The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Open accessAbstract
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase). To examine the mechanism by which fatty acids mediate this effect, rats were infused with either a lipid emulsion (consisting mostly of 18:2 fatty acids) or glycerol. Intracellular C18:2 CoA increased in a time-dependent fashion, reaching an approximately 6-fold elevation by 5 h, whereas there was no change in the concentration of any other fatty acyl-CoAs. Diacylglycerol (DAG) also increased transiently after 3-4 h of lipid infusion. In contrast there was no increase in intracellular ceramide or triglyceride concentrations during the lipid infusion. Increases in intracellular C18:2 CoA and DAG concentration were associated with protein kinase C (PKC)-theta activation and a reduction in both insulin-stimulated IRS-1 tyrosine phosphorylation and IRS-1 associated PI3-kinase activity, which were associated with an increase in IRS-1 Ser(307) phosphorylation. These data support the hypothesis that an increase in plasma fatty acid concentration results in an increase in intracellular fatty acyl-CoA and DAG concentrations, which results in activation of PKC-theta leading to increased IRS-1 Ser(307) phosphorylation. This in turn leads to decreased IRS-1 tyrosine phosphorylation and decreased activation of IRS-1-associated PI3-kinase activity resulting in decreased insulin-stimulated glucose transport activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Lipid accumulation in skeletal muscle (7) or metabolic overload in mitochondria (8) have also been shown to occur with IR”
From TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle (2019) · cites this paper as [7]
In the citing paper
“Both acute (4 hours) and chronic (4 days) physiologic elevation of plasma FFA concentration in insulin sensitive individuals impairs insulin signaling and causes insulin resistance in skeletal muscle [28, 62–68].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [64]
In the citing paper
“It is well established that chronically elevated plasma FFA levels cause insulin resistance in skeletal muscle [1, 12, 14, 62–65].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [64]
In the citing paper
“Rodent and human studies have suggested increased serine phosphorylation of IRS-1 in insulin resistant states [111, 171–173].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [173]
In the citing paper
“GLUT4, the insulin regulatable transporter, is found in skeletal muscle, has a Km of approximately 5 mmol/L, which is close to that of the plasma glucose concentration, and is associated with HK-II [173, 174].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [173]
In the citing paper
“While increased levels of fatty acyl-CoA in general are associated with IR and in C18:2-CoA accumulation is a potential indicator of IR [115,117].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [117]
In the citing paper
“In particular, an overabundance of SFA (e.g., Palmitate) can induce IR through the accumulation of lipid derivatives including DAGs, ceramides and long chain acyl-CoAs in the cytosol, which in turn can interfere with IRS1-PKB signalling [113,114,115,116,117,118].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [117]
In the citing paper
“In contrast, decreasing fatty acid flux in humans via pharmacological inhibition of lipolysis (49) or by discontinuing a lipid-plus-heparin infusion in rats (58) decreases IMTG concentration and/or the accumulation of fatty acid intermediates.”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [58]
In the citing paper
“Accordingly, increasing fatty acid flux via a lipid-plus-heparin infusion in humans (23,46) or rodents (58) results in a corresponding increase in the concentration of IMTG and/or fatty acid intermediates.”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [58]
In the citing paper
“Adipose tissue in obese people is insulin resistant, which raises nonesterified fatty acid levels, worsening insulin resistance in muscle 29,33 and altering hepatic metabolism 31 ;”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [33]
