Cited by 557Coenzyme Q10 studies and effectsMitochondrial Function and PathologyNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

Open access

Matthews, Russell T., Yang, Lichuan, Browne, Susan, Baik, Myong, Beal, M. Flint·1998·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.95.15.8892PMC PMC21173

Open this paper in CoChat — free account

Abstract

Coenzyme Q 10 is an essential cofactor of the electron transport chain as well as a potent free radical scavenger in lipid and mitochondrial membranes. Feeding with coenzyme Q 10 increased cerebral cortex concentrations in 12- and 24-month-old rats. In 12-month-old rats administration of coenzyme Q 10 resulted in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q 10 . Oral administration of coenzyme Q 10 markedly attenuated striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increased life span in a transgenic mouse model of familial amyotrophic lateral sclerosis. These results show that oral administration of coenzyme Q 10 increases both brain and brain mitochondrial concentrations. They provide further evidence that coenzyme Q 10 can exert neuroprotective effects that might be useful in the treatment of neurodegenerative diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.95.15.8892

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
Wong, P. C., Pardo, C. A., Borchelt, D., Lee, M. K., Copeland, N. G., Jenkins, N. A., Sisodia, S. S., Cleveland, D. W., & Price, D. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90259-7 · Cited by 1,439
Aging, energy, and oxidative stress in neurodegenerative diseases
Beal, M. F. (1995) · Annals of Neurology · doi:10.1002/ana.410380304 · Cited by 1,434
Self-citation
ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions
Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80272-x · Cited by 1,341
Biochemical, physiological and medical aspects of ubiquinone function
Ernster, L., & Dallner, G. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00028-3 · Cited by 1,246
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
Beal, M. F. (1992) · Annals of Neurology · doi:10.1002/ana.410310202 · Cited by 962
Self-citation
Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis
Gurney, M. E., Cutting, F. B., Zhai, P., Doble, A., Taylor, C. P., Andrus, P. K., & Hall, E. D. (1996) · Annals of Neurology · doi:10.1002/ana.410390203 · Cited by 647
Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.
Frei, B. B., Kim, M. C., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4879 · Cited by 623
Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease
Mutisya, E. M., Bowling, A. C., & Beal, M. F. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062179.x · Cited by 531
Self-citation

Show all 49 references

Research works printed but not linked: 6

S Sugiyama, K Yamada, T Ozawa Biochem Mol Biol Int 37, 1111–1120 (1995).
A Sanbe, K Tanonaka, Y Niwano, S Takeo J Pharmacol Exp Ther 269, 51–56 (1994).
S Takeo, K Tanonaka, T Tazuma, K Miyake, R Murai J Pharmacol Exp Ther 243, 1131–1138 (1987).
T Nakamura, H Sanma, M Himeno, K Kato Transfer of Exogenous Coenzyme Q to Inner Membrane of Heart Mitochondria in Rats, eds Y Yamamura, K Folkers, Y Ito (Elsevier, Amsterdam) 2, 3–11 (1989).
V Valls, C Castelluccio, R Fato, M L Genova, C Bovina, G Saez, M Marchetti, P Castelli, G Lenaz Biochem Mol Biol Int 33, 633–642 (1994).
S Reahal, J Wrigglesworth Drug Metab Dispos 20, 423–427 (1992).

