Schohn, H., Domenjoud, L., & Dauça, M. (2000) · The International Journal of Developmental Biology · doi:10.1387/ijdb.11032176 · Cited by 70
Peroxisome proliferator-activated receptors: Lipid binding proteins controling gene expression
van Bilsen, M., Vusse, G. J., Gilde, A. J., Lindhout, M., & van der Lee, K. A. J. M. (2002) · Springer eBooks · doi:10.1007/978-1-4419-9270-3_17 · Cited by 71
Vaidya, S., Somers, E. P., Wright, S. D., Detmers, P. A., & Bansal, V. S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.6187 · Cited by 83
Töröcsik, D., Szanto, A., & Nagy, L. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.02.002 · Cited by 82
Structural Characterization of Amorfrutins Bound to the Peroxisome Proliferator-Activated Receptor γ
de Groot, J. C., Weidner, C., Krausze, J., Kawamoto, K., Schroeder, F. C., Sauer, S., & Büssow, K. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm3013272 · Cited by 69
Cabezas, F., Lagos, J., Céspedes, C., Vio, C. P., Bronfman, M., & Marzolo, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016794 · Cited by 67
Effect of n‐3 fatty acids on nutritional status and inflammatory markers in haemodialysis patients
Peruničić-Peković, G., Rašić, Z., Plješa, S., Sobajic, S. S., Djuricic, I. D., Maletić, R., & Ristić-Medić, D. (2007) · Nephrology · doi:10.1111/j.1440-1797.2007.00777.x · Cited by 69
Schleicher, J., Tokarski, C., Marbach, E., Matz‐Soja, M., Zellmer, S., Gebhardt, R., & Schuster, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.004 · Cited by 75
Parker, J. C. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00093-5 · Cited by 69
Clay, C. E., Namen, A. M., Atsumi, G.-I., Trimboli, A. J., Fonteh, A. N., High, K. P., & Chilton, F. H. (2001) · Journal of Investigative Medicine · doi:10.2310/6650.2001.33786 · Cited by 67
Hoseini, R., Damirchi, A., & Babaei, P. (2016) · Nutrition · doi:10.1016/j.nut.2016.06.010 · Cited by 72
Mechanisms of Peroxisome Proliferation by Perfluorooctanoic Acid and Endogenous Fatty Acids
Intrasuksri, U., Rangwala, S. M., O'Brien, O., Noonan, D. J., & Feller, D. R. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(98)00029-9 · Cited by 68
Lampen, A., Zimnik, S., & Nau, H. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00014-0 · Cited by 69
The gene expression profile of extraskeletal myxoid chondrosarcoma
Subramanian, S., West, R. B., Marinelli, R. J., Nielsen, T. O., Rubin, B. P., Goldblum, J. R., Patel, R. M., Zhu, S., Montgomery, K. D., Ng, T., et al. (2005) · The Journal of Pathology · doi:10.1002/path.1792 · Cited by 68
Prowse, N. A., & Hayley, S. P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.018 · Cited by 72
PPARγ and human trophoblast differentiation
Fournier, T., Guibourdenche, J., Handschuh, K., Tsatsaris, V., Rauwel, B., Davrinche, C., & Evain‐Brion, D. (2011) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2011.05.003 · Cited by 67
Hasan, A. U., Ohmori, K., Konishi, K., Igarashi, J., Hashimoto, T., Kamitori, K., Yamaguchi, F., Tsukamoto, I., Uyama, T., Ishihara, Y., et al. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.02.012 · Cited by 67
LC-MS analysis and environmental risk of lipid regulators
Hernando, M. D., Agüera, A., & Fernández‐Alba, A. R. (2006) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-006-0781-y · Cited by 67
Peroxisome proliferator‐activated receptor (PPAR) modulators: Diabetes and beyond*
Jones, A. B. (2001) · Medicinal Research Reviews · doi:10.1002/med.1025 · Cited by 67
Effects of fatty acids on uncoupling protein‐2 expression in the rat heart
van der Lee, K. A. J. M., Willemsen, P. H. M., Vusse, G. J., & van Bilsen, M. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.3.495 · Cited by 67
Mater, M. K., Pan, D. A., Bergen, W. G., & Jump, D. Β. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32513-x · Cited by 67
PPAR Agonists Amplify iNOS Expression While Inhibiting NF-κB
Cernuda‐Morollón, E., Rodríguez‐Pascual, F., Klatt, P., Lamas, S., & Pérez‐Sala, D. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000025786.87646.b1 · Cited by 67
Bell, A. R., Savory, R., Horley, N., Choudhury, A. I., Dickins, M., Gray, T. J. B., Salter, A. M., & Bell, D. (1998) · Biochemical Journal · doi:10.1042/bj3320689 · Cited by 67
Cheang, W. S., Tian, X. Y., Wong, W. T., & Huang, Y. (2014) · British Journal of Pharmacology · doi:10.1111/bph.13029 · Cited by 66
