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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Open accessAbstract
Peroxisome proliferator-activated receptors (PPARs) alpha and gamma are key regulators of lipid homeostasis and are activated by a structurally diverse group of compounds including fatty acids, eicosanoids, and hypolipidemic drugs such as fibrates and thiazolidinediones. While thiazolidinediones and 15-deoxy-Delta12, 14-prostaglandin J2 have been shown to bind to PPARgamma, it has remained unclear whether other activators mediate their effects through direct interactions with the PPARs or via indirect mechanisms. Here, we describe a novel fibrate, designated GW2331, that is a high-affinity ligand for both PPARalpha and PPARgamma. Using GW2331 as a radioligand in competition binding assays, we show that certain mono- and polyunsaturated fatty acids bind directly to PPARalpha and PPARgamma at physiological concentrations, and that the eicosanoids 8(S)-hydroxyeicosatetraenoic acid and 15-deoxy-Delta12,14-prostaglandin J2 can function as subtype-selective ligands for PPARalpha and PPARgamma, respectively. These data provide evidence that PPARs serve as physiological sensors of lipid levels and suggest a molecular mechanism whereby dietary fatty acids can modulate lipid homeostasis.
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“PPARs are nuclear hormone receptors that respond to binding of endogenous fatty acids and fatty acid derivatives such as eicosanoids, by regulating expression of genes within diverse cellular pathways including lipid metabolism and inflammation (Kliewer et al., 1997; Chinetti et al., 2000).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Kliewer et al., 1997
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Cites
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,857
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint
Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,181
Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028
Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,652
Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,402
Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
Dreyer, C., Krey, G. D., Keller, H., Givel, F., Helftenbein, G., & Wahli, W. (1992) · Cell · doi:10.1016/0092-8674(92)90031-7 · Cited by 1,393
The PPARα–leukotriene B4 pathway to inflammation control
Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345
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- A L Catapano Pharmacol Rev 26, 331–340 (1992).
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Items 101–200 of 1,002
Combinatorial roles of nuclear receptors in inflammation and immunity
Glass, C. K., & Ogawa, S. (2005) · Nature reviews. Immunology · doi:10.1038/nri1748 · Cited by 472
Ravussin, É., & Smith, S. R. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04292.x · Cited by 466
Unsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells
Hannah, V. C., Ou, J., Luong, A., Goldstein, J. L., & Brown, M. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007273200 · Cited by 448
Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
Calder, P. C. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700289 · Cited by 465
Brandt, J. M., Djouadi, F., & Kelly, D. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23786 · Cited by 458
Braissant, O., & Wahli, W. (1998) · Endocrinology · doi:10.1210/endo.139.6.6049 · Cited by 457
PPARγ as a new therapeutic target in inflammatory bowel diseases
Dubuquoy, L., Rousseaux, C., Thuru, X., Peyrin-Biroulet, L., Romano, O., Chavatte, P., Chamaillard, M., & Desreumaux, P. (2006) · Gut · doi:10.1136/gut.2006.093484 · Cited by 450
Szántó, A., Bálint, B. L., Nagy, Z. S., Barta, E., Dezsö, B., Pap, A., Széles, L., Póliska, S., Oros, M., Evans, R. M., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.009 · Cited by 462
Rosiglitazone Causes Bone Loss in Mice by Suppressing Osteoblast Differentiation and Bone Formation