Sorted by citations

Items 101–200 of 556

A Bile Acid Protects against Motor and Cognitive Deficits and Reduces Striatal Degeneration in the 3-Nitropropionic Acid Model of Huntington's Disease
Keene, C. D., Rodrigues, C. M. P., Eich, T., Linehan-Stieers, C., Abt, A., Kren, B. T., Steer, C. J., & Low, W. C. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7755 · Cited by 132
Chronic fatigue syndrome: oxidative stress and dietary modifications.
Logan, A. C., & Wong, C. (2001) · PubMed · Cited by 132
Effect of Coenzyme Q10 Intake on Endogenous Coenzyme Q Content, Mitochondrial Electron Transport Chain, Antioxidative Defenses, and Life Span of Mice
Sohal, R. S., Kamzalov, S., Sumien, N., Ferguson, M., Rebrin, I., Heinrich, K. R., & Forster, M. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.037 · Cited by 131
Retinal energy metabolism in health and glaucoma
Casson, R. J., Chidlow, G., Crowston, J. G., Williams, P. A., & Wood, J. P. M. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100881 · Cited by 132
Prevention of Mitochondrial Oxidative Damage Using Targeted Antioxidants
Kelso, G. F., Porteous, C. M., Hughes, G., Ledgerwood, E. C., Gane, A. M., Smith, R. A. J., & Murphy, M. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02098.x · Cited by 132
Control of Reactive Oxygen Species for the Prevention of Parkinson’s Disease: The Possible Application of Flavonoids
Kim, T. Y., Leem, E., Lee, J. M., & Kim, S. R. (2020) · Antioxidants · doi:10.3390/antiox9070583 · Cited by 135
CoQ10 and Aging
de Barcelos, I. P., & Haas, R. (2019) · Biology · doi:10.3390/biology8020028 · Cited by 129
The uptake and distribution of coenzyme Q(10)
Miles, M. V. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.012 · Cited by 126
Mitochondria as targets for chemotherapy
Gogvadze, V. G., Orrenius, S., & Zhivotovsky, B. (2009) · APOPTOSIS · doi:10.1007/s10495-009-0323-0 · Cited by 127
Coenzyme Q, oxidative stress and aging
Sohal, R. S., & Forster, M. J. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.006 · Cited by 126
Mitochondrial Dysfunction during Brain Aging: Role of Oxidative Stress and Modulation by Antioxidant Supplementation.
Chakrabarti, S., Munshi, S., Banerjee, K., Thakurta, I. G., Sinha, M. S., & Bagh, M. B. (2011) · Europe PMC (PubMed Central) · Cited by 122
Cellular and molecular mechanisms of antioxidants in Parkinson's disease
Sutachan, J. J., Casas, Z., Albarracín, S. L., Stab, B. R., Samudio, I. J., González, J., Morales, L., & Barreto, G. E. (2012) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000033 · Cited by 127
The arachidonic acid 5‐lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor α activation of microglia and extends survival of G93A‐SOD1 transgenic mice
West, M. S., Mhatre, M., Ceballos, A., Floyd, R. A., Grammas, P., Gabbita, S. P., Hamdheydari, L., Mai, T., Mou, S., Pye, Q. N., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02700.x · Cited by 121
Mitochondrial respiratory chain super-complex I–III in physiology and pathology
Lenaz, G., Baracca, A., Barbero, G., Bergamini, C., Dalmonte, M. E., Sole, M. D., Faccioli, M., Falasca, A. I., Fato, R., Genova, M. L., et al. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.025 · Cited by 120
Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications☆
Bolaños, J. P., Moro, M. Á., Lizasoaín, I., & Almeida, Á. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.009 · Cited by 120
Statins and the Brain: More than Lipid Lowering Agents?
Fracassi, A., Marangoni, M., Rosso, P., Pallottini, V., Fioramonti, M., Siteni, S., & Segatto, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170703101816 · Cited by 116
Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice
Stack, E. C., Smith, K. M., Ryu, H., Cormier, K., Chen, M., Hagerty, S. W., Del Signore, S. J., Cudkowicz, M. E., Friedlander, R. M., & Ferrante, R. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.11.002 · Cited by 114
