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Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
Open accessAbstract
Coenzyme Q 10 is an essential cofactor of the electron transport chain as well as a potent free radical scavenger in lipid and mitochondrial membranes. Feeding with coenzyme Q 10 increased cerebral cortex concentrations in 12- and 24-month-old rats. In 12-month-old rats administration of coenzyme Q 10 resulted in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q 10 . Oral administration of coenzyme Q 10 markedly attenuated striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increased life span in a transgenic mouse model of familial amyotrophic lateral sclerosis. These results show that oral administration of coenzyme Q 10 increases both brain and brain mitochondrial concentrations. They provide further evidence that coenzyme Q 10 can exert neuroprotective effects that might be useful in the treatment of neurodegenerative diseases.
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“We also demonstrated that CoQ10 produces neuroprotective effects in transgenic mouse models of ALS and HD150, 151.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [150]
In the citing paper
“Oral administration of CoQ10 exerts significant neuroprotective effects against striatal lesions in rats produced by aminoxyacetic acid, and the mitochondrial toxins malonate and 3-NP148-150.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [150]
In the citing paper
“Similarly, oral administration of CoQ10 for 1 week, prior to administration of 3-NP resulted in a significant 90% neuroprotection against 3-NP induced striatal lesions150.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [150]
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Metadata
- Authors
- Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F.
- Affiliations
- Harvard University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1998-07-21
- Volume
- 95
- Issue
- 15
- Pages
- 8892-8897
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC21173
- OpenAlex
- W2100454943
- Cited by
- 557
- References
- 49
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 24 · 2020: 26 · 2019: 18 · 2018: 15 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 19 · 2013: 22 · 2012: 20
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ns031579-05)
- National Institute on Aging (P01 AG 12992, P01AG012992)
- National Institute of Neurological Disorders and Stroke (NS 16367, NS31579, P50NS016367)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- coenzyme Q10, cerebral cortex, neuroprotection, 3-nitropropionic acid, striatal lesions, amyotrophic lateral sclerosis, transgenic mouse model, lifespan, neurodegenerative diseases, electron transport chain, free radical scavenging, oral administration
- MeSH terms
- Administration, Oral, Animals, Brain, Coenzymes, Humans, Male, Mice, Transgenic, Mitochondria, Rats, Inbred F344, Superoxide Dismutase, Ubiquinone, Rats, Sprague-Dawley, Neuroprotective Agents, Mice, Rats
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