Ali, A., Weinstein, R. S., Stewart, S. A., PARFITT, A. M., Manolagas, S. C., & Jilka, R. L. (2005) · Endocrinology · doi:10.1210/en.2004-0735 · Cited by 444
Lecka‐Czernik, B., Moerman, E. J., Grant, D. F., Lehmann, J. M., Manolagas, S. C., & Jilka, R. L. (2002) · Endocrinology · doi:10.1210/endo.143.6.8834 · Cited by 449
PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action
Hernández-Quiles, M., Broekema, M. F., & Kalkhoven, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.624112 · Cited by 459
Savage, D. B., Tan, G. D., Acerini, C. L., Jebb, S. A., Agostini, M., Gurnell, M., Williams, R., Umpleby, A. M., Thomas, E. L., Bell, J. D., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.4.910 · Cited by 423
Chinetti, G., Gbaguidi, F. G., Griglio, S., Mallat, Z., Antonucci, M., Poulain, P., Chapman, J., Fruchart, J.-C., Tedgui, A., Najib-Fruchart, J., et al. (2000) · Circulation · doi:10.1161/01.cir.101.20.2411 · Cited by 428
Cellular Metabolism and Macrophage Functional Polarization
Zhu, L., Zhao, Q., Yang, T., Ding, W., & Zhao, Y. X. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.969421 · Cited by 438
mTOR , metabolism, and the regulation of T‐cell differentiation and function
Waickman, A. T., & Powell, J. D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01152.x · Cited by 420
Mueller, E., Smith, M. R., Sarraf, P., Kroll, T. G., Aiyer, A., Kaufman, D. S., Oh, W. K., Demetri, G. D., Figg, W. D., Zhou, X.-P., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180329197 · Cited by 427
A futile metabolic cycle activated in adipocytes by antidiabetic agents
Guan, H.-P., Li, Y., Jensen, M. V., Newgard, C. B., Steppan, C. M., & Lazar, M. A. (2002) · Nature Medicine · doi:10.1038/nm780 · Cited by 427
Yoshikawa, T., Shimano, H., Yahagi, N., Ide, T., Amemiya-Kudo, M., Matsuzaka, T., Nakakuki, M., Tomita, S., Okazaki, H., Tamura, Y., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105711200 · Cited by 426
Beffagna, G., Occhi, G., Nava, A. K., Vitiello, L., Ditadi, A., Basso, C., Bauce, B., Carraro, G., Thiene, G., & Towbin, J. A. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.10.005 · Cited by 433
Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors
Korbecki, J., Bobiński, R., & Dutka, M. (2019) · Inflammation Research · doi:10.1007/s00011-019-01231-1 · Cited by 415
Transcriptional activation of genes by 17β-estradiol through estrogen receptor-Sp1 interactions
Safe, S. H. (2001) · Vitamins and hormones · doi:10.1016/s0083-6729(01)62006-5 · Cited by 418
Statin-induced inhibition of the Rho-signaling pathway activates PPARα and induces HDL apoA-I
Martin, G., Duez, H., Blanquart, C., Bérézowski, V., Poulain, P., Fruchart, J., Najib-Fruchart, J., Glineur, C., & Staels, B. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10852 · Cited by 419
Clarke, S. D. (2001) · Journal of Nutrition · doi:10.1093/jn/131.4.1129 · Cited by 422
The cell biology of the retinal pigment epithelium
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422
Heilbronn, L. K., Smith, S. R., & Ravussin, É. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802853 · Cited by 416
Liberato, M. V., Nascimento, A. S., Ayers, S. D., Lin, J. Z., Čvoro, A., Silveira, R. L., Martínez, L., Souza, P. C. T., Saidemberg, D. M., Deng, T., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036297 · Cited by 421
Berger, J. P., Leibowitz, M. D., Doebber, T. W., Elbrecht, A., Zhang, B., Zhou, G., Biswas, C., Cullinan, C. A., Hayes, N. S., Li, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6718 · Cited by 412
PPARγ AND G LUCOSE H OMEOSTASIS
Picard, F., & Auwerx, J. H. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102808 · Cited by 412
Xu, J., Nakamura, M. T., Cho, H. P., & Clarke, S. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23577 · Cited by 499
Costet, P., Legendre, C., Moré, J., Edgar, A. D., Galtier, P., & Pineau, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29577 · Cited by 404
