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Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene
Open accessAbstract
Interleukin-5 (IL-5), which is produced by CD4(+) T helper 2 (Th2) cells, but not by Th1 cells, plays a key role in the development of eosinophilia in asthma. Despite increasing evidence that the outcome of many diseases is determined by the ratio of the two subsets of CD4(+) T helper cells, Th1 and Th2, the molecular basis for Th1- and Th2-specific gene expression remains to be elucidated. We previously established a critical role for the transcription factor GATA-3 in IL-5 promoter activation in EL-4 cells, which express both Th1- and Th2-type cytokines. Our studies reported here demonstrate that GATA-3 is critical for expression of the IL-5 gene in bona fide Th2 cells. Whereas mutations in the GATA-3 site abolished antigen- or cAMP-stimulated IL-5 promoter activation in Th2 cells, ectopic expression of GATA-3 in Th1 cells or in a non-lymphoid, non-IL-5-producing cell line activated the IL-5 promoter. During the differentiation of naive CD4(+) T cells isolated from T cell receptor transgenic mice, GATA-3 gene expression was up-regulated in developing Th2 cells, but was down-regulated in Th1 cells, and antigen- or cAMP-activated Th2 cells (but not Th1 cells) expressed the GATA-3 protein. Thus, GATA-3 may play an important role in the balance between Th1 and Th2 subsets in immune responses. Inhibition of GATA-3 activity has therapeutic potential in the treatment of asthma and other hypereosinophilic diseases.
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GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B., & Evans, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31636-8 · Cited by 558
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Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Das, J., Chen, C.-H., Yang, L., Cohn, L., Ray, P., & Ray, A. (2001) · Nature Immunology · doi:10.1038/83158 · Cited by 518
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Rengarajan, J., Szabo, S. J., & Glimcher, L. H. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01712-6 · Cited by 433
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Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M., McCright, B., Gridley, T., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.021 · Cited by 396
Lee, H. J., Takemoto, N., Kurata, H., Kamogawa, Y., Miyatake, S., O'Garra, A., & Arai, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.1.105 · Cited by 393
Kanhere, A., Hertweck, A., Bhatia, U., Gökmen, M. R., Perucha, E., Jackson, I., Lord, G. M., & Jenner, R. G. (2012) · Nature Communications · doi:10.1038/ncomms2260 · Cited by 345
Zhu, J., Jankovic, D., Oler, A. J., Wei, G., Sharma, S., Hu, G., Guo, L., Yagi, R., Yamane, H., Punkosdy, G., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.007 · Cited by 335
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Bao, K., & Reinhardt, R. L. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.008 · Cited by 316
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Cole, S. W., Arevalo, J. M. G., Takahashi, R., Sloan, E. K., Lutgendorf, S. K., Sood, A. K., Sheridan, J. F., & Seeman, T. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911515107 · Cited by 256
Krishnamoorthy, N., Khare, A., Oriss, T. B., Raundhal, M., Morse, C., Yarlagadda, M., Wenzel, S. E., Moore, M. L., Peebles, R. S., Ray, A., et al. (2012) · Nature Medicine · doi:10.1038/nm.2896 · Cited by 241
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Yu, Q., Sharma, A., Oh, S. Y., Moon, H.-G., Hossain, M. Z., Salay, T. M., Leeds, K. E., Du, H., Wu, B., Waterman, M. L., et al. (2009) · Nature Immunology · doi:10.1038/ni.1762 · Cited by 208
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Georas, S. N., Guo, J., De Fanis, U., & Casolaro, V. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00006005 · Cited by 181
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Lewis, G., Wang, B., Shafiei Jahani, P., Hurrell, B. P., Banie, H., Aleman Muench, G. R., Maazi, H., Helou, D. G., Howard, E., Galle-Treger, L., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02051 · Cited by 163
Lambert, K. C., Curran, E. M., Judy, B. M., Milligan, G. N., Lubahn, D. B., & Estes, D. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5716 · Cited by 142
Sundrud, M. S., Grill, S. M., Ni, D., Nagata, K., Alkan, S. S., Subramaniam, A., & Unutmaz, D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3542 · Cited by 112
Ray, A., Chakraborty, K., & Ray, P. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00052 · Cited by 108
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Tullius, S. G., Biefer, H. R. C., Li, S., Trachtenberg, A. J., Edtinger, K., Quante, M., Krenzien, F., Uehara, H., Yang, X., Kissick, H. T., et al. (2014) · Nature Communications · doi:10.1038/ncomms6101 · Cited by 107
Singh, S. P., Gundavarapu, S., Peña-Philippides, J. C., Rir-sima-ah, J., Mishra, N. C., Wilder, J. A., Langley, R. J., Smith, K. R., & Sopori, M. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101567 · Cited by 93
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Cook, K. D., & Miller, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902544 · Cited by 79
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Chang, H.-C., Han, L., Jabeen, R., Carotta, S., Nutt, S. L., & Kaplan, M. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900363 · Cited by 66
Overexpression of the transcription factor GATA-3 enhances the development of pulmonary fibrosis
Kimura, T., Ishii, Y., Yoh, K., Morishima, Y., Iizuka, T., Kiwamoto, T., Matsuno, Y., Homma, S., Nomura, A., Sakamoto, T., et al. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.051160 · Cited by 55
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Metadata
- Authors
- Zhang, D.-H., Cohn, L., Ray, P., Bottomly, K., & Ray, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 272
- Issue
- 34
- Pages
- 21597-21603
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2027378848
- Cited by
- 665
- References
- 1
- FWCI
- 11.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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