The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Norepinephrine Modulates the Motility of Resting and Activated Microglia via Different Adrenergic Receptors
Open accessAbstract
Microglia, the resident immune cells of the central nervous system (CNS), monitor the brain for disturbances of tissue homeostasis by constantly moving their fine processes. Microglia respond to tissue damage through activation of ATP/ADP receptors followed by directional process extension to the damaged area. A common feature of several neurodegenerative diseases is the loss of norepinephrine, which might contribute to the associated neuroinflammation. We carried out a high resolution analysis of the effects of norepinephrine (NE) on microglial process dynamics in acute brain slices from mice that exhibit microglia-specific enhanced green fluorescent protein expression. Bath application of NE to the slices resulted in significant process retraction in microglia. Analysis of adrenergic receptor expression with quantitative PCR indicated that resting microglia primarily express β 2 receptors but switch expression to α 2A receptors under proinflammatory conditions modeled by LPS treatment. Despite the differential receptor expression, NE caused process retraction in both resting and LPS-activated microglia cultured in the gelatinous substrate Matrigel in vitro . The use of subtype-selective receptor agonists and antagonists confirmed the involvement of β 2 receptors in mediating microglial process dynamics in resting cells and α 2A receptors in activated cells. Co-application of NE with ATP to resting microglia blocked the ATP-induced process extension and migration in isolated microglia, and β 2 receptor antagonists prolonged ATP effects in brain slice tissues, suggesting the presence of cross-talk between adrenergic and purinergic signaling in microglia. These data show that the neurotransmitter NE can modulate microglial motility, which could affect microglial functions in pathogenic situations of either elevated or reduced NE levels. Background: Microglia respond to cell death by extending their processes toward ATP released at the site of damage. Results: Norepinephrine induces process retraction in resting and activated microglia through β 2 and α 2A receptors, respectively. Conclusion: Norepinephrine alters the ability of microglia to respond to ATP. Significance: Adrenergic receptor signaling might alter the ability of microglia to detect and respond to tissue damage in vivo .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“guanfacine’s protective effects may involve anti-inflammatory actions through α2A-AR on glia”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Gyoneva & Traynelis, 2013
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“α2A-AR stimulation deactivates microglia and thus has anti-inflammatory actions.”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Gyoneva & Traynelis, 2013
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Microglia and astrocytes are activated by β-AR stimulation, while activated microglia are deactivated by α2A-AR stimulation102.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [102]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Microglia and astrocytes are activated by β-AR stimulation, while activated microglia are deactivated by α2A-AR stimulation102.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [102]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“α2A-AR are also expressed on activated microglia”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Gyoneva & Traynelis, 2013
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Thus, guanfacine may reduce microglial phagocytosis of spines.”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Gyoneva & Traynelis, 2013
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,712
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Microglia as a source and target of cytokines
Hanisch, U. (2002) · Glia · doi:10.1002/glia.10161 · Cited by 1,645
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D. (2006) · Nature Neuroscience · doi:10.1038/nn1805 · Cited by 1,542
β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor
Goodman, O. B., Krupnick, J. G., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. H., & Benovic, J. (1996) · Nature · doi:10.1038/383447a0 · Cited by 1,383
Cited by
Sorted by citations