Yoon, J. C., Chickering, T. W., Rosen, E. D., Dussault, B., Qin, Y., Soukas, A., Friedman, J. M., Holmes, W. E., & Spiegelman, B. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5343-5349.2000 · Cited by 356
Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα
Moya-Camarena, S. Y., Heuvel, J. P. V., Blanchard, S. G., Leesnitzer, L. M., & Belury, M. A. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33384-8 · Cited by 401
The role and regulation of the peroxisome proliferator activated receptor alpha in human liver
Kersten, S., & Stienstra, R. (2017) · Biochimie · doi:10.1016/j.biochi.2016.12.019 · Cited by 405
Partial Agonists Activate PPARγ Using a Helix 12 Independent Mechanism
Bruning, J. B., Chalmers, M. J., Prasad, S., Busby, S. A., Kamenecka, T. M., He, Y., Nettles, K. W., & Griffin, P. R. (2007) · Structure · doi:10.1016/j.str.2007.07.014 · Cited by 404
Fatty Acid Regulation of Gene Transcription
Duplus, E., Glorian, M., & Forest, C. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000015200 · Cited by 396
Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration
Feher, J., Kovacs, I., Artico, M., Cavallotti, C., Papale, A., & Balacco Gabrieli, C. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.012 · Cited by 388
Bassaganya-Riera, J., Reynolds, K., Martino‐Catt, S. J., Cui, Y., Hennighausen, L. G., Gonzalez, F. J., Rohrer, J., Uribe-Benninghoff, A., & Hontecillas, R. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.049 · Cited by 397
Peroxisome proliferator-activated receptors: insight into multiple cellular functions
Escher, P., & Wahli, W. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00231-6 · Cited by 491
Metabolic factors affecting the inflammatory response of periparturient dairy cows
Sordillo, L. M., Contreras, G. A., & Aitken, S. L. (2009) · Animal Health Research Reviews · doi:10.1017/s1466252309990016 · Cited by 386
Retinoid X Receptor Heterodimers in the Metabolic Syndrome
Shulman, A. I., & Mangelsdorf, D. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043590 · Cited by 383
Juge-Aubry, C. E., Pernin, A., Favez, T., Burger, A., Wahli, W., Meier, C. A., & Desvergne, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25252 · Cited by 385
trans-Activation of PPARα and PPARγ by Structurally Diverse Environmental Chemicals
Maloney, E. K., & Waxman, D. J. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8809 · Cited by 388
Wright, H. M., Clish, C. B., Mikami, T., Hauser, S., Yanagi, K., Hiramatsu, R., Serhan, C. N., & Spiegelman, B. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1873 · Cited by 371
Akiyama, T. E., Sakai, S., Lambert, G. C., Nicol, C. J. B., Matsusue, K., Pimprale, S., Lee, Y., Ricote, M., Glass, C. K., Brewer, H. B., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2607-2619.2002 · Cited by 368
Omiecinski, C. J., Heuvel, J. P. V., Perdew, G. H., & Peters, J. M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq338 · Cited by 385
Yahagi, N., Shimano, H., Hasty, A. H., Amemiya-Kudo, M., Okazaki, H., Tamura, Y., Iizuka, Y., Shionoiri, F., Ohashi, K., Osuga, J.-I., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35840 · Cited by 364
Peroxisome proliferator‐activated receptors in the cardiovascular system
Bishop‐Bailey, D. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703149 · Cited by 365
Marx, N., Bourcier, T., Sukhova, G. K., Libby, P., & Plutzky, J. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.546 · Cited by 361
Evidence for Gene-Nutrient Interaction at the PPAR γ Locus
Luan, J., Browne, P. O., Harding, A.-H., Halsall, D. J., O’Rahilly, S., Chatterjee, K., & Wareham, N. J. (2001) · Diabetes · doi:10.2337/diabetes.50.3.686 · Cited by 363
PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis
Li, A. C., & Glass, C. K. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400010-jlr200 · Cited by 357
Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases
Monsalve, F. A., Pyarasani, R. D., Delgado‐López, F., & Moore‐Carrasco, R. (2013) · Mediators of Inflammation · doi:10.1155/2013/549627 · Cited by 358
Peroxisome proliferator-activated receptor gamma and cancers.
