The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells
Open accessAbstract
We have identified a novel gene referred to as activation-induced deaminase (AID) by subtraction of cDNAs derived from switch-induced and uninduced murine B lymphoma CH12F3-2 cells, more than 80% of which switch exclusively to IgA upon stimulation. The amino acid sequence encoded by AID cDNA is homologous to that of apolipoprotein B (apoB) mRNA-editing enzyme, catalytic polypeptide 1 (APOBEC-1), a type of cytidine deaminase that constitutes a catalytic subunit for the apoB mRNA-editing complex. In vitro experiments using a glutathione S-transferase AID fusion protein revealed significant cytidine deaminase activity that is blocked by tetrahydrouridine and by zinc chelation. However, AID alone did neither demonstrate activity in C to U editing of apoB mRNA nor bind to AU-rich RNA targets. AID mRNA expression is induced in splenic B cells that were activated in vitro or by immunizations with sheep red blood cells. In situ hybridization of immunized spleen sections revealed the restricted expression of AID mRNA in developing germinal centers in which modulation of immunoglobulin gene information through somatic hypermutation and class switch recombination takes place. Taken together, these findings suggest that AID is a new member of the RNA-editing deaminase family and may play a role in genetic events in the germinal center B cell.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Tam, J. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5409 · Cited by 1,251
Cited by
Krokan, H. E., & Bjoras, M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012583 · Cited by 1,322
Humby, F., Bombardieri, M., Manzo, A., Kelly, S., Blades, M. C., Kirkham, B., Spencer, J., & Pitzalis, C. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.0060001 · Cited by 537
Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G
Sawyer, S. L., Emerman, M., & Malik, H. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020275 · Cited by 485
The APOBEC Protein Family: United by Structure, Divergent in Function
Salter, J. D., Bennett, R. P., & Smith, H. C. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.001 · Cited by 408
Kim, C. H. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-00987-1 · Cited by 420
The epigenetics of aging and neurodegeneration
Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381
Allergen Drives Class Switching to IgE in the Nasal Mucosa in Allergic Rhinitis
Takhar, P., Smurthwaite, L., Coker, H. A., Fear, D. J., Banfield, G. K., Carr, V. A., Durham, S. R., & Gould, H. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.5024 · Cited by 230
The who, where, and when of IgE in allergic airway disease
Dullaers, M., De Bruyne, R., Ramadani, F., Gould, H. J., Gevaert, P., & Lambrecht, B. N. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.10.029 · Cited by 194
Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination
Hwang*, J. K., Alt*, F. W., & Yeap, L.-S. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0037-2014 · Cited by 126
Ratcliff, J., & Simmonds, P. (2021) · Virology · doi:10.1016/j.virol.2020.12.018 · Cited by 108
EPELDEGUI, M., HUNG, Y., MCQUAY, A., AMBINDER, R., & MARTINEZMAZA, O. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.03.018 · Cited by 93
Rojas, A., Añazco, C., González, I., & Araya, P. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy012 · Cited by 82
Frasca, D., Diaz, A., Romero, M., Mendez, N. V., Landin, A. M., & Blomberg, B. B. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-14 · Cited by 77
Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases
Zanotti, K. J., & Gearhart, P. J. (2016) · DNA Repair · doi:10.1016/j.dnarep.2015.11.011 · Cited by 57
Reiniger, L., Bödör, C., Bognár, Á., Balogh, Z., Csomor, J., Szepesi, Á., Kopper, L., & Matolcsy, A. (2006) · Leukemia · doi:10.1038/sj.leu.2404183 · Cited by 54
Gruber, T. A., Chang, M. S., Sposto, R., & Müschen, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1438 · Cited by 38
The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity
Wolfe, A. D., Li, S., Goedderz, C., & Chen, X. S. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa027 · Cited by 28
Chen, X. S. (2021) · Viruses · doi:10.3390/v13030497 · Cited by 23
Sakamoto, A., & Maruyama, M. (2020) · ImmunoHorizons · doi:10.4049/immunohorizons.2000048 · Cited by 16
Lellek, H., Welker, S., Diehl, I., Kirsten, R., & Greeve, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203517200 · Cited by 13
Metadata
- Authors
- Muramatsu, M., Sankaranand, V. S., Anant, S., Sugai, M., Kinoshita, K., Davidson, N. O., & Honjo, T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 274
- Issue
- 26
- Pages
- 18470-18476
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2139387072
- Cited by
- 1,176
- References
- 2
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