Yakunin, E., Loeb, V., Kisos, H., Biala, Y., Yehuda, S., Yaari, Y., Selkoe, D. J., & Sharon, R. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00530.x · Cited by 66
Yan, Z. H., Karam, W. G., Staudinger, J. L., Medvedev, A. V., Ghanayem, B. I., & Jetten, A. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.10948 · Cited by 66
Innate immune mechanisms linking non-esterified fatty acids and respiratory disease
Wood, L. G., Scott, H. A., Garg, M. L., & Gibson, P. G. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.10.001 · Cited by 67
Ehara, T., Kamei, Y., Yuan, X., Takahashi, M. M., Kanai, S., Tamura, E., Tsujimoto, K., Tamiya, T., Nakagawa, Y., Shimano, H., et al. (2014) · Diabetes · doi:10.2337/db14-0158 · Cited by 66
Bai, N., He, K., Ibarra, A., Bily, A. C., Roller, M., Chen, X., & Rühl, R. (2009) · Journal of Natural Products · doi:10.1021/np9003118 · Cited by 66
THUILLIER, P., BRASH, A. R., Kehrer, J. P., Stimmel, J. B., Leesnitzer, L. M., Yang, P., Newman, R. A., & Fischer, S. M. (2002) · Biochemical Journal · doi:10.1042/bj20020377 · Cited by 65
Shimazaki, N., Togashi, N., Hanai, M., Isoyama, T., Wada, K., Fujita, T., Fujiwara, K., & Kurakata, S. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.04.016 · Cited by 65
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Khuchua, Z. A., Glukhov, A. I., Strauss, A. W., & Javadov, S. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113464 · Cited by 62
Nwankwo, J. O., & Robbins, M. E. C. (2001) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0266 · Cited by 65
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Lee, J., Hong, S., Park, S. E., Rhee, E., Park, C., Oh, K.-W., Park, S., & Lee, W. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.07.031 · Cited by 64
Avella, M., Olivotto, I., Gioacchini, G., Maradonna, F., & Carnevali, O. (2007) · Aquaculture · doi:10.1016/j.aquaculture.2007.09.032 · Cited by 64
Popeijus, H. E., van Otterdijk, S. D., van der Krieken, S. E., Konings, M. C. J. M., Serbonij, K., Plat, J., & Mensink, R. P. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400314 · Cited by 64
Jové, M., Salla, J., Planavila, A., Cabrero, À., Michalik, L., Wahli, W., Laguna, J. C., & Vázquez‐Carrera, M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300208-jlr200 · Cited by 64
Binding analyses between Human PPARγ–LBD and ligands
Yu, C., Chen, L., Luo, H., Chen, J., Cheng, F., Gui, C., Zhang, R., Shen, J., Chen, K., Jiang, H., et al. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03937.x · Cited by 64
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Ziboh, V. A., Cho, Y., Mani, I., & Xi, S. (2002) · Archives of Pharmacal Research · doi:10.1007/bf02976988 · Cited by 63
Bento‐Abreu, A., Tabernero, A., & Medina, J. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04807.x · Cited by 63
Icre, G., Wahli, W., & Michalik, L. (2006) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/sj.jidsymp.5650007 · Cited by 58
Belchior, T., Paschoal, V. A., Magdalon, J., Chimin, P., Farias, T. M., Chaves‐Filho, A. B., Gorjão, R., St.‐Pierre, P., Miyamoto, S., Kang, J. X., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400914 · Cited by 68
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Zheng, J., Luo, Z., Zhuo, M., Pan, Y., Song, Y., Hu, W., & Chen, Q.-L. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514001378 · Cited by 65
Löhrke, B., Viergutz, T., Shahi, S. K., Pöhland, R., Wollenhaupt, K., Goldammer, T., Walzel, H., & KANITZ, W. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1590429 · Cited by 63
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Werling, U., Siehler, S., Litfin, M., Nau, H., & Göttlicher, M. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.5.1269 · Cited by 63
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Gani, O. A. B. S. M., & Sylte, I. (2008) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2008.04.008 · Cited by 61
Chinetti, G., Fruchart, J., & Staels, B. (2001) · Zeitschrift für Kardiologie · doi:10.1007/s003920170034 · Cited by 61
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Ding, X., Lichti-Kaiser, K., & Staudinger, J. L. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj163 · Cited by 64
Krempler, F., Breban, D., Oberkofler, H., Esterbauer, H., Hell, E., Paulweber, B., & Patsch, W. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.443 · Cited by 62
Smith, S. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.010 · Cited by 62
Transcriptional regulation of inflammatory secreted phospholipases A2
