Cited by 2,164Peroxisome Proliferator-Activated ReceptorsFatty Acid Research and HealthCholesterol and Lipid Metabolism

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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

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Kliewer, Steven A., Sundseth, Scott S., Jones, Stacey A., Brown, Peter J., Wisely, G. Bruce, Koble, Cecilia S., Devchand, Pallavi, Wahli, Walter, Willson, Timothy M., Lenhard, James M., Lehmann, Jürgen M.·1997·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.94.9.4318PMC PMC20720

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Abstract

Peroxisome proliferator-activated receptors (PPARs) alpha and gamma are key regulators of lipid homeostasis and are activated by a structurally diverse group of compounds including fatty acids, eicosanoids, and hypolipidemic drugs such as fibrates and thiazolidinediones. While thiazolidinediones and 15-deoxy-Delta12, 14-prostaglandin J2 have been shown to bind to PPARgamma, it has remained unclear whether other activators mediate their effects through direct interactions with the PPARs or via indirect mechanisms. Here, we describe a novel fibrate, designated GW2331, that is a high-affinity ligand for both PPARalpha and PPARgamma. Using GW2331 as a radioligand in competition binding assays, we show that certain mono- and polyunsaturated fatty acids bind directly to PPARalpha and PPARgamma at physiological concentrations, and that the eicosanoids 8(S)-hydroxyeicosatetraenoic acid and 15-deoxy-Delta12,14-prostaglandin J2 can function as subtype-selective ligands for PPARalpha and PPARgamma, respectively. These data provide evidence that PPARs serve as physiological sensors of lipid levels and suggest a molecular mechanism whereby dietary fatty acids can modulate lipid homeostasis.

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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,857
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint
Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,181
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028
Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators
Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,652
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,402
Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
Dreyer, C., Krey, G. D., Keller, H., Givel, F., Helftenbein, G., & Wahli, W. (1992) · Cell · doi:10.1016/0092-8674(92)90031-7 · Cited by 1,393
The PPARα–leukotriene B4 pathway to inflammation control
Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345
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Show all 41 references

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A L Catapano Pharmacol Rev 26, 331–340 (1992).

