Proofreading of DNA Polymerase η-dependent Replication Errors
Open accessAbstract
Human DNA polymerase eta, the product of the skin cancer susceptibility gene XPV, bypasses UV photoproducts in template DNA that block synthesis by other DNA polymerases. Pol eta lacks an intrinsic proofreading exonuclease and copies DNA with low fidelity, such that pol eta errors could contribute to mutagenesis unless they are corrected. Here we provide evidence that pol eta can compete with other human polymerases during replication of duplex DNA, and in so doing it lowers replication fidelity. However, we show that pol eta has low processivity and extends mismatched primer termini less efficiently than matched termini. These properties could provide an opportunity for extrinsic exonuclease(s) to proofread pol eta-induced replication errors. When we tested this hypothesis during replication in human cell extracts, pol eta-induced replication infidelity was found to be modulated by changing the dNTP concentration and to be enhanced by adding dGMP to a replication reaction. Both effects are classical hallmarks of exonucleolytic proofreading. Thus, pol eta is ideally suited for its role in reducing UV-induced mutagenesis and skin cancer risk, in that its relaxed base selectivity may facilitate efficient bypass of UV photoproducts, while subsequent proofreading by extrinsic exonuclease(s) may reduce its mutagenic potential.
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Extrinsic exonucleolytic proofreading could improve the fidelity of Pol α during initiation of Okazaki fragments, the fidelity of Pol η at a replication fork, or the fidelity of Pol β during single-nucleotide BER.
“For example, extrinsic exonucleolytic proofreading could improve the fidelity of Pol ␣ (51) during initiation of Okazaki fragments, the fidelity of Pol at a replication fork (52), or the fidelity of Pol  during single-nucleotide BER (53).”
From DNA Replication Fidelity (2004) · cites this paper as [52]
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The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292 · see citing works
Self-citationKunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003 · see citing works
Self-citationEfficient Bypass of a Thymine-Thymine Dimer by Yeast DNA Polymerase, Polη
Johnson, R. E., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.283.5404.1001 · Cited by 736 · see citing works
<i>hRAD30</i> Mutations in the Variant Form of Xeroderma Pigmentosum
Johnson, R. E., Kondratick, C. M., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.285.5425.263 · Cited by 732 · see citing works
CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY
Johnson, K. A. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.003345 · Cited by 560 · see citing works
Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro
Waga, S., & Stillman, B. (1994) · Nature · doi:10.1038/369207a0 · Cited by 557 · see citing works
Mechanisms of accurate translesion synthesis by human DNA polymerase η
Masutani, C., Kusumoto, R., Iwai, S., & Hanaoka, F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.3100 · Cited by 504 · see citing works
Self-citationMasutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., & Hanaoka, F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.12.3491 · Cited by 434 · see citing works
Self-citationFidelity of Human DNA Polymerase η
Johnson, R. E., Washington, M. T., Prakash, S., & Prakash, L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7447 · Cited by 399 · see citing works
Low fidelity DNA synthesis by human DNA polymerase-η
Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., & Kunkel, T. A. (2000) · Nature · doi:10.1038/35010014 · Cited by 372 · see citing works
Self-citationEfficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η
Haracska, L., Yu, S.-L., Johnson, R. E., Prakash, L., & Prakash, S. (2000) · Nature Genetics · doi:10.1038/78169 · Cited by 349 · see citing works
MAHER, V. M., OUELLETTE, L. M., CURREN, R. D., & MCCORMICK, J. J. (1976) · Nature · doi:10.1038/261593a0 · Cited by 333 · see citing works
Modulation of RNA function by aminoglycoside antibiotics
Schroeder, R., Waldsich, C., & Wank, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.1.1 · Cited by 326 · see citing works
Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase.