Neuroinflammation: The Devil Is in the Details
DiSabato, D. J., Quan, N., & Godbout, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13607 · Cited by 1,640
Signaling inflammation across the gut-brain axis
Agirman, G., Yu, K. B., & Hsiao, E. Y. (2021) · Science · doi:10.1126/science.abi6087 · Cited by 867
Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten, A. F. T. (2015) · Nature Neuroscience · doi:10.1038/nn.4087 · Cited by 752
Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response
Bachiller, S., Jiménez-Ferrer, I., Paulus, A., Yang, Y., Swanberg, M., Deierborg, T., & Boza‐Serrano, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00488 · Cited by 750
Integrating neuroimmune systems in the neurobiology of depression
Wohleb, E. S., Franklin, T., Iwata, M., & Duman, R. S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.69 · Cited by 668
Young, K., & Morrison, H. W. (2018) · Journal of Visualized Experiments · doi:10.3791/57648 · Cited by 680
Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity
Xanthos, D. N., & Sandkühler, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3617 · Cited by 580
Madry, C., Kyrargyri, V., Arancibia-Cárcamo, I. L., Jolivet, R., Kohsaka, S., Bryan, R. M., & Attwell, D. (2018) · Neuron · doi:10.1016/j.neuron.2017.12.002 · Cited by 464
Wohleb, E. S., McKim, D. B., Sheridan, J. F., & Godbout, J. P. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00447 · Cited by 420
Liu, Y., Ying, Y., Li, Y., Eyo, U. B., Chen, T., Zheng, J., Umpierre, A. D., Zhu, J., Bosco, D. B., Dong, H., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0511-3 · Cited by 401
Stowell, R. D., Sipe, G. O., Dawes, R. P., Batchelor, H. N., Lordy, K. A., Whitelaw, B. S., Stoessel, M. B., Bidlack, J. M., Brown, E., Sur, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0514-0 · Cited by 321
Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
Bernier, L., York, E. M., Kamyabi, A., Choi, H. B., Weilinger, N. L., & MacVicar, B. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15267-z · Cited by 323
Neuronal regulation of immunity: why, how and where?
Schiller, M., Ben-Shaanan, T. L., & Rolls, A. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0387-1 · Cited by 284
Fatigue, Sleep, and Autoimmune and Related Disorders
Zielinski, M. R., Systrom, D. M., & Rose, N. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01827 · Cited by 281
How microglia sense and regulate neuronal activity
Umpierre, A. D., & Wu, L. (2021) · Glia · doi:10.1002/glia.23961 · Cited by 237
Mei, B., Li, J., & Zuo, Z. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.10.008 · Cited by 234
Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia
Bernier, L.-P., Bohlen, C. J., York, E. M., Choi, H. B., Kamyabi, A., Dissing-Olesen, L., Hefendehl, J. K., Collins, H. Y., Stevens, B., Barres, B. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.010 · Cited by 211
Microglia regulate synaptic development and plasticity
Andoh, M., & Koyama, R. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22814 · Cited by 195
The link between chronic pain and Alzheimer’s disease
Cao, S., Fisher, D. W., Yu, T., & Dong, H. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1608-z · Cited by 195
Nuclear Receptors License Phagocytosis by Trem2+Myeloid Cells in Mouse Models of Alzheimer's Disease
Savage, J. C., Jay, T., Goduni, E., Quigley, C., Mariani, M. M., Malm, T., Ransohoff, R. M., Lamb, B. T., & Landreth, G. E. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4586-14.2015 · Cited by 154
“We used an ex vivo slice phagocytosis assay (Gyoneva and Traynelis, 2013; Krabbe et al., 2013) to determine whether nuclear receptor activation could restore phagocytic competence to microglia residing in the AD brain.”
MethodNeuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”
Wohleb, E. S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00544 · Cited by 170
Microglia in neuronal plasticity: Influence of stress
Delpech, J.-C., Madore, C., Nadjar, A., Joffre, C., Wohleb, E. S., & Layé, S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.034 · Cited by 161
Neurobiology of resilience in depression: immune and vascular insights from human and animal studies
Dudek, K., Dion‐Albert, L., Kaufmann, F. N., Tuck, E., Lebel, M., & Ménard, C. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14547 · Cited by 168
Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?