In the citing paper
“This disconnection between intramyocellular triglyceride and peripheral insulin action confirms that intra myocellular triglyceride is only a crude marker for the active metabolite (putatively diacylglycerol) that causes fat-induced insulin resistance.38”
From Lipid-induced insulin resistance: unravelling the mechanism (2010) · cites this paper as [38]
In the citing paper
“Increased tissue lipid load, as with obesity, and/or sustained inactivity, may lead to the accumulation of fatty acyl coenzyme A (CoA), diacylglycerols, ceramides, products of incomplete oxidation, and ROS, all of which have been linked experimentally to reduced insulin signaling and action (96 -102).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [100]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Self-citationMechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Self-citationAguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487
Self-citationDresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311
Self-citationGriffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267
Self-citationKrssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264
Self-citationSkeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179
Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Laybutt, 1999, Am. J. Physiol., 277, E1070
Cited by
Sorted by citations
Items 501–600 of 1,002
Devries, M. C., Samjoo, I. A., Hamadeh, M. J., McCready, C., Raha, S., Watt, M. J., Steinberg, G. R., & Tarnopolsky, M. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2044 · Cited by 82
Fazakerley, D. J., van Gerwen, J., Cooke, K. C., Duan, X., Needham, E. J., Díaz‐Vegas, A., Madsen, S., Norris, D. M., Shun-Shion, A. S., Krycer, J. R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36549-2 · Cited by 83
Kim, D., Kim, J. R., Koh, M., Kim, Y. D., Lee, J.-M., Chanda, D., Park, S. B., Min, J., Lee, C., Park, T., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.250613 · Cited by 84
Self-citationMorrison, C. D., Huypens, P., Stewart, L. K., & Gettys, T. W. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.005 · Cited by 83
Persistent Organic Pollutants as Risk Factors for Obesity and Diabetes
Yang, C., Kong, A. P. S., Cai, Z., & Chung, A. C. K. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0966-0 · Cited by 81
Mansor, L. S., Fialho, M. D. L. S., Yea, G., Coumans, W. A., West, J. A., Kerr, M. J., Carr, C. A., Luiken, J. J. F. P., Glatz, J. F. C., Evans, R. D., et al. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx045 · Cited by 80
High Fat With High Sucrose Diet Leads to Obesity and Induces Myodegeneration
Rasool, S., Geetha, T., Broderick, T. L., & Babu, J. R. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01054 · Cited by 81
Time‐dependent effects of fatty acids on skeletal muscle metabolism
Hirabara, S. M., Silveira, L. R., Abdulkader, F., Carvalho, C. R. D. O., Procópio, J., & Curi, R. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20811 · Cited by 80
Jansen, P. L. M. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200411000-00001 · Cited by 80
Mullen, K. L., Smith, A. C., Junkin, K. A., & Dyck, D. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00545.2006 · Cited by 80
Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate
Ortega, Á., Berná, G., Rojas, A., Martín, F., & Soria, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061188 · Cited by 87
The Roles of Peroxisome Proliferator-Activated Receptors in the Metabolic Syndrome
Mansour, M. M. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00007-7 · Cited by 81
Cleasby, M. E., Dzamko, N. L., Hegarty, B. D., Cooney, G. J., Kraegen, E. W., & Ye, J. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3258 · Cited by 79
Self-citationGual, P., Gonzalez, T., Grémeaux, T., Barrès, R., MARCHAND‐BRUSTEL, Y. L., & Tanti, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212273200 · Cited by 78
Badin, P.-M., Vila, I. K., Louche, K., Mairal, A., Marqués, M.-A., Bourlier, V., Tavernier, G., Langin, D., & Moro, C. (2013) · Endocrinology · doi:10.1210/en.2012-2029 · Cited by 83