Mendelman, L. V., Petruska, J. A., & Goodman, M. F. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39981-8 · Cited by 290 · see citing works
Mazur, D. J., & Perrino, F. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19655 · Cited by 276 · see citing works
A plethora of lesion-replicating DNA polymerasesPreprint
Woodgate, R. (1999) · Genes & Development · doi:10.1101/gad.13.17.2191 · Cited by 246 · see citing works
The many faces of DNA polymerases: Strategies for mutagenesis and for mutational avoidance
Friedberg, E. C., Feaver, W. J., & Gerlach, V. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120152397 · Cited by 222 · see citing works
A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein
Höss, M., Robins, P., Naven, T. J. P., Pappin, D., SGOUROS, J. G., & Lindahl, T. L. (1999) · The EMBO Journal · doi:10.1093/emboj/18.13.3868 · Cited by 170 · see citing works
Wang, Y., Maher, V. M., Mitchell, D. L., & McCormick, J. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4276 · Cited by 161 · see citing works
Bridging the gap: A family of novel DNA polymerases that replicate faulty DNA
Johnson, R. E., Washington, M. T., Prakash, S., & Prakash, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12224 · Cited by 134 · see citing works
Kunkel, T. A. (1988) · Cell · doi:10.1016/s0092-8674(88)90189-4 · Cited by 134 · see citing works
Self-citationFidelity of mammalian DNA replication and replicative DNA polymerases
Thomas, D. C., Roberts, J. D., Sabatino, R. D., Myers, T. W., Tan, C. K., Downey, K. M., So, A. G., Bambara, R. A., & Kunkel, T. A. (1991) · Biochemistry · doi:10.1021/bi00115a003 · Cited by 121 · see citing works
Self-citationWang, H., Lawrence, C. W., Li, G., & Hays, J. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.16894 · Cited by 103 · see citing works
Fidelity of a human cell DNA replication complex.
Roberts, J. D., & Kunkel, T. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7064 · Cited by 92 · see citing works
Self-citationKokoska, R. J., Stefanovic, L., DeMai, J., & Petes, T. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7490-7504.2000 · Cited by 86 · see citing works
Ultraviolet mutagenesis of normal and xeroderma pigmentosum variant human fibroblasts
Myhr, B. C., Turnbull, D., & DiPaolo, J. A. (1979) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(79)90089-7 · Cited by 76 · see citing works
Wang, Y., Maher, V. M., & McCormick, J. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7810 · Cited by 71 · see citing works
Ultraviolet Hypermutablity of a Shuttle Vector Propagated in Xeroderma Pigmentosum Variant Cells
Waters, H. L., Seetharam, S., Seidman, M. M., & Kraemer, K. H. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12371686 · Cited by 65 · see citing works
Exonucleolytic proofreading of leading and lagging strand DNA replication errors.
Roberts, J. D., Thomas, D. C., & Kunkel, T. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3465 · Cited by 57 · see citing works
Self-citationFrameshift fidelity during replication of double-stranded DNA in HeLa cell extracts
Roberts, J. D., Dinh, N., & Kunkel, T. A. (1993) · Biochemistry · doi:10.1021/bi00066a033 · Cited by 40 · see citing works
Self-citationIzuta, S., Roberts, J. D., & Kunkel, T. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2595 · Cited by 28 · see citing works
Self-citationLiu, H., Hewitt, S. R., & Hays, J. B. (2000) · Genetics · doi:10.1093/genetics/154.2.503 · Cited by 21 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Wang, Y. C., Maher, V. M., and McCormick, J. J. (1991) Proc. Natl. Acad. Sci.
- Johnson, R. E., Washington, M. T., Prakash, S., and Prakash, L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 12224 -12226
- Friedberg, E. C., Feaver, W. J., and Gerlach, V. L. (2000) Proc. Natl. Acad. Sci.
- Roberts, J. D., and Kunkel, T. A. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 7064 -7068
- Roberts, J. D., Thomas, D. C., and Kunkel, T. A. (1991) Proc. Natl. Acad. Sci.
