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Cited by 1,004

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

15-Deoxy-Δ 12,14 -prostaglandin J 2 inhibits multiple steps in the NF-κB signaling pathway

Open access
Straus, Daniel S., Pascual, Gabriel, Li, Mei, Welch, John S., Ricote, Mercedes, Hsiang, Chin-Hui, Sengchanthalangsy, Lei Lei, Ghosh, Gourisankar, Glass, Christopher K.·2000·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.97.9.4844
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Abstract

Prostaglandin J 2 (PGJ 2 ) and its metabolites Δ 12 -PGJ 2 and 15-deoxy-Δ 12,14 -PGJ 2 (15d-PGJ 2 ) are naturally occurring derivatives of prostaglandin D 2 that have been suggested to exert antiinflammatory effects in vivo . 15d-PGJ 2 is a high-affinity ligand for the peroxisome proliferator-activated receptor γ (PPARγ) and has been demonstrated to inhibit the induction of inflammatory response genes, including inducible NO synthase and tumor necrosis factor α, in a PPARγ-dependent manner. We report here that 15d-PGJ 2 potently inhibits NF-κB-dependent transcription by two additional PPARγ-independent mechanisms. Several lines of evidence suggest that 15d-PGJ 2 directly inhibits NF-κB-dependent gene expression through covalent modifications of critical cysteine residues in IκB kinase and the DNA-binding domains of NF-κB subunits. These mechanisms act in combination to inhibit transactivation of the NF-κB target gene cyclooxygenase 2. Direct inhibition of NF-κB signaling by 15d-PGJ 2 may contribute to negative regulation of prostaglandin biosynthesis and inflammation, suggesting additional approaches to the development of antiinflammatory drugs.

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Metadata

Authors
Straus, D. S., Pascual, G., Li, M., Welch, J. S., Ricote, M., Hsiang, C.-H., Sengchanthalangsy, L. L., Ghosh, G., & Glass, C. K.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2000-04-25
Volume
97
Issue
9
Pages
4844-4849
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.97.9.4844
OpenAlex
W1812573520
Cited by
1,004
References
3
FWCI
29.80
Type
journal article
Language
en
Open access
green

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