Reappraisal of Adipose Tissue Inflammation in Obesity
Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_10 · Cited by 86
Videla, L. A., & Pettinelli, P. (2012) · PPAR Research · doi:10.1155/2012/107434 · Cited by 79
Ringseis, R., Geßner, D. K., & Eder, K. (2014) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.12263 · Cited by 84
Kim, J., Yeh, D. C., Ver, M. R., Li, Y., Carranza, A., Conrads, T. P., Veenstra, T. D., Harrington, M. A., & Quon, M. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501439200 · Cited by 79
Self-citationSalman, Z. K., Refaat, R., Selima, E., Sarha, A. E., & Ismail, M. A. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.002 · Cited by 77
Feyter, H. M. D., Lenaers, E., Houten, S. M., Schrauwen, P., Hesselink, M. K. C., Wanders, R. J. A., Nicolay, K., & Prompers, J. J. (2008) · The FASEB Journal · doi:10.1096/fj.08-112318 · Cited by 79
Morino, K., Petersen, K. F., Sono, S., Choi, C. S., Samuel, V. T., Lin, A., Gallo, A. E., Zhao, H., Kashiwagi, A., Goldberg, I. J., et al. (2012) · Diabetes · doi:10.2337/db11-1391 · Cited by 77
Self-citationCardiomyocyte lipids impair β-adrenergic receptor function via PKC activation
Drosatos, K., Bharadwaj, K. G., Lymperopoulos, A., Ikeda, S., Khan, R. S., Hu, Y., Agarwal, R., Yu, S., Jiang, H., Steinberg, S. F., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00569.2010 · Cited by 77
Eicosapentaenoic acid restores tamoxifen sensitivity in breast cancer cells with high Akt activity
deGraffenried, L. A., Friedrichs, W. E., Fulcher, L. C., Fernandes, G., Silva-Fisher, J., Peralba, J.-M., & Hidalgo, M. M. (2003) · Annals of Oncology · doi:10.1093/annonc/mdg291 · Cited by 77
Vatner, D. F., Goedeke, L., Camporez, J. P., Lyu, K., Nasiri, A. R., Zhang, D., Bhanot, S., Murray, S. F., Still, C. D., Gerhard, G. S., et al. (2018) · Diabetologia · doi:10.1007/s00125-018-4579-1 · Cited by 75
Self-citationGoedeke, L., Perry, R. J., & Shulman, G. I. (2019) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104727 · Cited by 76
Self-citationSmall, L., Brandon, A. E., Turner, N., & Cooney, G. J. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00337.2017 · Cited by 72
Self-citationWang, H., Sun, R., Zeng, X., Zhou, X., Li, S., Jo, E., Molero, J. C., & Ye, J. (2014) · Endocrinology · doi:10.1210/en.2014-1454 · Cited by 79
Abulizi, A., CARDONE, R. L., Stark, R., Lewandowski, S. L., Zhao, X., Hillion, J., Ma, L., Sehgal, R., Alves, T. C., Thomas, C. J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.006 · Cited by 74
Concurrent diabetes and heart failure: interplay and novel therapeutic approaches
Karwi, Q. G., Ho, K. L., Pherwani, S., Ketema, E. B., Sun, Q., & Lopaschuk, G. D. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab120 · Cited by 80
Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors
Wang, K., Tanimoto, A., Yamada, S., Guo, X., Ding, Y., Watanabe, T., Watanabe, T., Kohno, K., Hirano, K., Tsukada, H., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091198 · Cited by 83
Jornayvaz, F. R., Lee, H., Jurczak, M. J., Alves, T. C., Guebre‐Egziabher, F., Guigni, B. A., Zhang, D., Samuel, V. T., Silva, J. E., & Shulman, G. I. (2011) · Endocrinology · doi:10.1210/en.2011-1793 · Cited by 76
Self-citationInvolvement of novel PKC isoforms in FFA induced defects in insulin signaling
Dey, D., Basu, D., Roy, S. S., Bandyopadhyay, A., & Bhattacharya, S. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.12.014 · Cited by 77
Park, E., Wong, V. S. C., Guan, X., Oprescu, A. I., & Giacca, A. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0005 · Cited by 74
Wensaas, A. J., Rustan, A. C., Just, M., Berge, R. K., Drevon, C. A., & Gaster, M. (2009) · Diabetes · doi:10.2337/db08-1043 · Cited by 73
Lee, H.-Y., Lee, J. S., Alves, T., Ladiges, W., Rabinovitch, P. S., Jurczak, M. J., Choi, C. S., Shulman, G. I., & Samuel, V. T. (2017) · Diabetes · doi:10.2337/db16-1334 · Cited by 66
Self-citationLipid-mediated muscle insulin resistance: different fat, different pathways?