Cited by
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EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function
Prakash, S., Johnson, R. E., & Prakash, L. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133250 · Cited by 999 · see citing works
Kunkel, T. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400006200 · Cited by 754 · see citing works
Self-citationHübscher, U., Maga, G., & Spadari, S. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150041 · Cited by 691 · see citing works
UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer
de Gruijl, F. R., van Kranen, H. J., & Mullenders, L. H. F. (2001) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(01)00199-3 · Cited by 546 · see citing works
Somatic mutation hotspots correlate with DNA polymerase η error spectrum
Rogozin, I. B., Pavlov, Y. I., Bebenek, K., Matsuda, T., & Kunkel, T. A. (2001) · Nature Immunology · doi:10.1038/88732 · Cited by 298 · see citing works
Self-citationThe Translesion DNA Polymerase ζ Plays a Major Role in Ig and bcl-6 Somatic Hypermutation
Zan, H., Komori, A., Li, Z., Cerutti, A., Schaffer, A., Flajnik, M. F., Diaz, M., & Casali, P. (2001) · Immunity · doi:10.1016/s1074-7613(01)00142-x · Cited by 204 · see citing works
Cellular UV damage responses—Functions of tumor suppressor p53
Latonen, L., & Laiho, M. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.04.003 · Cited by 196 · see citing works
Evidence that Errors Made by DNA Polymerase α are Corrected by DNA Polymerase δ
Pavlov, Y. I., Frahm, C., McElhinny, S. A. N., Niimi, A., Suzuki, M., & Kunkel, T. A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.002 · Cited by 177 · see citing works
Self-citationError rate and specificity of human and murine DNA polymerase η
Matsuda, T., Bebenek, K., Masutani, C., Rogozin, I. B., Hanaoka, F., & Kunkel, T. A. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4937 · Cited by 170 · see citing works
Self-citationHigh incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading
Goldsby, R. E., Hays, L. E., Chen, X., Olmsted, E. A., Slayton, W. B., Spangrude, G. J., & Preston, B. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232340999 · Cited by 166 · see citing works
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Kavanagh, D., Spitzer, D., Kothari, P. H., Shaikh, A., Liszewski, M. K., Richards, A., & Atkinson, J. P. (2008) · Cell Cycle · doi:10.4161/cc.7.12.6162 · Cited by 132 · see citing works
Kunkel, T. A., Pavlov, Y. I., & Bebenek, K. (2003) · DNA Repair · doi:10.1016/s1568-7864(02)00224-0 · Cited by 125 · see citing works
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Pavlov, Y. I., Shcherbakova, P. V., & Rogozin, I. B. (2006) · International Review of Cytology · doi:10.1016/s0074-7696(06)55002-8 · Cited by 123 · see citing works
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Zhong, X., Garg, P., Stith, C. M. W., McElhinny, S. A. N., Kissling, G. E., Burgers, P., & Kunkel, T. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl465 · Cited by 124 · see citing works
Self-citationBiochemical, Structural, and Physiological Characterization of Terminal Deoxynucleotidyl Transferase
Fowler, J. D., & Suo, Z. (2006) · Chemical Reviews · doi:10.1021/cr040445w · Cited by 119 · see citing works
Pavlov, Y. I., Rogozin, I. B., Galkin, A. P., Aksenova, A. Y., Hanaoka, F., Rada, C., & Kunkel, T. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152126799 · Cited by 120 · see citing works
Self-citationMultiple Functions of DNA Polymerases
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Replication of damaged DNA in mammalian cells: new solutions to an old problem
Lehmann, A. R. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00227-0 · Cited by 111 · see citing works
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McCulloch, S. D., Kokoska, R., Garg, P., Burgers, P., & Kunkel, T. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp103 · Cited by 97 · see citing works
Self-citationKunz, C., Saito, Y., & Schär, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8739-9 · Cited by 101 · see citing works
The genetics of the hereditary xeroderma pigmentosum syndrome
Stary, A., & Sarasin, A. R. (2002) · Biochimie · doi:10.1016/s0300-9084(01)01358-x · Cited by 91 · see citing works
Choi, J., & Guengerich, F. P. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.06.079 · Cited by 89 · see citing works
Khare, V., & Eckert, K. A. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00251-8 · Cited by 90 · see citing works
Enzymatic switching for efficient and accurate translesion DNA replication.