Koeffler, H. P. (2003) · PubMed · Cited by 349
Zhu, Y., Qi, C., Jain, S. R., Rao, M. S., & Reddy, J. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25500 · Cited by 351
Fan, C.-Y., Pan, J., Usuda, N., Yeldandi, A. V., Rao, M. S., & Reddy, J. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15639 · Cited by 343
Li, H., Ruan, X. Z., Powis, S. H., Fernando, R. L., Mon, W. Y., Wheeler, D. C., Moorhead, J. F., & Varghese, Z. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00151.x · Cited by 351
Peroxisome Proliferator–Activated Receptors as Transcriptional Nodal Points and Therapeutic Targets
Brown, J. D., & Plutzky, J. (2007) · Circulation · doi:10.1161/circulationaha.104.475673 · Cited by 345
Corton, J. C., Anderson, S. P., & Stauber, A. J. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.491 · Cited by 336
Chung, S. W., Kang, B. Y., Kim, S. H., Pak, Y. K., Cho, D., Trinchieri, G., & Kim, T. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002577200 · Cited by 340
Yoon, M. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.02.004 · Cited by 336
Fatty acids, eicosanoids and PPAR gamma
Marion‐Letellier, R., Savoye, G., & Ghosh, S. K. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.004 · Cited by 337
PPAR Activators as Antiinflammatory Mediators in Human T Lymphocytes
Marx, N., Kehrle, B., Kohlhammer, K., Grüb, M., Köenig, W., Hombach, V., Libby, P., & Plutzky, J. (2002) · Circulation Research · doi:10.1161/01.res.0000014225.20727.8f · Cited by 336
Kuang, J., Wang, J., Li, Y., Li, M., Zhao, M., Ge, K., Zheng, D., Cheung, K. C.-P., Liao, B., Wang, S., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.07.011 · Cited by 330
Prostaglandins, Leukotrienes and Essential Fatty Acids
Kaur, G., Sinclair, A. J., Cameron‐Smith, D., Barr, D. P., Molero, J. C., & Konstantopoulos, N. (2009) · Cited by 321
Mascaró, C., Acosta, E., Ortiz, J. A., Marrero, P. F., Hegardt, F. G., & Haro, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8560 · Cited by 318
T RANSCRIPTIONAL C ONTROL OF A DIPOGENESIS
Rangwala, S. M., & Lazar, M. A. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.535 · Cited by 318
Cardiac fatty acid uptake and transport in health and disease
Vusse, G. J. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00263-1 · Cited by 318
Fatty Acids as Modulators of the Immune Response
Fritsche, K. L. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092610 · Cited by 316
A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation
Oberfield, J. L., Collins, J. L., Holmes, C. P., Goreham, D. M., Cooper, J. P., Cobb, J. E., Lenhard, J. M., Hull-Ryde, E. A., Mohr, C. P., Blanchard, S. G., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6102 · Cited by 311
Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression
Kitajka, K., Sinclair, A. J., Weisinger, R. S., Weisinger, H. S., Mathai, M. L., Jayasooriya, A. P., Halver, J. E., & Puskás, L. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402342101 · Cited by 314
Yu, Y.-B., Correll, P. H., & Heuvel, J. P. V. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00126-9 · Cited by 312
PPARs: transcriptional effectors of fatty acids and their derivatives
Hihi, A. K., Michalik, L., & Wahli, W. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8467-x · Cited by 310
Todoric, J., Löffler, M. G., Huber, J., Bilban, M., Reimers, M., Kadl, A., Zeyda, M., Waldhäusl, W., & Stulnig, T. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0300-x · Cited by 318
Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation
Castrillo, A., & Tontonoz, P. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.012103.134432 · Cited by 260
Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells
Yang, X., Rodriguez, M. L., Leonard, A., Sun, L., Fischer, K. A., Wang, Y., Ritterhoff, J., Zhao, L., Kolwicz, S. C., Pabon, L., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.08.013 · Cited by 313
Ricote, M., Huang, J. T., Welch, J. S., & Glass, C. K. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.5.733 · Cited by 306
Anandamide induced PPARγ transcriptional activation and 3T3-L1 preadipocyte differentiation
Bouaboula, M., Hilairet, S., Marchand, J., Fajas, L., Fur, G. L., & Casellas, P. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.05.032 · Cited by 298