Ritter, O., Jelenik, T., & Roden, M. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1310-2 · Cited by 74
Savikj, M., Stocks, B., Sato, S., Caidahl, K., Krook, A., Deshmukh, A. S., Zierath, J. R., & Wallberg‐Henriksson, H. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155268 · Cited by 77
Kim, J. K., Kim, H., Park, S., Cederberg, A., Westergren, R., Nilsson, D., Higashimori, T., Cho, Y.-R., Liu, Z., Dong, J., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1657 · Cited by 75
Self-citationLipid metabolism, exercise and insulin action
Bonen, A., Dohm, G. L., & van Loon, L. J. C. (2006) · Essays in Biochemistry · doi:10.1042/bse0420047 · Cited by 74
Chai, W., Zhang, X., Barrett, E. J., & Liu, Z. (2014) · Diabetes · doi:10.2337/db13-1597 · Cited by 73
Scioscia, M., Gumaa, K. A., Kunjara, S., Paine, M. A., Selvaggi, L. E., Rodeck, C. H., & Rademacher, T. W. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1965 · Cited by 73
IRS‐1 Regulation in Health and Disease
Schmitz‐Peiffer, C., & Whitehead, J. P. (2003) · IUBMB Life · doi:10.1080/1521654031000138569 · Cited by 78
Insulin-resistance and benign prostatic hyperplasia: The connection
Vikram, A., Jena, G., & Ramarao, P. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.05.042 · Cited by 73
Phua, W. W. T., Wong, M. X. Y., Liao, Z., & Tan, N. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051425 · Cited by 72
Spasticity may defend skeletal muscle size and composition after incomplete spinal cord injury
Gorgey, A. S., & Dudley, G. A. (2007) · Spinal Cord · doi:10.1038/sj.sc.3102087 · Cited by 72
Rossmeisl, M., Flachs, P., Brauner, P., Sponarova, J., Matejkova, O., Prazak, T., Ruzickova, J., Bardova, K., Kuda, O., & Kopecky, J. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802855 · Cited by 71
Insulin resistance metabolic stress and atherosclerosis
Wang, H. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s308 · Cited by 75
Leiria, L. O., Sollon, C. S., Calixto, M. C., Lintomen, L., Mónica, F. Z., Anhê, G. F., Nucci, G. D., Zanesco, A., Grant, A. D., & Antunes, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048507 · Cited by 71
Mitochondrial involvement in skeletal muscle insulin resistance: A case of imbalanced bioenergetics
Affourtit, C. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.07.008 · Cited by 67
Role of macrophages in the endocrine system
Rehman, A., Pacher, P., & Haskó, G. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.12.001 · Cited by 71
Minireview: Mitochondrial Energetics and Insulin Resistance
Civitarese, A. E., & Ravussin, E. (2008) · Endocrinology · doi:10.1210/en.2007-1444 · Cited by 70
Insulin Resistance, Obesity, and Lipotoxicity
Yazıcı, D., Demir, S. Ç., & Sezer, H. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_14 · Cited by 85
MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling
Ahn, B. Y., Soundarapandian, M. M., Sessions, H., Peddibhotla, S., Roth, G. P., Li, J., Sugarman, E. D., Koo, A., Malany, S., Wang, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87382 · Cited by 71
Zabielski, P., Hady, H. R., Chacińska, M., Roszczyc-Owsiejczuk, K., Górski, J., & Błachnio-Zabielska, A. U. (2018) · Scientific Reports · doi:10.1038/s41598-018-25397-6 · Cited by 70
Stewart, L. K., Wang, Z., Ribnicky, D., Soileau, J. L., Cefalu, W. T., & Gettys, T. W. (2009) · Diabetologia · doi:10.1007/s00125-008-1252-0 · Cited by 71
Bhatt, B. A., Dubé, J. J., Dedousis, N., Reider, J. A., & O'Doherty, R. M. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00097.2005 · Cited by 69
UFRGS-UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL
Saúde, B. D., & Pós-Graduação, P. R. D. (2009) · Cited by 68
Lipodystrophy: A paradigm for understanding the consequences of "overloading" adipose tissue
Lim, K., Haider, A., Adams, C., Sleigh, A., & Savage, D. B. (2020) · Physiological Reviews · doi:10.1152/physrev.00032.2020 · Cited by 71
Lipin — The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism
Khalil, M. B., Blais, A., Figeys, D., & Yao, Z. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.07.008 · Cited by 68
Cellular inflammatory responses: Novel insights for obesity and insulin resistance
Chen, H. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2006.03.003 · Cited by 68
Fat storage in pancreas and in insulin-sensitive tissues in pathogenesis of type 2 diabetes
Assimacopoulos‐Jeannet, F. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802857 · Cited by 68
XBP1s Is an Anti-lipogenic Protein
Herrema, H., Zhou, Y., Zhang, D., Lee, J., Hernández, M. A. S., Shulman, G. I., & Özcan, U. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.728949 · Cited by 67
Self-citationAlipourfard, I., Datukishvili, N., & Mikeladze, D. (2019) · Mediators of Inflammation · doi:10.1155/2019/3560819 · Cited by 70
Deshmukh, A. S., Cox, J., Jensen, L. J., Meissner, F., & Mann, M. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00720 · Cited by 68
Al‐Sulaiti, H., Diboun, I., Banu, S., Al-Emadi, M., Amani, P., Harvey, T. M., Dömling, A. S. S., Latiff, A. A., & Elrayess, M. A. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1548-x · Cited by 66
Liu, L., Shi, X., Choi, C. S., Shulman, G. I., Klaus, K., Nair, K. S., Schwartz, G. J., Zhang, Y., Goldberg, I. J., & Yu, Y.-H. (2009) · Diabetes · doi:10.2337/db08-1096 · Cited by 66
Self-citationEffect of hyperglycemia on mitochondrial respiration in type 2 diabetes.