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Helledie, T., Antonius, M., Sørensen, R. V., Hertzel, A. V., Bernlohr, D., Kølvraa, S., Kristiansen, K., & Mandrup, S. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31967-2 · Cited by 117
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Ogata, T., Miyauchi, T., Sakai, S., Irukayama‐Tomobe, Y., Goto, K., & Yamaguchi, I. (2002) · Clinical Science · doi:10.1042/cs103s284s · Cited by 115
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
Iershov, A., Nemazanyy, I., Alkhoury, C., Girard, M., Barth, E., Cagnard, N., Montagner, A., Chretien, D., Rugarli, E. I., Guillou, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09598-9 · Cited by 109
PPARγ-Mediated and Arachidonic Acid–Dependent Signaling Is Involved in Differentiation and Lipid Production of Human Sebocytes
Dózsa, A., Dezsö, B., Tóth, B. I., Bácsi, A., Póliska, S., Camera, E., Picardo, M., Zouboulis, C. C., Bı́ró, T., Schmitz, G., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.413 · Cited by 118
The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders
Cullingford, T. E. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.09.008 · Cited by 116
Insights into the Mechanism of Partial Agonism
Pochetti, G., Godio, C., Mitro, N., Caruso, D., Galmozzi, A., Scurati, S., Loiodice, F., Fracchiolla, G., Tortorella, P., Laghezza, A., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702316200 · Cited by 115
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Keelan, J. A., Sato, T. A., Marvin, K. W., Lander, J., Gilmour, R. S., & Mitchell, M. D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1257 · Cited by 112
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Marion‐Letellier, R., Butler, M., Déchelotte, P., Playford, R. J., & Ghosh, S. K. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.939 · Cited by 115
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Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., & Lizard, G. (2012) · Current Drug Metabolism · doi:10.2174/138920012803762729 · Cited by 111
Differential Regulation of Vascular Endothelial Growth Factor Expression by Peroxisome Proliferator-activated Receptors in Bladder Cancer Cells
Fauconnet, S., Lascombe, I., Chabannes, É., Adessi, G., Desvergne, B., Wahli, W., & Bittard, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200172200 · Cited by 109
Down-Regulation of Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 by High-Fat Feeding in Mice: A Potential Adaptive Mechanism Counteracting Metabolic Disease
Morton, N. M., Ramage, L. E., & Seckl, J. R. (2004) · Endocrinology · doi:10.1210/en.2003-1674 · Cited by 108
14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-α
Fang, X., Hu, S., Bingkun, X., Snyder, G. D., Harmon, S. D., Yao, J., Liu, Y., Sangras, B., Falck, J. R., Weintraub, N. L., et al. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00427.2005 · Cited by 111
Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
Wouters, K., van Bilsen, M., van Gorp, P. J., Bieghs, V., Lütjohann, D., Kerksiek, A., Staels, B., Hofker, M. H., & Shiri-Sverdlov, R. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.046 · Cited by 109
Adipose tissue as an endocrine organ
Prins, J. B. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2002.0222 · Cited by 121
The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization
Zizzo, G., & Cohen, P. (2015) · Journal of Inflammation · doi:10.1186/s12950-015-0081-4 · Cited by 94
Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health
Kumar, N. G., Contaifer, D., Madurantakam, P. A., Carbone, S., Price, E. T., Tassell, B. W. V., Brophy, D. F., & Wijesinghe, D. S. (2019) · Nutrients · doi:10.3390/nu11122974 · Cited by 116
Polyunsaturated Fatty Acids in Inflammatory Bowel Diseases
Marion‐Letellier, R., Savoye, G., Beck, P. L., Panaccione, R., & Ghosh, S. K. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182810122 · Cited by 110
Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library
Brown, P. J., Smith-Oliver, T. A., Charifson, P. S., Tomkinson, N. C. O., Fivush, A. M., Sternbach, D. D., Wade, L., Orband‐Miller, L. A., Parks, D. J., Blanchard, S. G., et al. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90299-4 · Cited by 110
Normal mammalian skeletal muscle and its phenotypic plasticity
Hoppeler, H. H., & Flück, M. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.205.15.2143 · Cited by 111
IL-4, but not vitamin D3, induces monoblastic cell line UG3 to differentiate into multinucleated giant cells on osteoclast lineage
Kaji, Y., Ikeda, K., Ikeda, T., Kawakami, K., Sasaki, K., Shindo, M., Hatake, K., Harada, M., Motoyoshi, K., Mori, S., et al. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200002)182:2 · Cited by 10
Cancer chemoprevention through interruption of multistage carcinogenesis
Marks, F., & Fürstenberger, G. (2000) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00318-4 · Cited by 110
Development of a Scintillation Proximity Assay for Peroxisome Proliferator-Activated Receptor γ Ligand Binding Domain
Nichols, J. S., Parks, D. J., Consler, T. G., & Blanchard, S. G. (1998) · Analytical Biochemistry · doi:10.1006/abio.1997.2557 · Cited by 110
Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver
Duwaerts, C. C., & Maher, J. J. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.02.001 · Cited by 113
PPARγ in Placental Angiogenesis
Nadra, K., Quignodon, L., Sardella, C., Joye, E., Mucciolo, A., Chrast, R., & Desvergne, B. (2010) · Endocrinology · doi:10.1210/en.2010-0131 · Cited by 109
Regulation of inflammation by PPARs: a future approach to treat lung inflammatory diseases?
Becker, J., Delayre‐Orthez, C., Frossard, N., & Pons, F. (2006) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2006.00425.x · Cited by 109
Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.
Haydon, R. C., Zhou, L., Tao, F., Breyer, B. N., Cheng, H., Jiang, W., Ishikawa, A., Peabody, T. D., MONTAG, A. G., Simon, M. A., et al. (2002) · PubMed · Cited by 109
Chemopreventive n-3 fatty acids activate RXR in colonocytes
Fan, Y. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg110 · Cited by 108
Dietary supplementation with ω-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload
Duda, M. K., O’Shea, K. M., LEI, B., Barrows, B. R., Azimzadeh, A., McElfresh, T. A., Hoit, B. D., Kop, W. J., & Stanley, W. C. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.07.002 · Cited by 105
Differential effect of waterborne cadmium exposure on lipid metabolism in liver and muscle of yellow catfish Pelteobagrus fulvidraco
Chen, Q.-L., Gong, Y., Luo, Z., Zheng, J., & Zhu, Q. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.09.011 · Cited by 106
-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential
Duda, M. K., O’Shea, K. M., & Stanley, W. C. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp169 · Cited by 105
Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial
Soleimani, Z., Hashemdokht, F., Bahmani, F., Taghizadeh, M., Memarzadeh, M. R., & Asemi, Z. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.06.010 · Cited by 107

Authors: Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., & Lehmann, J. M.
Affiliations: University of Lausanne (CH)
ORCID: Kliewer, Steven A.
Sundseth, Scott S.
Brown, Peter J.
Wahli, Walter
Willson, Timothy M.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1997-04-29
Volume: 94
Issue: 9
Pages: 4318-4323
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.94.9.4318
PMC: PMC20720
OpenAlex: W2139002144
Cited by: 2,164
References: 41
Citations by year: 2026: 33 · 2025: 37 · 2024: 47 · 2023: 34 · 2022: 47 · 2021: 62 · 2020: 54 · 2019: 59 · 2018: 59 · 2017: 56 · 2016: 49 · 2015: 76 · 2014: 76 · 2013: 61 · 2012: 64
FWCI: 35.08
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: peroxisome proliferator-activated receptors, PPARα, PPARγ, fatty acids, eicosanoids, fibrates, thiazolidinediones, 15-deoxy-Δ12,14-prostaglandin J2, ligand binding, lipid homeostasis, gene expression regulation, dietary fatty acids
MeSH terms: Animals, Hypolipidemic Agents, Binding, Competitive, Butyrates, Fatty Acids, Gene Expression Regulation, Humans, Ligands, Phenylurea Compounds, Recombinant Fusion Proteins, Species Specificity, Transcription Factors, Xenopus, Eicosanoids, Receptors, Cytoplasmic and Nuclear, Mice

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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

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