Yoshikawa, T., Ide, T., Shimano, H., Yahagi, N., Amemiya-Kudo, M., Matsuzaka, T., Yatoh, S., Kitamine, T., Okazaki, H., Tamura, Y., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0190 · Cited by 306
Vu‐Dac, N., Delannoy, S., Gervois, P. P., Bonnelye, E., Martin, G., Fruchart, J., Laudet, V., & Staels, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25713 · Cited by 297
Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease
Guan, Y., & Breyer, M. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00766.x · Cited by 292
Mechanisms of Gene Regulation by Fatty Acids
Georgiadi, A., & Kersten, S. (2012) · Advances in Nutrition · doi:10.3945/an.111.001602 · Cited by 304
Tamori, Y., Masugi, J., Nishino, N., & Kasuga, M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2045 · Cited by 294
Clarke, S. D. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000969 · Cited by 295
Peroxisome Proliferators Enhance Cyclooxygenase-2 Expression in Epithelial Cells
Meade, E. A., McIntyre, T. M., Zimmerman, G. A., & Prescott, S. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8328 · Cited by 292
Lee, H., Shi, W., Tontonoz, P., Wang, S., Subbanagounder, G., Hedrick, C. C., Hama, S. Y., Borromeo, C. M., Evans, R. M., Berliner, J. A., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.6.516 · Cited by 292
Prostacyclin therapies for the treatment of pulmonary arterial hypertension
Gomberg‐Maitland, M., & Olschewski, H. (2008) · European Respiratory Journal · doi:10.1183/09031936.00097107 · Cited by 291
Skeletal muscle mitochondrial remodeling in exercise and diseases
Gan, Z., Fu, T., Kelly, D. P., & Vega, R. B. (2018) · Cell Research · doi:10.1038/s41422-018-0078-7 · Cited by 297
Kimmel, A. R., & Sztalryd, C. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105410 · Cited by 297
Intestinal epithelial cells: At the interface of the microbiota and mucosal immunity
Soderholm, A. T., & Pedicord, V. A. (2019) · Immunology · doi:10.1111/imm.13117 · Cited by 281
Wei, M. Y., & Jacobson, T. A. (2011) · Current Atherosclerosis Reports · doi:10.1007/s11883-011-0210-3 · Cited by 284
Kohno, H., Suzuki, R., Yasui, Y., Hosokawa, M., Miyashita, K., & Tanaka, T. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03236.x · Cited by 284
Essential fatty acids in early life: structural and functional role
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Imamura, M., Inoguchi, T., Ikuyama, S., Taniguchi, S., Kobayashi, K., Nakashima, N., & Nawata, H. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00040.2002 · Cited by 281
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FORMAN, B. M., Ruan, B. H., Chen, J., Schroepfer, G. J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10588 · Cited by 280
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Reginato, M. J., Krakow, S. L., Bailey, S. T., & Lazar, M. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1855 · Cited by 286
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Metadata
- Authors
- Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., & Lehmann, J. M.
- Affiliations
- University of Lausanne (CH)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1997-04-29
- Volume
- 94
- Issue
- 9
- Pages
- 4318-4323
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC20720
- OpenAlex
- W2139002144
- Cited by
- 2,164
- References
- 41
- Citations by year
- 2026: 33 · 2025: 37 · 2024: 47 · 2023: 34 · 2022: 47 · 2021: 62 · 2020: 54 · 2019: 59 · 2018: 59 · 2017: 56 · 2016: 49 · 2015: 76 · 2014: 76 · 2013: 61 · 2012: 64
- FWCI
- 35.08
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- peroxisome proliferator-activated receptors, PPARα, PPARγ, fatty acids, eicosanoids, fibrates, thiazolidinediones, 15-deoxy-Δ12,14-prostaglandin J2, ligand binding, lipid homeostasis, gene expression regulation, dietary fatty acids
- MeSH terms
- Animals, Hypolipidemic Agents, Binding, Competitive, Butyrates, Fatty Acids, Gene Expression Regulation, Humans, Ligands, Phenylurea Compounds, Recombinant Fusion Proteins, Species Specificity, Transcription Factors, Xenopus, Eicosanoids, Receptors, Cytoplasmic and Nuclear, Mice
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