Atzori, M., Cuevas‐Olguin, R., Esquivel‐Rendon, E., García‐Oscos, F., Salgado‐Delgado, R., Saderi, N., Miranda‐Morales, M., Treviño, M., Pineda, J. C., & Salgado, H. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00025 · Cited by 156
Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain
Gu, N., Eyo, U. B., Murugan, M., Peng, J., Matta, S., Dong, H., & Wu, L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.11.007 · Cited by 135
Systemic inflammation regulates microglial responses to tissue damage in vivo
Gyoneva, S., Davalos, D., Biswas, D., Swanger, S. A., Garnier‐Amblard, E. C., Loth, F., Akassoglou, K., & Traynelis, S. F. (2014) · Glia · doi:10.1002/glia.22686 · Cited by 131
Self-citationMaternal immune activation induces sustained changes in fetal microglia motility
Ozaki, K., Kato, D., Ikegami, A., Hashimoto, A., Sugio, S., Guo, Z., Shibushita, M., Tatematsu, T., Haruwaka, K., Moorhouse, A. J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78294-2 · Cited by 123
The Locus Coeruleus in Aging and Alzheimer’s Disease: A Postmortem and Brain Imaging Review
Beardmore, R., Hou, R. H., Darekar, A., Holmes, C., & Boche, D. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210191 · Cited by 132
Tuning neural circuits and behaviors by microglia in the adult brain
Zhao, S., Umpierre, A. D., & Wu, L. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2023.12.003 · Cited by 122
Barnes, M. A., Carson, M. J., & Nair, M. G. (2015) · Cytokine · doi:10.1016/j.cyto.2015.01.008 · Cited by 110
Xu, H., Gelyana, E., Rajsombath, M., Yang, T., Li, S., & Selkoe, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1023-16.2016 · Cited by 109
Alboni, S., Poggini, S., Garofalo, S., Milior, G., Hajj, H. E., Lecours, C., Girard, I., Gagnon, S., Boisjoly‐Villeneuve, S., Brunello, N., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.155 · Cited by 114
Receptors, Ion Channels, and Signaling Mechanisms Underlying Microglial Dynamics
Madry, C., & Attwell, D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.637157 · Cited by 109
“Noradrenaline also abolished ATP-induced process outgrowth, suggesting a regulation of purinergic signaling by adrenergic signaling in microglia (58).”
BackgroundResultPankratov, Y., & Lalo, U. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00230 · Cited by 104
Ion Channels and Receptors as Determinants of Microglial Function
Izquierdo, P., Attwell, D., & Madry, C. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.007 · Cited by 102
Gyoneva, S., Shapiro, L. P., Lazo, C. R., Garnier‐Amblard, E. C., Smith, Y., Miller, G. W., & Traynelis, S. F. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.03.004 · Cited by 102
Self-citationDeciphering Resting Microglial Morphology and Process Motility from a Synaptic Prospect
Hristovska, I., & Pascual, O. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00073 · Cited by 92
Microglia enhance post-anesthesia neuronal activity by shielding inhibitory synapses
Haruwaka, K., Ying, Y., Liang, Y., Umpierre, A. D., Yi, M., Křemen, V., Chen, T., Xie, T., Qi, F., Zhao, S., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01537-8 · Cited by 85
Datta, D., & Arnsten, A. (2019) · Brain Sciences · doi:10.3390/brainsci9050113 · Cited by 78
Arnsten, A. F. T. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107327 · Cited by 75
Enriched environment enhances β‐adrenergic signaling to prevent microglia inflammation by amyloid‐β
Xu, H., Rajsombath, M. M., Weikop, P., & Selkoe, D. J. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201808931 · Cited by 74
Song, S., Jiang, L., Oyarzabal, E. A., Wilson, B. C., Li, Z., Shih, Y. I., Wang, Q., & Hong, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1235-1 · Cited by 74
Kyrargyri, V., Madry, C., Rifat, A., Arancibia‐Cárcamo, I. L., Jones, S. P., Chan, V. T. T., Xu, Y., Robaye, B., & Attwell, D. (2019) · Glia · doi:10.1002/glia.23719 · Cited by 69
Hains, A. B., Yabe, Y., & Arnsten, A. F. T. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.01.001 · Cited by 70
“Microglia and astroctyes are activated by beta adrenoceptor stimulation (Sutin and Griffith, 1993; Gyoneva and Traynelis, 2013), and activated microglia are deactivated by alpha-2A-adrenoceptor stimulation (Gyoneva and Traynelis, 2013).”
