Cited by 557Coenzyme Q10 studies and effectsMitochondrial Function and PathologyNeuroprotection in Cerebral Ischemia

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Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

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Matthews, Russell T., Yang, Lichuan, Browne, Susan, Baik, Myong, Beal, M. Flint·1998·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.95.15.8892PMC PMC21173

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Abstract

Coenzyme Q 10 is an essential cofactor of the electron transport chain as well as a potent free radical scavenger in lipid and mitochondrial membranes. Feeding with coenzyme Q 10 increased cerebral cortex concentrations in 12- and 24-month-old rats. In 12-month-old rats administration of coenzyme Q 10 resulted in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q 10 . Oral administration of coenzyme Q 10 markedly attenuated striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increased life span in a transgenic mouse model of familial amyotrophic lateral sclerosis. These results show that oral administration of coenzyme Q 10 increases both brain and brain mitochondrial concentrations. They provide further evidence that coenzyme Q 10 can exert neuroprotective effects that might be useful in the treatment of neurodegenerative diseases.

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Authors: Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F.
Affiliations: Harvard University (US)
ORCID: Matthews, Russell T.
Browne, Susan
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1998-07-21
Volume: 95
Issue: 15
Pages: 8892-8897
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.95.15.8892
PMC: PMC21173
OpenAlex: W2100454943
Cited by: 557
References: 49
Citations by year: 2026: 4 · 2025: 12 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 24 · 2020: 26 · 2019: 18 · 2018: 15 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 19 · 2013: 22 · 2012: 20
FWCI: 6.87
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ns031579-05)
National Institute on Aging (P01 AG 12992, P01AG012992)
National Institute of Neurological Disorders and Stroke (NS 16367, NS31579, P50NS016367)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: coenzyme Q10, cerebral cortex, neuroprotection, 3-nitropropionic acid, striatal lesions, amyotrophic lateral sclerosis, transgenic mouse model, lifespan, neurodegenerative diseases, electron transport chain, free radical scavenging, oral administration
MeSH terms: Administration, Oral, Animals, Brain, Coenzymes, Humans, Male, Mice, Transgenic, Mitochondria, Rats, Inbred F344, Superoxide Dismutase, Ubiquinone, Rats, Sprague-Dawley, Neuroprotective Agents, Mice, Rats

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Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

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