Rabøl, R., Højberg, P. M. V., Almdal, T., Boushel, R., Haugaard, S. B., Madsbad, S., & Dela, F. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1475 · Cited by 66
Weigert, C., Kron, M., Kalbacher, H., Pohl, A. K., Runge, H., Häring, H., Schleicher, E. D., & Lehmann, R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0102 · Cited by 68
Błachnio-Zabielska, A. U., Baranowski, M., Zabielski, P., & Górski, J. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22283 · Cited by 66
Boudina, S., Sena, S., Sloan, C., Tebbi, A., Han, Y. H., O'Neill, B. T., Cooksey, R. C., Jones, D., Holland, W. L., McClain, D. A., et al. (2012) · Endocrinology · doi:10.1210/en.2011-2147 · Cited by 67
Innate immune mechanisms linking non-esterified fatty acids and respiratory disease
Wood, L. G., Scott, H. A., Garg, M. L., & Gibson, P. G. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.10.001 · Cited by 67
Jessen, N., Djurhuus, C., Jørgensen, J. O. L., Jensen, L. S., Møller, N., Lund, S. A., & Schmitz, O. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00149.2004 · Cited by 66
Gao, Z., Wang, Z., Zhang, X., Butler, A. A., Zuberi, A. R., Gawrońska‐Kozak, B., Lefevre, M., York, D., Ravussin, É., Berthoud, H., et al. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00178.2006 · Cited by 66
Mechanism by which arylamine N -acetyltransferase 1 ablation causes insulin resistance in mice
Camporez, J. P., Wang, Y., Faarkrog, K., Chukijrungroat, N., Petersen, K. F., & Shulman, G. I. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716990115 · Cited by 67
Self-citationYap, K. H., Gan, S. Y., Candasamy, M., Tan, S. C., Md, S., Majeed, A. B. A., & Bhattamisra, S. K. (2020) · Biomolecules · doi:10.3390/biom10101360 · Cited by 66
Yin, X., Zheng, Y., Zhai, X.-J., Zhao, X., & Cai, L. F. (2011) · Experimental Diabetes Research · doi:10.1155/2012/198048 · Cited by 63
Escarcega, R. O., García‐Carrasco, M., Fuentes-Alexandro, S. A., Jara, L. J., Rojas-Rodríguez, J., Escobar-Linares, L. E., & Cervera, R. (2006) · Autoimmunity Reviews · doi:10.1016/j.autrev.2006.07.001 · Cited by 65
Diet, obesity and diabetes: a current update
Walker, C. G., Zariwala, M. G., Holness, M. J., & Sugden, M. C. (2006) · Clinical Science · doi:10.1042/cs20060150 · Cited by 62
Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis
Perry, R. J., Peng, L., Abulizi, A., Kennedy, L., Cline, G. W., & Shulman, G. I. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88477 · Cited by 68
Self-citationLipotoxicity: the obese and endurance-trained paradox
Russell, A. P. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802859 · Cited by 64
Induction of heat shock proteins may combat insulin resistance
McCarty, M. F. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2004.08.033 · Cited by 65
PPARs and the orchestration of metabolic fuel selection
Sugden, M. C., Zariwala, M. G., & Holness, M. J. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.03.014 · Cited by 64
Macronutrient Determinants of Obesity, Insulin Resistance and Metabolic Health
Wali, J. A., Solon‐Biet, S. M., Freire, T., & Brandon, A. E. (2021) · Biology · doi:10.3390/biology10040336 · Cited by 74
Hénin, G., Loumaye, A., Leclercq, I. A., & Lanthier, N. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100963 · Cited by 73
Serra, C., Federici, M., Buongiorno, A. M., Senni, M., Morelli, S., Segratella, E., Pascuccio, M., Tiveron, C., Mattei, E., Tatangelo, L., et al. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10278 · Cited by 62
Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance
Cree‐Green, M., Aarsland, A. A., Herndon, D. N., & Wolfe, R. R. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000278066.05354.53 · Cited by 63