BackgroundZhang, Y., Xu, Y., Sun, Q., Xue, S., Guan, H., & Ji, M. J. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107771 · Cited by 65
Mishima, T., Nagai, T., Yahagi, K., Akther, S., Oe, Y., Monai, H., Kohsaka, S., & Hirase, H. (2019) · eNeuro · doi:10.1523/eneuro.0204-19.2019 · Cited by 70
Butkovich, L. M., Houser, M. C., Chalermpalanupap, T., Porter‐Stransky, K. A., Iannitelli, A. F., Boles, J. S., Lloyd, G. M., Coomes, A. S., Eidson, L. N., Rodrigues, M. E. D. S., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1468-19.2020 · Cited by 63
Madry, C., Arancibia‐Cárcamo, I. L., Kyrargyri, V., Chan, V. T. T., Hamilton, N. B., & Attwell, D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715354115 · Cited by 58
Lechtenberg, K. J., Meyer, S. T., Doyle, J. B., Peterson, T. C., & Buckwalter, M. S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1506-4 · Cited by 60
Locus coeruleus in memory formation and Alzheimer's disease
James, T., Kula, B., Choi, S., Khan, S. S., Bekar, L. K., & Smith, N. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15045 · Cited by 65
Role of Glia in Stress-Induced Enhancement and Impairment of Memory
Pearson-Leary, J., Osborne, D. M., & McNay, E. C. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00063 · Cited by 60
Yamanaka, D., Kawano, T., Nishigaki, A., Aoyama, B., Tateiwa, H., Shigematsu-Locatelli, M., Locatelli, F. M., & Yokoyama, M. (2016) · Journal of Anesthesia · doi:10.1007/s00540-016-2264-4 · Cited by 55
In Vivo Imaging of Microglial Calcium Signaling in Brain Inflammation and Injury
Tvrdík, P., & Kalani, M. Y. S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112366 · Cited by 52
Importance of GPCR-Mediated Microglial Activation in Alzheimer’s Disease
Haque, M. E., Kim, I., Jakaria, M., Akther, M., & Choi, D. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00258 · Cited by 55
Altered motility of plaque-associated microglia in a model of Alzheimer’s disease
Gyoneva, S., Swanger, S. A., Zhang, J., Weinshenker, D., & Traynelis, S. F. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.061 · Cited by 51
Self-citationNoradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease?
Mather, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.013 · Cited by 57
Arnsten, A. F. T., & Wang, M. (2016) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103617 · Cited by 50
Finnell, J. E., Moffitt, C. M., Hesser, L. A., Harrington, E. N., Melson, M. N., Wood, C. S., & Wood, S. K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.01.021 · Cited by 49
Sleep decreases neuronal activity control of microglial dynamics in mice
Hristovska, I., Robert, M., Combet, K., Honnorat, J., Comte, J.-C., & Pascual, O. (2022) · Nature Communications · doi:10.1038/s41467-022-34035-9 · Cited by 52
The role of catecholamines in HIV neuropathogenesis
Nolan, R. A., & Gaskill, P. J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.030 · Cited by 50
Saggu, S., Bai, A., Aida, M., Rehman, H., Pless, A., Ware, D., Deák, F., Jiao, K., & Wang, Q. (2024) · GeroScience · doi:10.1007/s11357-024-01359-x · Cited by 48
Noradrenaline in Alzheimer’s Disease: A New Potential Therapeutic Target
Gutiérrez, I. L., Russo, C. D., Novellino, F., Caso, J. R., García‐Bueno, B., Leza, J. C., & Madrigal, J. L. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116143 · Cited by 53
Feeding the beast: Can microglia in the senescent brain be regulated by diet?