Current status of SOD1 mutations in familial amyotrophic lateral sclerosis
Gaudette, M. (2000) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820050515377 · Cited by 114
Coenzyme Q10 Combined With Mild Hypothermia After Cardiac Arrest
Damian, M. S., Ellenberg, D., Gildemeister, R., Lauermann, J., Simonis, G., Sauter, W., & Georgi, C. (2004) · Circulation · doi:10.1161/01.cir.0000146894.45533.c2 · Cited by 113
The Emerging Roles of Ferroptosis in Huntington’s Disease
Mi, Y., Gao, X., Xu, H., Cui, Y., Zhang, Y., & Gou, X. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8518-6 · Cited by 115
Coenzyme Q10administration and its potential for treatment of neurodegenerative diseases
Beal, M. F. (1999) · BioFactors · doi:10.1002/biof.5520090222 · Cited by 111
Self-citation
Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review
Fujimoto, C., & Yamasoba, T. (2019) · Antioxidants · doi:10.3390/antiox8040109 · Cited by 109
Complex Genetics of Amyotrophic Lateral Sclerosis
Kunst, C. B. (2004) · The American Journal of Human Genetics · doi:10.1086/426001 · Cited by 107
Quercetin, Coenzyme Q10, and l -canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain
Abdelgawad, H. M., & Khalifa, A. E. (2001) · Pharmacological Research · doi:10.1006/phrs.2000.0781 · Cited by 104
Uptake of Exogenous Coenzyme Q and Transport to Mitochondria Is Required for bc1 Complex Stability in Yeast coq Mutants
Santos‐Ocaña, C., Do, T. Q., Clarke, C. F., Padilla, S., & Navas, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112222200 · Cited by 104
The Mitochondrial Toxin 3-Nitropropionic Acid Induces Striatal Neurodegeneration via a c-Jun N-Terminal Kinase/c-Jun Module
García, M., Vanhoutte, P., Pagès, C., Besson, M., Brouillet, E., & Caboche, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02174.2002 · Cited by 102
Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments
Tefera, T. W., & Borges, K. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00611 · Cited by 100
Bioenergetics in Huntington's Disease
Grünewald, T. G. P., & Beal, M. F. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07827.x · Cited by 100
Self-citation
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Bartman, S., Coppotelli, G., & Ross, J. M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46030130 · Cited by 110
Therapy development in Huntington disease: From current strategies to emerging opportunities
Dickey, A. S., & Spada, A. R. L. (2017) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38494 · Cited by 103
Evaluation of Coenzyme Q as an Antioxidant Strategy for Alzheimer's Disease
Wadsworth, T. L., Bishop, J. A., Pappu, A. S., Woltjer, R. L., & Quinn, J. F. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14210 · Cited by 95
Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications
Morris, G., Anderson, G., Berk, M., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8477-8 · Cited by 96
α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging
Shrader, W. D., Amagata, A., Barnes, A. J., Enns, G. M., Hinman, A., Jankowski, O. D., Kheifets, V., Komatsuzaki, R., Lee, E., Mollard, P., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.04.085 · Cited by 98
Amyotrophic lateral sclerosis and oxidative stress: a double-blind therapeutic trial after curcumin supplementation
Chico, L., Ienco, E. C., Bisordi, C., Lo Gerfo, A., Petrozzi, L., Petrucci, A., Mancuso, M., & Siciliano, G. (2018) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527317666180720162029 · Cited by 95
Seizure-Induced Oxidative Stress in Status Epilepticus: Is Antioxidant Beneficial?
Lin, T., Chen, S., Lin, K.-J., & Chuang, Y. (2020) · Antioxidants · doi:10.3390/antiox9111029 · Cited by 96
Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease
Yoritaka, A., Kawajiri, S., Yamamoto, Y., Nakahara, T., Ando, M., Hashimoto, K., Nagase, M., Saito, Y., & Hattori, N. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.05.022 · Cited by 94