Yi, Z., Langlais, P. R., Filippis, E. A. D., Luo, M., Flynn, C. R., Schroeder, S., Weintraub, S. T., Mapes, R., & Mandarino, L. J. (2007) · Diabetes · doi:10.2337/db06-1355 · Cited by 65
Cho, Y.-R., Kim, H., Park, S., Ko, H. J., Hong, E., Higashimori, T., Zhang, Z., Jung, D. Y., Ola, M. S., LaNoue, K. F., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00376.2006 · Cited by 63
Self-citationExercise-Induced Alterations in Muscle Lipid Metabolism Improve Insulin Sensitivity
Horowitz, J. F. (2007) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e318156e084 · Cited by 68
Ceramides and diabetes mellitus: an update on the potential molecular relationships
Yaribeygi, H., Bo, S., Ruscica, M., & Sahebkar, A. (2019) · Diabetic Medicine · doi:10.1111/dme.13943 · Cited by 63
Wendel, A. A., Li, L. O., Li, Y., Cline, G. W., Shulman, G. I., & Coleman, R. A. (2010) · Diabetes · doi:10.2337/db09-1380 · Cited by 63
Self-citationSharma, S. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113528 · Cited by 70
Luo, M., Langlais, P. R., Yi, Z., Lefort, N., Filippis, E. A. D., Hwang, H., Christ-Roberts, C. Y., & Mandarino, L. J. (2007) · Endocrinology · doi:10.1210/en.2007-0049 · Cited by 63
Dey, D., Mukherjee, M., Basu, D., Datta, M., Roy, S. S., Bandyopadhyay, A., & Bhattacharya, S. (2005) · Cellular Physiology and Biochemistry · doi:10.1159/000089847 · Cited by 63
Whole food approach for type 2 diabetes prevention
Xi, P., & Liu, R. H. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500963 · Cited by 63
Glycosphingolipids and Insulin Resistance
Aerts, J. M. F. G., Boot, R. G., van Eijk, M., Groener, J. E. M., Bijl, N., Lombardo, E., Biétrix, F., Dekker, N., Groen, A. K., Ottenhoff, R., et al. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0650-1_7 · Cited by 63
Jani, S., Eira, D. D., Hadday, I., Bikopoulos, G. J., Mohasses, A., Pinho, R. A., & Ceddia, R. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-98819-7 · Cited by 63
Mottillo, E. P., & Granneman, J. G. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2011 · Cited by 61
Lanner, J. T., Bruton, J. D., Assefaw‐Redda, Y., Andronache, Z., Zhang, S., Severa, D., Zhang, Z., Melzer, W., Zhang, S., Katz, A., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-116814 · Cited by 62
Metadata
- Authors
- Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., Atcheson, B., White, M. F., Kraegen, E. W., & Shulman, G. I.
- Affiliations
- Howard Hughes Medical Institute (US)
- National Institutes of Health (US)
- Garvan Institute of Medical Research (AU)
- Joslin Diabetes Center (US)
- Corresponding author
- Shulman, Gerald I.
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 277
- Issue
- 52
- Pages
- 50230-50236
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2130850001
- Cited by
- 1,561
- References
- 21
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 36 · 2023: 27 · 2022: 26 · 2021: 47 · 2020: 55 · 2019: 52 · 2018: 56 · 2017: 71 · 2016: 65 · 2015: 65 · 2014: 77 · 2013: 97 · 2012: 101
- FWCI
- 22.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P30 DK, DK-45735)
- Medical Research Council
- National Health and Medical Research Council
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK45735, R01-DK40936, R01DK040936, P30DK045735)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- fatty acids, insulin resistance, skeletal muscle, IRS-1, phosphatidylinositol 3-kinase, protein kinase C theta, diacylglycerol, fatty acyl-CoA, IRS-1 serine phosphorylation, IRS-1 tyrosine phosphorylation, glucose transport, lipid emulsions
- MeSH terms
- Animals, Diglycerides, Fat Emulsions, Intravenous, Fatty Acids, Nonesterified, Insulin, Kinetics, Male, Phosphoproteins, Phosphorylation, Rats, Wistar, Muscle, Skeletal, Phosphotyrosine, Phosphatidylinositol 3-Kinases, Rats, Insulin Receptor Substrate Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