Johnson, R. W. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.022 · Cited by 44
MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia
Hansen, J. N., Brückner, M., Pietrowski, M. J., Jikeli, J. F., Plescher, M., Beckert, H., Schnaars, M., Fülle, L., Reitmeier, K., Langmann, T., et al. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-11-0585 · Cited by 44
Microglia modulate general anesthesia through P2Y12 receptor
Cao, K., Qiu, L., Lü, X., Wu, W., Hu, Y., Cui, Z., Jiang, C., Luo, Y., Shao, Y., Wang, X., et al. (2023) · Current Biology · doi:10.1016/j.cub.2023.04.047 · Cited by 42
Wong, R., & Schlichter, L. C. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2014.11.711 · Cited by 43
Iida, T., Yoshikawa, T., Kárpáti, A., Matsuzawa, T., Kitano, H., Mogi, A., Harada, R., Naganuma, F., Nakamura, T., & Yanai, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.081 · Cited by 43
Rotterman, T. M., & Álvarez, F. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-65363-9 · Cited by 44
Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline
González‐Prieto, M., Gutiérrez, I. L., García‐Bueno, B., Caso, J. R., Leza, J. C., Ortega‐Hernández, A., Gómez‐Garré, D., & Madrigal, J. L. M. (2020) · Glia · doi:10.1002/glia.23885 · Cited by 42
An emerging role for microglia in stress‐effects on memory
Sanguino‐Gómez, J., Buurstede, J. C., Abiega, O., Fitzsimons, C. P., Lucassen, P. J., Eggen, B. J. L., Lesuis, S. L., Meijer, O. C., & Krugers, H. J. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15188 · Cited by 43
Bossuyt, J., Herrewegen, Y. V. D., Nestor, L., Buckinx, A., Bundel, D. D., & Smolders, I. J. (2023) · Glia · doi:10.1002/glia.24390 · Cited by 44
Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing
Marques, C. F., Marques, M. M., & Justino, G. C. (2022) · Pharmaceuticals · doi:10.3390/ph15091039 · Cited by 47
Neuronal influence behind the central nervous system regulation of the immune cells
Chavarría, A., & Cárdenas, G. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00064 · Cited by 40
Basic Concept of Microglia Biology and Neuroinflammation in Relation to Psychiatry
Mattei, D., & Notter, T. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_83 · Cited by 37
O′Neill, E., Griffin, É. W., O'Sullivan, R., Murray, C., Ryan, L., Yssel, J. D., Harkin, A., & Cunningham, C. M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.002 · Cited by 38
α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis
Butkovich, L. M., Houser, M. C., & Tansey, M. G. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00626 · Cited by 39
Mineur, Y. S., Garcia‐Rivas, V., Thomas, M. A., Soares, A. R., McKee, S. A., & Picciotto, M. R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06120-w · Cited by 34
Evans, A. K., Defensor, E. B., & Shamloo, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1030609 · Cited by 40
Datta, D., & Arnsten, A. F. T. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00505 · Cited by 38
He, H., Zhou, Y., Zhou, Y., Zhuang, J., He, X., Wang, S., & Lin, W. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5625 · Cited by 36
Regulation of microglia by neuromodulators: Modulations in major and minor modes
Albertini, G., Etienne, F., & Roumier, A. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135000 · Cited by 35
An overview of microglia ontogeny and maturation in the homeostatic and pathological brain
Mendes, M. S., & Majewska, A. K. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15225 · Cited by 35
Physical exercise regulates microglia in health and disease
Strohm, A. O., & Majewska, A. K. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1420322 · Cited by 37
Microglial tissue surveillance: The never‐resting gardener in the developing and adult CNS
Petry, P., Oschwald, A., & Kierdorf, K. (2023) · European Journal of Immunology · doi:10.1002/eji.202250232 · Cited by 36
Ernest James Phillips, T., & Maguire, E. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.652593 · Cited by 33
