Circulating microRNAs as biomarkers for depression: Many candidates, few finalists
Abstract
Background Recent research has highlighted the potential of microRNAs to serve as physiological indicators of disease process among clinically depressed patients.Methods In a comprehensive literature search through PubMed, we identified 23 articles comparing circulating (blood, plasma, or serum) microRNA expression levels in depressed versus healthy human subjects. Six studies examining circulatory microRNA expression through animal models of depression were also identified through the search and details of each study were outlined. A meta-analytic evaluation of these studies was not considered feasible, given the absence of concordance in the literature to date.Results A total of 178 specific microRNA candidates were identified in the human studies as significantly expressed among depressed samples. Ninety-seven of these microRNAs were upregulated, 75 were downregulated, and 6 showed mixed expression in depressed samples. Few microRNAs were consistently expressed across studies; the most consistent evidence was for microRNA-132, with replication in 4 different studies. Among animal studies, 2 studies investigated microRNA-16 through distinct stress-induced depression models.Limitations Structural variations in microRNA sequences, methodological inconsistencies in technology used among studies to measure microRNA expression levels, differences in the clinical severity and forms of depression among subjects, and the overall paucity of studies make it difficult to ascertain any robust, preliminary targets deserving of biomarker potential.Conclusions Ongoing research needs to address this high rate of non-replication as well as the methodological and reporting challenges of microRNA experimentation in order to determine valid effect sizes for the more proliferative candidates associated with depression.
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Studies show altered levels of specific miRNAs in patients with psychiatric disorders, including MDD.
“Indeed, studies show altered levels of specific miRNAs in patients with psychiatric disorders, including MDD.”
From Epigenetics and depression (2019) · cites this paper as [29]
In a review of 23 studies assessing miRNAs in peripheral tissues of patients with MDD, 178 different miRNAs were altered in cases versus controls.
“In a recent review of 23 studies assessing miRNAs in peripheral tissues of patients with MDD, 178 different miRNAs were altered in cases versus controls.”
From Epigenetics and depression (2019) · cites this paper as [29]
With the exception of miRNA-132, which was replicated in four independent studies, the altered miRNAs were not consistently altered across studies.
“However, with the exception of miRNA-132 which was replicated in four independent studies, these miRNAs were not consistently altered across studies”
From Epigenetics and depression (2019) · cites this paper as [29]
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- Authors
- Yuan, H., Mischoulon, D., Fava, M., & Otto, M. W.
- Affiliations
- Boston University (US)
- Harvard University (US)
- Corresponding author
- Otto, Michael W.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 233
- Pages
- 68-78
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2731022850
- Cited by
- 86
- References
- 95
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 9 · 2022: 16 · 2021: 6 · 2020: 22 · 2019: 12 · 2018: 6 · 2017: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- circulating microRNAs, depression, biomarkers, microRNA expression, blood microRNA, plasma microRNA, serum microRNA, animal models of depression, microRNA-132, miR-16, stress-induced depression, replication, methodological heterogeneity
- MeSH terms
- Circulating MicroRNA, Animals, Depression, Humans, Biomarkers, Down-Regulation, Up-Regulation, MicroRNAs, Healthy Volunteers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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