Cited by 813Advanced Glycation End Products researchProtein Kinase Regulation and GTPase SignalingNitric Oxide and Endothelin Effects

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Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

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Lander, Harry M., Tauras, James M., Ogiste, Jason S., Hori, Osamu, Moss, Rebecca A., Schmidt, Ann Marie·1997·Journal of Biological Chemistry

DOI 10.1074/jbc.272.28.17810

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Abstract

Advanced glycation end products (AGEs) exert their cellular effects on cells by interacting with specific cellular receptors, the best characterized of which is the receptor for AGE (RAGE). The transductional processes by which RAGE ligation transmits signals to the nuclei of cells is unknown and was investigated. AGE-albumin, a prototypic ligand, activated p21(ras) in rat pulmonary artery smooth muscle cells that express RAGE, whereas nonglycated albumin was without effect. MAP kinase activity was enhanced at concentrations of AGE-albumin, which activated p21(ras) and NF-kappaB. Depletion of intracellular glutathione rendered cells more sensitive to AGE-mediated activation of this signaling pathway. In contrast, signaling was blocked by preventing p21(ras) from associating with the plasma membrane or mutating Cys118 on p21(ras) to Ser. Signaling was receptor-dependent, because it was prevented by blocking access to RAGE with either anti-RAGE IgG or by excess soluble RAGE. These data suggest that RAGE-mediated induction of cellular oxidant stress triggers a cascade of intracellular signals involving p21(ras) and MAP kinase, culminating in transcription factor activation. The molecular mechanism that triggers this pathway likely involves oxidant modification and activation of p21(ras).

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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,793
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791
Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal Transduction
Sundaresan, M., Yu, Z.-X., Ferrans, V. J., Irani, K., & Finkel, T. (1995) · Science · doi:10.1126/science.270.5234.296 · Cited by 2,520
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512
Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis
Cybulsky, M. I., & Gimbrone, M. A. (1991) · Science · doi:10.1126/science.1990440 · Cited by 1,710
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,545
Self-citation
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins
Yan, S. D., Schmidt, A. M., Anderson, G. M., Zhang, J., Brett, J., Zou, Y., Pinsky, D. J., & Stern, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36966-1 · Cited by 1,305
Self-citation
Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix
Sell, D. R., & Monnier, V. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88225-8 · Cited by 1,082
Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.
Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J., & Stern, D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118175 · Cited by 896
Self-citation
Stimulation of p21ras upon T-cell activation
Downward, J., Graves, J. D., Warne, P. H., Rayter, S., & Cantrell, D. A. (1990) · Nature · doi:10.1038/346719a0 · Cited by 841

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Show all 34 references

Research works printed but not linked: 4

Brett, 1993, Am. J. Pathol., 143, 1699
Schmidt, 1994, Proc. Natl. Acad. Sci. U. S. A., 91, 8011
Fiedman, 1994, Circulation, 90, 1567
Stevenson, 1994, Cancer Res., 54, 12

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Authors: Lander, H. M., Tauras, J. M., Ogiste, J. S., Hori, O., Moss, R. A., & Schmidt, A. M.
Affiliations: Cornell University (US)
Columbia University Irving Medical Center (US)
Corresponding author: Lander, Harry M.
ORCID: Tauras, James M.
Hori, Osamu
Moss, Rebecca A.
Schmidt, Ann Marie
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1997-07
Volume: 272
Issue: 28
Pages: 17810-17814
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.272.28.17810
OpenAlex: W2047964022
Cited by: 813
References: 34
Citations by year: 2026: 8 · 2025: 10 · 2024: 11 · 2023: 14 · 2022: 13 · 2021: 12 · 2020: 14 · 2019: 9 · 2018: 19 · 2017: 26 · 2016: 24 · 2015: 28 · 2014: 31 · 2013: 32 · 2012: 36
FWCI: 14.73
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8502 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health (5r29ai037637-02, 5r01gm055509-03)
National Institute on Aging (AG00602)
National Institute of General Medical Sciences (GM55509)
National Institute of Allergy and Infectious Diseases (AI37637)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: advanced glycation end products, receptor for advanced glycation end products, RAGE, p21ras, MAPK signaling, oxidative stress, glutathione depletion, NF-κB activation, pulmonary artery smooth muscle cells, receptor tyrosine kinase signaling
MeSH terms: Receptor for Advanced Glycation End Products, Animals, Enzyme Activation, Glutathione, Receptors, Immunologic, Transferases, Signal Transduction, PC12 Cells, Glycation End Products, Advanced, Calcium-Calmodulin-Dependent Protein Kinases, Oxidative Stress, Alkyl and Aryl Transferases, Rats

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Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

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