McCulloch, S. D., Kokoska, R., Chilkova, O., Welch, C. M., Johansson, E., Burgers, P., & Kunkel, T. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh777 · Cited by 97 · see citing works
Boudsocq, F. (2002) · DNA Repair · doi:10.1016/s1568-7864(02)00019-8 · Cited by 79 · see citing works
Accuracy of lesion bypass by yeast and human DNA polymerase η
Washington, M. T., Johnson, R. E., Prakash, L., & Prakash, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121007298 · Cited by 71 · see citing works
Kusumoto, R., Masutani, C., Shimmyo, S., Iwai, S., & Hanaoka, F. (2004) · Genes to Cells · doi:10.1111/j.1365-2443.2004.00797.x · Cited by 69 · see citing works
Self-citationHirota, K., Sonoda, E., Kawamoto, T., Motegi, A., Masutani, C., Hanaoka, F., Szüts, D., Iwai, S., Sale, J. E., Lehmann, A. R., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001151 · Cited by 69 · see citing works
Self-citationPerrino, F. W., Harvey, S. E., McMillin, S. M., & Hollis, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500108200 · Cited by 57 · see citing works
Brucet, M., Querol‐Audí, J., Serra, M., Ramirez‐Espain, X., Bertlik, K., Ruiz, L., Lloberas, J., Macías, M. J., Fita, I., & Celada, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700236200 · Cited by 56 · see citing works
Involvement of DNA polymerase β in DNA replication and mutagenic consequences
Servant, L., Bieth, A., Hayakawa, H., Cazaux, C., & Hoffmann, J. (2002) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5307 · Cited by 53 · see citing works
The influence of base pair tautomerism on single point mutations in aqueous DNA
Gheorghiu, A., Coveney, P. V., & Arabi, A. A. (2020) · Interface Focus · doi:10.1098/rsfs.2019.0120 · Cited by 52 · see citing works
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Self-citationWeiss, K. K., Bambara, R. A., & Kim, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200202200 · Cited by 44 · see citing works
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Shimizu, K., Hashimoto, K., Kirchner, J. M., Nakai, W., Nishikawa, H., Resnick, M. A., & Sugino, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204476200 · Cited by 42 · see citing works
Pavlov, Y. I., Maki, S., Maki, H., & Kunkel, T. A. (2004) · BMC Biology · doi:10.1186/1741-7007-2-11 · Cited by 41 · see citing works
Self-citationDNA polymerase <b>η</b> mutational signatures are found in a variety of different types of cancer
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Masuda, Y., Piao, J., & Kamiya, K. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.01.003 · Cited by 39 · see citing works
Emond, S., Mondon, P., Pizzut‐Serin, S., Douchy, L., Crozet, F., Bouayadi, K., Kharrat, H., Potocki-Véronèse, G., MONSAN, P. F., & Remaud‐Siméon, M. (2008) · Protein Engineering Design and Selection · doi:10.1093/protein/gzn004 · Cited by 30 · see citing works
Vaisman, A., Lehmann, A. R., & Woodgate, R. (2004) · Advances in protein chemistry · doi:10.1016/s0065-3233(04)69007-3 · Cited by 30 · see citing works
Yagi, Y., Ogawara, D., Iwai, S., Hanaoka, F., Akiyama, M., & Maki, H. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.06.010 · Cited by 28 · see citing works
Self-citationKing, N. M., Nikolaishvili‐Feinberg, N., Bryant, M. F., Luche, D. D., Heffernan, T. P., Simpson, D. A., Hanaoka, F., Kaufmann, W. K., & Cordeiro‐Stone, M. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.04.002 · Cited by 28 · see citing works
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Self-citationHow asymmetric DNA replication achieves symmetrical fidelity