Regulation of the Mitochondrial Permeability Transition Pore by Ubiquinone Analogs. A Progress Report
Walter, L., Miyoshi, H., Leverve, X. M., Bernardi, P., & Fontaine, E. M. (2002) · Free Radical Research · doi:10.1080/10715760290021252 · Cited by 94
Co‐enzyme Q10 and idebenone use in Friedreich's ataxia
Parkinson, M. H., Schulz, J. B., & Giunti, P. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12322 · Cited by 92
Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis
Corona, J. C., Tovar‐y‐Romo, L. B., & Tapia, R. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.11.1415 · Cited by 91
The effect of 5-aminolevulinic acid on cytochrome c oxidase activity in mouse liver
Ogura, S., Maruyama, K., Hagiya, Y., Sugiyama, Y., Tsuchiya, K., Takahashi, K., Abe, F., Tabata, K., Okura, I., Nakajima, M., et al. (2011) · BMC Research Notes · doi:10.1186/1756-0500-4-66 · Cited by 93
Dietary Coenzyme Q10 and Vitamin E Alter the Status of These Compounds in Rat Tissues and Mitochondria
Ibrahim, W. H., Chow, C. K., Bhagavan, H. N., & Chopra, R. K. (2000) · Journal of Nutrition · doi:10.1093/jn/130.9.2343 · Cited by 91
Kaempferol protects against rat striatal degeneration induced by 3‐nitropropionic acid
Lagoa, R., López-Sánchez, C., Samhan-Arias, A., Gañan, C. M., García-Martínez, V., & Gutiérrez-Merino, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06331.x · Cited by 88
Isolation and Functional Expression of Human COQ3, a Gene Encoding a Methyltransferase Required for Ubiquinone Biosynthesis
Jonassen, T., & Clarke, C. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12381 · Cited by 89
Coenzyme Q Intake Elevates the Mitochondrial and Tissue Levels of Coenzyme Q and α-Tocopherol in Young Mice
Kamzalov, S., Sohal, R. S., Sumien, N., & Forster, M. J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3175 · Cited by 89
Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid
Rizzardini, M., Lupi, M., Bernasconi, S., Mangolini, A., & Cantoni, L. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00357-x · Cited by 89
Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer’s disease
Komaki, H., Faraji, N., Komaki‬, A., Shahidi, ‬., Etaee, F., Raoufi, S., & Mirzaei, F. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.025 · Cited by 91
Emerging Mitochondrial Therapeutic Targets in Optic Neuropathies
Sanchez, M. I. G. L., Crowston, J. G., Mackey, D. A., & Trounce, I. A. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.06.004 · Cited by 87
Development and Fertility in Caenorhabditis elegans clk-1 Mutants Depend upon Transport of Dietary Coenzyme Q8 to Mitochondria
Jonassen, T., Marbois, B. N., Faull, K. F., Clarke, C. F., & Larsen, P. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204758200 · Cited by 87
Mitochondrially targeted antioxidants and thiol reagents
Coulter, C. V., Kelso, G. F., Lin, T., Smith, R. A. J., & Murphy, M. P. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00255-0 · Cited by 89
Friedreich's Ataxia: Disease mechanisms, antioxidant and Coenzyme Q10therapy
Cooper, J. A. D., & Schapira, A. H. V. (2003) · BioFactors · doi:10.1002/biof.5520180219 · Cited by 86
Targeting Antioxidants to Mitochondria: A Potential New Therapeutic Strategy for Cardiovascular Diseases
Víctor, V. M., & Rocha, M. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780363077 · Cited by 85
Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice
Schilling, G., Savonenko, A. V., Coonfield, M. L., Morton, J. L., Vorovich, E. B., Gale, A., Neslon, C., Chan, N., Eaton, M., Fromholt, D., et al. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.003 · Cited by 85
Mitochondrial Targeting with Antioxidant Peptide SS-31 Prevents Mitochondrial Depolarization, Reduces Islet Cell Apoptosis, Increases Islet Cell Yield, and Improves Posttransplantation Function
Thomas, D. A., Stauffer, C., Zhao, K., Yang, H., Sharma, V. K., Szeto, H. H., & Suthanthiran, M. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006080825 · Cited by 84