Andréani, M., Olivier, J. L., Berenbaum, F., Raymondjean, M., & Bereziat, G. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00117-7 · Cited by 63
Petridou, A., Tsalouhidou, S., Tsalis, G., Schulz, T., Michna, H., & Mougios, V. (2007) · Metabolism · doi:10.1016/j.metabol.2007.03.011 · Cited by 61
Kostenis, E. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.04.005 · Cited by 61
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Mersmann, H. J., & Ding, S. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00136-4 · Cited by 61
Nakamura, M., Cho, H. P., & Clarke, S. D. (2000) · Journal of Nutrition · doi:10.1093/jn/130.6.1561 · Cited by 61
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Nicolakakis, N. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00021 · Cited by 60
Differential expression, distribution, and function of PPAR-γ in the proximal and distal colon
Su, W., Bush, C. R., Necela, B. M., Calcagno, S. R., Murray, N. R., Fields, A. P., & Thompson, E. A. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00042.2007 · Cited by 60
Prostaglandins as PPAR γ Modulators in Adipogenesis
Fujimori, K. (2012) · PPAR Research · doi:10.1155/2012/527607 · Cited by 60
Raygan, F., Taghizadeh, M., Mirhosseini, N. Z., Akbari, E., Bahmani, F., Memarzadeh, M. R., Sharifi, N., Jafarnejad, S., Banikazemi, Z., & Asemi, Z. (2019) · Phytotherapy Research · doi:10.1002/ptr.6393 · Cited by 61
Xu, Y., Wang, Q., Cook, T. J., & Knipp, G. T. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20973 · Cited by 62
Lampen, A., Siehler, S., Ellerbeck, U., Göttlicher, M., & Nau, H. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8770 · Cited by 60
Lampen, A., Leifheit‐Nestler, M., Voss, J., & Nau, H. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.01.007 · Cited by 60
Izquierdo, M. S., & Koven, W. (2011) · doi:10.1002/9780470959862.ch2 · Cited by 60
Sant, K. E., Annunziato, K. M., Conlin, S. M., Teicher, G., Chen, P. B., Venezia, O. L., Downes, G. B., Park, Y., & Timme‐Laragy, A. R. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116644 · Cited by 59
Grabacka, M., Pierzchalska, M., & Reiss, K. (2013) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201011314030009 · Cited by 61
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Burniston, J. G. (2008) · PROTEOMICS · doi:10.1002/pmic.200800268 · Cited by 59
Kohno, H., Yoshitani, S., Takashima, S., Okumura, A., Hosokawa, M., Yamaguchi, N., & Tanaka, T. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb01108.x · Cited by 59
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Sauma, L., Stenkula, K. G., Kjølhede, P., Strålfors, P., Söderström, M., & Nyström, F. H. (2005) · Nutrition · doi:10.1016/j.nut.2005.04.011 · Cited by 59
Kewalramani, G., An, D., Kim, M. S., Ghosh, S., Qi, D., Abrahani, A., Pulinilkunnil, T., Sharma, V. S., Wambolt, R. B., Allard, M. F., et al. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.11.010 · Cited by 59
Shinohara, H., Taniguchi, K., Kumazaki, M., Yamada, N. O., Ito, Y., Otsuki, Y., Uno, B., Hayakawa, F., Minami, Y., Naoe, T., et al. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.01.039 · Cited by 60
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Metadata
- Authors
- Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., & Lehmann, J. M.
- Affiliations
- University of Lausanne (CH)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1997-04-29
- Volume
- 94
- Issue
- 9
- Pages
- 4318-4323
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC20720
- OpenAlex
- W2139002144
- Cited by
- 2,164
- References
- 41
- Citations by year
- 2026: 33 · 2025: 37 · 2024: 47 · 2023: 34 · 2022: 47 · 2021: 62 · 2020: 54 · 2019: 59 · 2018: 59 · 2017: 56 · 2016: 49 · 2015: 76 · 2014: 76 · 2013: 61 · 2012: 64
- FWCI
- 35.08
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- peroxisome proliferator-activated receptors, PPARα, PPARγ, fatty acids, eicosanoids, fibrates, thiazolidinediones, 15-deoxy-Δ12,14-prostaglandin J2, ligand binding, lipid homeostasis, gene expression regulation, dietary fatty acids
- MeSH terms
- Animals, Hypolipidemic Agents, Binding, Competitive, Butyrates, Fatty Acids, Gene Expression Regulation, Humans, Ligands, Phenylurea Compounds, Recombinant Fusion Proteins, Species Specificity, Transcription Factors, Xenopus, Eicosanoids, Receptors, Cytoplasmic and Nuclear, Mice
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