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Self-citationMcCulloch, S. D., Wood, A., Garg, P., Burgers, P., & Kunkel, T. (2007) · Biochemistry · doi:10.1021/bi700234t · Cited by 31 · see citing works
Self-citationJAŁOSZYŃSKI, P. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg829 · Cited by 21 · see citing works
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Ogawa, M., Limsirichaikul, S., Niimi, A., Iwai, S., Yoshida, S., & Suzuki, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208605200 · Cited by 19 · see citing works
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Hidaka, K., Yamada, M., Kamiya, H., Masutani, C., Harashima, H., Hanaoka, F., & Nohmi, T. (2008) · DNA repair · doi:10.1016/j.dnarep.2007.12.005 · Cited by 17 · see citing works
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Takezawa, J., Aiba, N., Kajiwara, K., & Yamada, K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12128513 · Cited by 7 · see citing works
Potential inhibition of somatic hypermutation by nucleoside analogues
Franklin, A., & Blanden, R. V. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.02.022 · Cited by 5 · see citing works
Ramadan, K., Maga, G., & Hübscher, U. (2006) · Springer eBooks · doi:10.1007/7050_005 · Cited by 5 · see citing works
Translesion DNA Synthesis and Damage Tolerance Pathways
Masuda, Y., Hanaoka, F., & Masutani, C. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_11 · Cited by 3 · see citing works
Self-citationBelyakova, N. V., Kravetskaya, T. P., Legina, O. K., Ronzhina, N. L., Shevelev, I. V., & Krutyakov, V. M. (2007) · Biology Bulletin · doi:10.1134/s1062359007050019 · Cited by 3 · see citing works
Takezawa, J., Shimazaki, A., Takimoto, H., Kajiwara, K., & Yamada, K. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.103031 · Cited by 2 · see citing works
UV radiation, mutations and oncogenic pathways in skin cancer
de Gruijl, F. R., & van Kranen, H. J. (2001) · Comprehensive series in photosciences · doi:10.1016/s1568-461x(01)80049-1 · Cited by 2 · see citing works
Masutani, C., & Hanaoka, F. (2018) · Springer eBooks · doi:10.1007/978-981-10-6722-8_12 · Cited by 1 · see citing works
Self-citationBhadouria, N., Alam, A., & Kaur, A. (2024) · Pharmaceutical Nanotechnology · doi:10.2174/0122117385282163240220072251 · Cited by 1 · see citing works
Tumor suppressor p53 and transcriptional changes in cellular stress responses to UV radiation
Latonen, L. (2003) · Työväentutkimus Vuosikirja
Masuda, Y. (2012) · Genes and Environment · doi:10.3123/jemsge.34.70
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Stary, A., & Sarasin, A. R. (2001)
Kajiwara, K., & Yamada, K. (2025) · Genes to Cells · doi:10.1111/gtc.13189
- Authors
- Bebenek, K., Matsuda, T., Masutani, C., Hanaoka, F., & Kunkel, T. A.
- Affiliations
- National Institutes of Health (US)
- The University of Osaka (JP)
- RIKEN (JP)
- Corresponding author
- Kunkel, Thomas A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 276
- Issue
- 4
- Pages
- 2317-2320
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2045684550
- Cited by
- 76
- References
- 32
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2012: 1
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- DNA polymerase eta, UV photoproducts, replication fidelity, exonuclease proofreading, polymerase processivity, dGMP, dNTP concentration, UV mutagenesis, skin cancer predisposition
- MeSH terms
- Y-Family DNA Polymerases, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Exodeoxyribonucleases, Humans, Models, Genetic, Mutagenesis, Base Pair Mismatch
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