Metabolic Reprogramming in Amyotrophic Lateral Sclerosis
Szelechowski, M., Amoêdo, N. D., Obre, É., Leger, C., Allard, L., Bonneu, M., Claverol, S., Lacombe, D., Oliet, S. H. R., Chevallier, S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22318-5 · Cited by 84
The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future
Wobst, H. J., Mack, K. L., Brown, D. G., Brandon, N. J., & Shorter, J. (2020) · Medicinal Research Reviews · doi:10.1002/med.21661 · Cited by 90
Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review
Carrera‐Juliá, S., Moreno, M. L., Barrios, C., Ortí, J. E. D. L. R., & Drehmer, E. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00063 · Cited by 87
Mitochondrial NAD+‐linked State 3 respiration and complex‐I activity are compromised in the cerebral cortex of 3‐nitropropionic acid‐induced rat model of Huntington’s disease
Pandey, M., Varghese, M., Madathil, S. K., Sreetama, S. C., Kaidery, N. A., Mohanakumar, K. P., & Rajamma, U. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04996.x · Cited by 83
Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases?
Dessolin, J., Schuler, M., Quinart, A., Giorgi, F. D., Ghosez, L., & Ichas, F. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01839-3 · Cited by 85
CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy
Sun, J. M., Zhu, H., Wang, X., Gao, Q., Li, Z., & Huang, H. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0578 · Cited by 86
Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet
Quiles, J. L., Ochoa, J. J., Huertas, J. R., & Mataix, J. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.002 · Cited by 82
Mitochondrial Dysfunction in Parkinson's Disease: Pathogenesis and Neuroprotection
Mounsey, R. B., & Teismann, P. (2010) · Parkinson s Disease · doi:10.4061/2011/617472 · Cited by 86
Antioxidant Therapeutics in Parkinson’s Disease: Current Challenges and Opportunities
Duarte-Jurado, A. P., Gopar‐Cuevas, Y., Cárdenas, O. S., Loera‐Arias, M. D. J., Montes‐de‐Oca‐Luna, R., García‐García, A., & Rodríguez‐Rocha, H. (2021) · Antioxidants · doi:10.3390/antiox10030453 · Cited by 83
Mitochondrial medicine for neurodegenerative diseases
Du, H., & Yan, S. S. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.01.004 · Cited by 82
Coenzyme Q and the Respiratory Chain: Coenzyme Q Pool and Mitochondrial Supercomplexes
Enrı́quez, J. A., & Lenaz, G. (2014) · Molecular Syndromology · doi:10.1159/000363364 · Cited by 84
Nutraceuticals in Migraine: A Summary of Existing Guidelines for Use
Rajapakse, T., & Pringsheim, T. M. (2016) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12789 · Cited by 80
Comprehensive Research on Past and Future Therapeutic Strategies Devoted to Treatment of Amyotrophic Lateral Sclerosis
Sever, B., Ciftci, H. I., DeMi̇rci̇, H., Sever, H., Ocak, F., Yuluğ, B., Tateishi, H., Tateishi, T., Otsuka, M., Fujita, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052400 · Cited by 80
Treatment of Parkinson???s Disease
Wu, S., & Frucht, S. J. (2005) · CNS Drugs · doi:10.2165/00023210-200519090-00001 · Cited by 78
Coenzyme Q treatment of neurodegenerative diseases of aging
Galpern, W. R., & Cudkowicz, M. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.01.004 · Cited by 78
Clinico‐Genetic, Imaging and Molecular Delineation of COQ8A ‐Ataxia: A Multicenter Study of 59 Patients
Traschütz, A., Schirinzi, T., Laugwitz, L., Murray, N. H., Bingman, C. A., Reich, S., Kern, J., Heinzmann, A., Vasco, G., Bertini, E., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25751 · Cited by 80
Coenzyme Q10 a mitochondrial restorer for various brain disorders
Pradhan, N., Singh, C., & Singh, A. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02161-8 · Cited by 79
Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway
