Cited by 531Virus-based gene therapy researchRNA Interference and Gene DeliveryBarrier Structure and Function Studies

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Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system

Davidson, Beverly L., Stein, Colleen S., Heth, Jason A., Martins, Inês, Kotin, Robert M., Derksen, Todd A., Zabner, Joseph, Ghodsi, Abdi, Chiorini, John A.·2000·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.97.7.3428

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Abstract

Recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) can direct transgene expression in the central nervous system (CNS), but it is not known how other rAAV serotypes perform as CNS gene transfer vectors. Serotypes 4 and 5 are distinct from rAAV2 and from each other in their capsid regions, suggesting that they may direct binding and entry into different cell types. In this study, we examined the tropisms and transduction efficiencies of β-galactosidase-encoding vectors made from rAAV4 and rAAV5 compared with similarly designed rAAV2-based vectors. Injection of rAAV5 β-galactosidase (βgal) or rAAV4βgal into the lateral ventricle resulted in stable transduction of ependymal cells, with approximately 10-fold more positive cells than in mice injected with rAAV2βgal. Major differences between the three vectors were revealed upon striatal injections. Intrastriatal injection of rAAV4βgal resulted again in striking ependyma-specific expression of transgene, with a notable absence of transduced cells in the parenchyma. rAAV2βgal and rAAV5βgal intrastriatal injections led to β-gal-positive parenchymal cells, but, unlike rAAV2βgal, rAAV5βgal transduced both neurons and astrocytes. The number of transgene-positive cells in rAAV5βgal-injected brains was 130 and 5,000 times higher than in rAAV2βgal-injected brains at 3 and 15 wk, respectively. Moreover, transgene-positive cells were widely dispersed throughout the injected hemisphere in rAAV5βgal-transduced animals. Together, our data provide in vivo support for earlier in vitro work, suggesting that rAAV4 and rAAV5 gain cell entry by means of receptors distinct from rAAV2. These differences could be exploited to improve gene therapy for CNS disorders.

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Authors: Davidson, B. L., Stein, C. S., Heth, J. A., Martins, I., Kotin, R. M., Derksen, T. A., Zabner, J., Ghodsi, A., & Chiorini, J. A.
Affiliations: University of Iowa (US)
ORCID: Davidson, Beverly L.
Stein, Colleen S.
Heth, Jason A.
Kotin, Robert M.
Zabner, Joseph
Chiorini, John A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2000-02-25
Volume: 97
Issue: 7
Pages: 3428-3432
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.97.7.3428
OpenAlex: W4245307762
Cited by: 531
References: 35
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 14 · 2020: 9 · 2019: 18 · 2018: 25 · 2017: 16 · 2016: 14 · 2015: 26 · 2014: 22 · 2013: 18 · 2012: 14
FWCI: 18.13
Type: journal article
Language: en
Open access: closed
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Funders: Roy J. Carver Charitable Trust
National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-33531, R01HD033531)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: recombinant adeno-associated virus, AAV2, AAV5, serotype differences, ependymal cells, striatum, lateral ventricle injection, intrastriatal injection, transduction efficiency, cell tropism, beta-galactosidase expression, CNS gene therapy

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Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system

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