Mei, B., Xu, X., Weng, J., Yang, Y., Wang, P., Qiu, G., Zhang, C., Zhang, Q., Lu, Y., & Liu, X. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.005 · Cited by 35
Monoaminergic regulation of nociceptive circuitry in a Parkinson's disease rat model
Campos, A. C. P., Berzuino, M. B., Hernandes, M. S., Fonoff, E. T., & Pagano, R. L. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.04.015 · Cited by 36
Imaging microglia surveillance during sleep-wake cycles in freely behaving mice
Gu, X., Zhao, Z., Chen, X., Zhang, L., Fang, H., Zhao, T., Ju, S., Gao, W., Qian, X., Wang, X., et al. (2023) · eLife · doi:10.7554/elife.86749 · Cited by 36
Λεάνδρου, Ε., Chalatsa, I., Anagnostou, D., Machalia, C., Semitekolou, M., Filippa, V., Makridakis, M., Vlahou, A., Anastasiadou, E., Vekrellis, K., et al. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00401-4 · Cited by 33
Voluntary exercise ameliorates synaptic pruning deficits in sleep-deprived adolescent mice
Tuan, L., Tsao, C.-Y., Lee, L. J., & Lee, L.-J. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.017 · Cited by 34
Ossola, B., Rifat, A., Rowland, A., Hunter, H., Drinkall, S., Bender, C., Hamlischer, M., Teall, M. R., Burley, R., Barker, D. F., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109330 · Cited by 30
Pathogenesis of sepsis-associated encephalopathy: more than blood–brain barrier dysfunction
Yang, K., Chen, J., Wang, T., & Zhang, Y. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07592-x · Cited by 35
Khan, M. A. S., & Chang, S. L. (2023) · Cells · doi:10.3390/cells12202475 · Cited by 30
Sun, Q., Peng, S., Xu, Q., Weikop, P., Hussain, R., Song, W., Nedergaard, M., & Ding, F. (2024) · Nature Communications · doi:10.1038/s41467-024-53430-y · Cited by 32
Microglia-mediated synaptic elimination in neuronal development and disease
Whitelaw, B. S. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00021.2017 · Cited by 31
Arnsten, A. F. T., Ishizawa, Y., & Xie, Z. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02057-4 · Cited by 30
Loss of P2Y12 Has Behavioral Effects in the Adult Mouse
Lowery, R. L., Mendes, M. S., Sanders, B. T., Murphy, A. J., Whitelaw, B. S., Lamantia, C. E., & Majewska, A. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041868 · Cited by 25
Activation of β2-Adrenergic Receptors in Microglia Alleviates Neuropathic Hypersensitivity in Mice
Damo, E., Agarwal, A., & Simonetti, M. (2023) · Cells · doi:10.3390/cells12020284 · Cited by 28
Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID
Zadeh, A. F., Arnsten, A. F. T., & Wang, M. (2023) · Neurology International · doi:10.3390/neurolint15020045 · Cited by 27
Handa, J., Sekiguchi, M., Krupkova, O., & Konno, S. (2015) · European Spine Journal · doi:10.1007/s00586-015-4239-9 · Cited by 27
Metadata
- Authors
- Gyoneva, S., & Traynelis, S. F.
- Affiliations
- Emory University (US)
- Corresponding author
- Gyoneva, Stefka
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 288
- Issue
- 21
- Pages
- 15291-15302
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3663549
- OpenAlex
- W2008810019
- Cited by
- 204
- References
- 64
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 27 · 2023: 21 · 2022: 20 · 2021: 10 · 2020: 19 · 2019: 25 · 2018: 17 · 2017: 8 · 2016: 14 · 2015: 14 · 2014: 5 · 2013: 2
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM008602)
- National Institute of Neurological Disorders and Stroke (F31NS076215, P50NS071669)
- National Institute of Environmental Health Sciences (5T32ES12870, T32ES012870)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- norepinephrine, microglia, microglial motility, adrenergic receptors, beta2-adrenergic receptor, alpha2A-adrenergic receptor, purinergic signaling, microglial activation, lipopolysaccharide, neuroinflammation, neurodegenerative diseases
- MeSH terms
- Adenosine Triphosphate, Adrenergic alpha-Agonists, Animals, Cell Movement, Cells, Cultured, Mice, Transgenic, Norepinephrine, Signal Transduction, Microglia, Receptors, Adrenergic, alpha-2, Receptors, Adrenergic, beta-2, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