Zahiri, H. S., Yoon, S. H., Keasling, J. D., Lee, S. H., Kim, S. W., Yoon, S. C., & Shin, Y. C. (2006) · Metabolic Engineering · doi:10.1016/j.ymben.2006.05.002 · Cited by 77
Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism
Abdin, A. A., & Hamouda, H. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.033 · Cited by 77
Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging
Vajó, Z., Jonassen, T., Wilkin, D. J., Ho, N. C., Münnich, A., Clarke, C. F., & Francomano, C. A. (1999) · Mammalian Genome · doi:10.1007/s003359901147 · Cited by 77
Therapeutic role of coenzyme Q10 in Parkinson's disease
Shults, C. W. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.02.002 · Cited by 81
Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection
Russo, R., Cavaliere, F., Rombolà, L., Gliozzi, M., Cerulli, A., Nucci, C., Fazzi, E. M., Bagetta, G., Corasaniti, M. T., & Morrone, L. A. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)01139-4 · Cited by 76
Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction
Murphy, M. P. (2001) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.1.5.753 · Cited by 76
Microencapsulation of ubiquinone-10 in carbohydrate matrices for improved stability
Bule, M. V., Singhal, R. S., & Kennedy, J. F. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.07.012 · Cited by 77
Concurrent Administration of Neu2000 and Lithium Produces Marked Improvement of Motor Neuron Survival, Motor Function, and Mortality in a Mouse Model of Amyotrophic Lateral Sclerosis
Shin, J. H., Cho, S. I., Lim, H. R., Lee, J. K., Lee, Y. A., Noh, J. S., Joo, I. S., Kim, K.-W., & Gwag, B. J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.030676 · Cited by 74
Coenzyme Q and Its Role in the Dietary Therapy against Aging
Varela-López, A., Giampieri, F., Battino, M., & Quiles, J. (2016) · Molecules · doi:10.3390/molecules21030373 · Cited by 86
Mitochondrial Dysfunction in Lysosomal Storage Disorders
de la Mata, M., Cotán, D., Paz, M. V., de Lavera, I., Álvarez-Córdoba, M., Luzón–Hidalgo, R., Suarez-Rivero, J. M., Tiscórnia, G., & Oropesa-Ávila, M. (2016) · Diseases · doi:10.3390/diseases4040031 · Cited by 78
Clinical trials in mitochondrial disorders, an update
Almannai, M., El‐Hattab, A. W., Ali, M. N., Soler‐Alfonso, C., & Scaglia, F. (2020) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2020.10.002 · Cited by 75
Nutraceuticals and Headache: The Biological Basis
Taylor, F. R. (2011) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2011.01847.x · Cited by 73
Apoptosis and its clinical impact
Gastman, B. (2001) · Head & Neck · doi:10.1002/hed.1052 · Cited by 72
Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system
Fernández‐Ayala, D. J. M., Brea‐Calvo, G., López‐Lluch, G., & Navas, P. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.05.010 · Cited by 74
Nanomicellar formulation of coenzyme Q10 (Ubisol-Q10) effectively blocks ongoing neurodegeneration in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model: potential use as an adjuvant treatment in Parkinson's disease
Sikorska, M., Lanthier, P., Miller, H., Beyers, M., Sodja, C., Zurakowski, B., Gangaraju, S., Pandey, S., & Sandhu, J. K. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.032 · Cited by 70
Comprehensive Behavioral Testing in the R6/2 Mouse Model of Huntington's Disease Shows No Benefit from CoQ10 or Minocycline
Menalled, L., Patry, M., Ragland, N., Lowden, P. A. S., Goodman, J., Minnich, J., Zahasky, B., Park, L., Leeds, J. M., Howland, D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009793 · Cited by 70
Coculture of Primary Motor Neurons and Schwann Cells as a Model for In Vitro Myelination
Hyung, S., Lee, B. Y., Park, J., Kim, J., Hur, E., & Suh, J. F. (2015) · Scientific Reports · doi:10.1038/srep15122 · Cited by 73
Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen
Wood-Allum, C. A. (2006) · Brain · doi:10.1093/brain/awl118 · Cited by 67
New developments on the functions of coenzyme Q in mitochondria
Genova, M. L., & Lenaz, G. (2011) · BioFactors · doi:10.1002/biof.168 · Cited by 69
Evidence of Mitochondrial Dysfunction in Autism and Implications for Treatment
Rossignol, D. A., & Bradstreet, J. (2008) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2008.208.217 · Cited by 69
Effects of age and dietary antioxidants on cerebral electron transport chain activity
Sharman, E. H., & Bondy, S. C. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00226-3 · Cited by 67
Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis
Jiang, Z., Wang, W., Perry, G., Zhu, X., & Wang, X. (2015) · Translational Neurodegeneration · doi:10.1186/s40035-015-0037-x · Cited by 66
Current state of coenzyme Q10 production and its applications
Jeya, M., Moon, H.-J., Lee, J.-L., Kim, I., & Lee, J.-K. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2380-2 · Cited by 66
Solanesol: a review of its resources, derivatives, bioactivities, medicinal applications, and biosynthesis
Yan, N., Liu, Y., Gong, D., Du, Y., Zhang, H., & Zhang, Z. (2015) · Phytochemistry Reviews · doi:10.1007/s11101-015-9393-5 · Cited by 66
Protective Effects of Antioxidants in Huntington’s Disease: an Extensive Review
Essa, M. M., Moghadas, M., Ba-Omar, T., Qoronfleh, M. W., Guillemin, G. J., Manivasagam, T., Justin‐Thenmozhi, A., Ray, B., Bhat, A., Chidambaram, S. B., et al. (2019) · Neurotoxicity Research · doi:10.1007/s12640-018-9989-9 · Cited by 68
Iron Brain Menace: The Involvement of Ferroptosis in Parkinson Disease
Lin, K.-J., Chen, S., Lin, K.-L., Liou, C., Lan, M., Chuang, Y., Wang, P., Lee, J., Wang, F., Lin, H., et al. (2022) · Cells · doi:10.3390/cells11233829 · Cited by 68
Kenyan purple tea anthocyanins ability to cross the blood brain barrier and reinforce brain antioxidant capacity in mice
Rashid, K., Wachira, F. N., Nyariki, J. N., Wanyonyi, B., Murilla, G. A., & Isaac, A. O. (2013) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000081 · Cited by 65
The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/− mice
Lapointe, J., Wang, Y., Bigras, E., & Hekimi, S. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201203090 · Cited by 64
Neuroprotective effects of coenzyme Q10 on neurological diseases: a review article
Bagheri, S., Haddadi, R., Saki, S., Kourosh‐Arami, M., Rashno, M., Mojaver, A., & Komaki‬, A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1188839 · Cited by 74
Ubiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing
Ma, W., Qin, L., Liu, F.-T., Gu, Z., Wang, J., Pan, Z. G., James, T. D., & Long, Y. (2013) · Scientific Reports · doi:10.1038/srep01537 · Cited by 64

Authors: Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F.
Affiliations: Harvard University (US)
ORCID: Matthews, Russell T.
Browne, Susan
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1998-07-21
Volume: 95
Issue: 15
Pages: 8892-8897
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.95.15.8892
PMC: PMC21173
OpenAlex: W2100454943
Cited by: 557
References: 49
Citations by year: 2026: 4 · 2025: 12 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 24 · 2020: 26 · 2019: 18 · 2018: 15 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 19 · 2013: 22 · 2012: 20
FWCI: 6.87
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ns031579-05)
National Institute on Aging (P01 AG 12992, P01AG012992)
National Institute of Neurological Disorders and Stroke (NS 16367, NS31579, P50NS016367)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: coenzyme Q10, cerebral cortex, neuroprotection, 3-nitropropionic acid, striatal lesions, amyotrophic lateral sclerosis, transgenic mouse model, lifespan, neurodegenerative diseases, electron transport chain, free radical scavenging, oral administration
MeSH terms: Administration, Oral, Animals, Brain, Coenzymes, Humans, Male, Mice, Transgenic, Mitochondria, Rats, Inbred F344, Superoxide Dismutase, Ubiquinone, Rats, Sprague-Dawley, Neuroprotective Agents, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks